WO2012157900A3 - 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 - Google Patents

18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 Download PDF

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WO2012157900A3
WO2012157900A3 PCT/KR2012/003713 KR2012003713W WO2012157900A3 WO 2012157900 A3 WO2012157900 A3 WO 2012157900A3 KR 2012003713 W KR2012003713 W KR 2012003713W WO 2012157900 A3 WO2012157900 A3 WO 2012157900A3
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medical supplies
preparation
radioactive medical
precursor
pet
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WO2012157900A2 (ko
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지대윤
이병세
박찬수
이민형
차효진
조우진
강희원
김경훈
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서강대학교산학협력단
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Priority to CN201280023659.8A priority Critical patent/CN103608337B/zh
Priority to US14/117,271 priority patent/US9505799B2/en
Publication of WO2012157900A2 publication Critical patent/WO2012157900A2/ko
Publication of WO2012157900A3 publication Critical patent/WO2012157900A3/ko

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Abstract

본 발명은 양전자방출 단층촬영술(PET)용 방사성의약품의 전구체, 그 제조방법과 응용에 관한 것으로, 더욱 상세하게는 4가 유기염의 이탈기를 갖는 전구체, 그 제조방법 및 이를 이용하여 단일 단계로 18F를 도입함으로써 짧은 제조시간 내에 원하는 PET 방사성의약품을 높은 방사화학적 수율로 제조하는 방법에 관한 것이다. 본 발명의 4가 유기염 이탈기를 포함하는 전구체는 기존의 다단계의 복잡한 방사성의약품 제조를 단일 단계로 단순화시킬 수 있으며, 과량의 상전이 촉매가 필요 없어 생산 비용을 절감할 수 있고, 반응 후 화합물 분리가 용이하고, 반응속도가 빠른 장점이 있다. 이러한 특징은 자동화 합성 시스템에 의한 PET 방사성의약품 대량생산에 적합하다.
PCT/KR2012/003713 2011-05-13 2012-05-11 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 WO2012157900A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201280023659.8A CN103608337B (zh) 2011-05-13 2012-05-11 Pet放射性医疗用品的18f-标记前体及其制备方法
US14/117,271 US9505799B2 (en) 2011-05-13 2012-05-11 18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof

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Application Number Priority Date Filing Date Title
KR10-2011-0045390 2011-05-13
KR20110045390 2011-05-13

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WO2012157900A2 WO2012157900A2 (ko) 2012-11-22
WO2012157900A3 true WO2012157900A3 (ko) 2013-01-17

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US (1) US9505799B2 (ko)
KR (1) KR101879181B1 (ko)
CN (1) CN103608337B (ko)
WO (1) WO2012157900A2 (ko)

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KR101602912B1 (ko) * 2013-09-13 2016-03-11 주식회사 바이오이미징코리아 [18ｆ]플루오르메틸기가 도입된 뇌신경염증 표적 양성자방출단층촬영 방사성추적자, 이의 합성 및 그를 이용한 생물학적 결과 평가 방법
CN106890345B (zh) * 2015-12-17 2020-09-01 中国科学院苏州纳米技术与纳米仿生研究所 一种靶向线粒体的造影剂分子作为t2造影剂的用途
KR102137001B1 (ko) * 2018-09-21 2020-07-24 주식회사 비아이케이테라퓨틱스 선택적 아자이드 치환반응과 전구체 제거화를 이용한 플루오린-18이 표지 된 플루오르메틸 치환 방사성의약품의 제조방법

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US20100111864A1 (en) * 2007-04-11 2010-05-06 Merck Eprova Ag 18f-labelled folates

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KR20140113622A (ko) 2014-09-24
CN103608337B (zh) 2016-07-06
CN103608337A (zh) 2014-02-26
WO2012157900A2 (ko) 2012-11-22
KR101879181B1 (ko) 2018-07-17
US9505799B2 (en) 2016-11-29
US20140194620A1 (en) 2014-07-10

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