WO2012081880A3 - 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용 - Google Patents

18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용 Download PDF

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WO2012081880A3
WO2012081880A3 PCT/KR2011/009571 KR2011009571W WO2012081880A3 WO 2012081880 A3 WO2012081880 A3 WO 2012081880A3 KR 2011009571 W KR2011009571 W KR 2011009571W WO 2012081880 A3 WO2012081880 A3 WO 2012081880A3
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manufacturing
solid support
application
precursor
radiopharmaceutical
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WO2012081880A2 (ko
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지대윤
이병세
이재학
추소영
정운정
권혜림
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서강대학교산학협력단
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Priority to CN201180059657.XA priority Critical patent/CN103347909B/zh
Priority to US13/994,339 priority patent/US9751844B2/en
Publication of WO2012081880A2 publication Critical patent/WO2012081880A2/ko
Publication of WO2012081880A3 publication Critical patent/WO2012081880A3/ko

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Abstract

본 발명은 고체 지지체를 포함하는 유기염 형태의 고체 전구체 및 이의 제조방법과 응용에 관한 것이다. 본 발명의 고체 전구체는 별도의 카트리지를 이용한 [18F]플루오라이드 정제 과정과 과량의 상전이 촉매 사용을 생략할 수 있고, 전구체 내 고체 지지체에 의해 반응 후 남은 물질의 제거가 용이하다. 본 발명의 고체 전구체를 카트리지에 충전하여 사용할 경우, [18F]플루오르화 반응의 전반적인 과정을 수행할 수 있는 올인원(all-in-one) 시스템으로 자동화 합성 장치에 매우 적합하다.
PCT/KR2011/009571 2010-12-14 2011-12-13 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용 WO2012081880A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201180059657.XA CN103347909B (zh) 2010-12-14 2011-12-13 用以制备18f放射性药物的固体载体上所连接的前体化合物及其制备方法与应用
US13/994,339 US9751844B2 (en) 2010-12-14 2011-12-13 Precursor compound connected to solid support for manufacturing 18F radiopharmaceutical, method for manufacturing same, and application thereof

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Application Number Priority Date Filing Date Title
KR20100127934 2010-12-14
KR10-2010-0127934 2010-12-14

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WO2012081880A2 WO2012081880A2 (ko) 2012-06-21
WO2012081880A3 true WO2012081880A3 (ko) 2012-08-23

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US (1) US9751844B2 (ko)
KR (1) KR101351878B1 (ko)
CN (1) CN103347909B (ko)
TW (1) TWI435884B (ko)
WO (1) WO2012081880A2 (ko)

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CN104470547B (zh) 2012-05-24 2018-01-26 未来化学株式会社 利用筒状物合成放射性药物的方法
KR102234360B1 (ko) * 2014-06-10 2021-04-01 서강대학교산학협력단 유기염을 갖는 설포네이트 화합물, 이를 이용한 유기염을 갖는 유기플루오로 화합물 및 그 제조방법
KR20150142869A (ko) 2014-06-12 2015-12-23 서강대학교산학협력단 구아니딘이 결합된 고분자를 이용한 방사성 의약품의 제조방법
CN111574515B (zh) * 2014-11-07 2023-01-10 财团法人峨山社会福祉财团 有机氟化脂肪族化合物的制备方法及纯化方法
KR101519425B1 (ko) * 2014-11-07 2015-05-12 재단법인 아산사회복지재단 역류방지 반응용기를 포함하는 카세트를 이용한 방사성 의약품의 제조방법
FR3052775B1 (fr) * 2016-06-20 2020-03-13 Commissariat A L'energie Atomique Et Aux Energies Alternatives Composes aptes a complexer au moins un element metallique et materiaux polymeriques obtenus a partir desdits composes
KR102063498B1 (ko) * 2019-06-25 2020-01-08 (주)퓨쳐켐 불포화 탄화수소기를 갖는 알코올 용매를 이용한 플루오로 화합물의 제조방법

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US9751844B2 (en) 2017-09-05
WO2012081880A2 (ko) 2012-06-21
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