MX378183B - Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares. - Google Patents

Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares.

Info

Publication number
MX378183B
MX378183B MX2014013910A MX2014013910A MX378183B MX 378183 B MX378183 B MX 378183B MX 2014013910 A MX2014013910 A MX 2014013910A MX 2014013910 A MX2014013910 A MX 2014013910A MX 378183 B MX378183 B MX 378183B
Authority
MX
Mexico
Prior art keywords
compositions
hpps
high penetration
render
treatment
Prior art date
Application number
MX2014013910A
Other languages
English (en)
Spanish (es)
Other versions
MX2014013910A (es
Inventor
Chongxi Yu
Lina Xu
Original Assignee
Techfields Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techfields Pharma Co Ltd filed Critical Techfields Pharma Co Ltd
Publication of MX2014013910A publication Critical patent/MX2014013910A/es
Publication of MX378183B publication Critical patent/MX378183B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/18—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
    • G05B19/409—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using manual data input [MDI] or by using control panel, e.g. controlling functions with the panel; characterised by control panel details or by setting parameters
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/33—Director till display
    • G05B2219/33192—Radio link, wireless

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Human Computer Interaction (AREA)
  • Manufacturing & Machinery (AREA)
  • Pain & Pain Management (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
MX2014013910A 2012-01-18 2013-03-15 Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares. MX378183B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210151555 2012-01-18
PCT/CN2013/072693 WO2013170655A1 (en) 2012-01-18 2013-03-15 High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions

Publications (2)

Publication Number Publication Date
MX2014013910A MX2014013910A (es) 2015-06-04
MX378183B true MX378183B (es) 2025-03-10

Family

ID=49583088

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013910A MX378183B (es) 2012-01-18 2013-03-15 Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares.

Country Status (17)

Country Link
US (4) US11857545B2 (OSRAM)
EP (2) EP4356912A3 (OSRAM)
JP (2) JP6445967B2 (OSRAM)
KR (6) KR102232625B1 (OSRAM)
CN (4) CN116898848A (OSRAM)
AU (2) AU2013262320B2 (OSRAM)
BR (1) BR112014028643A8 (OSRAM)
CA (2) CA2872121C (OSRAM)
ES (1) ES2969344T3 (OSRAM)
HK (1) HK1207562A1 (OSRAM)
IN (1) IN2014KN02583A (OSRAM)
MX (1) MX378183B (OSRAM)
PL (1) PL2849738T3 (OSRAM)
RU (1) RU2683934C2 (OSRAM)
TW (1) TWI658836B (OSRAM)
WO (1) WO2013170655A1 (OSRAM)
ZA (1) ZA201407777B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3104853T3 (pl) 2014-02-10 2020-05-18 Respivant Sciences Gmbh Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych
HUE049323T2 (hu) 2014-02-10 2020-09-28 Respivant Sciences Gmbh Hízósejt-stabilizálók tüdõbetegség kezelésére
NO2723977T3 (OSRAM) * 2014-03-19 2018-03-10
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
EP3331522A1 (en) 2015-08-07 2018-06-13 Patara Pharma LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2018044942A1 (en) 2016-08-31 2018-03-08 Patara Pharma, LLC Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
CA3037746A1 (en) 2016-10-07 2018-04-12 Respivant Sciences Gmbh Cromolyn compositions for treatment of pulmonary fibrosis
JP7311902B2 (ja) * 2018-05-10 2023-07-20 慶應義塾 前立腺がんの予防又は治療剤
LT3678705T (lt) 2018-09-14 2023-08-10 Enlitisa (Shanghai) Pharmaceutical Co., Ltd. Montelukasto ir peptidų konjugatai
WO2021175250A1 (en) * 2020-03-03 2021-09-10 Aptorum Therapeutics Limited Compounds and methods for treating diseases and/or conditions caused by coronavirus
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN113933401B (zh) * 2020-06-29 2023-07-21 重庆华邦制药有限公司 分离检测阿伐斯汀中间体z3中基因毒性杂质的方法
CN114409673B (zh) * 2022-01-04 2023-08-08 广东克冠达医药科技有限公司 一种吗啡喃类化合物及其制备方法与应用
AU2023207742A1 (en) * 2022-01-17 2024-08-29 Techfields Inc. Treatment of signs, symptoms and/or complications of viral, bacterial, protozoal, and/or fungal infections by high penetration prodrugs

