JP2013526577A5 - - Google Patents
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- Publication number
- JP2013526577A5 JP2013526577A5 JP2013511354A JP2013511354A JP2013526577A5 JP 2013526577 A5 JP2013526577 A5 JP 2013526577A5 JP 2013511354 A JP2013511354 A JP 2013511354A JP 2013511354 A JP2013511354 A JP 2013511354A JP 2013526577 A5 JP2013526577 A5 JP 2013526577A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound represented
- reaction mixture
- buffer
- acylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C*C[C@@](C(N[C@@](CC(O)=O)C(N[C@](*)CS)=O)=O)NC(CNC([C@](C)NC(CC[C@@](C(O)=O)NC(c(cc1)ccc1NCc1nc(*=O)c(N*)nc1)=O)=O)=O)=O Chemical compound C*C[C@@](C(N[C@@](CC(O)=O)C(N[C@](*)CS)=O)=O)NC(CNC([C@](C)NC(CC[C@@](C(O)=O)NC(c(cc1)ccc1NCc1nc(*=O)c(N*)nc1)=O)=O)=O)=O 0.000 description 35
- KRPACOYLOTZHII-UHFFFAOYSA-N O=C(OCCSSc1ccccn1)O[n]1nnc2c1cccc2 Chemical compound O=C(OCCSSc1ccccn1)O[n]1nnc2c1cccc2 KRPACOYLOTZHII-UHFFFAOYSA-N 0.000 description 2
- BPCWEXKVIAISEV-UHFFFAOYSA-N Cc(cc1)ccc1NCc1nc(C(NN2)=O)c2nc1 Chemical compound Cc(cc1)ccc1NCc1nc(C(NN2)=O)c2nc1 BPCWEXKVIAISEV-UHFFFAOYSA-N 0.000 description 1
- FCWZGVQTBMHYKD-UHFFFAOYSA-N Cc(cc1)ccc1NCc1nc(CNN2)c2nc1 Chemical compound Cc(cc1)ccc1NCc1nc(CNN2)c2nc1 FCWZGVQTBMHYKD-UHFFFAOYSA-N 0.000 description 1
- ADEUBFAWQRMQQZ-UHFFFAOYSA-N N=C(OCCSSc1ncccc1)O[n]1nnc2ccccc12 Chemical compound N=C(OCCSSc1ncccc1)O[n]1nnc2ccccc12 ADEUBFAWQRMQQZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34644410P | 2010-05-19 | 2010-05-19 | |
| US61/346,444 | 2010-05-19 | ||
| US35102210P | 2010-06-03 | 2010-06-03 | |
| US61/351,022 | 2010-06-03 | ||
| PCT/US2011/037134 WO2011146707A1 (en) | 2010-05-19 | 2011-05-19 | Improved process for a folate-targeted agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013526577A JP2013526577A (ja) | 2013-06-24 |
| JP2013526577A5 true JP2013526577A5 (https=) | 2014-07-10 |
Family
ID=44992057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511354A Withdrawn JP2013526577A (ja) | 2010-05-19 | 2011-05-19 | 葉酸を標的にする薬剤用の改善されたプロセス |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130065841A1 (https=) |
| JP (1) | JP2013526577A (https=) |
| KR (1) | KR20130079431A (https=) |
| CN (1) | CN102984943B (https=) |
| BR (1) | BR112012029458A2 (https=) |
| CA (1) | CA2799391A1 (https=) |
| IL (1) | IL222964A0 (https=) |
| MX (1) | MX2012013250A (https=) |
| RU (1) | RU2012154914A (https=) |
| SG (1) | SG185592A1 (https=) |
| WO (1) | WO2011146707A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6676650B2 (ja) | 2015-03-13 | 2020-04-08 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 疾患を処置するためのコンジュゲート |
| US20200323991A1 (en) * | 2016-03-29 | 2020-10-15 | Endocyte, Inc. | Pbd conjugates for treating diseases |
| WO2019196999A1 (en) | 2018-04-11 | 2019-10-17 | Radisurf Aps | Compositions for forming polymer brushes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381177C (zh) * | 2003-01-27 | 2008-04-16 | 恩多塞特公司 | 维生素受体结合递药缀合物 |
| CN100423778C (zh) * | 2003-11-25 | 2008-10-08 | 上海复旦张江生物医药股份有限公司 | 用于上载抗肿瘤药物的脂质体载体及其制备方法和应用 |
| EP2382995A3 (en) * | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
-
2011
- 2011-05-19 CA CA2799391A patent/CA2799391A1/en not_active Abandoned
- 2011-05-19 JP JP2013511354A patent/JP2013526577A/ja not_active Withdrawn
- 2011-05-19 US US13/698,215 patent/US20130065841A1/en not_active Abandoned
- 2011-05-19 MX MX2012013250A patent/MX2012013250A/es not_active Application Discontinuation
- 2011-05-19 WO PCT/US2011/037134 patent/WO2011146707A1/en not_active Ceased
- 2011-05-19 BR BR112012029458A patent/BR112012029458A2/pt not_active IP Right Cessation
- 2011-05-19 CN CN201180035630.7A patent/CN102984943B/zh not_active Expired - Fee Related
- 2011-05-19 SG SG2012084190A patent/SG185592A1/en unknown
- 2011-05-19 KR KR1020127032401A patent/KR20130079431A/ko not_active Withdrawn
- 2011-05-19 RU RU2012154914/13A patent/RU2012154914A/ru not_active Application Discontinuation
-
2012
- 2012-11-11 IL IL222964A patent/IL222964A0/en unknown
-
2013
- 2013-03-14 US US13/803,150 patent/US20140066593A1/en not_active Abandoned
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