WO2012033374A3 - 1,2,3-트리아졸륨 염을 갖는 설포네이트 전구체, 그 제조방법 및 이를 사용하는 분자내 친핵성 플루오르화반응 - Google Patents

1,2,3-트리아졸륨 염을 갖는 설포네이트 전구체, 그 제조방법 및 이를 사용하는 분자내 친핵성 플루오르화반응 Download PDF

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WO2012033374A3
WO2012033374A3 PCT/KR2011/006682 KR2011006682W WO2012033374A3 WO 2012033374 A3 WO2012033374 A3 WO 2012033374A3 KR 2011006682 W KR2011006682 W KR 2011006682W WO 2012033374 A3 WO2012033374 A3 WO 2012033374A3
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Prior art keywords
precursor
sulphonate
production method
intramolecular nucleophilic
same
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PCT/KR2011/006682
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English (en)
French (fr)
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WO2012033374A2 (ko
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지대윤
이병세
추소영
이재학
권혜림
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서강대학교 산학협력단
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Publication of WO2012033374A2 publication Critical patent/WO2012033374A2/ko
Publication of WO2012033374A3 publication Critical patent/WO2012033374A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

본 발명은 1,2,3-트리아졸륨 염을 갖는 설포네이트 전구체, 이의 제조방법 및 응용에 관한 것으로, 보다 상세하게는 상전이 촉매 효과를 갖는 유기 염을 전구체의 이탈기 부분에 도입하여 친핵체와 설포네이트 전구체의 분자내 친핵성 치환반응을 유도하여 반응 속도를 증가시킬 수 있으며, 별도의 상전이 촉매의 사용을 회피하는 효과를 나타낸다. 이는 양전자방출 단층촬영술 (Positron Emission Tomography)에 사용되는 [18F]방사성의약품의 효과적인 제조를 위한 설포네이트 전구체로 응용될 수 있다.
PCT/KR2011/006682 2010-09-09 2011-09-08 1,2,3-트리아졸륨 염을 갖는 설포네이트 전구체, 그 제조방법 및 이를 사용하는 분자내 친핵성 플루오르화반응 WO2012033374A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100088184 2010-09-09
KR10-2010-0088184 2010-09-09

Publications (2)

Publication Number Publication Date
WO2012033374A2 WO2012033374A2 (ko) 2012-03-15
WO2012033374A3 true WO2012033374A3 (ko) 2012-06-28

Family

ID=45811095

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/006682 WO2012033374A2 (ko) 2010-09-09 2011-09-08 1,2,3-트리아졸륨 염을 갖는 설포네이트 전구체, 그 제조방법 및 이를 사용하는 분자내 친핵성 플루오르화반응

Country Status (2)

Country Link
KR (1) KR101407970B1 (ko)
WO (1) WO2012033374A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102234360B1 (ko) * 2014-06-10 2021-04-01 서강대학교산학협력단 유기염을 갖는 설포네이트 화합물, 이를 이용한 유기염을 갖는 유기플루오로 화합물 및 그 제조방법
WO2020018613A1 (en) * 2018-07-17 2020-01-23 Wake Forest University Health Sciences Compounds useful for in vivo imaging of protein oxidation and/or cancer treatment
KR101923383B1 (ko) 2018-07-26 2019-02-22 (주)코리아에스이 탄소섬유와 고황산염시멘트를 이용한 콘크리트 인공암 조형물과 이를 시공하는 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080544A1 (en) * 2002-03-22 2003-10-02 Amersham Plc Radiofluorination methods
KR20040065076A (ko) * 2003-01-15 2004-07-21 학교법인 인하학원 플루오린-18로 표지된 유기플루오로화합물의 제조방법
WO2004108636A2 (en) * 2003-05-30 2004-12-16 Perkinelmer Las, Inc. Isotopically labeled chemically stable reagents and process for the synthesis thereof
WO2006116629A2 (en) * 2005-04-27 2006-11-02 Siemens Medical Solutions Usa, Inc. The preparation of molecular imaging probes using click chemistry

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2110367A1 (en) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080544A1 (en) * 2002-03-22 2003-10-02 Amersham Plc Radiofluorination methods
KR20040065076A (ko) * 2003-01-15 2004-07-21 학교법인 인하학원 플루오린-18로 표지된 유기플루오로화합물의 제조방법
WO2004108636A2 (en) * 2003-05-30 2004-12-16 Perkinelmer Las, Inc. Isotopically labeled chemically stable reagents and process for the synthesis thereof
WO2006116629A2 (en) * 2005-04-27 2006-11-02 Siemens Medical Solutions Usa, Inc. The preparation of molecular imaging probes using click chemistry

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEPORE, S.D. ET AL.: "Recent advances in heterolytic nucleofugal leaving group", TETRAHEDRON, vol. 63, 2007, pages 5103 - 5122 *

Also Published As

Publication number Publication date
KR101407970B1 (ko) 2014-06-19
WO2012033374A2 (ko) 2012-03-15
KR20120026461A (ko) 2012-03-19

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