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB100208A (en) 1915-03-24 1917-03-01 Isidore Swientoslawsk Morrison Improvements in Watch Movements.
US2694061A (en) 1949-07-07 1954-11-09 Leo Pharm Prod Ltd Method of producing aminoalcohol esters of penicillin
US2694031A (en) 1949-07-07 1954-11-09 Leo Pharm Prod Ltd Hydroiodides of amino esters of penicillin and oil composition thereof
US2694063A (en) 1949-07-07 1954-11-09 Leo Pharm Prod Ltd Quaternary ammonium addition salts of penicillin esters
US2671805A (en) 1952-07-02 1954-03-09 Searle & Co Basically substituted o-arylamino-benzamides
GB759603A (en) 1952-07-10 1956-10-24 Yvan Villax Method for the production of esters of penicillin
GB768347A (en) 1953-02-06 1957-02-13 Knud Abildgaard Sulphanilate salts of amino alcohol esters of penicillin
GB984471A (en) 1961-01-12 1965-02-24 Parke Davis & Co Anthranilic acid esters and methods for producing the same
CH399486A (fr) 1962-10-02 1965-09-30 Biosedra Lab Procédé de préparation de nouvelles salicylamides
US3365483A (en) 1963-06-05 1968-01-23 Starogardzkie Zakl Farma Process for obtaining diethylaminoethanol acetylsalicylate hydrochloride
US3420871A (en) 1964-09-01 1969-01-07 Parke Davis & Co Anthranilic acid esters
FR5342M (OSRAM) 1966-03-08 1967-09-04
DK121236B (da) 1967-07-03 1971-09-27 Gea As Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf.
GB1187259A (en) 1967-10-23 1970-04-08 Hexachimie New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture
US3956363A (en) 1969-08-08 1976-05-11 Merck & Co., Inc. Substituted indenyl acetic acids
US3957764A (en) 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
CA996929A (en) 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
GB1335317A (en) 1971-06-23 1973-10-24 Leo Pharm Prod Ltd Cephalosporin esters salts thereof and methods for their pre paration
US3966923A (en) 1972-06-05 1976-06-29 Pierre Fabre S.A. Medicaments intended for the prevention and treatment of ischemic disturbances
US4006181A (en) 1972-07-27 1977-02-01 Pierre Fabre S.A. Process for the obtaining of esters of acetylsalicylic acid and amino alcohols
US3914811A (en) 1972-07-31 1975-10-28 Jonathan Francis Lightweight, compact air mattress with improved casing and inflatable members
ES428213A1 (es) 1974-07-12 1976-07-16 Andreu Sa Dr Procedimiento para la obtencion de esteres dialquilaminoal-quilicos de penicilina.
US4012508A (en) 1975-02-03 1977-03-15 Burton Verna M Topical composition and method
FR2348701A1 (fr) 1976-04-22 1977-11-18 Hexachimie Nouveau derive du p-acetamidophenol,sa preparation et son utilisation en therapeutique
US4150157A (en) 1976-06-11 1979-04-17 Beecham Group Limited Penicillin compositions
US4215120A (en) 1977-07-14 1980-07-29 Beecham Group Limited Penicillin esters and their preparation
AU518216B2 (en) 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
US4206220A (en) 1978-07-13 1980-06-03 Interx Research Corporation Prodrugs for the improved delivery of non-steroidal anti-inflammatory agents
US4244948A (en) 1979-05-07 1981-01-13 Allergan Pharmaceuticals, Inc. Medical use of esters of acetylsalicylic acid to treat acne
IN153407B (OSRAM) 1979-09-28 1984-07-14 Ciba Geigy Ag
DE3023206A1 (de) 1979-11-02 1982-01-14 Efeka Friedrich & Kaufmann GmbH & Co KG, 3000 Hannover Indometacin-ester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS57183738A (en) 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
JPS5852291A (ja) 1981-09-22 1983-03-28 Kureha Chem Ind Co Ltd ペニシリン系抗生物質誘導体とその医薬剤
FR2542998B1 (fr) 1983-03-24 1986-01-31 Rhone Poulenc Sante Nouvelle forme transdermale du dinitrate d'isosorbide
US4640689A (en) 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
DE3347128A1 (de) 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0152379A3 (de) 1984-02-15 1986-10-29 Ciba-Geigy Ag Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
GB2157284B (en) 1984-04-11 1987-11-04 Leo Pharm Prod Ltd 6-b-halopenicillanic acid salts
GB8511988D0 (en) 1985-05-11 1985-06-19 Beecham Group Plc Compounds
US4822773A (en) 1985-06-28 1989-04-18 Merck & Co., Inc. Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts
IT1213579B (it) 1986-07-03 1989-12-20 Angelo Signor Marino Nicolini Flogistica. esteri di salsalato con guaiacolo atti al trattamento di broncopneumapatie a base
AU1508988A (en) 1987-04-27 1988-10-27 Syntex Pharmaceuticals International Ltd. Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
US5321020A (en) 1989-03-28 1994-06-14 Pfizer Inc. Antibacterial 2-carbapenem derivatives
JP2672363B2 (ja) 1989-03-29 1997-11-05 帝人株式会社 有機非線形光学材料
US5760261A (en) 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US5109011A (en) 1990-07-30 1992-04-28 Hoechst-Roussel Pharmaceuticals Incorporated P-acylaminophenoxycarbamates and derivatives
