SA113350005B1 - عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا - Google Patents
عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانياInfo
- Publication number
- SA113350005B1 SA113350005B1 SA113350005A SA113350005A SA113350005B1 SA 113350005 B1 SA113350005 B1 SA 113350005B1 SA 113350005 A SA113350005 A SA 113350005A SA 113350005 A SA113350005 A SA 113350005A SA 113350005 B1 SA113350005 B1 SA 113350005B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- synthesis
- dimethoxyphenyl
- ivabradine
- enenitrile
- prop
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
يتعلق الاختراع الحالي بعملية (P1) لتخليق (2E)-3-(3، 4-داي ميثوكسي فينيل)بروب-2-ين نيتريل (I): تشتمل على تعريض 4-برومو-1، 2-داي ميثوكسي بنزين (II) لتفاعل إقران بأكريلو نيتريل في وجود محفز من البالاديوم، ومركب ترابطي، ومادة قاعدية وعامل لنقل الطور في مذيب عضوي للحصول على (I). علاوة على ذلك تشتمل العملية المذكورة على تعريض 4-برومو-1، 2-داي ميثوكسي بنزين له الصيغة (II) لتفاعل إقران بأكريلو نيتريل في وجود محفز من البالاديوم، ومركب ترابطي، ومادة قاعدية وعامل لنقل الطور في مذيب عضوي للحصول على (I). وتطبيقها في تخليق إيڤابرادين، وأملاح الإضافة منه مع حمض مقبول صيدلانياً.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1260576A FR2997696B1 (fr) | 2012-11-08 | 2012-11-08 | Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
Publication Number | Publication Date |
---|---|
SA113350005B1 true SA113350005B1 (ar) | 2015-12-06 |
Family
ID=47598957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA113350005A SA113350005B1 (ar) | 2012-11-08 | 2013-11-06 | عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا |
Country Status (36)
Country | Link |
---|---|
US (1) | US8779122B2 (ar) |
EP (1) | EP2730562B1 (ar) |
JP (2) | JP6058519B2 (ar) |
KR (1) | KR20140059731A (ar) |
CN (1) | CN103804225B (ar) |
AR (1) | AR093373A1 (ar) |
AU (1) | AU2013245452C1 (ar) |
BR (1) | BR102013028259A2 (ar) |
CA (1) | CA2831289C (ar) |
CY (1) | CY1116253T1 (ar) |
DK (1) | DK2730562T3 (ar) |
EA (1) | EA027080B1 (ar) |
ES (1) | ES2539618T3 (ar) |
FR (1) | FR2997696B1 (ar) |
GE (1) | GEP20156308B (ar) |
HK (2) | HK1193408A1 (ar) |
HR (1) | HRP20150570T1 (ar) |
HU (1) | HUE026525T2 (ar) |
JO (1) | JO3189B1 (ar) |
MA (1) | MA35147B1 (ar) |
MD (1) | MD4392C1 (ar) |
ME (1) | ME02120B (ar) |
MX (1) | MX355590B (ar) |
MY (1) | MY159701A (ar) |
NZ (1) | NZ616768A (ar) |
PL (1) | PL2730562T3 (ar) |
PT (1) | PT2730562E (ar) |
RS (1) | RS53993B1 (ar) |
SA (1) | SA113350005B1 (ar) |
SG (1) | SG2013077235A (ar) |
SI (1) | SI2730562T1 (ar) |
TW (1) | TWI488833B (ar) |
UA (1) | UA118008C2 (ar) |
UY (1) | UY35108A (ar) |
WO (1) | WO2014072640A1 (ar) |
ZA (1) | ZA201308001B (ar) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
CN105541605A (zh) * | 2016-02-04 | 2016-05-04 | 扬州大学 | 一种轴手性联萘配体前体(s)-2,2’-二羧酸-1,1’-联萘的合成方法 |
SG11202001514XA (en) | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Novel method for producing antibody-drug conjugate |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5310598B2 (ar) * | 1972-01-28 | 1978-04-14 | ||
JPH0753692B2 (ja) * | 1990-10-30 | 1995-06-07 | 工業技術院長 | 芳香族カルボン酸エステル類の製造方法 |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
DE4333711A1 (de) * | 1993-10-02 | 1995-04-06 | Hoechst Ag | 2,4,5-Trihalogenzimtsäurenitrile und Verfahren zu ihrer Herstellung |
DE10159270A1 (de) * | 2001-12-03 | 2003-06-12 | Bayer Ag | Verfahren zur Arylierung von Olefinen |
WO2005123662A1 (en) * | 2004-06-18 | 2005-12-29 | Janssen Pharmaceutica N.V. | Modified heck reaction |
CN101407474B (zh) * | 2008-11-18 | 2011-12-14 | 东华大学 | 一种2-溴-4,5-二甲氧基苯丙腈的制备方法 |
WO2011138825A1 (ja) | 2010-05-06 | 2011-11-10 | 株式会社島津製作所 | 材料試験機 |
HUP1000245A2 (en) * | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
CN102464595B (zh) * | 2010-11-17 | 2015-02-25 | 山东新时代药业有限公司 | 一种伊伐布雷定中间体的合成方法 |
-
2012
- 2012-11-08 FR FR1260576A patent/FR2997696B1/fr not_active Expired - Fee Related
-
2013
- 2013-10-15 AU AU2013245452A patent/AU2013245452C1/en not_active Ceased
- 2013-10-16 MY MYPI2013701948A patent/MY159701A/en unknown
- 2013-10-17 NZ NZ616768A patent/NZ616768A/en not_active IP Right Cessation
- 2013-10-17 SG SG2013077235A patent/SG2013077235A/en unknown
- 2013-10-24 CA CA2831289A patent/CA2831289C/en not_active Expired - Fee Related
- 2013-10-24 JO JOP/2013/0312A patent/JO3189B1/ar active
