JP2019503994A5 - - Google Patents
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- Publication number
- JP2019503994A5 JP2019503994A5 JP2018526713A JP2018526713A JP2019503994A5 JP 2019503994 A5 JP2019503994 A5 JP 2019503994A5 JP 2018526713 A JP2018526713 A JP 2018526713A JP 2018526713 A JP2018526713 A JP 2018526713A JP 2019503994 A5 JP2019503994 A5 JP 2019503994A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peg
- combination
- reaction
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- WPBZMCGPFHZRHJ-UHFFFAOYSA-N 4-aminobenzohydrazide Chemical compound NNC(=O)C1=CC=C(N)C=C1 WPBZMCGPFHZRHJ-UHFFFAOYSA-N 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 8
- 239000000654 additive Substances 0.000 claims 6
- 230000000996 additive effect Effects 0.000 claims 6
- 235000019270 ammonium chloride Nutrition 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 230000021615 conjugation Effects 0.000 claims 6
- UENRXLSRMCSUSN-UHFFFAOYSA-N 3,5-diaminobenzoic acid Chemical compound NC1=CC(N)=CC(C(O)=O)=C1 UENRXLSRMCSUSN-UHFFFAOYSA-N 0.000 claims 5
- 150000003863 ammonium salts Chemical class 0.000 claims 5
- 150000004982 aromatic amines Chemical class 0.000 claims 5
- ZXSBHXZKWRIEIA-JTQLQIEISA-N (2s)-3-(4-acetylphenyl)-2-azaniumylpropanoate Chemical group CC(=O)C1=CC=C(C[C@H](N)C(O)=O)C=C1 ZXSBHXZKWRIEIA-JTQLQIEISA-N 0.000 claims 4
- 108091006006 PEGylated Proteins Proteins 0.000 claims 4
- 239000013066 combination product Substances 0.000 claims 4
- 229940127555 combination product Drugs 0.000 claims 4
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 3
- 239000005695 Ammonium acetate Substances 0.000 claims 3
- 229940043376 ammonium acetate Drugs 0.000 claims 3
- 235000019257 ammonium acetate Nutrition 0.000 claims 3
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 claims 2
- WZCQRUWWHSTZEM-UHFFFAOYSA-N 1,3-phenylenediamine Chemical compound NC1=CC=CC(N)=C1 WZCQRUWWHSTZEM-UHFFFAOYSA-N 0.000 claims 2
- PDNHLCRMUIGNBV-UHFFFAOYSA-N 1-pyridin-2-ylethanamine Chemical compound CC(N)C1=CC=CC=N1 PDNHLCRMUIGNBV-UHFFFAOYSA-N 0.000 claims 2
- WOXFMYVTSLAQMO-UHFFFAOYSA-N 2-Pyridinemethanamine Chemical compound NCC1=CC=CC=N1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 claims 2
- XXYDEJAJDOABCE-UHFFFAOYSA-N 2-hydrazinyl-n,n-dimethylethanamine Chemical compound CN(C)CCNN XXYDEJAJDOABCE-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 229940018564 m-phenylenediamine Drugs 0.000 claims 2
- 230000006320 pegylation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 1
- 102000003743 Relaxin Human genes 0.000 claims 1
- 108090000103 Relaxin Proteins 0.000 claims 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021123154A JP7257457B2 (ja) | 2015-11-23 | 2021-07-28 | タンパク質のｐｅｇ化に用いるための添加物系 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258644P | 2015-11-23 | 2015-11-23 | |
| US62/258,644 | 2015-11-23 | ||
| PCT/US2016/063313 WO2017091568A1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021123154A Division JP7257457B2 (ja) | 2015-11-23 | 2021-07-28 | タンパク質のｐｅｇ化に用いるための添加物系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503994A JP2019503994A (ja) | 2019-02-14 |
| JP2019503994A5 true JP2019503994A5 (https=) | 2019-12-26 |
| JP6921821B2 JP6921821B2 (ja) | 2021-08-18 |
Family
ID=57589163
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526713A Active JP6921821B2 (ja) | 2015-11-23 | 2016-11-22 | タンパク質のｐｅｇ化に用いるための添加物系 |
| JP2021123154A Active JP7257457B2 (ja) | 2015-11-23 | 2021-07-28 | タンパク質のｐｅｇ化に用いるための添加物系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021123154A Active JP7257457B2 (ja) | 2015-11-23 | 2021-07-28 | タンパク質のｐｅｇ化に用いるための添加物系 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10617765B2 (https=) |