WO1993007902A1 (en) 1991-10-16 1993-04-29 Richardson-Vicks, Inc. Enhanced skin penetration system for improved topical delivery of drugs
HRP921157A2 (en) 1991-12-20 1994-10-31 Lohmann Therapie Syst Lts Transdermal system of applying acetilsalicilyc acid in antithrombosys therapy
US5629019A (en) 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
US5190953A (en) 1992-03-26 1993-03-02 A. H. Robins Company, Incorporated Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
US5300512A (en) 1992-06-24 1994-04-05 G. D. Searle & Co. Benzimidazole compounds
US5554627A (en) 1992-10-30 1996-09-10 Merck, Sharp & Dohme Ltd. Tachykinin antagonists
US5399562A (en) 1994-02-04 1995-03-21 G. D. Searle & Co. Indolones useful as serotonergic agents
GB9404756D0 (en) 1994-03-11 1994-04-27 Knx Limited Data output control
WO1995034813A1 (en) 1994-06-14 1995-12-21 Smithkline Beecham Corporation Resins for solid state synthesis
US5626838A (en) 1995-03-13 1997-05-06 The Procter & Gamble Company Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
US5654337A (en) 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
AUPN531195A0 (en) 1995-09-11 1995-10-05 J.W. Broadbent Nominees Pty. Ltd. Lipid extract having anti-inflamatory activity
US5570559A (en) 1995-09-26 1996-11-05 Lewis; Thomas D. Fall arrestor
US5929086A (en) 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
ATE229805T1 (de) 1996-05-10 2003-01-15 Upjohn Co Topische verabreichung von premafloxacin zur behandlung von systemischen bakteriellen erkrankungen
IT1282736B1 (it) 1996-05-21 1998-03-31 Angelini Ricerche Spa Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative
KR100213465B1 (ko) 1996-11-01 1999-08-02 최좌진 케토프로펜 패취 조성물
US6011049A (en) 1997-02-19 2000-01-04 Warner-Lambert Company Combinations for diabetes
DE69832695T2 (de) 1997-03-10 2006-09-14 Loma Linda University Medical Center, Loma Linda Verwendung von r-enantiomeren nichtsteroidaler entzündungshemmer zur vorbeugung der alzheimerschen krankheit
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
US5885597A (en) 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain
EE04089B1 (et) 1998-01-29 2003-08-15 Bristol-Myers Squibb Company 1,3,4-oksadiasolooni derivaadid
ATE399565T1 (de) 1998-07-07 2008-07-15 Transdermal Technologies Inc Zusammensetzungen für die schnelle und nicht- irritierende transdermale verabreichung von pharmazeutika and verfahren zur formuliering davon und ihren verabreichung
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
SE9900941D0 (sv) 1998-12-23 1999-03-16 Nomet Management Serv Bv Novel retinoic acid derivatives and their use
AU4841700A (en) 1999-05-12 2000-11-21 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
US6368618B1 (en) 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
AU3104301A (en) 2000-01-20 2001-07-31 Noven Pharmaceuticals, Inc. Compositions and methods to effect the release profile in the transdermal administration of active agents
US6429223B1 (en) 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
DE10034802A1 (de) 2000-07-18 2002-01-31 Bayer Ag Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren
US6416772B1 (en) 2001-01-12 2002-07-09 H. Wayne Van Engelen Topical dermal anaesthetic
US6528040B1 (en) 2001-01-18 2003-03-04 Maurine Pearson EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic
ITMI20010395A1 (it) 2001-02-27 2002-08-27 Dompe Spa Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
WO2003022270A1 (en) 2001-09-13 2003-03-20 Noven Pharmaceuticals, Inc. Transdermal administration of an enalapril ester
AU2002347906A2 (en) 2001-10-16 2003-04-28 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20030143165A1 (en) 2002-01-25 2003-07-31 Allan Evans NSAID-containing topical formulations that demonstrate chemopreventive activity
ITMI20021399A1 (it) 2002-06-25 2003-12-29 Nicox Sa Inibitori della cicloossigenasi 2
HK1080447B (zh) 2002-07-23 2008-10-31 Ardenia Investments, Ltd. 视黄醇衍生物、它们在治疗癌症和增强其它细胞毒性剂功效中的应用
RU2332425C2 (ru) * 2002-09-06 2008-08-27 Инсёрт Терапьютикс, Инк. Полимеры на основе циклодекстрина для доставки терапевтических средств
ES2377318T3 (es) 2002-09-06 2012-03-26 Cerulean Pharma Inc. Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
MXPA05009595A (es) 2003-03-12 2005-11-04 Celgene Corp Compuestos 7-amino-isoindolilo y sus usos farmaceuticos.
US7052715B2 (en) 2003-04-11 2006-05-30 All Natural Fmg, Inc. Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof
BRPI0411347A (pt) 2003-06-10 2006-07-11 Pfizer combinações terapêuticas compreendendo inibidores de pde e antagonistas dos receptores de vasopressina para o tratamanento de dismenorréia
