MX364708B - Formulaciones y metodos para tratar la rinosinusitis. - Google Patents

Formulaciones y metodos para tratar la rinosinusitis.

Info

Publication number
MX364708B
MX364708B MX2013007993A MX2013007993A MX364708B MX 364708 B MX364708 B MX 364708B MX 2013007993 A MX2013007993 A MX 2013007993A MX 2013007993 A MX2013007993 A MX 2013007993A MX 364708 B MX364708 B MX 364708B
Authority
MX
Mexico
Prior art keywords
formulations
methods
rhinosinusitis
formulation
treating
Prior art date
Application number
MX2013007993A
Other languages
English (en)
Inventor
A Chaudry Imtiaz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/414,756 external-priority patent/US7811606B2/en
Priority claimed from US10/414,682 external-priority patent/US9808471B2/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX364708B publication Critical patent/MX364708B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029Radiation
    • A61L2/0035Gamma radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04Heat
    • A61L2/06Hot gas
    • A61L2/07Steam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La invención implica métodos y formulaciones para tratar o prevenir la rinosinusitis, incluyendo la rinosinusitis inducida por hongos en mamíferos. En una modalidad, la formulación de la presente invención comprende un agente antiinflamatorio esteroideo que tiene un perfil de distribución de tamaño de partícula específico. La formulación también puede comprender un agente antimicótico, agente antibiótico o antiviral.
MX2013007993A 2003-04-16 2004-03-29 Formulaciones y metodos para tratar la rinosinusitis. MX364708B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/414,756 US7811606B2 (en) 2003-04-16 2003-04-16 Nasal pharmaceutical formulations and methods of using the same
US10/414,682 US9808471B2 (en) 2003-04-16 2003-04-16 Nasal pharmaceutical formulations and methods of using the same
US10/657,550 US8912174B2 (en) 2003-04-16 2003-09-04 Formulations and methods for treating rhinosinusitis
PCT/EP2004/003316 WO2004091576A1 (en) 2003-04-16 2004-03-29 Formulations and methods for treating rhinosinusitis

Publications (1)

Publication Number Publication Date
MX364708B true MX364708B (es) 2019-05-06

Family

ID=33303857

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013007993A MX364708B (es) 2003-04-16 2004-03-29 Formulaciones y metodos para tratar la rinosinusitis.
MXPA05011106A MXPA05011106A (es) 2003-04-16 2004-03-29 Formulaciones y metodos para tratar la rinosinusitis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA05011106A MXPA05011106A (es) 2003-04-16 2004-03-29 Formulaciones y metodos para tratar la rinosinusitis.

Country Status (11)

