MX370672B - Animales con il-4 e il-4r alfa humanizadas. - Google Patents

Animales con il-4 e il-4r alfa humanizadas.

Info

Publication number
MX370672B
MX370672B MX2016014563A MX2016014563A MX370672B MX 370672 B MX370672 B MX 370672B MX 2016014563 A MX2016014563 A MX 2016014563A MX 2016014563 A MX2016014563 A MX 2016014563A MX 370672 B MX370672 B MX 370672B
Authority
MX
Mexico
Prior art keywords
human
humanized
animals
gene
human animals
Prior art date
Application number
MX2016014563A
Other languages
English (en)
Spanish (es)
Other versions
MX2016014563A (es
Inventor
Stevens Sean
J Murphy Andrew
Hsien WANG Li-
Xue Yingzi
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016014563A publication Critical patent/MX2016014563A/es
Publication of MX370672B publication Critical patent/MX370672B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX2016014563A 2014-05-07 2015-05-07 Animales con il-4 e il-4r alfa humanizadas. MX370672B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (2)

Publication Number Publication Date
MX2016014563A MX2016014563A (es) 2017-02-23
MX370672B true MX370672B (es) 2019-12-19

Family

ID=53284509

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014563A MX370672B (es) 2014-05-07 2015-05-07 Animales con il-4 e il-4r alfa humanizadas.

Country Status (26)

Country Link
US (7) US9565841B2 (show.php)
EP (3) EP3906781A1 (show.php)
JP (5) JP6640740B2 (show.php)
KR (2) KR102517112B1 (show.php)
CN (2) CN106470545B (show.php)
AU (3) AU2015255977B2 (show.php)
BR (1) BR112016025745A2 (show.php)
CA (2) CA2947307C (show.php)
CY (2) CY1119773T1 (show.php)
DK (2) DK3027015T3 (show.php)
ES (2) ES2887852T3 (show.php)
HR (2) HRP20180242T1 (show.php)
HU (2) HUE055860T2 (show.php)
IL (3) IL248358B2 (show.php)
LT (2) LT3027015T (show.php)
MX (1) MX370672B (show.php)
NO (1) NO2785538T3 (show.php)
PH (1) PH12016502058A1 (show.php)
PL (2) PL3281521T3 (show.php)
PT (2) PT3281521T (show.php)
RS (2) RS62345B1 (show.php)
RU (1) RU2703139C2 (show.php)
SG (2) SG11201608570YA (show.php)
SI (2) SI3281521T1 (show.php)
SM (2) SMT202100560T1 (show.php)
WO (1) WO2015171861A1 (show.php)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (show.php) * 2014-05-07 2018-08-04
BR112016029650A2 (pt) 2014-06-19 2017-10-24 Regeneron Pharma roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor?
PL3212819T3 (pl) * 2014-09-17 2023-10-16 Oerlikon Surface Solutions Ag, Pfäffikon Sposób wytwarzania narzędzia skrawającego powleczonego podwójną warstwą o polepszonej odporności na zużycie
MX2017006802A (es) 2014-11-24 2018-01-30 Regeneron Pharma Animales no humanos que expresan el complejo cd3 humanizado.
WO2016089692A1 (en) 2014-12-05 2016-06-09 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
CA2968675C (en) 2014-12-09 2023-10-17 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
US10306874B2 (en) 2015-11-20 2019-06-04 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
MX2018009513A (es) 2016-02-04 2019-01-31 Regeneron Pharma Animales no humanos que tienen un gen angptl8 modificado genéticamente.
EP3422845B1 (en) * 2016-02-29 2021-06-02 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
TWI784988B (zh) * 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
IL314591A (en) 2017-04-13 2024-09-01 Regeneron Pharma Treatment and prevention of inflammatory lung diseases in patients with risk alleles in the genes encoding IL33 and IL1RL1
CN118994394A (zh) 2017-06-12 2024-11-22 蓝鳍生物医药公司 抗-il1rap抗体和抗体药物缀合物
ES2962277T3 (es) 2017-09-29 2024-03-18 Regeneron Pharma Roedores que comprenden un locus Ttr humanizado y métodos de uso
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
WO2019190990A1 (en) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
AU2019308205B2 (en) 2018-07-16 2025-11-06 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
WO2020074005A1 (en) * 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
CN114164177A (zh) * 2019-01-17 2022-03-11 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
CN117178959A (zh) 2019-04-04 2023-12-08 瑞泽恩制药公司 包括人源化凝血因子12基因座的非人动物
EP3801011A1 (en) 2019-06-04 2021-04-14 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
CN112300265B (zh) * 2019-07-29 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il33基因人源化的非人动物的构建方法和应用
CN112430621B (zh) * 2019-08-09 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il2ra基因人源化的非人动物的构建方法及应用
CN112779285B (zh) * 2019-11-11 2023-01-06 百奥赛图(北京)医药科技股份有限公司 人源化il-10和il-10ra基因改造动物的构建方法和应用
CN114786479B (zh) * 2019-12-25 2023-12-15 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
CA3169272A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485B (zh) * 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
CN116802200A (zh) * 2020-12-21 2023-09-22 瑞泽恩制药公司 具有人源化tslp基因、人源化tslp受体基因和/或人源化il7ra基因的非人动物
CN114835798B (zh) * 2021-05-28 2024-02-23 百奥赛图(北京)医药科技股份有限公司 Cd36基因人源化非人动物的构建方法及应用
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物
JP2026502506A (ja) * 2023-01-11 2026-01-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 規制に準拠した自動化されたアッセイのためのシステム及び方法
WO2025175099A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. A rodent copd model