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
WO2005046575A2 (en) 2003-07-29 2005-05-26 Signature R & D Holdings, Lcc Amino acid prodrugs
DE10335726A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Verwendung von Hydroxyaromaten als Safener
WO2005030331A1 (en) 2003-09-26 2005-04-07 Fairfield Clinical Trials, Llc Combination antihistamine medication
US7186744B2 (en) 2003-11-13 2007-03-06 Allergan, Inc. Prostamides for the treatment of glaucoma and related diseases
CA2562219A1 (en) 2004-04-05 2005-10-20 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising a carbinol combined to at least an nsaid
DE102004025324A1 (de) 2004-05-19 2005-12-08 Boehringer Ingelheim Vetmedica Gmbh Flüssige Zubereitung für die Veterinärmedizin, Verfahren zu deren Herstellung und deren Verwendung
TWI276687B (en) 2004-06-30 2007-03-21 Univ Nat Cheng Kung Method for kinetic resolution of alpha-substituted acids and esters thereof by using papaya lipases
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
EP1863450A1 (en) 2005-03-16 2007-12-12 Elan Pharma International Limited Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations
US20060222692A1 (en) 2005-03-31 2006-10-05 Fairfield Clinical Trials Llc Method and compositions for transdermal administration of antimicrobial medications
CA2608890C (en) 2005-05-20 2011-08-02 Alantos-Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
CN100500149C (zh) * 2005-06-22 2009-06-17 晟德大药厂股份有限公司 白三烯素拮抗剂口服液组成
WO2008010025A1 (en) 2006-07-18 2008-01-24 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
EP2610242A1 (en) 2006-07-09 2013-07-03 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aspirin
EP2756843A3 (en) 2006-07-25 2014-08-20 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of diclofenac with very fast skin penetration rate
CN101500983B (zh) 2006-07-26 2015-09-16 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性二氟尼柳及相关化合物的前药
ES2559781T3 (es) * 2006-08-08 2016-02-15 Techfields Biochem Co. Ltd Profármacos de ácidos aril- y heteroarilacéticos solubles en agua y con carga positiva con una tasa de penetración en piel muy rápida
US8458932B2 (en) 2006-08-11 2013-06-11 Alameda Technology, Llc Optical illusion device
EP2054384A4 (en) 2006-08-15 2010-11-03 Techfields Biochem Co Ltd POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF ARYL AND HETEROARYLPROPIONIC ACIDS WITH A VERY FAST SKIN PUNCHING RATE
JP5183478B2 (ja) 2006-08-31 2013-04-17 ナノキャリア株式会社 活性成分内包ポリマーミセル含有経皮組成物、経皮医薬品組成物および経皮化粧品組成物
CN101506168B (zh) * 2006-09-03 2014-12-10 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的芳基邻氨基苯甲酸的前药
PL2061749T3 (pl) 2006-09-03 2018-11-30 Techfields Biochem Co. Ltd Dodatnio naładowane, rozpuszczalne w wodzie proleki acetaminofenu i związków pokrewnych o bardzo dużej szybkości przenikania przez skórę
ES2466346T3 (es) 2006-10-02 2014-06-10 Techfields Biochem Co. Ltd Profármacos de prostaglandinas solubles en agua con carga positiva y compuestos relacionados con índices de penetración en la piel muy altos
EP2077991B1 (en) 2006-10-03 2014-02-26 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates
CN101522692A (zh) 2006-10-11 2009-09-02 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
CN101547898B (zh) * 2006-12-10 2014-09-24 于崇曦 β-内酰胺类抗生素的透皮给药系统
PL2115140T3 (pl) * 2007-01-31 2017-03-31 Yu Dodatnio naładowane rozpuszczalne w wodzie proleki 1H-imidazo[4,5-c]chinolino-4-amin i powiązane związki o bardzo wysokich wskaźnikach penetracji przez skórę
US7781580B2 (en) * 2007-04-23 2010-08-24 Virginia Commonwealth University Stilbene derivatives as new cancer therapeutic agents
MX2009013136A (es) * 2007-06-04 2010-04-30 Techfields Inc Profarmacos de nsaias con piel y membranas con indices de penetracion muy altos y nuevos usos medicinales.
WO2009037584A2 (en) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009122187A2 (en) * 2008-04-03 2009-10-08 Cipla Limited Pharmaceutical composition
BR122021011394B1 (pt) * 2008-12-04 2021-09-28 Chongxi Yu Composição de alta penetração de um fármaco principal, e uso de uma hpc
US8084896B2 (en) 2008-12-31 2011-12-27 Electro Scientific Industries, Inc. Monolithic stage positioning system and method
KR20180110187A (ko) * 2009-05-08 2018-10-08 테크필즈 바이오켐 코., 엘티디. 펩티드 및 펩티드­관련 화합물의 고침투성 전구약물 조성물
MX338552B (es) * 2009-06-10 2016-04-20 Techfields Biochem Co Ltd Composiciones o pro-farmacos de alta penetracion de compuestos antimicrobianos o relacionados a los antimicrobianos.
TWI496577B (zh) * 2010-06-10 2015-08-21 Shanghai Techfields Biochem Co Ltd 抗菌劑和抗菌劑相關化合物的高滲透性前藥組合物
EP2407161A1 (en) * 2010-07-13 2012-01-18 Sanofi An antitumoral combination comprising ombrabulin and bevacizumab