Country Link
US (5) US8912174B2 (es)
EP (1) EP1613282B1 (es)
JP (1) JP4718445B2 (es)
KR (1) KR101396262B1 (es)
BR (1) BRPI0409348B8 (es)
CA (1) CA2522294C (es)
HK (1) HK1089676A1 (es)
MX (2) MX364708B (es)
PL (1) PL222059B1 (es)
RU (1) RU2410083C2 (es)
WO (1) WO2004091576A1 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
US7544192B2 (en) * 2003-03-14 2009-06-09 Sinexus, Inc. Sinus delivery of sustained release therapeutics
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
WO2005065185A2 (en) * 2003-12-24 2005-07-21 Collegium Pharmaceuticals, Inc. Temperature-stable formulations, and methods of development thereof
DK1711164T3 (da) * 2004-01-21 2010-07-19 Schering Corp Fremgangsmåde til behandling af akut rhinosinusitis
SI1750683T1 (sl) * 2004-04-23 2013-04-30 Amgen Inc. M/S 27-4-A, Amgen Inc. Formulacije s podaljĺ anim sproĺ äśanjem
KR100675379B1 (ko) * 2005-01-25 2007-01-29 삼성전자주식회사 프린팅 시스템 및 프린팅 방법
JP5816406B2 (ja) 2005-03-23 2015-11-18 オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド 酸化還元電位水溶液を使用する皮膚潰瘍の治療方法
CA2603081C (en) * 2005-04-04 2013-09-03 Sinexus, Inc. Device and methods for treating paranasal sinus conditions
WO2007070875A1 (en) * 2005-12-15 2007-06-21 Aerosol Science Laboratories, Inc. Treatment of active infections and related compositions
CA2637175C (en) * 2006-01-20 2015-07-14 Oculus Innovative Sciences, Inc. Methods of treating or preventing inflammation and hypersensitivity with oxidative reductive potential water solution
US8535707B2 (en) * 2006-07-10 2013-09-17 Intersect Ent, Inc. Devices and methods for delivering active agents to the osteomeatal complex
US20100323998A1 (en) * 2007-08-06 2010-12-23 Glenmark Pharmaceuticals Ltd. Topical composition containing the combination of mupirocin and beclomethasone
WO2009037855A1 (ja) * 2007-09-21 2009-03-26 Nihon Kodoiryo Kenkyukai Co., Ltd. 口腔用及び皮膚用組成物
DK2231065T3 (da) 2007-12-18 2021-02-01 Intersect Ent Inc Selvekspanderende anordninger
WO2010084505A2 (en) * 2008-06-06 2010-07-29 Glenmark Pharmaceuticals Limited Stable topical formulation comprising voriconazole
CA2732355A1 (en) 2008-08-01 2010-02-04 Intersect Ent, Inc. Methods and devices for crimping self-expanding devices
US20140336463A1 (en) * 2009-03-16 2014-11-13 Alan H. Shikani Rhinotopic therapy for the treatment of chronic rhinosinusitis biofilm disruption, treatment of mucosal granulation and sinus polyps
EP3103502A1 (en) * 2009-05-15 2016-12-14 Intersect ENT, Inc. Expandable devices and methods therefor
MX348304B (es) 2009-06-15 2017-06-02 Invekra S A P I De C V Solucion que contiene acido hipocloroso y metodos para usar la misma.
US8431539B2 (en) * 2009-09-17 2013-04-30 Eagle Pharmaceuticals, Inc. Formulations of daptomycin
AR079127A1 (es) 2009-11-23 2011-12-28 Cubist Pharm Inc Composiciones de daptomicina y metodos relacionados
US8916171B2 (en) 2010-04-27 2014-12-23 Topical Sinus Therapeutics, Inc. Topical delivery of viscous medications for the treatment of diseases associated with chronic sinusitis
DE102010048604A1 (de) 2010-10-15 2012-04-19 Automotive Lighting Reutlingen Gmbh Verfahren und elektrische Schaltung zum Betrieb einer Lichtquelle eines Kraftfahrzeugscheinwerfers mit Gleichstrom, sowie Lichtmodul eines Kraftfahrzeugscheinwerfers mit einer solchen Schaltung und Kraftfahrzeugscheinwerfers mit einem solchen Lichtmodul
EP2502616A1 (fr) * 2011-03-21 2012-09-26 Matthew Krayenbuhl Composition pharmaceutique nasale
ES2612257T3 (es) * 2011-05-03 2017-05-16 Chiesi Farmaceutici S.P.A. Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación
