BR112013029203A2 - método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humano - Google Patents
método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humanoInfo
- Publication number
- BR112013029203A2 BR112013029203A2 BR112013029203A BR112013029203A BR112013029203A2 BR 112013029203 A2 BR112013029203 A2 BR 112013029203A2 BR 112013029203 A BR112013029203 A BR 112013029203A BR 112013029203 A BR112013029203 A BR 112013029203A BR 112013029203 A2 BR112013029203 A2 BR 112013029203A2
- Authority
- BR
- Brazil
- Prior art keywords
- human milk
- milk oligosaccharides
- preparing
- oligosaccharides
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166137 | 2011-05-13 | ||
| PCT/IB2012/051314 WO2012127410A1 (en) | 2011-03-18 | 2012-03-19 | Synthesis of new fucose-containing carbohydrate derivatives |
| PCT/IB2012/052401 WO2012156898A1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013029203A2 true BR112013029203A2 (pt) | 2016-08-09 |
Family
ID=47176364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013029203A BR112013029203A2 (pt) | 2011-05-13 | 2012-05-14 | método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humano |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9382564B2 (pt) |
| EP (2) | EP3744725A1 (pt) |
| JP (1) | JP6106160B2 (pt) |
| KR (1) | KR20140036226A (pt) |
| CN (1) | CN103562214B9 (pt) |
| BR (1) | BR112013029203A2 (pt) |
| CA (1) | CA2835989A1 (pt) |
| DK (1) | DK2707380T3 (pt) |
| ES (1) | ES2820429T3 (pt) |
| IL (1) | IL229047A0 (pt) |
| MX (1) | MX349153B (pt) |
| PL (1) | PL2707380T3 (pt) |
| RU (1) | RU2013155453A (pt) |
| WO (1) | WO2012156898A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2805499A1 (en) | 2010-07-16 | 2012-01-19 | Glycom A/S | Derivatization of oligosaccharides |
| WO2013091660A1 (en) * | 2011-12-23 | 2013-06-27 | Glycom A/S | A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof |
| EP2931737A4 (en) * | 2012-12-14 | 2016-11-16 | Glycom As | MIXTURE FROM FUCOSYLATE LACTOSES |
| CN105246911B (zh) * | 2013-04-12 | 2019-10-01 | 丹麦科技大学 | 用于产生唾液酸化聚糖之具有转唾液酸酶活性的突变体唾液酸酶 |
| GB201306689D0 (en) * | 2013-04-12 | 2013-05-29 | Glycom As | Synthesis of sialylated/fucosylated human milk oligosaccharides |
| EP2999358B1 (en) | 2013-05-22 | 2021-07-07 | Glycom A/S | Synthetic mixture of oligosaccharides for the treating a microbiota of a mammal |
| EP3041947A4 (en) | 2013-09-06 | 2017-07-26 | Glycom A/S | Fermentative production of oligosaccharides |
| EP2857410A1 (en) * | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
| US10314852B2 (en) | 2014-10-24 | 2019-06-11 | Glycom A/S | Mixtures of HMOs |
| EP3209772A4 (en) * | 2014-10-24 | 2018-08-08 | Glycom A/S | Mutated fucosidase |
| US20160346303A1 (en) | 2014-10-29 | 2016-12-01 | Glycom A/S | Synthetic composition and method for treating irritable bowel syndrome |
| US11040049B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US11040050B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| WO2016066174A1 (en) | 2014-10-29 | 2016-05-06 | Glycom A/S | Synthetic composition and method for promoting mucosal healing |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| WO2016091265A1 (en) | 2014-12-08 | 2016-06-16 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| PL3277287T3 (pl) * | 2015-03-31 | 2024-04-22 | Glycom A/S | Mieszaniny oligosacharydów mleka ludzkiego zawierające 3'-O-sialilolaktozę |
| EP3307882B1 (en) | 2015-06-09 | 2020-04-15 | Glycom A/S | Mutated photobacterium transsialidases |
| EP3307752B1 (en) * | 2015-06-09 | 2021-04-07 | Glycom A/S | Ternary mixtures of 6'-sl, lnnt and lst c |