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (en) * 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PT1802193E (pt) 2004-10-19 2014-06-23 Regeneron Pharma Método para gerar um murganho homozigótico para uma modificação genética
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
EP2449094A4 (en) * 2009-06-29 2013-07-10 Qingfeng Chen METHOD FOR PRODUCING HUMANIZED NON-MAMMAL MAMMALS
JP2013500018A (ja) * 2009-07-24 2013-01-07 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー ゲノム編集のための方法
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
ES2908587T3 (es) 2009-10-06 2022-05-03 Regeneron Pharma Ratones modificados genéticamente e injerto
EP3375284B1 (en) * 2011-02-15 2023-03-29 Regeneron Pharmaceuticals, Inc. Humanized m-csf mice and uses thereof
KR102295746B1 (ko) 2011-10-28 2021-09-01 리제너론 파아마슈티컬스, 인크. 유전자 변형된 주요 조직적합성 복합체 마우스
HUE033400T2 (en) * 2011-10-28 2017-12-28 Regeneron Pharma Humanized IL-6 and IL-6 receptor
LT3590332T (lt) 2011-10-28 2022-08-10 Regeneron Pharmaceuticals, Inc. Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
KR102307248B1 (ko) * 2012-08-21 2021-10-01 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
CA2881468C (en) 2012-09-07 2023-03-21 Yale University Genetically modified mice which express human cytokines and methods of use thereof, including engraftment
NZ724353A (en) 2012-11-05 2022-05-27 Regeneron Pharma Genetically modified non-human animals and methods of use thereof
JP6444895B2 (ja) 2013-02-20 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｔ細胞補助受容体を発現するマウス
DK2958937T3 (en) 2013-02-22 2018-11-26 Regeneron Pharma Mice expressing humanized major histocompatibility complex
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
KR102407354B1 (ko) 2013-09-23 2022-06-10 리제너론 파마슈티칼스 인코포레이티드 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물
SI2908626T1 (sl) 2013-10-15 2017-02-28 Regeneron Pharmaceuticals, Inc. Humanizirane živali IL-15
SG10201900003WA (en) 2013-11-19 2019-02-27 Regeneron Pharma Non-human animals having a humanized b-cell activating factor gene
AU2014353347B2 (en) 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
SG11201604886WA (en) 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
SG11201608696RA (en) 2014-05-05 2016-11-29 Regeneron Pharma Humanized c5 and c3 animals
NO2785538T3 (show.php) 2014-05-07 2018-08-04

