MX349153B - Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos. - Google Patents

Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos.

Info

Publication number
MX349153B
MX349153B MX2013013027A MX2013013027A MX349153B MX 349153 B MX349153 B MX 349153B MX 2013013027 A MX2013013027 A MX 2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A MX 349153 B MX349153 B MX 349153B
Authority
MX
Mexico
Prior art keywords
lacto
independently
compound
general formula
derivatives
Prior art date
Application number
MX2013013027A
Other languages
English (en)
Other versions
MX2013013027A (es
Inventor
Dekany Gyula
Champion Elise
Schroven Andreas
Hederos Markus
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/051314 external-priority patent/WO2012127410A1/en
Application filed by Glycom As filed Critical Glycom As
Publication of MX2013013027A publication Critical patent/MX2013013027A/es
Publication of MX349153B publication Critical patent/MX349153B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Dairy Products (AREA)

Abstract

La presente invención se refiere a un método de diversificación de oligosacáridos de leche humana (HMO) o precursores de estos, compuestos obtenibles por el método y usos y composiciones que comprenden estos compuestos. El método comprende los pasos de a) proporcionar al menos un compuesto o una mezcla de los compuestos seleccionados del grupo que consiste de: derivados de lactosa opcionalmente sialidados y/o fucosilados de la fórmula general 2 y sales de estos; 2) en donde R es grupo removible por hidrogenólisis, R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 2 no es R-glicósido de lactosa, si se proporciona solo; derivados de lactosa opcionalmente sialilados y/o fucosilados de la fórmula general 4 y sales de estos; 4) donde R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 4 no es lactosa, si se proporciona solo; lacto-N-tetraosa (LNT); I) derivados de lacto-N-tetraosa (LNT) de la siguiente fórmula: II) en donde R1 es un grupo removible por hidrogenólisis; lacto-N-neotetraosa (LNnT); III) derivados de lacto-N-neotetraosa (LNnT) de la siguiente fórmula. IV) en donde R es un grupo removible por hidrogenólisis; b) adicionar al menos una enzima que comprende una actividad de trans-glicosidasa al por lo menos un compuesto o una mezcla de compuestos proporcionados de acuerdo al paso a); y c) incubar la mezcla definida de acuerdo al paso b).
MX2013013027A 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos. MX349153B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11166137 2011-05-13
PCT/IB2012/051314 WO2012127410A1 (en) 2011-03-18 2012-03-19 Synthesis of new fucose-containing carbohydrate derivatives
PCT/IB2012/052401 WO2012156898A1 (en) 2011-05-13 2012-05-14 DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

Publications (2)

Publication Number Publication Date
MX2013013027A MX2013013027A (es) 2013-12-02
MX349153B true MX349153B (es) 2017-07-14

Family

ID=47176364

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013027A MX349153B (es) 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos.

Country Status (14)