Also Published As

Publication number Publication date
WO2013170655A1 (en) 2013-11-21
AU2018203612A1 (en) 2018-06-14
AU2013262320B2 (en) 2018-02-22
US20240115562A1 (en) 2024-04-11
KR102309973B1 (ko) 2021-10-06
CN107929743A (zh) 2018-04-20
KR102332837B1 (ko) 2021-12-01
RU2014150779A (ru) 2016-07-10
US11857545B2 (en) 2024-01-02
EP2849738B1 (en) 2023-12-06
US20190142818A1 (en) 2019-05-16
US20240226084A9 (en) 2024-07-11
MX2014013910A (es) 2015-06-04
CN107929743B (zh) 2023-09-01
ES2969344T3 (es) 2024-05-17
US20240131017A1 (en) 2024-04-25
EP2849738C0 (en) 2023-12-06
KR102232625B1 (ko) 2021-03-25
PL2849738T3 (pl) 2024-05-13
CA3189252A1 (en) 2013-11-21
EP4356912A3 (en) 2024-10-30
JP2019069948A (ja) 2019-05-09
HK1207562A1 (en) 2016-02-05
TWI658836B (zh) 2019-05-11
US11813256B2 (en) 2023-11-14
KR102443057B1 (ko) 2022-09-14
IN2014KN02583A (OSRAM) 2015-05-08
AU2013262320A1 (en) 2014-11-13
ZA201407777B (en) 2020-01-29
HK1254324A1 (zh) 2019-07-19
JP6445967B2 (ja) 2018-12-26
CA2872121A1 (en) 2013-11-21
HK1208633A1 (en) 2016-03-11
KR20200039029A (ko) 2020-04-14
CA2872121C (en) 2023-02-14
TW201402148A (zh) 2014-01-16
JP7235487B2 (ja) 2023-03-08
CN104540504A (zh) 2015-04-22
JP2015516444A (ja) 2015-06-11
CN116898848A (zh) 2023-10-20
KR20210034109A (ko) 2021-03-29
KR20240145521A (ko) 2024-10-07
US20150072961A1 (en) 2015-03-12
BR112014028643A8 (pt) 2021-11-03
CN111012914A (zh) 2020-04-17
EP4356912A2 (en) 2024-04-24
KR20220130239A (ko) 2022-09-26
EP2849738A1 (en) 2015-03-25
BR112014028643A2 (pt) 2021-08-03
RU2683934C2 (ru) 2019-04-03
KR20210148394A (ko) 2021-12-07
EP2849738A4 (en) 2016-03-30
KR20150020301A (ko) 2015-02-25