WO2013112865A1 (en) 2012-01-27 2013-08-01 The Trustees Of The University Of Pennsylvania Diagnosis and treatment for respiratory tract diseases
EP2938339B1 (en) 2012-12-27 2020-08-19 Massachusetts Eye & Ear Infirmary Treatment of rhinosinusitis with p-glycoprotein inhibitors
US20140242040A1 (en) * 2013-02-23 2014-08-28 Stemnion, Inc. Methods for preventing and/or treating nasal polyps and rhinosinusitis
EP3636227B1 (en) 2013-03-14 2024-08-28 Intersect ENT, Inc. Systems and devices for treating a sinus condition
CA2946832A1 (en) * 2013-04-25 2014-10-30 Seachaid Pharmaceuticals, Inc. Oral cefepime compositions and uses thereof
US9078853B2 (en) 2013-06-18 2015-07-14 Cmpd Licensing, Llc Dry pharmaceutical compositions for topical delivery of oral medications, nasal delivery and to treat ear disorders
MX367674B (es) * 2013-09-13 2019-08-30 Glenmark Specialty Sa Composición farmacéutica de dosis fija estable que comprende mometasona y olopatadina.
US9937189B2 (en) * 2013-09-13 2018-04-10 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
US9370483B2 (en) 2013-09-13 2016-06-21 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
US10758550B2 (en) 2013-10-04 2020-09-01 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10548907B2 (en) 2013-10-04 2020-02-04 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10653661B2 (en) 2013-10-04 2020-05-19 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
UA120587C2 (uk) 2013-10-04 2020-01-10 Гленмарк Спешіалті С.А. Спосіб лікування алергічного риніту з використанням комбінації мометазону та олопатадину
US10016443B2 (en) 2013-10-04 2018-07-10 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US11679210B2 (en) 2014-10-03 2023-06-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
WO2016057563A1 (en) 2014-10-08 2016-04-14 Pacific Northwest Diabetes Research Institute Methods and compositions for increasing the potency of antifungal agents
RU2564006C1 (ru) * 2014-12-03 2015-09-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) Способ лечения больных риносинуситом
CN113679931A (zh) 2015-01-22 2021-11-23 因特尔赛克特耳鼻喉公司 药物涂覆的气囊
US9744192B2 (en) * 2015-03-16 2017-08-29 Lee A. Flippin Methods of treating chronic rhinosinusitis
JP7085485B2 (ja) 2016-01-15 2022-06-16 マサチューセッツ アイ アンド イヤー インファーマリー 分泌型p-糖タンパク質は、慢性鼻副鼻腔炎の非侵襲的バイオマーカーである
WO2017198702A1 (en) * 2016-05-17 2017-11-23 Proponent Biotech Gmbh Carboxylic acid for treating/preventing nasal congestion
US20180071281A1 (en) * 2016-08-19 2018-03-15 Gerbe Labs Inc. Treating chronic rhinosinusitis
US10525025B2 (en) 2016-11-17 2020-01-07 Cmpd Licensing, Llc Compounded compositions and methods for treating pain
US11737975B2 (en) 2016-11-17 2023-08-29 Cmpd Licensing, Llc Compounded compositions and methods for treating pain
US10966946B2 (en) 2016-11-17 2021-04-06 Cmpd Licensing, Llc Compounded compositions and methods for treating pain
US9999604B2 (en) 2016-11-17 2018-06-19 Cmpd Licensing, Llc Compounded solutions of diclofenac and lidocaine and methods
US11986448B2 (en) 2016-11-17 2024-05-21 Cmpd Licensing, Llc Compounded compositions and methods for treating pain
KR102581802B1 (ko) * 2016-11-21 2023-09-25 삼성전자주식회사 디스플레이장치, 시스템 및 기록매체
EA033231B1 (ru) * 2017-02-17 2019-09-30 Государственное Учреждение "Республиканский Научно-Практический Центр Оториноларингологии" (Рнпц Оториноларингологии) Способ лечения хронического полипозного риносинусита у пациентов с аспириновой триадой
CN111491639A (zh) * 2017-09-20 2020-08-04 异位性医疗有限责任公司 用于治疗和改善呼吸道病况和粘膜炎症的组合物和方法