Also Published As

Publication number Publication date
JP6640740B2 (ja) 2020-02-05
US12310340B2 (en) 2025-05-27
RU2016143376A (ru) 2018-06-09
JP2024159985A (ja) 2024-11-08
IL297105B2 (en) 2024-01-01
NZ725615A (en) 2024-05-31
AU2021218060C1 (en) 2024-11-07
AU2015255977B2 (en) 2021-09-02
AU2021218060A1 (en) 2021-09-09
DK3027015T3 (en) 2018-01-22
HUE055860T2 (hu) 2021-12-28
PT3027015T (pt) 2018-02-09
KR102517112B1 (ko) 2023-04-03
IL304841B2 (en) 2026-01-01
JP6838131B2 (ja) 2021-03-03
NO2785538T3 (show.php) 2018-08-04
US20150320021A1 (en) 2015-11-12
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
AU2015255977A1 (en) 2016-11-17
KR102473565B1 (ko) 2022-12-02
US20150320022A1 (en) 2015-11-12
RU2703139C2 (ru) 2019-10-15
CA2947307C (en) 2023-09-26
US11963521B2 (en) 2024-04-23
IL304841A (en) 2023-09-01
CN110269047A (zh) 2019-09-24
US20170311580A1 (en) 2017-11-02
EP3281521A1 (en) 2018-02-14
EP3027015A1 (en) 2016-06-08
CA3207834A1 (en) 2015-11-12
US9565841B2 (en) 2017-02-14
US20180000056A1 (en) 2018-01-04
CY1124605T1 (el) 2022-07-22
IL248358B2 (en) 2023-03-01
HRP20211455T1 (hr) 2022-01-07
IL297105A (en) 2022-12-01
US20200022344A1 (en) 2020-01-23
LT3027015T (lt) 2018-01-25
PH12016502058A1 (en) 2017-01-09
AU2024204694A1 (en) 2024-09-05
RU2019131253A (ru) 2019-12-06
SI3281521T1 (sl) 2021-11-30
CN106470545A (zh) 2017-03-01
PT3281521T (pt) 2021-09-16
PL3281521T3 (pl) 2022-01-03
CN106470545B (zh) 2019-08-20
EP3906781A1 (en) 2021-11-10
JP2020058379A (ja) 2020-04-16
SI3027015T1 (en) 2018-02-28
US9743647B2 (en) 2017-08-29
SMT201800018T1 (it) 2018-03-08
LT3281521T (lt) 2021-09-27
IL248358A0 (en) 2016-11-30
IL297105B1 (en) 2023-09-01
CN110269047B (zh) 2021-11-02
CA2947307A1 (en) 2015-11-12
JP2022171841A (ja) 2022-11-11
EP3027015B1 (en) 2017-11-08
US10588298B2 (en) 2020-03-17
WO2015171861A1 (en) 2015-11-12
SMT202100560T1 (it) 2021-11-12
HUE038028T2 (hu) 2018-09-28
SG11201608570YA (en) 2016-11-29
EP3281521B1 (en) 2021-06-30
JP2017514501A (ja) 2017-06-08
CY1119773T1 (el) 2018-06-27
KR20220165814A (ko) 2022-12-15
HRP20180242T1 (hr) 2018-03-09
ES2656529T3 (es) 2018-02-27
US20210368753A1 (en) 2021-12-02
ES2887852T3 (es) 2021-12-28
DK3281521T3 (da) 2021-09-20
BR112016025745A2 (pt) 2018-01-16
AU2021218060B2 (en) 2024-04-11
MX2016014563A (es) 2017-02-23
NZ763861A (en) 2024-05-31
SG10201912354PA (en) 2020-02-27
IL248358B (en) 2022-11-01
JP7755699B2 (ja) 2025-10-16
RS62345B1 (sr) 2021-10-29
RU2016143376A3 (show.php) 2018-11-22
JP7145250B2 (ja) 2022-09-30
KR20160150637A (ko) 2016-12-30
IL304841B1 (en) 2025-09-01
US20230027494A1 (en) 2023-01-26
JP2021087434A (ja) 2021-06-10
CA3207834C (en) 2025-10-14
PL3027015T3 (pl) 2018-04-30
RS57073B1 (sr) 2018-06-29

Similar Documents

Publication Publication Date Title
PH12016502058A1 (en) Humanized il-4 and il-4r alpha animals
MX2016014504A (es) Animales c5 y c3 humanizados.
PH12016502170A1 (en) Humanized dipeptidyl peptidase iv (dpp4) animals
HK1203761A1 (en) Humanized il-7 rodents
PH12016500342A1 (en) Non-human animals having a humanized signal-regulatory protein gene
MX2016016903A (es) Animales no humanos que tienen un gen de muerte celular programada 1 humanizado.
EP3392337A4 (en) GENETIC CHANGE OF NON-HUMAN ORGANISM, EGGS, BURIED EGGS AND METHOD OF MODIFYING TARGET GENES
MX358390B (es) Interleucina 6 y receptor de interleucina 6, humanizados.
MY183189A (en) Non-human animals having a humanized a proliferation-inducing ligand gene
EP3507373A4 (en) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERAL PD-L1
AR102888A1 (es) Animales no humanos que tienen un gen humanizado de agrupamiento de diferenciación 47
MX2017007636A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 274 humanizado.
MX2022001201A (es) Ratones con genes insertados de sirp¿-il15 humanizadas y métodos para usarlos.
AU2018338790A8 (en) Non-human animals comprising a humanized TTR locus and methods of use
CY1118675T1 (el) Εξανθρωποποιημενα il-15 ζωα
SG10201900003WA (en) Non-human animals having a humanized b-cell activating factor gene
MX2018005389A (es) Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado.
MX2016013241A (es) Animales no humanos que tienen receptores fc gamma humanizados.
O’Rourke et al. Biology and diseases of amphibians
HK1244511A1 (zh) 与嗜酸细胞食管炎相关的基因改变的诊断和治疗
NZ763861B2 (en) Humanized il-4 and il-4r alpha animals

Legal Events

Date Code Title Description
FG Grant or registration