| EP (2) | EP3380487B1 (https=) |
| JP (2) | JP6921821B2 (https=) |
| KR (1) | KR102688003B1 (https=) |
| CN (2) | CN115819494A (https=) |
| CY (1) | CY1123699T1 (https=) |
| DK (1) | DK3380487T3 (https=) |
| ES (2) | ES2827776T3 (https=) |
| HR (1) | HRP20201832T1 (https=) |
| HU (1) | HUE052634T2 (https=) |
| LT (1) | LT3380487T (https=) |
| PL (1) | PL3380487T3 (https=) |
| PT (1) | PT3380487T (https=) |
| RS (1) | RS61072B1 (https=) |
| SI (1) | SI3380487T1 (https=) |
| SM (1) | SMT202000649T1 (https=) |
| WO (1) | WO2017091568A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000649T1 (it) * | 2015-11-23 | 2021-01-05 | Bristol Myers Squibb Co | Sistemi di additivi per l'uso nella pegilazione di proteine |
| CA3111576A1 (en) * | 2018-09-11 | 2020-03-19 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| CN111484551B (zh) * | 2020-03-19 | 2022-02-11 | 北京翼方生物科技有限责任公司 | 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| EP0885613A1 (de) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| KR20120134158A (ko) * | 2004-03-17 | 2012-12-11 | 안티캔서, 인코포레이티드 | 폴리에틸렌 글리콜(ｐｅｇ) 단백질 결합을 증가시키기 위한 방법 |
| TW200722521A (en) * | 2005-06-01 | 2007-06-16 | Alza Corp | Novel bioconjugation reactions for acylating polyethylene glycol reagents |
| CN101400646A (zh) * | 2005-11-08 | 2009-04-01 | Ambrx公司 | 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂 |
| CN107501407B (zh) * | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
| EA031930B1 (ru) | 2013-01-30 | 2019-03-29 | Авелас Байосайенсиз, Инк. | Молекула селективной доставки для визуализации злокачественной ткани |
| EP2988786A4 (en) | 2013-04-22 | 2016-12-21 | Avelas Biosciences Inc | COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE |
| CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| SMT202000649T1 (it) * | 2015-11-23 | 2021-01-05 | Bristol Myers Squibb Co | Sistemi di additivi per l'uso nella pegilazione di proteine |
-
2016
- 2016-11-22 SM SM20200649T patent/SMT202000649T1/it unknown
- 2016-11-22 HR HRP20201832TT patent/HRP20201832T1/hr unknown
- 2016-11-22 EP EP16816042.2A patent/EP3380487B1/en active Active
- 2016-11-22 PL PL16816042T patent/PL3380487T3/pl unknown
- 2016-11-22 HU HUE16816042A patent/HUE052634T2/hu unknown
- 2016-11-22 ES ES16816042T patent/ES2827776T3/es active Active
- 2016-11-22 RS RS20201382A patent/RS61072B1/sr unknown
- 2016-11-22 LT LTEP16816042.2T patent/LT3380487T/lt unknown
- 2016-11-22 CN CN202211743414.4A patent/CN115819494A/zh active Pending
- 2016-11-22 WO PCT/US2016/063313 patent/WO2017091568A1/en not_active Ceased
- 2016-11-22 ES ES20189107T patent/ES3055983T3/es active Active
- 2016-11-22 SI SI201630957T patent/SI3380487T1/sl unknown
- 2016-11-22 JP JP2018526713A patent/JP6921821B2/ja active Active
- 2016-11-22 DK DK16816042.2T patent/DK3380487T3/da active
- 2016-11-22 EP EP20189107.4A patent/EP3789395B1/en active Active
- 2016-11-22 KR KR1020187017508A patent/KR102688003B1/ko active Active
- 2016-11-22 CN CN201680067897.7A patent/CN108350025B/zh active Active
- 2016-11-22 PT PT168160422T patent/PT3380487T/pt unknown
- 2016-11-22 US US15/776,923 patent/US10617765B2/en active Active
-
2020
- 2020-02-21 US US16/797,361 patent/US11213589B2/en active Active
- 2020-11-20 CY CY20201101102T patent/CY1123699T1/el unknown
-
2021
- 2021-07-28 JP JP2021123154A patent/JP7257457B2/ja active Active
- 2021-12-03 US US17/541,636 patent/US20220160883A1/en not_active Abandoned
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