RS61072B1 - Sistemi aditiva za upotrebu u pegilaciji proteina - Google Patents
Sistemi aditiva za upotrebu u pegilaciji proteinaInfo
- Publication number
- RS61072B1 RS61072B1 RS20201382A RSP20201382A RS61072B1 RS 61072 B1 RS61072 B1 RS 61072B1 RS 20201382 A RS20201382 A RS 20201382A RS P20201382 A RSP20201382 A RS P20201382A RS 61072 B1 RS61072 B1 RS 61072B1
- Authority
- RS
- Serbia
- Prior art keywords
- peg
- reaction
- protein
- equiv
- additive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258644P | 2015-11-23 | 2015-11-23 | |
| PCT/US2016/063313 WO2017091568A1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
| EP16816042.2A EP3380487B1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS61072B1 true RS61072B1 (sr) | 2020-12-31 |
Family
ID=57589163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20201382A RS61072B1 (sr) | 2015-11-23 | 2016-11-22 | Sistemi aditiva za upotrebu u pegilaciji proteina |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10617765B2 (https=) |
| EP (2) | EP3789395B1 (https=) |
| JP (2) | JP6921821B2 (https=) |
| KR (1) | KR102688003B1 (https=) |
| CN (2) | CN115819494A (https=) |
| CY (1) | CY1123699T1 (https=) |
| DK (1) | DK3380487T3 (https=) |
| ES (2) | ES3055983T3 (https=) |
| HR (1) | HRP20201832T1 (https=) |
| HU (1) | HUE052634T2 (https=) |
| LT (1) | LT3380487T (https=) |
| PL (1) | PL3380487T3 (https=) |
| PT (1) | PT3380487T (https=) |
| RS (1) | RS61072B1 (https=) |
| SI (1) | SI3380487T1 (https=) |
| SM (1) | SMT202000649T1 (https=) |
| WO (1) | WO2017091568A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3380487T (pt) * | 2015-11-23 | 2020-10-29 | Bristol Myers Squibb Co | Sistemas de aditivos para utilização na peguilação de proteínas |
| HRP20240016T1 (hr) * | 2018-09-11 | 2024-03-29 | Ambrx, Inc. | Konjugati polipeptida interleukina-2 i njihove uporabe |
| CN111484551B (zh) * | 2020-03-19 | 2022-02-11 | 北京翼方生物科技有限责任公司 | 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| EP0885613A1 (de) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| US7329516B2 (en) * | 2004-03-17 | 2008-02-12 | Anticancer, Inc. | Methods for increasing protein polyethylene glycol (PEG) conjugation |
| US20060286657A1 (en) * | 2005-06-01 | 2006-12-21 | Samuel Zalipsky | Novel bioconjugation reactions for acylating polyethylene glycol reagents |
| CN104710503B (zh) * | 2005-11-08 | 2023-04-25 | Ambrx 公司 | 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂 |
| CA2682147C (en) * | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| AU2014212308B2 (en) | 2013-01-30 | 2018-08-09 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
| WO2014176284A1 (en) | 2013-04-22 | 2014-10-30 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
| SMT202100388T1 (it) | 2014-10-24 | 2021-09-14 | Bristol Myers Squibb Co | Polipeptidi fgf-21 modificati e loro usi |
| PT3380487T (pt) * | 2015-11-23 | 2020-10-29 | Bristol Myers Squibb Co | Sistemas de aditivos para utilização na peguilação de proteínas |
-
2016
- 2016-11-22 PT PT168160422T patent/PT3380487T/pt unknown
- 2016-11-22 SM SM20200649T patent/SMT202000649T1/it unknown
- 2016-11-22 DK DK16816042.2T patent/DK3380487T3/da active
- 2016-11-22 HU HUE16816042A patent/HUE052634T2/hu unknown
- 2016-11-22 ES ES20189107T patent/ES3055983T3/es active Active
- 2016-11-22 KR KR1020187017508A patent/KR102688003B1/ko active Active
- 2016-11-22 RS RS20201382A patent/RS61072B1/sr unknown
- 2016-11-22 CN CN202211743414.4A patent/CN115819494A/zh active Pending
- 2016-11-22 LT LTEP16816042.2T patent/LT3380487T/lt unknown
- 2016-11-22 SI SI201630957T patent/SI3380487T1/sl unknown
- 2016-11-22 EP EP20189107.4A patent/EP3789395B1/en active Active
- 2016-11-22 WO PCT/US2016/063313 patent/WO2017091568A1/en not_active Ceased
- 2016-11-22 JP JP2018526713A patent/JP6921821B2/ja active Active
- 2016-11-22 PL PL16816042T patent/PL3380487T3/pl unknown
- 2016-11-22 CN CN201680067897.7A patent/CN108350025B/zh active Active
- 2016-11-22 US US15/776,923 patent/US10617765B2/en active Active
- 2016-11-22 ES ES16816042T patent/ES2827776T3/es active Active
- 2016-11-22 EP EP16816042.2A patent/EP3380487B1/en active Active
- 2016-11-22 HR HRP20201832TT patent/HRP20201832T1/hr unknown
-
2020
- 2020-02-21 US US16/797,361 patent/US11213589B2/en active Active
- 2020-11-20 CY CY20201101102T patent/CY1123699T1/el unknown
-
2021
- 2021-07-28 JP JP2021123154A patent/JP7257457B2/ja active Active
- 2021-12-03 US US17/541,636 patent/US20220160883A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2827776T3 (es) | 2021-05-24 |
| EP3789395A1 (en) | 2021-03-10 |
| JP7257457B2 (ja) | 2023-04-13 |
| PT3380487T (pt) | 2020-10-29 |
| US11213589B2 (en) | 2022-01-04 |
| SI3380487T1 (sl) | 2020-11-30 |
| HRP20201832T1 (hr) | 2021-01-08 |
| LT3380487T (lt) | 2020-12-28 |
| WO2017091568A1 (en) | 2017-06-01 |
| US20190351065A1 (en) | 2019-11-21 |
| CN108350025B (zh) | 2023-02-21 |
| US20220160883A1 (en) | 2022-05-26 |
| ES3055983T3 (en) | 2026-02-17 |
| WO2017091568A8 (en) | 2018-01-04 |
| EP3380487A1 (en) | 2018-10-03 |
| JP2019503994A (ja) | 2019-02-14 |
| PL3380487T3 (pl) | 2020-12-28 |
| HUE052634T2 (hu) | 2021-05-28 |
| EP3380487B1 (en) | 2020-09-02 |
| US20200276319A1 (en) | 2020-09-03 |
| CY1123699T1 (el) | 2022-03-24 |
| JP6921821B2 (ja) | 2021-08-18 |
| CN115819494A (zh) | 2023-03-21 |
| EP3789395B1 (en) | 2025-08-27 |
| US10617765B2 (en) | 2020-04-14 |
| JP2021176890A (ja) | 2021-11-11 |
| KR20180081610A (ko) | 2018-07-16 |
| SMT202000649T1 (it) | 2021-01-05 |
| CN108350025A (zh) | 2018-07-31 |
| KR102688003B1 (ko) | 2024-07-23 |
| DK3380487T3 (da) | 2020-12-07 |
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