MX363538B - Solucion de eluyente. - Google Patents

Solucion de eluyente.

Info

Publication number
MX363538B
MX363538B MX2013007699A MX2013007699A MX363538B MX 363538 B MX363538 B MX 363538B MX 2013007699 A MX2013007699 A MX 2013007699A MX 2013007699 A MX2013007699 A MX 2013007699A MX 363538 B MX363538 B MX 363538B
Authority
MX
Mexico
Prior art keywords
radiofluorination
preparation
present
prepared
eluent solution
Prior art date
Application number
MX2013007699A
Other languages
English (en)
Spanish (es)
Other versions
MX2013007699A (es
Inventor
Kristian Hjelstuen Ole
Wickstrom Torild
Svadberg Anders
M Evje Dag
Ochsenfeld Liane
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2013007699A publication Critical patent/MX2013007699A/es
Publication of MX363538B publication Critical patent/MX363538B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00General methods of preparing halides
    • C01B9/08Fluorides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001Acyclic or carbocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MX2013007699A 2010-12-29 2011-12-21 Solucion de eluyente. MX363538B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution

Publications (2)

Publication Number Publication Date
MX2013007699A MX2013007699A (es) 2013-08-15
MX363538B true MX363538B (es) 2019-03-27

Family

ID=45495902

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007699A MX363538B (es) 2010-12-29 2011-12-21 Solucion de eluyente.

Country Status (16)

Country Link
US (3) US11504430B2 (cg-RX-API-DMAC7.html)
EP (2) EP2658831B1 (cg-RX-API-DMAC7.html)
JP (1) JP6018581B2 (cg-RX-API-DMAC7.html)
KR (3) KR102218263B1 (cg-RX-API-DMAC7.html)
CN (2) CN103270004A (cg-RX-API-DMAC7.html)
AU (1) AU2011351550B2 (cg-RX-API-DMAC7.html)
BR (2) BR112013015396B1 (cg-RX-API-DMAC7.html)
CA (1) CA2823063C (cg-RX-API-DMAC7.html)
DK (3) DK2658831T3 (cg-RX-API-DMAC7.html)
ES (2) ES2621950T3 (cg-RX-API-DMAC7.html)
MX (1) MX363538B (cg-RX-API-DMAC7.html)
PL (2) PL2658831T3 (cg-RX-API-DMAC7.html)
PT (2) PT2793954T (cg-RX-API-DMAC7.html)
RU (1) RU2608932C2 (cg-RX-API-DMAC7.html)
SG (1) SG10201805198TA (cg-RX-API-DMAC7.html)
WO (1) WO2012089594A1 (cg-RX-API-DMAC7.html)

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CN103270004A (zh) * 2010-12-29 2013-08-28 通用电气健康护理有限公司 洗脱溶液
CA2852840A1 (en) * 2011-10-19 2013-04-25 Piramal Imaging Sa Improved method for production of f-18 labeled a.beta. ligands
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB2509476B (en) * 2011-12-21 2018-08-08 Ge Healthcare Ltd Ip 18F - Fluciclovine compositions in citrate buffers
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
FI3068747T3 (fi) 2013-11-13 2024-12-30 Ge Healthcare Ltd Kaksoisajettava kasetti 18f-leimattujen yhdisteiden synteesiä varten
US9988336B2 (en) * 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
NL2014828B1 (en) * 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 2−[18f]フルオロ−2−デオキシ−d−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種18fの精製方法
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

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ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
RU2165266C1 (ru) 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
AU2002337926B8 (en) 2002-11-05 2008-02-28 Ion Beam Applications S.A. Stabilization of radiopharmaceuticals labeled with 18-F
GB0422004D0 (en) * 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
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US7235216B2 (en) * 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
WO2007148088A2 (en) * 2006-06-21 2007-12-27 Ge Healthcare Limited Radiopharmaceutical products
WO2008056481A1 (en) 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
US8790620B2 (en) 2006-12-21 2014-07-29 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
CN101636183B (zh) * 2007-02-13 2014-03-19 日本医事物理股份有限公司 放射性诊断显像剂的制备方法
EP2017359A3 (en) * 2007-06-11 2009-08-05 Trasis S.A. Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step
KR101009712B1 (ko) 2007-02-22 2011-01-19 재단법인 아산사회복지재단 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
WO2008106442A1 (en) * 2007-02-27 2008-09-04 Ge Healthcare Limited Synthesis of [18f] fluoromethyl benzene using benzyl pentafluorobenzenesulfonate
EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
WO2009045535A2 (en) * 2007-10-04 2009-04-09 Sloan-Kettering Institute For Cancer Research Fluorine-18 derivative of dasatinib and uses thereof
CA2709558C (en) * 2007-12-19 2016-08-16 Fumie Kurosaki Process for production of radioactive-fluorine-labeled organic compound
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RU2475448C2 (ru) * 2008-01-03 2013-02-20 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ обработки фторида
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CN103270004A (zh) * 2010-12-29 2013-08-28 通用电气健康护理有限公司 洗脱溶液
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Also Published As

Publication number Publication date
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
DK3766522T3 (da) 2022-06-13
EP2658831A1 (en) 2013-11-06
DK2793954T3 (da) 2021-01-04
SG10201805198TA (en) 2018-07-30
KR20190008994A (ko) 2019-01-25
BR112013015396B1 (pt) 2021-11-03
US11504430B2 (en) 2022-11-22
EP2658831B1 (en) 2017-02-15
DK2658831T3 (en) 2017-04-24
CN103270004A (zh) 2013-08-28
BR112014015042A2 (pt) 2017-06-13
JP6018581B2 (ja) 2016-11-02
EP3766522B1 (en) 2022-03-23
MX2013007699A (es) 2013-08-15
BR112014015042A8 (pt) 2017-07-04
PL2658831T3 (pl) 2017-07-31
CN108218650A (zh) 2018-06-29
KR102137348B1 (ko) 2020-07-23
PL3766522T3 (pl) 2022-07-04
JP2014508731A (ja) 2014-04-10
RU2013126979A (ru) 2015-03-20
EP3766522A1 (en) 2021-01-20
RU2608932C2 (ru) 2017-01-26
WO2012089594A1 (en) 2012-07-05
US20130324715A1 (en) 2013-12-05
US20190192660A1 (en) 2019-06-27
AU2011351550A1 (en) 2013-07-25
PT2793954T (pt) 2021-01-06
KR102218263B1 (ko) 2021-02-22
PT3766522T (pt) 2022-06-14
BR112013015396A2 (pt) 2016-09-20
BR112014015042B1 (pt) 2021-10-26
ES2917875T3 (es) 2022-07-12
AU2011351550B2 (en) 2017-02-02
ES2621950T3 (es) 2017-07-05
US20230068052A1 (en) 2023-03-02
KR20190119673A (ko) 2019-10-22
KR20130132892A (ko) 2013-12-05

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