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989437A (en) 1955-06-08 1961-06-20 Upjohn Co Anti-inflammatory and anti-bacterial decongestant nasal spray compositions
US3091569A (en) 1960-08-26 1963-05-28 Mead Johnson & Co Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
GB2107715B (en) 1981-10-19 1985-11-13 Glaxo Group Ltd Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it
GB8432063D0 (en) 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
US4674319A (en) * 1985-03-20 1987-06-23 The Regents Of The University Of California Integrated circuit sensor
US4665610A (en) * 1985-04-22 1987-05-19 Stanford University Method of making a semiconductor transducer having multiple level diaphragm structure
DE3887591T2 (de) 1987-07-07 1994-05-19 Beecham Group Plc Pinacidil zur Behandlung von pulmonaler Hypertonie oder Rechtsversagen.
AU610175B2 (en) 1988-05-25 1991-05-16 Biogal Gyogyszergyar Pharmaceutical composition comprising a compound containing sulfhydryl group(s) for the treatment of otitis
CA2010894A1 (en) 1989-02-28 1990-08-31 Isamu Horikoshi Method of forming a suspension and composition formed by said method
JPH03165833A (ja) 1989-02-28 1991-07-17 Isamu Horikoshi 新規懸濁化方法及びこの方法によって得られる組成物
US4990462A (en) * 1989-04-12 1991-02-05 Advanced Micro Devices, Inc. Method for coplanar integration of semiconductor ic devices
SE9000207L (sv) 1990-01-22 1991-07-23 Nobel Chemicals Ab Laekemedel samt anvaendningen av detsamma
US5417111A (en) * 1990-08-17 1995-05-23 Analog Devices, Inc. Monolithic chip containing integrated circuitry and suspended microstructure
US5620931A (en) * 1990-08-17 1997-04-15 Analog Devices, Inc. Methods for fabricating monolithic device containing circuitry and suspended microstructure
CA2091360C (en) 1990-09-10 1997-04-08 Pui-Ho Yuen Mometasone furoate monohydrate, process for making same and pharmaceutical compositions
US5587735A (en) * 1991-07-24 1996-12-24 Hitachi, Ltd. Video telephone
US5174475A (en) 1991-03-26 1992-12-29 Glaxo Inc. Sequential dosing of antifungal and antiinflammatory compositions
JP3367113B2 (ja) * 1992-04-27 2003-01-14 株式会社デンソー 加速度センサ
US5461916A (en) * 1992-08-21 1995-10-31 Nippondenso Co., Ltd. Mechanical force sensing semiconductor device
US5491604A (en) * 1992-12-11 1996-02-13 The Regents Of The University Of California Q-controlled microresonators and tunable electronic filters using such resonators
US6199874B1 (en) * 1993-05-26 2001-03-13 Cornell Research Foundation Inc. Microelectromechanical accelerometer for automotive applications
US5616514A (en) * 1993-06-03 1997-04-01 Robert Bosch Gmbh Method of fabricating a micromechanical sensor
US5593688A (en) 1993-06-25 1997-01-14 Nexstar Pharmaceuticals, Inc. Liposomal targeting of ischemic tissue
JPH0753358A (ja) 1993-08-17 1995-02-28 Teijin Ltd 吸入剤
GB9410222D0 (en) 1994-05-21 1994-07-06 Glaxo Wellcome Australia Ltd Medicaments
DE4419844B4 (de) * 1994-06-07 2009-11-19 Robert Bosch Gmbh Beschleunigungssensor
US5613611A (en) * 1994-07-29 1997-03-25 Analog Devices, Inc. Carrier for integrated circuit package
US5510156A (en) * 1994-08-23 1996-04-23 Analog Devices, Inc. Micromechanical structure with textured surface and method for making same
US5517123A (en) * 1994-08-26 1996-05-14 Analog Devices, Inc. High sensitivity integrated micromechanical electrostatic potential sensor
DE4442033C2 (de) * 1994-11-25 1997-12-18 Bosch Gmbh Robert Drehratensensor
US5640039A (en) * 1994-12-01 1997-06-17 Analog Devices, Inc. Conductive plane beneath suspended microstructure
