WO2012157900A3 - 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 - Google Patents
18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 Download PDFInfo
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- WO2012157900A3 WO2012157900A3 PCT/KR2012/003713 KR2012003713W WO2012157900A3 WO 2012157900 A3 WO2012157900 A3 WO 2012157900A3 KR 2012003713 W KR2012003713 W KR 2012003713W WO 2012157900 A3 WO2012157900 A3 WO 2012157900A3
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Abstract
본 발명은 양전자방출 단층촬영술(PET)용 방사성의약품의 전구체, 그 제조방법과 응용에 관한 것으로, 더욱 상세하게는 4가 유기염의 이탈기를 갖는 전구체, 그 제조방법 및 이를 이용하여 단일 단계로 18F를 도입함으로써 짧은 제조시간 내에 원하는 PET 방사성의약품을 높은 방사화학적 수율로 제조하는 방법에 관한 것이다. 본 발명의 4가 유기염 이탈기를 포함하는 전구체는 기존의 다단계의 복잡한 방사성의약품 제조를 단일 단계로 단순화시킬 수 있으며, 과량의 상전이 촉매가 필요 없어 생산 비용을 절감할 수 있고, 반응 후 화합물 분리가 용이하고, 반응속도가 빠른 장점이 있다. 이러한 특징은 자동화 합성 시스템에 의한 PET 방사성의약품 대량생산에 적합하다.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201280023659.8A CN103608337B (zh) | 2011-05-13 | 2012-05-11 | Pet放射性医疗用品的18f-标记前体及其制备方法 |
US14/117,271 US9505799B2 (en) | 2011-05-13 | 2012-05-11 | 18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof |
Applications Claiming Priority (2)
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KR10-2011-0045390 | 2011-05-13 | ||
KR20110045390 | 2011-05-13 |
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WO2012157900A2 WO2012157900A2 (ko) | 2012-11-22 |
WO2012157900A3 true WO2012157900A3 (ko) | 2013-01-17 |
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PCT/KR2012/003713 WO2012157900A2 (ko) | 2011-05-13 | 2012-05-11 | 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 |
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US (1) | US9505799B2 (ko) |
KR (1) | KR101879181B1 (ko) |
CN (1) | CN103608337B (ko) |
WO (1) | WO2012157900A2 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101602912B1 (ko) * | 2013-09-13 | 2016-03-11 | 주식회사 바이오이미징코리아 | [18f]플루오르메틸기가 도입된 뇌신경염증 표적 양성자방출단층촬영 방사성추적자, 이의 합성 및 그를 이용한 생물학적 결과 평가 방법 |
CN106890345B (zh) * | 2015-12-17 | 2020-09-01 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种靶向线粒体的造影剂分子作为t2造影剂的用途 |
KR102137001B1 (ko) * | 2018-09-21 | 2020-07-24 | 주식회사 비아이케이테라퓨틱스 | 선택적 아자이드 치환반응과 전구체 제거화를 이용한 플루오린-18이 표지 된 플루오르메틸 치환 방사성의약품의 제조방법 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100549213B1 (ko) * | 2003-01-15 | 2006-02-03 | 학교법인 인하학원 | 플루오린-18로 표지된 유기플루오로화합물의 제조방법 |
WO2006065038A1 (en) * | 2004-12-15 | 2006-06-22 | Futurechem Co., Ltd. | Method for preparation of organofluoro compounds in alcohol solvents |
US20100111864A1 (en) * | 2007-04-11 | 2010-05-06 | Merck Eprova Ag | 18f-labelled folates |
Family Cites Families (9)
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US20060018966A1 (en) * | 2003-07-22 | 2006-01-26 | Lin Victor S | Antimicrobial mesoporous silica nanoparticles |
GB0512770D0 (en) * | 2005-06-23 | 2005-07-27 | Hammersmith Imanet Ltd | Imaging compounds |
CN100560548C (zh) * | 2006-06-01 | 2009-11-18 | 郭启勇 | 采用离子液体作为相转移催化剂合成18f标记正电子放射性示踪剂的方法 |
EP1897885A1 (en) * | 2006-09-08 | 2008-03-12 | Bayer Schering Pharma Aktiengesellschaft | Compounds and methods for F labelled agents |
EP2220058A4 (en) * | 2007-12-11 | 2011-07-13 | Univ Colorado | HETEROARYL SALTS AND METHODS OF MAKING AND USING THEM |
AU2009253046A1 (en) * | 2008-05-30 | 2009-12-03 | Foster Wheeler Energia Oy | Method of and system for generating power by oxyfuel combustion |
GB0812923D0 (en) * | 2008-07-15 | 2008-08-20 | Isis Innovation | Preparation of flourine-labelled compounds |
WO2010096426A2 (en) * | 2009-02-20 | 2010-08-26 | Emory University | Compounds, compositions, methods of synthesis, and methods of treatment |
KR101478140B1 (ko) * | 2011-05-13 | 2014-12-31 | (주)퓨쳐켐 | 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 |
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2012
- 2012-05-11 WO PCT/KR2012/003713 patent/WO2012157900A2/ko active Application Filing
- 2012-05-11 CN CN201280023659.8A patent/CN103608337B/zh active Active
- 2012-05-11 US US14/117,271 patent/US9505799B2/en active Active
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2014
- 2014-08-27 KR KR1020140112162A patent/KR101879181B1/ko active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100549213B1 (ko) * | 2003-01-15 | 2006-02-03 | 학교법인 인하학원 | 플루오린-18로 표지된 유기플루오로화합물의 제조방법 |
WO2006065038A1 (en) * | 2004-12-15 | 2006-06-22 | Futurechem Co., Ltd. | Method for preparation of organofluoro compounds in alcohol solvents |
US20100111864A1 (en) * | 2007-04-11 | 2010-05-06 | Merck Eprova Ag | 18f-labelled folates |
Non-Patent Citations (1)
Title |
---|
MOON, BYUNG SUK ET AL.: "A Novel Aromatic Fluorine-18 Labeling Method Using Lodonium Salts Precursor", NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 43, no. 1, 2009, pages 1 - 9 * |
Also Published As
Publication number | Publication date |
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KR20140113622A (ko) | 2014-09-24 |
CN103608337B (zh) | 2016-07-06 |
CN103608337A (zh) | 2014-02-26 |
WO2012157900A2 (ko) | 2012-11-22 |
KR101879181B1 (ko) | 2018-07-17 |
US9505799B2 (en) | 2016-11-29 |
US20140194620A1 (en) | 2014-07-10 |
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