MX369114B - Proceso para la preparación de nanopartículas de polisacáridos. - Google Patents
Proceso para la preparación de nanopartículas de polisacáridos.Info
- Publication number
- MX369114B MX369114B MX2014010979A MX2014010979A MX369114B MX 369114 B MX369114 B MX 369114B MX 2014010979 A MX2014010979 A MX 2014010979A MX 2014010979 A MX2014010979 A MX 2014010979A MX 369114 B MX369114 B MX 369114B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- amino
- aldehyde groups
- aliphatic
- aldehyde
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 5
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- -1 aromatic organic acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B1/00—Preparatory treatment of cellulose for making derivatives thereof, e.g. pre-treatment, pre-soaking, activation
- C08B1/08—Alkali cellulose
- C08B1/10—Apparatus for the preparation of alkali cellulose
- C08B1/12—Steeping devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/02—Alkyl or cycloalkyl ethers
- C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
- C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
- C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/02—Dextran; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL398450A PL221351B1 (pl) | 2012-03-14 | 2012-03-14 | Sposób otrzymywania nanocząstek polisacharydowych |
| PCT/PL2013/000030 WO2013137755A1 (en) | 2012-03-14 | 2013-03-12 | Process for the preparation of polysaccharide nanoparticles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014010979A MX2014010979A (es) | 2015-02-24 |
| MX369114B true MX369114B (es) | 2019-10-29 |
Family
ID=48014274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014010979A MX369114B (es) | 2012-03-14 | 2013-03-12 | Proceso para la preparación de nanopartículas de polisacáridos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10258579B2 (https=) |
| EP (1) | EP2825563B1 (https=) |
| JP (1) | JP6470169B2 (https=) |
| CN (1) | CN104169305B (https=) |
| AU (1) | AU2013232850B2 (https=) |
| BR (1) | BR112014022767B1 (https=) |
| CA (1) | CA2866682C (https=) |
| ES (1) | ES2780387T3 (https=) |
| IL (1) | IL234572A (https=) |
| IN (1) | IN2014MN01651A (https=) |
| MX (1) | MX369114B (https=) |
| PL (1) | PL221351B1 (https=) |
| RU (1) | RU2632019C2 (https=) |
| WO (1) | WO2013137755A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016093352A1 (ja) * | 2014-12-12 | 2016-06-16 | 日本化薬株式会社 | 核酸代謝拮抗剤が結合した多分岐化合物 |
| MX2019001316A (es) * | 2016-08-01 | 2019-12-02 | Hppe Llc | Biopolimeros para control de polvo fugitivo. |
| US10736964B2 (en) * | 2017-05-01 | 2020-08-11 | China Medical University | Immunomagnetic nanocapsule and kit for treating cancer |
| CN107446054B (zh) * | 2017-08-11 | 2021-05-18 | 武汉理工大学 | 一种生物质基纳米粒子及其制备方法和应用 |
| PL424773A1 (pl) * | 2018-03-06 | 2019-09-09 | Nanovelos Spółka Akcyjna | Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów |
| CN108553448A (zh) * | 2018-05-30 | 2018-09-21 | 江西师范大学 | 一种pH响应的药物缓释纤维素纳米颗粒的制备方法 |
| CN108676181B (zh) * | 2018-05-30 | 2022-05-17 | 江西师范大学 | 通过二醛基纤维素制备纤维素纳米颗粒的方法 |
| PL240772B1 (pl) | 2018-06-11 | 2022-06-06 | Nanothea Spolka Akcyjna | Sposób wytwarzania nanocząstek polimerowych chelatujących izotopy promieniotwórcze do zastosowania w diagnostyce i terapii |
| CN112353781B (zh) * | 2020-11-12 | 2022-08-19 | 云南开放大学 | 一种药物载体空心纳米球的制备方法 |
| CN112516310B (zh) * | 2020-12-11 | 2022-11-29 | 武汉理工大学 | 一种肿瘤酸环境响应的纳米前药的制备方法及其应用 |
| CN112830979A (zh) * | 2021-01-15 | 2021-05-25 | 江南大学 | 一种改性黄原胶及其制备方法与应用 |
| CN113800501B (zh) * | 2021-10-08 | 2023-04-18 | 山西大学 | 一种用于检测pH和精氨酸的橙红色荧光碳点的制备方法及其应用 |
| WO2023092208A1 (pt) * | 2021-11-25 | 2023-06-01 | Universidade Estadual De Campinas | Processo de obtenção de solução polimérica injetável fotoreticulável, solução polimérica injetável fotoreticulável e seus usos |
| CN115463262B (zh) * | 2022-08-11 | 2024-06-04 | 南方医科大学第五附属医院 | 一种水凝胶复合修复补片及其制备方法与应用 |
| CN117898426A (zh) * | 2023-12-05 | 2024-04-19 | 江苏蓝果临床营养科技有限公司 | 一种调节肠道功能紊乱的纳米颗粒及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU825542A1 (ru) * | 1979-04-04 | 1981-04-30 | Inst Orch Chimii Aka | Способ получения n-производных полисахаридов 1 |