US6113894A (en) 1995-01-23 2000-09-05 Smith; S. Gregory Ophthalmic compositions and process of using
DE19503236B4 (de) * 1995-02-02 2006-05-24 Robert Bosch Gmbh Sensor aus einem mehrschichtigen Substrat
FR2732467B1 (fr) * 1995-02-10 1999-09-17 Bosch Gmbh Robert Capteur d'acceleration et procede de fabrication d'un tel capteur
DE19509868A1 (de) * 1995-03-17 1996-09-19 Siemens Ag Mikromechanisches Halbleiterbauelement
IT1275955B1 (it) 1995-03-22 1997-10-24 Dompe Spa Formulazioni farmaceutiche in forma di gel tissotropico
US5504026A (en) * 1995-04-14 1996-04-02 Analog Devices, Inc. Methods for planarization and encapsulation of micromechanical devices in semiconductor processes
DE19526903B4 (de) * 1995-07-22 2005-03-10 Bosch Gmbh Robert Drehratensensor
DE19530007C2 (de) * 1995-08-16 1998-11-26 Bosch Gmbh Robert Drehratensensor
AU7106996A (en) 1995-09-07 1997-03-27 Fuisz Technologies Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
DE19539049A1 (de) * 1995-10-20 1997-04-24 Bosch Gmbh Robert Verfahren zur Herstellung eines Coriolis-Drehratensensors
JPH09115999A (ja) * 1995-10-23 1997-05-02 Denso Corp 半導体集積回路装置
US5761957A (en) * 1996-02-08 1998-06-09 Denso Corporation Semiconductor pressure sensor that suppresses non-linear temperature characteristics
US5818227A (en) * 1996-02-22 1998-10-06 Analog Devices, Inc. Rotatable micromachined device for sensing magnetic fields
US5880369A (en) * 1996-03-15 1999-03-09 Analog Devices, Inc. Micromachined device with enhanced dimensional control
JP3423855B2 (ja) * 1996-04-26 2003-07-07 株式会社デンソー 電子部品搭載用構造体および電子部品の実装方法
DE19617666B4 (de) * 1996-05-03 2006-04-20 Robert Bosch Gmbh Mikromechanischer Drehratensensor
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5992233A (en) * 1996-05-31 1999-11-30 The Regents Of The University Of California Micromachined Z-axis vibratory rate gyroscope
US5976573A (en) * 1996-07-03 1999-11-02 Rorer Pharmaceutical Products Inc. Aqueous-based pharmaceutical composition
US5958378A (en) 1996-07-03 1999-09-28 Research Development Foundation High dose liposomal aerosol formulations containing cyclosporin A or budesonide
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
JP3584635B2 (ja) * 1996-10-04 2004-11-04 株式会社デンソー 半導体装置及びその製造方法
FR2756739B1 (fr) 1996-12-05 2000-04-28 Astra Ab Nouvelle formulation de budesonide
DE19653969A1 (de) 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
TW503113B (en) * 1997-01-16 2002-09-21 Senju Pharma Co Aqueous suspension for nasal administration
US6191007B1 (en) * 1997-04-28 2001-02-20 Denso Corporation Method for manufacturing a semiconductor substrate
US6388279B1 (en) * 1997-06-11 2002-05-14 Denso Corporation Semiconductor substrate manufacturing method, semiconductor pressure sensor and manufacturing method thereof
US6199430B1 (en) * 1997-06-17 2001-03-13 Denso Corporation Acceleration sensor with ring-shaped movable electrode
US6048774A (en) * 1997-06-26 2000-04-11 Denso Corporation Method of manufacturing dynamic amount semiconductor sensor
JP3555388B2 (ja) * 1997-06-30 2004-08-18 株式会社デンソー 半導体ヨーレートセンサ
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
AUPP653898A0 (en) * 1998-10-16 1998-11-05 Silverbrook Research Pty Ltd Micromechanical device and method (ij46F)
DE69804998T2 (de) 1997-10-09 2002-12-12 Schering Corp., Kenilworth Mometasonfuroat-suspensionen zum zerstäuben
EE200000253A (et) 1997-10-22 2001-06-15 Ponikau Jens Seentevastase toimeaine kasutamine ravimite valmistamiseks, mis on ette nähtud mitteinvasiivsetest seenorganismidest tingitud haiguste raviks või vältimiseks
