EP3041947A4 - Fermentative production of oligosaccharides - Google Patents

Fermentative production of oligosaccharides Download PDF

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Publication number
EP3041947A4
EP3041947A4 EP14842536.6A EP14842536A EP3041947A4 EP 3041947 A4 EP3041947 A4 EP 3041947A4 EP 14842536 A EP14842536 A EP 14842536A EP 3041947 A4 EP3041947 A4 EP 3041947A4
Authority
EP
European Patent Office
Prior art keywords
oligosaccharides
fermentative production
fermentative
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP14842536.6A
Other languages
German (de)
French (fr)
Other versions
EP3041947A1 (en
Inventor
Gyula Dekany
Pauline Peltier-Pain
Dóra MOLNÁR-GÁBOR
Markus Hederos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycom AS
Original Assignee
Glycom AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom AS filed Critical Glycom AS
Publication of EP3041947A1 publication Critical patent/EP3041947A1/en
Publication of EP3041947A4 publication Critical patent/EP3041947A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01065—3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (2.4.1.65), i.e. alpha-1-3 fucosyltransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01087—N-Acetyllactosaminide 3-alpha-galactosyltransferase (2.4.1.87), i.e. alpha-1,3-galactosyltransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01099—Sucrose:sucrose fructosyltransferase (2.4.1.99)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP14842536.6A 2013-09-06 2014-09-05 Fermentative production of oligosaccharides Pending EP3041947A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201370497 2013-09-06
PCT/DK2014/050273 WO2015032413A1 (en) 2013-09-06 2014-09-05 Fermentative production of oligosaccharides

Publications (2)

Publication Number Publication Date
EP3041947A1 EP3041947A1 (en) 2016-07-13
EP3041947A4 true EP3041947A4 (en) 2017-07-26

Family

ID=52627835

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14842536.6A Pending EP3041947A4 (en) 2013-09-06 2014-09-05 Fermentative production of oligosaccharides

Country Status (3)

Country Link
US (1) US10364449B2 (en)
EP (1) EP3041947A4 (en)
WO (1) WO2015032413A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016162514A1 (en) * 2015-04-10 2016-10-13 Ares Trading S.A. Methods for modulating protein glycosylation profiles of recombinant proteins
EP3141610A1 (en) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
US10864224B2 (en) 2015-11-17 2020-12-15 Glycom A/S Synthetic composition for treating antibiotic associated complications
US10829508B2 (en) 2015-12-18 2020-11-10 Glycom A/S Fermentative production of oligosaccharides
US11312741B2 (en) 2016-04-19 2022-04-26 Glycom A/S Separation of oligosaccharides from fermentation broth
DK3375291T3 (en) * 2017-03-17 2022-10-31 Chr Hansen Hmo Gmbh METHOD FOR INHIBITING ISOMERIZATION OF A REDUCING SACCHARIDE AFTER HEAT TREATMENT
WO2019003136A1 (en) 2017-06-30 2019-01-03 Glycom A/S Synthesis of oligosaccharides
CN110914284A (en) 2017-07-12 2020-03-24 格礼卡姆股份公司 Amorphous mixture comprising neutral mono-or oligosaccharides and acidic non-carbohydrate component
KR20210013138A (en) * 2018-05-23 2021-02-03 디에스엠 아이피 어셋츠 비.브이. Preparation of oligosaccharide
WO2021061991A1 (en) 2019-09-24 2021-04-01 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
EP3848471A1 (en) * 2020-01-10 2021-07-14 Chr. Hansen HMO GmbH Sequential fermentative production of oligosaccharides
CA3188645A1 (en) 2020-08-14 2022-02-17 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
EP4277634A1 (en) 2021-01-12 2023-11-22 Prolacta Bioscience, Inc. Synbiotic treatment regimens
DK181310B1 (en) * 2021-05-17 2023-08-08 Dsm Ip Assets Bv Cell factories for lnt-ii production
AU2021446678A1 (en) 2021-05-20 2023-12-07 Chr. Hansen A/S Sequential fermentative production of oligosaccharides
WO2023099680A1 (en) 2021-12-01 2023-06-08 Dsm Ip Assets B.V. Cells with tri-, tetra- or pentasaccharide importers useful in oligosaccharide production
WO2024042235A1 (en) * 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007101862A1 (en) * 2006-03-09 2007-09-13 Centre National De La Recherche Scientifique (Cnrs) Method of producing sialylated oligosaccharides

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2664150C (en) 1996-09-17 2013-01-08 Kyowa Hakko Bio Co., Ltd. Processes for producing sugar nucleotides and complex carbohydrates
FR2796082B1 (en) 1999-07-07 2003-06-27 Centre Nat Rech Scient PROCESS FOR PRODUCING OLIGOSACCHARIDES
DE60236441D1 (en) 2001-08-24 2010-07-01 Kyowa Hakko Bio Co Ltd ALPHA-1,2-FUCOSYL TRANSFERASE AND THIS CODING DNA
SG171814A1 (en) 2008-12-19 2011-07-28 Jennewein Biotechnologie Gmbh Synthesis of fucosylated compounds
DE202011111124U1 (en) 2010-02-19 2020-05-22 Glycom A/S Polymorph of a tretrasaccharide containing N-acetyllactosamine
AU2011217614A1 (en) 2010-02-19 2012-08-02 Glycom A/S Production of 6'-O-sialyllactose and intermediates
RU2013106896A (en) 2010-07-16 2014-08-27 Глюком А/С SYNTHESIS OF NEW SIALOOLIGOSACCHARIDES DERIVATIVES
CA3098403C (en) * 2011-02-16 2022-05-10 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
KR20140006026A (en) 2011-02-21 2014-01-15 글리콤 에이/에스 Catalytic hydrogenolysis of a composition of a mixture of oligosaccharide precursors and uses thereof
AU2012232727A1 (en) 2011-03-18 2013-09-26 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
US20140323705A1 (en) 2011-05-13 2014-10-30 Markus Hederos Manufacture of lacto-n-tetraose
AU2012257395A1 (en) 2011-05-13 2013-12-12 Glycom A/S Method for generating human milk oligosaccharides (HMOs) or precursors thereof
DK2707380T3 (en) 2011-05-13 2020-10-12 Glycom As DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR THEREOF PRECURSORS
ES2671555T3 (en) 2011-06-07 2018-06-07 Hero Ag Obtaining oligosaccharides through a biotechnological process
WO2013044928A1 (en) 2011-09-30 2013-04-04 Glycom A/S Synthesis of hmo core structures
WO2013091660A1 (en) 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007101862A1 (en) * 2006-03-09 2007-09-13 Centre National De La Recherche Scientifique (Cnrs) Method of producing sialylated oligosaccharides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015032413A1 *

Also Published As

Publication number Publication date
EP3041947A1 (en) 2016-07-13
WO2015032413A1 (en) 2015-03-12
US10364449B2 (en) 2019-07-30
US20160215315A1 (en) 2016-07-28

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