| US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4693912A (en) * | 1985-02-28 | 1987-09-15 | Technicon Instruments Corporation | Lyophilization of reagent-coated particles |
| US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| JPS62221637A (ja) * | 1986-03-24 | 1987-09-29 | Green Cross Corp:The | 制癌剤−抗体複合体の製造方法 |
| JPS62283101A (ja) * | 1986-05-30 | 1987-12-09 | Green Cross Corp:The | 制癌作用物質複合体の製造方法 |
| JPS63264427A (ja) * | 1986-12-17 | 1988-11-01 | Green Cross Corp:The | 制癌作用物質複合体 |
| JPH01190636A (ja) * | 1988-01-22 | 1989-07-31 | Green Cross Corp:The | 制癌作用物質複合体 |
| EP0999222A1 (en) | 1998-11-02 | 2000-05-10 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Carbohydrate oxidation products |
| SK288117B6 (sk) * | 1998-11-20 | 2013-09-03 | Skyepharma Canada Inc. | Rapidly dispersing solid dry therapeutic dosage form |
| IL131074A0 (en) * | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
| EP1298145A4 (en) | 2000-06-29 | 2004-12-08 | Daiichi Seiyaku Co | DDS CONNECTION AND METHOD FOR PRODUCING THE SAME |
| DE10129369C1 (de) * | 2001-06-21 | 2003-03-06 | Fresenius Kabi De Gmbh | Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats |
| TWI313609B (en) | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| DE10209821A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| JP2005535604A (ja) * | 2002-06-03 | 2005-11-24 | アルニス バイオサイエンシーズ， インコーポレイテッド | 治療剤を含むポリマーナノ物品 |
| KR100578382B1 (ko) * | 2004-07-16 | 2006-05-11 | 나재운 | 항암제의 전달체용 수용성 키토산 나노입자 및 그 제조방법 |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| ES2387195T3 (es) * | 2005-05-27 | 2012-09-17 | Royer Biomedical, Inc. | Matrices de polímero y métodos de fabricación y uso de las mismas |
| AU2006283302B2 (en) | 2005-08-24 | 2012-11-15 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| CN101273066B (zh) * | 2005-09-09 | 2013-10-16 | 郑特来 | 用于递送抗癌剂的水溶性壳聚糖纳米颗粒及其制备方法 |
| CN101443044A (zh) * | 2005-09-22 | 2009-05-27 | 哈达斯特医学研究服务与开发有限公司 | 治疗活性化合物的葡聚糖和阿拉伯半乳聚糖结合物 |
| US8563066B2 (en) * | 2007-12-17 | 2013-10-22 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
| WO2010059280A2 (en) * | 2008-11-19 | 2010-05-27 | E. I. Du Pont De Nemours And Company | Fibrous tissue sealant and method of using same |
| CZ302503B6 (cs) * | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
| EP2590680A1 (en) | 2010-07-09 | 2013-05-15 | Fresenius Kabi Deutschland GmbH | Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation |
-
2012
- 2012-03-14 PL PL398450A patent/PL221351B1/pl unknown
-
2013
- 2013-03-12 EP EP13712947.4A patent/EP2825563B1/en active Active
- 2013-03-12 MX MX2014010979A patent/MX369114B/es active IP Right Grant
- 2013-03-12 IN IN1651MUN2014 patent/IN2014MN01651A/en unknown
- 2013-03-12 WO PCT/PL2013/000030 patent/WO2013137755A1/en not_active Ceased
- 2013-03-12 AU AU2013232850A patent/AU2013232850B2/en active Active
- 2013-03-12 RU RU2014133962A patent/RU2632019C2/ru active
- 2013-03-12 CA CA2866682A patent/CA2866682C/en active Active
- 2013-03-12 JP JP2015500386A patent/JP6470169B2/ja active Active
- 2013-03-12 BR BR112014022767-5A patent/BR112014022767B1/pt active IP Right Grant
- 2013-03-12 ES ES13712947T patent/ES2780387T3/es active Active
- 2013-03-12 CN CN201380014214.8A patent/CN104169305B/zh active Active
-
2014
- 2014-09-10 IL IL234572A patent/IL234572A/en active IP Right Grant
- 2014-09-12 US US14/485,309 patent/US10258579B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10258579B2 (en) | 2019-04-16 |
| RU2014133962A (ru) | 2016-03-20 |
| CA2866682A1 (en) | 2013-09-19 |
| US20150072946A1 (en) | 2015-03-12 |
| AU2013232850A1 (en) | 2014-09-11 |
| CN104169305B (zh) | 2016-07-27 |
| CA2866682C (en) | 2016-05-17 |
| IN2014MN01651A (https=) | 2015-05-29 |
| PL398450A1 (pl) | 2013-09-16 |
| CN104169305A (zh) | 2014-11-26 |
| EP2825563B1 (en) | 2020-02-05 |
| JP2015514059A (ja) | 2015-05-18 |
| WO2013137755A1 (en) | 2013-09-19 |
| RU2632019C2 (ru) | 2017-10-02 |
| EP2825563A1 (en) | 2015-01-21 |
| BR112014022767B1 (pt) | 2021-08-31 |
| BR112014022767A2 (https=) | 2017-10-03 |
| AU2013232850B2 (en) | 2016-01-07 |
| ES2780387T3 (es) | 2020-08-25 |
| IL234572A (en) | 2017-01-31 |
| MX2014010979A (es) | 2015-02-24 |
| PL221351B1 (pl) | 2016-03-31 |
| JP6470169B2 (ja) | 2019-02-13 |
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