JP3386349B2 (ja) 1997-10-30 2003-03-17 帝人株式会社 水性懸濁医薬品組成物
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
JP3900644B2 (ja) * 1998-01-16 2007-04-04 株式会社デンソー 半導体圧力センサの製造方法
US6065341A (en) * 1998-02-18 2000-05-23 Denso Corporation Semiconductor physical quantity sensor with stopper portion
DE19817311B4 (de) * 1998-04-18 2007-03-22 Robert Bosch Gmbh Herstellungsverfahren für mikromechanisches Bauelement
US6423423B2 (en) 1998-05-06 2002-07-23 Calsonic Kansei Corporation Formed strip and roll forming
US6389899B1 (en) * 1998-06-09 2002-05-21 The Board Of Trustees Of The Leland Stanford Junior University In-plane micromachined accelerometer and bridge circuit having same
US6241969B1 (en) 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
JP3309808B2 (ja) * 1998-08-04 2002-07-29 株式会社デンソー 圧力検出装置
CA2341732C (en) 1998-08-26 2008-08-19 Teijin Limited Powder composition for nasal administration
US6204085B1 (en) * 1998-09-15 2001-03-20 Texas Instruments Incorporated Reduced deformation of micromechanical devices through thermal stabilization
IT1303692B1 (it) 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US20040141925A1 (en) 1998-11-12 2004-07-22 Elan Pharma International Ltd. Novel triamcinolone compositions
US6534340B1 (en) * 1998-11-18 2003-03-18 Analog Devices, Inc. Cover cap for semiconductor wafer devices
WO2000042231A2 (en) * 1999-01-15 2000-07-20 The Regents Of The University Of California Polycrystalline silicon germanium films for forming micro-electromechanical systems
US6521212B1 (en) 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
US6507044B1 (en) * 1999-03-25 2003-01-14 Advanced Micro Devices, Inc. Position-selective and material-selective silicon etching to form measurement structures for semiconductor fabrication
JP4389326B2 (ja) * 1999-05-06 2009-12-24 株式会社デンソー 圧力センサ
WO2000074699A1 (en) 1999-06-03 2000-12-14 Johnson & Johnson Consumer France Sas Extracts of feverfew (tanacetum parthenium) against inflammatory disorders
JP2001002589A (ja) 1999-06-18 2001-01-09 Teijin Ltd 穏やかな薬物血中濃度の上昇を可能とする経鼻投与用組成物
US20020061281A1 (en) 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6230567B1 (en) * 1999-08-03 2001-05-15 The Charles Stark Draper Laboratory, Inc. Low thermal strain flexure support for a micromechanical device
GB9918559D0 (en) 1999-08-07 1999-10-06 Glaxo Wellcome Kk Novel pharmaceutical formulation
AU6852900A (en) 1999-08-20 2001-03-19 Norton Healthcare Ltd Method to produce powders for pulmonary or nasal administration
US6386032B1 (en) * 1999-08-26 2002-05-14 Analog Devices Imi, Inc. Micro-machined accelerometer with improved transfer characteristics
DE69938658D1 (de) * 1999-09-10 2008-06-19 St Microelectronics Srl Gegen mechanische Spannungen unempfindliche mikroelektromechanische Struktur
US6512255B2 (en) * 1999-09-17 2003-01-28 Denso Corporation Semiconductor pressure sensor device having sensor chip covered with protective member
GB9925934D0 (en) 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
US6524890B2 (en) * 1999-11-17 2003-02-25 Denso Corporation Method for manufacturing semiconductor device having element isolation structure
FI20002217A (fi) 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
KR100327596B1 (ko) * 1999-12-31 2002-03-15 박종섭 Seg 공정을 이용한 반도체소자의 콘택 플러그 제조방법
US6352935B1 (en) * 2000-01-18 2002-03-05 Analog Devices, Inc. Method of forming a cover cap for semiconductor wafer devices
