MX349153B - Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos. - Google Patents

Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos.

Info

Publication number
MX349153B
MX349153B MX2013013027A MX2013013027A MX349153B MX 349153 B MX349153 B MX 349153B MX 2013013027 A MX2013013027 A MX 2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A MX 349153 B MX349153 B MX 349153B
Authority
MX
Mexico
Prior art keywords
lacto
independently
compound
general formula
derivatives
Prior art date
Application number
MX2013013027A
Other languages
English (en)
Other versions
MX2013013027A (es
Inventor
Dekany Gyula
Champion Elise
Schroven Andreas
Hederos Markus
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/051314 external-priority patent/WO2012127410A1/en
Application filed by Glycom As filed Critical Glycom As
Publication of MX2013013027A publication Critical patent/MX2013013027A/es
Publication of MX349153B publication Critical patent/MX349153B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Dairy Products (AREA)

Abstract

La presente invención se refiere a un método de diversificación de oligosacáridos de leche humana (HMO) o precursores de estos, compuestos obtenibles por el método y usos y composiciones que comprenden estos compuestos. El método comprende los pasos de a) proporcionar al menos un compuesto o una mezcla de los compuestos seleccionados del grupo que consiste de: derivados de lactosa opcionalmente sialidados y/o fucosilados de la fórmula general 2 y sales de estos; 2) en donde R es grupo removible por hidrogenólisis, R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 2 no es R-glicósido de lactosa, si se proporciona solo; derivados de lactosa opcionalmente sialilados y/o fucosilados de la fórmula general 4 y sales de estos; 4) donde R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 4 no es lactosa, si se proporciona solo; lacto-N-tetraosa (LNT); I) derivados de lacto-N-tetraosa (LNT) de la siguiente fórmula: II) en donde R1 es un grupo removible por hidrogenólisis; lacto-N-neotetraosa (LNnT); III) derivados de lacto-N-neotetraosa (LNnT) de la siguiente fórmula. IV) en donde R es un grupo removible por hidrogenólisis; b) adicionar al menos una enzima que comprende una actividad de trans-glicosidasa al por lo menos un compuesto o una mezcla de compuestos proporcionados de acuerdo al paso a); y c) incubar la mezcla definida de acuerdo al paso b).
MX2013013027A 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos. MX349153B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11166137 2011-05-13
PCT/IB2012/051314 WO2012127410A1 (en) 2011-03-18 2012-03-19 Synthesis of new fucose-containing carbohydrate derivatives
PCT/IB2012/052401 WO2012156898A1 (en) 2011-05-13 2012-05-14 DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

Publications (2)

Publication Number Publication Date
MX2013013027A MX2013013027A (es) 2013-12-02
MX349153B true MX349153B (es) 2017-07-14

Family

ID=47176364

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013027A MX349153B (es) 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos.

Country Status (14)

