SA113350005B1 - عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا - Google Patents

عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا

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Publication number
SA113350005B1
SA113350005B1 SA113350005A SA113350005A SA113350005B1 SA 113350005 B1 SA113350005 B1 SA 113350005B1 SA 113350005 A SA113350005 A SA 113350005A SA 113350005 A SA113350005 A SA 113350005A SA 113350005 B1 SA113350005 B1 SA 113350005B1
Authority
SA
Saudi Arabia
Prior art keywords
synthesis
dimethoxyphenyl
ivabradine
enenitrile
prop
Prior art date
Application number
SA113350005A
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English (en)
Inventor
لورينزو غونزاليز خوسيه
سانشيز فريديريك
إيزابيل جارسيا اراندا ماريا
ديل بيلار كارانزا ماريا
Original Assignee
لي لابوراتوريز سيرفير
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Publication date
Application filed by لي لابوراتوريز سيرفير filed Critical لي لابوراتوريز سيرفير
Publication of SA113350005B1 publication Critical patent/SA113350005B1/ar

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/32Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44Palladium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/34Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

يتعلق الاختراع الحالي بعملية (P1) لتخليق (2E)-3-(3، 4-داي ميثوكسي فينيل)بروب-2-ين نيتريل (I): تشتمل على تعريض 4-برومو-1، 2-داي ميثوكسي بنزين (II) لتفاعل إقران بأكريلو نيتريل في وجود محفز من البالاديوم، ومركب ترابطي، ومادة قاعدية وعامل لنقل الطور في مذيب عضوي للحصول على (I). علاوة على ذلك تشتمل العملية المذكورة على تعريض 4-برومو-1، 2-داي ميثوكسي بنزين له الصيغة (II) لتفاعل إقران بأكريلو نيتريل في وجود محفز من البالاديوم، ومركب ترابطي، ومادة قاعدية وعامل لنقل الطور في مذيب عضوي للحصول على (I). وتطبيقها في تخليق إيڤابرادين، وأملاح الإضافة منه مع حمض مقبول صيدلانياً.
SA113350005A 2012-11-08 2013-11-06 عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا SA113350005B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1260576A FR2997696B1 (fr) 2012-11-08 2012-11-08 Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
SA113350005B1 true SA113350005B1 (ar) 2015-12-06

Family

ID=47598957

Family Applications (1)

Application Number Title Priority Date Filing Date
SA113350005A SA113350005B1 (ar) 2012-11-08 2013-11-06 عملية جديدة لتصنيع ( e2)-3-(3، 4-داي ميثوكسي فينيل) بروب-2-إنينيتريل، وتطبيقها في تصنيع إيڤابرادين وأملاحه مضافة مع حمض مقبول صيدلانيا

Country Status (36)