US6507082B2 (en) * 2000-02-22 2003-01-14 Texas Instruments Incorporated Flip-chip assembly of protected micromechanical devices
US6392144B1 (en) * 2000-03-01 2002-05-21 Sandia Corporation Micromechanical die attachment surcharge
GB0009605D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
US6373007B1 (en) * 2000-04-19 2002-04-16 The United States Of America As Represented By The Secretary Of The Air Force Series and shunt mems RF switch
JP2001326367A (ja) * 2000-05-12 2001-11-22 Denso Corp センサおよびその製造方法
US6396711B1 (en) * 2000-06-06 2002-05-28 Agere Systems Guardian Corp. Interconnecting micromechanical devices
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
GB0016040D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
DK2153819T3 (da) 2000-07-14 2012-12-03 Allergan Inc Anvendelse af en opløselighedsforbedrende bestanddel i en vandig sammensætning omfattende brimonidintartrat
US6508126B2 (en) * 2000-07-21 2003-01-21 Denso Corporation Dynamic quantity sensor having movable and fixed electrodes with high rigidity
US6521965B1 (en) * 2000-09-12 2003-02-18 Robert Bosch Gmbh Integrated pressure sensor
US6621137B1 (en) * 2000-10-12 2003-09-16 Intel Corporation MEMS device integrated chip package, and method of making same
US6608054B2 (en) * 2001-03-20 2003-08-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and endothelin antagonists
US20020090388A1 (en) 2000-12-01 2002-07-11 Humes H. David Intravascular drug delivery device and use therefor
US7022546B2 (en) * 2000-12-05 2006-04-04 Analog Devices, Inc. Method and device for protecting micro electromechanical systems structures during dicing of a wafer
DE10060890C2 (de) 2000-12-07 2003-04-03 Meta Motoren Energietech Vorrichtung zum Umschalten des Betriebs eines Ladungswechselventils einer Brennkraftmaschine
JP3964184B2 (ja) * 2000-12-28 2007-08-22 株式会社デンソー 積層型圧電アクチュエータ
US20020132803A1 (en) 2001-01-05 2002-09-19 Mahendra Dedhiya Fluticasone suspension formulation, spray pattern method, and nasal spray apparatus
MXPA03006958A (es) 2001-02-05 2003-11-18 Upjohn Co Composicion para administracion rectal de farmaco antibacterial de oxazolidinona.
US6555904B1 (en) * 2001-03-05 2003-04-29 Analog Devices, Inc. Electrically shielded glass lid for a packaged device
GB0105560D0 (en) 2001-03-07 2001-04-25 Glaxo Group Ltd Pharmaceutical formulations
US8552054B2 (en) 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
EP1423107B1 (en) 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
US6531767B2 (en) * 2001-04-09 2003-03-11 Analog Devices Inc. Critically aligned optical MEMS dies for large packaged substrate arrays and method of manufacture
US6552404B1 (en) * 2001-04-17 2003-04-22 Analog Devices, Inc. Integratable transducer structure
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
AU2002355419A1 (en) 2001-08-06 2003-02-24 Genomed, Llc Methods and compositions for treating diseases associated with excesses in ace
US6508561B1 (en) * 2001-10-17 2003-01-21 Analog Devices, Inc. Optical mirror coatings for high-temperature diffusion barriers and mirror shaping
FR2831446B1 (fr) 2001-10-26 2004-03-05 Sanofi Synthelabo Utilisation de l'irbesartan pour la preparation de medicaments utiles pour la prevention ou le traitement de l'hypertension pulmonaire
KR20030045246A (ko) 2001-12-01 2003-06-11 엘지전자 주식회사 휴대용 단말기의 특정 기능 실행 방법 및 장치
US7008644B2 (en) 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
US20040208833A1 (en) 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US9808471B2 (en) 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same