Country Link
US (2) US9382564B2 (es)
EP (2) EP3744725A1 (es)
JP (1) JP6106160B2 (es)
KR (1) KR20140036226A (es)
CN (1) CN103562214B9 (es)
BR (1) BR112013029203A2 (es)
CA (1) CA2835989A1 (es)
DK (1) DK2707380T3 (es)
ES (1) ES2820429T3 (es)
IL (1) IL229047A0 (es)
MX (1) MX349153B (es)
PL (1) PL2707380T3 (es)
RU (1) RU2013155453A (es)
WO (1) WO2012156898A1 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013531049A (ja) 2010-07-16 2013-08-01 グリコム アー／エス オリゴ糖の誘導体化
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
EP2931737A4 (en) * 2012-12-14 2016-11-16 Glycom As MIXTURE FROM FUCOSYLATE LACTOSES
BR112015025951A2 (pt) * 2013-04-12 2017-10-17 Univ Danmarks Tekniske sialidase mutante com atividade trans-sialidase, para uso em produção de glicanos sialilados
GB201306689D0 (en) 2013-04-12 2013-05-29 Glycom As Synthesis of sialylated/fucosylated human milk oligosaccharides
ES2891731T3 (es) 2013-05-22 2022-01-31 Glycom As Mezcla sintética de oligosacáridos para el tratamiento de la microbiota de un mamífero
EP3041947A4 (en) 2013-09-06 2017-07-26 Glycom A/S Fermentative production of oligosaccharides
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
CN107108677B (zh) * 2014-10-24 2020-08-07 格礼卡姆股份公司 Hmo的混合物
EP3209772A4 (en) 2014-10-24 2018-08-08 Glycom A/S Mutated fucosidase
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US20170258820A1 (en) 2014-10-29 2017-09-14 Glycom A/S Synthetic composition and method for promoting mucosal healing
CN115364113A (zh) 2014-10-29 2022-11-22 格礼卡姆股份公司 合成组合物以及用于治疗肠易激综合症的方法
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
CN115350200A (zh) 2014-12-08 2022-11-18 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
EP3277287B8 (en) * 2015-03-31 2023-12-27 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
ES2870973T3 (es) * 2015-06-09 2021-10-28 Glycom As Mezclas ternarias de 6'-SL, LNnT y LST c
US10428318B2 (en) 2015-06-09 2019-10-01 Glycom A/S Mutated sialidases
WO2017021476A1 (en) 2015-08-04 2017-02-09 Nestec S.A. Nutritional compositions with 2fl and lnnt for use in inducing a gut microbiota close to the one of breast fed infants
PL3349763T3 (pl) 2015-09-14 2022-01-03 Glycom A/S Kompozycja do zastosowania w modulowaniu mikrobioty
EP3368046B1 (en) 2015-10-28 2022-07-27 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
ES2950489T3 (es) 2015-10-28 2023-10-10 Glycom As Composición sintética y método para modular los trastornos de la emoción y del ánimo
WO2017084673A1 (en) 2015-11-17 2017-05-26 Glycom A/S Synthetic Composition for Treating Antibiotic Associated Complications
US11432578B2 (en) 2015-12-15 2022-09-06 Glycom A/S Mixture of HMOs
WO2017144062A1 (en) 2016-02-24 2017-08-31 Glycom A/S Synthetic composition for microbiota modulation
WO2017190754A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for the treatment of non-infectious diarrhoea
PL3452051T3 (pl) 2016-05-05 2022-11-14 Glycom A/S Kompozycja zawierająca hmos do zastosowania w leczeniu nadwrażliwości trzewnej i/lub bólu trzewnego mediowanych komórkami tucznymi
US11224605B2 (en) 2016-05-19 2022-01-18 Glycom A/S Synthetic composition
CN109414447A (zh) 2016-06-24 2019-03-01 格礼卡姆股份公司 包括hmo的组合物、其制备和用于预防和/或治疗病毒和/或细菌感染的用途
NZ750365A (en) 2016-07-28 2022-07-01 Fonterra Cooperative Group Ltd Dairy product and process
WO2018157900A1 (en) 2017-03-01 2018-09-07 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
US11142541B2 (en) 2017-06-30 2021-10-12 Glycom A/S Purification of oligosaccharides
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CA3081496A1 (en) 2017-11-02 2019-05-09 Glycom A/S Mixture of hmos for reducing or preventing fatigue
CN111698994A (zh) 2017-11-30 2020-09-22 格礼卡姆股份公司 治疗小麦敏感性的hmo混合物
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
EP3722412A4 (en) * 2017-12-08 2021-11-17 Morinaga Milk Industry Co., Ltd. NEW BIFIDOBACTERIUM, AND COMPOSITION CONTAINING THIS BACTERIA
US11304966B2 (en) 2017-12-22 2022-04-19 Glycom A/S Composition comprising HMOs for preventing or reducing nociception
US11554131B2 (en) 2018-05-31 2023-01-17 Glycom A/S Mixture of HMOs for treating autoimmune diseases
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
CN110016066B (zh) * 2019-04-02 2021-11-02 江西师范大学 一种i型n-聚糖天线的合成方法
CN114350640B (zh) * 2019-12-13 2023-09-08 中国科学院天津工业生物技术研究所 一株表达几丁质酶重组菌的构建及高酶活突变体的筛选
WO2022089707A1 (en) 2020-10-30 2022-05-05 Mille International Aps A method of producing a human milk oligosaccharide (hmo)
CN112795583A (zh) * 2020-11-16 2021-05-14 上海大学 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
WO2024042235A1 (en) 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos
WO2024110667A1 (en) 2022-11-25 2024-05-30 Dsm Ip Assets B.V. Two-strain system for producing oligosaccharides
DK202201151A1 (en) 2022-12-14 2024-07-02 Dsm Ip Assets B V Mutated lacto-n-biosidase

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586687A4 (en) * 1992-03-25 1996-04-17 Univ New York Trans-sialidase and methods of use and making thereof
JPH0686684A (ja) 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
US5409817A (en) 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
JPH11503328A (ja) * 1995-04-11 1999-03-26 サイテル コーポレイション オリゴ糖類の改善された酵素合成法
US6323008B1 (en) * 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
JP2005500058A (ja) * 2001-08-17 2005-01-06 ネオーズ テクノロジーズ， インコーポレイテッド シアリル化したオリゴサッカリドの化学的酵素的合成
JP5236189B2 (ja) * 2003-12-05 2013-07-17 チルドレンズ ホスピタル メディカル センター オリゴ糖組成物および感染症の治療における該組成物の使用
RU2442438C2 (ru) * 2005-02-21 2012-02-20 Нестек С.А. Смесь олигосахаридов
JP4937288B2 (ja) 2009-03-02 2012-05-23 シャープ株式会社 画像読取装置及び画像形成装置
DE202011111124U1 (de) * 2010-02-19 2020-05-22 Glycom A/S Polymorph eines Tretrasaccharids, das N-Acetyllactosamin enthält
JP2013531049A (ja) 2010-07-16 2013-08-01 グリコム アー／エス オリゴ糖の誘導体化
EP2686330A4 (en) 2011-03-18 2014-11-12 Glycom As SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES

Also Published As

Publication number Publication date
IL229047A0 (en) 2013-12-31
WO2012156898A1 (en) 2012-11-22
ES2820429T3 (es) 2021-04-21
BR112013029203A2 (pt) 2016-08-09
EP2707380B1 (en) 2020-07-08
RU2013155453A (ru) 2015-06-20
US20160289721A1 (en) 2016-10-06
CA2835989A1 (en) 2012-11-22
PL2707380T3 (pl) 2021-01-11
DK2707380T3 (da) 2020-10-12
EP3744725A1 (en) 2020-12-02
US9382564B2 (en) 2016-07-05
KR20140036226A (ko) 2014-03-25
CN103562214B (zh) 2016-10-19
MX2013013027A (es) 2013-12-02
EP2707380A1 (en) 2014-03-19
EP2707380A4 (en) 2014-10-08
JP6106160B2 (ja) 2017-03-29
CN103562214A (zh) 2014-02-05
JP2014513986A (ja) 2014-06-19
US20140212930A1 (en) 2014-07-31
US9963729B2 (en) 2018-05-08
CN103562214B9 (zh) 2016-12-14

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