Country Link
US (1) US8779122B2 (ar)
EP (1) EP2730562B1 (ar)
JP (2) JP6058519B2 (ar)
KR (1) KR20140059731A (ar)
CN (1) CN103804225B (ar)
AR (1) AR093373A1 (ar)
AU (1) AU2013245452C1 (ar)
BR (1) BR102013028259A2 (ar)
CA (1) CA2831289C (ar)
CY (1) CY1116253T1 (ar)
DK (1) DK2730562T3 (ar)
EA (1) EA027080B1 (ar)
ES (1) ES2539618T3 (ar)
FR (1) FR2997696B1 (ar)
GE (1) GEP20156308B (ar)
HK (2) HK1193408A1 (ar)
HR (1) HRP20150570T1 (ar)
HU (1) HUE026525T2 (ar)
JO (1) JO3189B1 (ar)
MA (1) MA35147B1 (ar)
MD (1) MD4392C1 (ar)
ME (1) ME02120B (ar)
MX (1) MX355590B (ar)
MY (1) MY159701A (ar)
NZ (1) NZ616768A (ar)
PL (1) PL2730562T3 (ar)
PT (1) PT2730562E (ar)
RS (1) RS53993B1 (ar)
SA (1) SA113350005B1 (ar)
SG (1) SG2013077235A (ar)
SI (1) SI2730562T1 (ar)
TW (1) TWI488833B (ar)
UA (1) UA118008C2 (ar)
UY (1) UY35108A (ar)
WO (1) WO2014072640A1 (ar)
ZA (1) ZA201308001B (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN105541605A (zh) * 2016-02-04 2016-05-04 扬州大学 一种轴手性联萘配体前体(s)-2,2’-二羧酸-1,1’-联萘的合成方法
SG11202001514XA (en) 2017-08-31 2020-03-30 Daiichi Sankyo Co Ltd Novel method for producing antibody-drug conjugate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5310598B2 (ar) * 1972-01-28 1978-04-14
JPH0753692B2 (ja) * 1990-10-30 1995-06-07 工業技術院長 芳香族カルボン酸エステル類の製造方法
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DE4333711A1 (de) * 1993-10-02 1995-04-06 Hoechst Ag 2,4,5-Trihalogenzimtsäurenitrile und Verfahren zu ihrer Herstellung
DE10159270A1 (de) * 2001-12-03 2003-06-12 Bayer Ag Verfahren zur Arylierung von Olefinen
WO2005123662A1 (en) * 2004-06-18 2005-12-29 Janssen Pharmaceutica N.V. Modified heck reaction
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
WO2011138825A1 (ja) 2010-05-06 2011-11-10 株式会社島津製作所 材料試験機
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102464595B (zh) * 2010-11-17 2015-02-25 山东新时代药业有限公司 一种伊伐布雷定中间体的合成方法

Also Published As

Publication number Publication date
AU2013245452A1 (en) 2014-05-22
CA2831289C (en) 2016-02-09
JP2014114275A (ja) 2014-06-26
MD20130082A2 (en) 2014-05-31
JP2016047837A (ja) 2016-04-07
US8779122B2 (en) 2014-07-15
CA2831289A1 (en) 2014-05-08
HK1193408A1 (en) 2014-09-19
TW201418197A (zh) 2014-05-16
FR2997696A1 (fr) 2014-05-09
HK1198159A1 (zh) 2015-03-13
MX355590B (es) 2018-04-24
AU2013245452C1 (en) 2017-06-22
SI2730562T1 (sl) 2015-07-31
MY159701A (en) 2017-01-13
ME02120B (me) 2015-10-20
MD4392B1 (ro) 2016-01-31
ZA201308001B (en) 2014-07-30
CY1116253T1 (el) 2017-02-08
MA35147B1 (fr) 2014-06-02
EA027080B1 (ru) 2017-06-30
EA201301136A2 (ru) 2014-05-30
EP2730562A1 (fr) 2014-05-14
TWI488833B (zh) 2015-06-21
HRP20150570T1 (en) 2015-07-03
WO2014072640A1 (fr) 2014-05-15
EA201301136A3 (ru) 2014-07-30
MX2013012858A (es) 2014-08-07
PT2730562E (pt) 2015-05-20
CN103804225A (zh) 2014-05-21
PL2730562T3 (pl) 2015-08-31
JP6058519B2 (ja) 2017-01-11
BR102013028259A2 (pt) 2014-10-07
US20140128598A1 (en) 2014-05-08
UA118008C2 (uk) 2018-11-12
CN103804225B (zh) 2016-02-17
AR093373A1 (es) 2015-06-03
AU2013245452B2 (en) 2017-02-16
EP2730562B1 (fr) 2015-03-25
UY35108A (es) 2014-05-30
MD4392C1 (ro) 2016-08-31
KR20140059731A (ko) 2014-05-16
NZ616768A (en) 2015-02-27
GEP20156308B (en) 2015-06-25
SG2013077235A (en) 2014-06-27
RS53993B1 (en) 2015-10-30
FR2997696B1 (fr) 2014-12-05
JO3189B1 (ar) 2018-03-08
HUE026525T2 (en) 2016-06-28
ES2539618T3 (es) 2015-07-02
DK2730562T3 (en) 2015-06-29

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