Country Link
US (2) US9382564B2 (es)
EP (2) EP3744725A1 (es)
JP (1) JP6106160B2 (es)
KR (1) KR20140036226A (es)
CN (1) CN103562214B9 (es)
BR (1) BR112013029203A2 (es)
CA (1) CA2835989A1 (es)
DK (1) DK2707380T3 (es)
ES (1) ES2820429T3 (es)
IL (1) IL229047A0 (es)
MX (1) MX349153B (es)
PL (1) PL2707380T3 (es)
RU (1) RU2013155453A (es)
WO (1) WO2012156898A1 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013532470A (ja) 2010-07-16 2013-08-19 グリコム アー／エス 新規のシアロオリゴ糖誘導体の合成
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
US20150320780A1 (en) * 2012-12-14 2015-11-12 Glycom A/S Mixture of fucosylate lactoses
GB201306689D0 (en) * 2013-04-12 2013-05-29 Glycom As Synthesis of sialylated/fucosylated human milk oligosaccharides
WO2014167112A1 (en) * 2013-04-12 2014-10-16 Danmarks Tekniske Universitet A mutant sialidase having trans-sialidase activity for use in production of sialylated glycans
US20160113952A1 (en) 2013-05-22 2016-04-28 Glycom As Synthetic Mixture of Oligosaccharides for Treating a Microbiota of a Mammal
EP3041947A4 (en) 2013-09-06 2017-07-26 Glycom A/S Fermentative production of oligosaccharides
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
DK3209673T4 (da) 2014-10-24 2023-10-02 Glycom As Mixtures of human milk oligosaccharides
US10415021B2 (en) 2014-10-24 2019-09-17 Glycom A/S Mutated fucosidase
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
ES2856053T3 (es) 2014-10-29 2021-09-27 Glycom As Composición sintética y procedimiento para promover la cicatrización de la mucosa
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
JP7182872B2 (ja) 2014-10-29 2022-12-05 グリコム・アクティーゼルスカブ 過敏性腸症候群の治療のための合成組成物および方法
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
EP3229812A4 (en) 2014-12-08 2018-10-03 Glycom A/S Synthetic composition for treating metabolic disorders
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
CN115300517A (zh) * 2015-03-31 2022-11-08 格礼卡姆股份公司 包含3’-o-唾液乳糖的人乳寡糖的混合物
WO2016199071A1 (en) * 2015-06-09 2016-12-15 Glycom A/S TERNARY MIXTURES OF 6'-SL, LNnT and LST c
DK3307882T3 (da) * 2015-06-09 2020-05-18 Glycom As Mutated photobacterium transsialidases
US20180220690A1 (en) 2015-08-04 2018-08-09 Nestec S.A. Nutritional compositions with 2fl and lnnt for use in inducing a gut microbiota close to the one of breast fed infants
PL3349763T3 (pl) 2015-09-14 2022-01-03 Glycom A/S Kompozycja do zastosowania w modulowaniu mikrobioty
ES2927009T3 (es) 2015-10-28 2022-10-31 Glycom As Composición sintética y método para modular la función cerebral y la conducta
WO2017071716A1 (en) 2015-10-28 2017-05-04 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
CN108348536B (zh) 2015-11-17 2021-09-24 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
CN108289492A (zh) 2015-12-15 2018-07-17 雀巢产品技术援助有限公司 Hmo的混合物
EP3419630A4 (en) 2016-02-24 2019-11-06 Glycom A/S SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
EP3452050B1 (en) 2016-05-05 2022-11-23 Glycom A/S Composition comprising hmos for the treatment of non-infectious diarrhoea
WO2017198276A1 (en) 2016-05-19 2017-11-23 Glycom A/S Synthetic composition
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
CA3030809A1 (en) 2016-07-28 2018-02-01 Fonterra Co-Operative Group Limited Sialyloligosaccharide product and process
US11278558B2 (en) 2017-03-01 2022-03-22 Glycom A/S Synthetic composition for microbiota modulation
WO2018207110A1 (en) 2017-05-09 2018-11-15 Glycom A/S Synthetic composition for microbiota modulation
US11541067B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing detrimental proteolytic metabolites
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
WO2019003135A1 (en) 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
US11541069B2 (en) 2017-11-02 2023-01-03 Glycom A/S One or more HMOs for reducing or preventing fatigue and/or improving focus or concentration
JP7327724B2 (ja) 2017-11-30 2023-08-16 グリコム・アクティーゼルスカブ 小麦過敏症を処置するためのｈｍｏの混合物
EP3720446A4 (en) 2017-12-05 2021-09-15 Glycom A/S HUMAN MILK OLIGOSACCHARIDES FOR THE TREATMENT OF MIGRAINE
CN111542593B (zh) * 2017-12-08 2024-05-24 森永乳业株式会社 新型双歧杆菌属细菌和包含该细菌的组合物
EP3743078A4 (en) 2017-12-22 2022-01-19 Glycom A/S COMPOSITION WITH HMOs TO PREVENT OR REDUCE NOCICEPTION
CN112165947A (zh) 2018-05-31 2021-01-01 格礼卡姆股份公司 用于治疗自身免疫性疾病的hmo混合物
KR20210104773A (ko) 2018-12-19 2021-08-25 글리콤 에이/에스 저-포드맵 식단을 사용한 인간 치료를 위한 조성물 및 방법
CN110016066B (zh) * 2019-04-02 2021-11-02 江西师范大学 一种i型n-聚糖天线的合成方法
CN112831510B (zh) * 2019-12-13 2022-04-22 中国科学院天津工业生物技术研究所 一株高效表达几丁质酶重组菌的构建及高酶活突变体的筛选
WO2022089707A1 (en) 2020-10-30 2022-05-05 Mille International Aps A method of producing a human milk oligosaccharide (hmo)
CN112795583A (zh) * 2020-11-16 2021-05-14 上海大学 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
WO2024042235A1 (en) 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586687A4 (en) * 1992-03-25 1996-04-17 Univ New York Trans-sialidase and methods of use and making thereof
JPH0686684A (ja) 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
US5409817A (en) 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
DE69623005T2 (de) * 1995-04-11 2003-04-03 Neose Technologies Inc Verbesserte verfahren zur enzymatischen synthese von oligosacchariden
US6323008B1 (en) * 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
NZ531093A (en) 2001-08-17 2007-12-21 Neose Technologies Inc Chemo-enzymatic synthesis of sialylated oligosaccharides
WO2005055944A2 (en) * 2003-12-05 2005-06-23 Cincinnati Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
AU2006215603A1 (en) * 2005-02-21 2006-08-24 Nestec S.A. Oligosaccharide mixture
JP4937288B2 (ja) 2009-03-02 2012-05-23 シャープ株式会社 画像読取装置及び画像形成装置
DE202011111124U1 (de) 2010-02-19 2020-05-22 Glycom A/S Polymorph eines Tretrasaccharids, das N-Acetyllactosamin enthält
JP2013532470A (ja) 2010-07-16 2013-08-19 グリコム アー／エス 新規のシアロオリゴ糖誘導体の合成
CA2830025A1 (en) 2011-03-18 2012-09-27 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives

Also Published As

Publication number Publication date
WO2012156898A1 (en) 2012-11-22
RU2013155453A (ru) 2015-06-20
US9963729B2 (en) 2018-05-08
EP3744725A1 (en) 2020-12-02
EP2707380B1 (en) 2020-07-08
CN103562214A (zh) 2014-02-05
DK2707380T3 (da) 2020-10-12
CN103562214B (zh) 2016-10-19
JP6106160B2 (ja) 2017-03-29
US20160289721A1 (en) 2016-10-06
ES2820429T3 (es) 2021-04-21
EP2707380A1 (en) 2014-03-19
IL229047A0 (en) 2013-12-31
US20140212930A1 (en) 2014-07-31
MX2013013027A (es) 2013-12-02
PL2707380T3 (pl) 2021-01-11
CN103562214B9 (zh) 2016-12-14
US9382564B2 (en) 2016-07-05
BR112013029203A2 (pt) 2016-08-09
KR20140036226A (ko) 2014-03-25
JP2014513986A (ja) 2014-06-19
EP2707380A4 (en) 2014-10-08
CA2835989A1 (en) 2012-11-22

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