MX381183B - Proteínas de fusión de serpina-fc de inmunoglobulina de humano y método de purificación de las mismas. - Google Patents

Proteínas de fusión de serpina-fc de inmunoglobulina de humano y método de purificación de las mismas.

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Publication number
MX381183B
MX381183B MX2018006710A MX2018006710A MX381183B MX 381183 B MX381183 B MX 381183B MX 2018006710 A MX2018006710 A MX 2018006710A MX 2018006710 A MX2018006710 A MX 2018006710A MX 381183 B MX381183 B MX 381183B
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Mexico
Prior art keywords
polypeptide
serpin
derived
fusion proteins
purification
Prior art date
Application number
MX2018006710A
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English (en)
Inventor
Quinn Deveraux
Brendan P Eckelman
Grant B Guenther
Peter L Nguy
John C Timmer
Original Assignee
Inhibrx Inc
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Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of MX381183B publication Critical patent/MX381183B/es

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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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    • C07K14/8125—Alpha-1-antitrypsin
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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Abstract

La presente invención se refiere a un método para purificar una proteína de fusión y prevenir la oligomerización de AAT en la proteína de fusión, el método caracterizado porque comprende los pasos de; (a) cultivar una célula que comprende un constructo de ácido nucleico que codifica la proteína de fusión bajo condiciones que permiten la expresión de la proteína de fusión, en donde la proteína de fusión comprende por lo menos un polipéptido de serpina de humano que comprende un polipéptido de alfa-1 antitripsina (AAT) enlazado operablemente a un polipéptido de Fc de inmunoglobulina de humano, en donde el polipéptido de ATT comprende una secuencia de aminoácidos seleccionada del grupo que consiste de SEQ ID NO: 2, 34 y 35 o un bucle de sitio reactivo de AAT que comprende la secuencia de aminoácidos de SEQ ID NO: 1, 32, 033; (b) poner un sobrenadante de la célula con una resina de afinidad bajo condiciones que permiten la unión entre la resina de afinidad y la proteína de fusión, en donde la resina de afinidad comprende proteína A; y (c) eluir la proteína de fusión de la resina de afinidad usando un regulador de pH condiciones que permiten el desprendimiento de la proteína de fusión de la resina de afinidad y previenen la oligomerización de ATT en la proteína de fusión, en donde el regulador de p H está en pH casi neutro, en donde la proteína de fusión purificada inhibe la actividad de la elastasa de los nuetrófilos (NE).
MX2018006710A 2011-06-28 2012-06-28 Proteínas de fusión de serpina-fc de inmunoglobulina de humano y método de purificación de las mismas. MX381183B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161502055P 2011-06-28 2011-06-28
US201161570394P 2011-12-14 2011-12-14
US201161577204P 2011-12-19 2011-12-19
US201261638168P 2012-04-25 2012-04-25
PCT/US2012/044730 WO2013003641A2 (en) 2011-06-28 2012-06-28 Serpin fusion polypeptides and methods of use thereof

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MX381183B true MX381183B (es) 2025-03-12

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MX2018006710A MX381183B (es) 2011-06-28 2012-06-28 Proteínas de fusión de serpina-fc de inmunoglobulina de humano y método de purificación de las mismas.
MX2013015323A MX356517B (es) 2011-06-28 2012-06-28 Polipéptidos de fusión de serpina y métodos de uso de los mismos.

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MX2013015323A MX356517B (es) 2011-06-28 2012-06-28 Polipéptidos de fusión de serpina y métodos de uso de los mismos.

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EP (2) EP3569243A1 (es)
JP (5) JP2014523900A (es)
KR (6) KR20220003656A (es)
CN (3) CN110066340B (es)
AU (4) AU2012275287B2 (es)
BR (1) BR112013033799A2 (es)
CA (2) CA3132298A1 (es)
CY (1) CY1122195T1 (es)
DK (1) DK2726092T3 (es)
ES (1) ES2746052T3 (es)
HR (1) HRP20191652T1 (es)
HU (1) HUE046156T2 (es)
IL (3) IL312872A (es)
IN (1) IN2013MN02441A (es)
LT (1) LT2726092T (es)
ME (1) ME03473B (es)
MX (2) MX381183B (es)
NZ (1) NZ744257A (es)
PL (1) PL2726092T3 (es)
PT (1) PT2726092T (es)
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US10400029B2 (en) * 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
IL312872A (en) * 2011-06-28 2024-07-01 Inhibrx Inc Methods for purifying fusion proteins containing serphin
AU2013202648B2 (en) * 2012-01-10 2016-05-19 Konkuk University Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2013156054A1 (en) 2012-04-16 2013-10-24 Universität Stuttgart The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity
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EP3042201B1 (en) * 2014-07-23 2020-03-04 Inova Diagnostics, Inc. Compositions and methods for the diagnosis of rheumatoid arthritis
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