MX2021002657A - Nuevos conjugados de montelukast y péptidos. - Google Patents

Nuevos conjugados de montelukast y péptidos.

Info

Publication number
MX2021002657A
MX2021002657A MX2021002657A MX2021002657A MX2021002657A MX 2021002657 A MX2021002657 A MX 2021002657A MX 2021002657 A MX2021002657 A MX 2021002657A MX 2021002657 A MX2021002657 A MX 2021002657A MX 2021002657 A MX2021002657 A MX 2021002657A
Authority
MX
Mexico
Prior art keywords
sub
peptide
containing compound
montelukast
sup
Prior art date
Application number
MX2021002657A
Other languages
English (en)
Inventor
Ming Gu
Bengt Ingemar Samuelsson
Original Assignee
Jiangyin Usun Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangyin Usun Pharmaceutical Co Ltd filed Critical Jiangyin Usun Pharmaceutical Co Ltd
Publication of MX2021002657A publication Critical patent/MX2021002657A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un compuesto que contiene péptido que comprende un componente peptídico que es una secuencia de aminoácidos de 2 a 45 aminoácidos, cuyo componente peptídico está unido covalentemente a uno o más compuestos de la Fórmula I: (ver formula I) en donde: R1 se selecciona del grupo que consiste en -C(CH3)2OH, -COCH3, -C(CH3)=CH2 y -C(CH3)2H; y n es 0, 1 o 2, así como regioisómeros, estereoisómeros y sales farmacéutica o cosméticamente aceptables de dicho compuesto que contiene péptido. El compuesto de la Fórmula I es preferentemente montelukast, montelukast estireno o montelukast estireno hidrogenado. El compuesto que contiene péptido es particularmente útil en el tratamiento de afecciones caracterizadas por inflamación, que incluyen heridas, hemorroides, quemaduras, psoriasis, acné, dermatitis atópica, rinitis alérgica, conjuntivitis alérgica, enfermedad pulmonar obstructiva crónica, enfermedad inflamatoria del intestino (como colitis ulcerosa). Los compuestos de la invención son útiles además en el tratamiento de la fibrosis pulmonar idiopática.
MX2021002657A 2018-09-14 2019-09-14 Nuevos conjugados de montelukast y péptidos. MX2021002657A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018105703 2018-09-14
CN2018119072 2018-12-04
PCT/CN2019/105832 WO2020052677A1 (en) 2018-09-14 2019-09-14 New conjugates of montelukast and peptides

Publications (1)

Publication Number Publication Date
MX2021002657A true MX2021002657A (es) 2021-07-21

Family

ID=69777394

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021002657A MX2021002657A (es) 2018-09-14 2019-09-14 Nuevos conjugados de montelukast y péptidos.

Country Status (25)

Country Link
US (2) US11680082B2 (es)
EP (2) EP4253404A3 (es)
JP (1) JP2022500437A (es)
KR (1) KR20210061372A (es)
CN (2) CN116785447A (es)
AU (1) AU2019338582A1 (es)
BR (1) BR112021004823A2 (es)
CA (1) CA3112420A1 (es)
DK (1) DK3678705T5 (es)
ES (1) ES2956509T3 (es)
FI (1) FI3678705T3 (es)
HR (1) HRP20230946T1 (es)
HU (1) HUE062848T2 (es)
IL (1) IL281426A (es)
LT (1) LT3678705T (es)
MX (1) MX2021002657A (es)
PL (1) PL3678705T3 (es)
PT (1) PT3678705T (es)
RS (1) RS64436B1 (es)
SA (1) SA521421448B1 (es)
SG (1) SG11202102119RA (es)
SI (1) SI3678705T1 (es)
TW (1) TW202023623A (es)
WO (1) WO2020052677A1 (es)
ZA (1) ZA202101398B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11672792B2 (en) * 2017-07-05 2023-06-13 Enlitisa (Shanghai) Pharmaceutical Co., Ltd Topical formulations comprising montelukast and combinations with mussel adhesive proteins
WO2021047648A1 (en) * 2019-09-14 2021-03-18 Jiangyin Usun Pharmaceutical Co., Ltd. New peptides
CA3173187A1 (en) * 2020-04-10 2021-10-14 Ralph A. Tripp Methods for treatment of coronavirus infections
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
KR102596264B1 (ko) * 2020-11-30 2023-11-01 주식회사 바이오빛 기능성 펩티드가 결합된 생체적합 폴리펩티드를 포함하는 염증 질환의 억제용 조성물
WO2022193186A1 (en) * 2021-03-17 2022-09-22 Jiangyin Usun Pharmaceutical Co., Ltd. New diagnostic and therapeutic agents
WO2022193185A1 (en) * 2021-03-17 2022-09-22 Jiangyin Usun Pharmaceutical Co., Ltd. New conjugates
WO2023225107A1 (en) * 2022-05-17 2023-11-23 Emory University Diroximel fumarate, inhalation administration methods, pharmaceutical uses and compositions
WO2024169972A1 (en) * 2023-02-13 2024-08-22 Enlitisa (Shanghai) Pharmaceutical Co., Ltd. New multi-functional oligopeptides

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US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
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WO2003020200A2 (en) * 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
CN1649614A (zh) * 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
JP2005536488A (ja) 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
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US11672792B2 (en) * 2017-07-05 2023-06-13 Enlitisa (Shanghai) Pharmaceutical Co., Ltd Topical formulations comprising montelukast and combinations with mussel adhesive proteins

Also Published As

Publication number Publication date
US11680082B2 (en) 2023-06-20
EP4253404A2 (en) 2023-10-04
HUE062848T2 (hu) 2023-12-28
SI3678705T1 (sl) 2023-10-30
KR20210061372A (ko) 2021-05-27
PL3678705T3 (pl) 2023-10-09
RS64436B1 (sr) 2023-09-29
ES2956509T3 (es) 2023-12-22
EP3678705B1 (en) 2023-05-31
CN116785447A (zh) 2023-09-22
DK3678705T5 (da) 2024-09-16
EP3678705A4 (en) 2021-06-09
US20230348536A1 (en) 2023-11-02
US20210309696A1 (en) 2021-10-07
EP3678705A1 (en) 2020-07-15
HRP20230946T1 (hr) 2023-11-24
SA521421448B1 (ar) 2024-03-14
PT3678705T (pt) 2023-07-19
FI3678705T3 (fi) 2023-07-04
ZA202101398B (en) 2022-09-28
JP2022500437A (ja) 2022-01-04
SG11202102119RA (en) 2021-04-29
IL281426A (en) 2021-04-29
EP4253404A3 (en) 2023-12-13
DK3678705T3 (en) 2023-06-26
CA3112420A1 (en) 2020-03-19
TW202023623A (zh) 2020-07-01
AU2019338582A1 (en) 2020-11-19
LT3678705T (lt) 2023-08-10
WO2020052677A1 (en) 2020-03-19
BR112021004823A2 (pt) 2021-06-08
CN111601618A (zh) 2020-08-28

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