Similar Documents

Publication Publication Date Title
MX378183B (es) Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares.
MX386251B (es) Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson.
CY1120832T1 (el) Τροποποιητες πυρηνικης μεταφορας και χρησεις αυτων
CY1121150T1 (el) Νευροδραστικα 19-αλκοξυ-17-υποκατεστημενα στεροειδη, χρησιμα σε μεθοδους θεραπειας
MX379054B (es) Composiciones de alta penetracion y sus aplicaciones.
CY1119490T1 (el) Παραγωγα πυραζολοπυρρολιδινης και η χρηση τους στην θεραπεια νοσηματων
UA117103C2 (uk) Сполука, яка має активність агоніста глюкагону
MX2021008113A (es) Composiciones farmaceuticas que comprenden un antagonista de il-4r para usarse en el tratamiento del asma.
AR092177A1 (es) Metodos para tratar o prevenir asma administrando un antagonista de il-4r
EA201591363A1 (ru) Аналоги тиадиазола и способы лечения состояний, связанных с дефицитом smn
BR112016017193A2 (pt) Derivados de insulina, seus usos, e composição farmacêutica
BR112015020139A2 (pt) compostos terapêuticos e usos dos mesmos
BR112015018168A2 (pt) inibidores de rock suaves
GT201400059A (es) Derivados de estra-1,3,5(10),16-tetraen-3-carboxamida, proceidmientos para su preparación, preparados farmacéuticos que los contienen, así como su uso para la preparacion de medicamentos
BR112016024421A2 (pt) composição farmacêutica, cápsula e uso da composição farmacêutica
CL2013003497A1 (es) Producto farmacéutico de combinación en forma de polvo seco para administración por medio de un inhalador que comprende una sal de umeclidinio de un grupo definido y 100 mcg/dosis de furoato de fluticasona, sin otros activos adicionales; uso para el tratamiento de enfermedades inflamatorias o del aparato respiratorio.
CO7160008A2 (es) Derivados de estra- 1,3,5(10),16- tetraeno 3-sustituidos, métodos para su preparación, prepara-ciones farmaceúticas que los contienen, así como su uso para la preparación de medicamentos
EA201890532A1 (ru) Новые аннелированные бензамиды
ES2525451T3 (es) Uso de óxido nitroso inhalado para prevenir el dolor neuropático inducido por sales de platino
EP2871187A4 (en) A NEW CONNECTION OR PHARMACEUTICALALLY SALT AND PHARMACEUTICAL COMPOSITION THEREFOR AS AN ACTIVE SUBSTANCE
MX2016016400A (es) Formulaciones de oximetazolina estabilizadas y sus usos.
EA201691231A1 (ru) Фармацевтические лекарственные формы
EA201591415A1 (ru) Фармацевтические композиции, включающие многокомпонентные кристаллические частицы, подходящие для применения в ингаляционной терапии
BR102012028120B8 (pt) Uso de um ou mais derivados de ingenol, composição farmacêutica e medicamento
BR112014015578A8 (pt) composições farmacêuticas tópicas compreendendo bexaroteno e um corticosteróide