Also Published As

Publication number Publication date
US20050180925A1 (en) 2005-08-18
US8129364B2 (en) 2012-03-06
US20080058296A1 (en) 2008-03-06
JP4718445B2 (ja) 2011-07-06
CA2522294A1 (en) 2004-10-28
US8663695B2 (en) 2014-03-04
MXPA05011106A (es) 2005-12-12
US20040209852A1 (en) 2004-10-21
JP2006523631A (ja) 2006-10-19
AU2004229149A1 (en) 2004-10-28
RU2410083C2 (ru) 2011-01-27
BRPI0409348B1 (pt) 2019-04-24
PL222059B1 (pl) 2016-06-30
KR20060003019A (ko) 2006-01-09
EP1613282B1 (en) 2018-05-02
US20120237559A1 (en) 2012-09-20
US20060051300A1 (en) 2006-03-09
WO2004091576A1 (en) 2004-10-28
HK1089676A1 (en) 2006-12-08
EP1613282A1 (en) 2006-01-11
US8912174B2 (en) 2014-12-16
RU2005135333A (ru) 2006-03-20
PL377855A1 (pl) 2006-02-20
KR101396262B1 (ko) 2014-05-19
US9180126B2 (en) 2015-11-10
US8309061B2 (en) 2012-11-13
BRPI0409348B8 (pt) 2021-05-25
CA2522294C (en) 2014-05-06
BRPI0409348A (pt) 2006-04-25

Similar Documents

Publication Publication Date Title
MX364708B (es) Formulaciones y metodos para tratar la rinosinusitis.
WO2002072022A3 (en) Substituted tetracycline compounds as antifungal agents
WO2002072031A3 (en) Substituted tetracycline compounds as synergistic antifungal agents
WO2004034990A3 (en) Methods and compositions for use in treating cancer
MY138285A (en) Fab i inhibitors
AU2003293194A1 (en) Compositions and methods for treating prostate cancer
HK1091814A1 (en) Aminocyclohexyl ether compounds and uses thereof
ZA200503967B (en) Agent for preventing or treating neuropathy
AU2003230750A1 (en) Compositions and methods for treating cancer
AU2002344842A1 (en) Highly impact-resistant granules
MX2009008411A (es) Ectoparasiticida de accion prolongada con alta dosis para un control prolongado.
WO2004058153A9 (en) Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476.
AU2003225535A1 (en) Methods and compositions for treating cancer
WO2003099217A3 (en) Methods of treating bacterial infections and diseases associated therewith
WO2002030465A3 (en) Compositions that inhibit proliferation of cancer cells
WO2005000214A3 (en) Method for treating diseases using hsp90-inhibiting agents in combination with antibiotics
WO2004028474A3 (en) Caspase inhibitors as anticancer agents
MXPA04005417A (es) Uso de antagonista de h1 y un esteroide seguro para el tratamiento de la rinitis.
AU2003233222A1 (en) Aqueous polyurethane preparations
AU2003239132A1 (en) Methods and compositions for preventing and treating microbial infections
AU2003296963A1 (en) Methods and compositions for treating and preventing ear infections
WO2002041831A3 (en) Inositol derivatives for increasing chloride secretion and inhibiting inflammation
WO2003053365A3 (en) Syn3 compositions and methods
WO2003059332A3 (en) Use of an anti-microtubule agent for the treatment of uveitis
AU2003298708A1 (en) GPC99 AND GPC99a: METHODS AND COMPOSITIONS FOR TREATING CANCER