- 2013-10-29 ZA ZA2013/08001A patent/ZA201308001B/en unknown
- 2013-10-29 TW TW102139148A patent/TWI488833B/zh not_active IP Right Cessation
- 2013-10-29 UY UY0001035108A patent/UY35108A/es not_active Application Discontinuation
- 2013-10-30 MD MDA20130082A patent/MD4392C1/ro not_active IP Right Cessation
- 2013-11-01 BR BR102013028259-6A patent/BR102013028259A2/pt not_active Application Discontinuation
- 2013-11-04 MA MA36388A patent/MA35147B1/fr unknown
- 2013-11-04 MX MX2013012858A patent/MX355590B/es active IP Right Grant
- 2013-11-05 GE GEAP201313282A patent/GEP20156308B/en unknown
- 2013-11-05 KR KR1020130133365A patent/KR20140059731A/ko not_active Application Discontinuation
- 2013-11-06 AR ARP130104055A patent/AR093373A1/es unknown
- 2013-11-06 US US14/073,213 patent/US8779122B2/en not_active Expired - Fee Related
- 2013-11-06 SA SA113350005A patent/SA113350005B1/ar unknown
- 2013-11-07 RS RS20150297A patent/RS53993B1/en unknown
- 2013-11-07 ME MEP-2015-74A patent/ME02120B/me unknown
- 2013-11-07 PL PL13191850T patent/PL2730562T3/pl unknown
- 2013-11-07 EP EP13191850.0A patent/EP2730562B1/fr active Active
- 2013-11-07 EA EA201301136A patent/EA027080B1/ru not_active IP Right Cessation
- 2013-11-07 DK DK13191850.0T patent/DK2730562T3/en active
- 2013-11-07 PT PT131918500T patent/PT2730562E/pt unknown
- 2013-11-07 ES ES13191850.0T patent/ES2539618T3/es active Active
- 2013-11-07 HU HUE13191850A patent/HUE026525T2/en unknown
- 2013-11-07 UA UAA201312954A patent/UA118008C2/uk unknown
- 2013-11-07 JP JP2013230752A patent/JP6058519B2/ja active Active
- 2013-11-07 SI SI201330038T patent/SI2730562T1/sl unknown
- 2013-11-07 WO PCT/FR2013/052653 patent/WO2014072640A1/fr active Application Filing
- 2013-11-07 CN CN201310548260.8A patent/CN103804225B/zh not_active Expired - Fee Related
-
2014
- 2014-07-04 HK HK14106802.9A patent/HK1193408A1/xx not_active IP Right Cessation
- 2014-11-18 HK HK14111643.2A patent/HK1198159A1/zh not_active IP Right Cessation
-
2015
- 2015-05-07 CY CY20151100400T patent/CY1116253T1/el unknown
- 2015-05-28 HR HRP20150570TT patent/HRP20150570T1/hr unknown
- 2015-11-02 JP JP2015215831A patent/JP2016047837A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GEP20125512B (en) | Process for synthesis of agomelatin | |
MX2009009355A (es) | Compuesto de bencimidazol y uso farmaceutico del mismo. | |
MY145992A (en) | New process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3-5-trien-7-yl)nitrile and application in the synthesis of ivabradine | |
GEP20125407B (en) | New process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2h-3- benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
SA113350005B1 (ar) | عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا | |
ME00986B (me) | Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom | |
NZ716462A (en) | Optically active pde10 inhibitor | |
HU1000668D0 (en) | New palladium catalysts, process for their preparation and use thereof | |
GEP20125460B (en) | New process for the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts | |
WO2015022702A3 (en) | Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof | |
MD4443C1 (ro) | Procedeu de sinteză a 3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carbonitrilului şi aplicarea lui în sinteza ivabradinei şi a sărurilor sale de adiţie cu un acid acceptabil farmaceutic | |
SA113350048B1 (ar) | عملية جديدة لتصنيع 3-(2-برومو-4، 5- داي ميثوكسي فينيل) بروبان نيتريل، واستخدامها في تصنيع افابرادين وإضافة أملاح منه مع حمض مقبول صيدلانياً | |
RU2013110311A (ru) | Синтез соединений тиазолидиндиона | |
WO2011048612A3 (en) | Process for preparation of propargylated aminoindans or pharmaceutically acceptable salts thereof | |
MD20130071A2 (en) | New process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
RS54652B1 (en) | NEW PROCEDURE FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALALLY ACCEPTABLE ACID ADDITIVE SALTS | |
MD20140028A2 (ro) | Procedeu de sinteză a compuşilor 7,8-dimetoxi-1,3-dihidro-2H-3-benzazepin-2-onei şi aplicarea în sinteza ivabradinei | |
IN2013DE03349A (ar) | ||
TH159831A (th) | วิธีการสำหรับการผลิตเมทธิลฟอร์เมตโดยการเกิดปฏิกิริยาของเมทธานอลกับคาร์บอน มอนนอกไซด์ในการมีอยู่ของระบบคะตะลิสต์ ซึ่งประกอบด้วยอัลคาไลฟอร์เมต และอัลคาไลแอลกฮอเลต |