| AU2016303000B2 (en) | 2015-08-04 | 2021-01-21 | Société des Produits Nestlé S.A. | Nutritional compositions with 2FL and LNnT for use in inducing a gut microbiota close to the one of breast fed infants |
| ES2886951T3 (es) | 2015-09-14 | 2021-12-21 | Glycom As | Composición para su uso en la modulación de la microbiota |
| ES2950489T3 (es) | 2015-10-28 | 2023-10-10 | Glycom As | Composición sintética y método para modular los trastornos de la emoción y del ánimo |
| US10835545B2 (en) | 2015-10-28 | 2020-11-17 | Glycom A/S | Synthetic composition and method for modulating brain function and behaviour |
| US10864224B2 (en) | 2015-11-17 | 2020-12-15 | Glycom A/S | Synthetic composition for treating antibiotic associated complications |
| BR112018010505B1 (pt) | 2015-12-15 | 2021-11-16 | Société des Produits Nestlé S.A. | Composições para bebês e crianças pequenas, e uso de uma mistura sintética de hmos |
| WO2017144062A1 (en) | 2016-02-24 | 2017-08-31 | Glycom A/S | Synthetic composition for microbiota modulation |
| PL3452050T3 (pl) | 2016-05-05 | 2023-06-12 | Glycom A/S | Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej |
| EP3452051B1 (en) | 2016-05-05 | 2022-06-01 | Glycom A/S | Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain |
| WO2017198276A1 (en) | 2016-05-19 | 2017-11-23 | Glycom A/S | Synthetic composition |
| EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
| JP2019523278A (ja) | 2016-07-28 | 2019-08-22 | フォンテラ コ−オペレイティブ グループ リミティド | 乳製品およびプロセス |
| WO2018157900A1 (en) | 2017-03-01 | 2018-09-07 | Glycom A/S | Synthetic composition for microbiota modulation |
| US11291677B2 (en) | 2017-05-09 | 2022-04-05 | Glycom A/S | Synthetic composition for microbiota modulation |
| US11541067B2 (en) | 2017-05-24 | 2023-01-03 | Glycom A/S | HMO compositions and methods for reducing detrimental proteolytic metabolites |
| EP3630124A4 (en) | 2017-05-24 | 2021-02-24 | Glycom A/S | SYNTHETIC COMPOSITION CONSISTING OF OLIGOSACCHARIDES AND ITS USE IN MEDICAL TREATMENT |
| WO2019003135A1 (en) | 2017-06-30 | 2019-01-03 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| EP3672600A4 (en) | 2017-08-21 | 2021-05-19 | Glycom A/S | SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| CA3081496A1 (en) | 2017-11-02 | 2019-05-09 | Glycom A/S | Mixture of hmos for reducing or preventing fatigue |
| KR20200096263A (ko) | 2017-11-30 | 2020-08-11 | 글리콤 에이/에스 | 밀 민감증을 치료하기 위한 hmo 혼합물 |
| US11602545B2 (en) | 2017-12-05 | 2023-03-14 | Glycom A/S | Human milk oligosaccharides for treating migraine |
| EP3722412A4 (en) * | 2017-12-08 | 2021-11-17 | Morinaga Milk Industry Co., Ltd. | NEW BIFIDOBACTERIUM, AND COMPOSITION CONTAINING THIS BACTERIA |
| US11304966B2 (en) | 2017-12-22 | 2022-04-19 | Glycom A/S | Composition comprising HMOs for preventing or reducing nociception |
| BR112020022892A2 (pt) | 2018-05-31 | 2021-02-23 | Glycom A/S | mistura de hmos para tratamento de doenças autoi-munes |
| JP2022513524A (ja) | 2018-12-19 | 2022-02-08 | グリコム・アクティーゼルスカブ | 低ｆｏｄｍａｐ食を使用してヒトを治療するための組成物および方法 |
| CN110016066B (zh) * | 2019-04-02 | 2021-11-02 | 江西师范大学 | 一种i型n-聚糖天线的合成方法 |
| CN112831510B (zh) * | 2019-12-13 | 2022-04-22 | 中国科学院天津工业生物技术研究所 | 一株高效表达几丁质酶重组菌的构建及高酶活突变体的筛选 |
| WO2022089707A1 (en) | 2020-10-30 | 2022-05-05 | Mille International Aps | A method of producing a human milk oligosaccharide (hmo) |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2022223430A1 (en) | 2021-04-19 | 2022-10-27 | Dsm Ip Assets B.V. | A composition of enzymes and human milk oligosaccharides |
| CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
| WO2023235555A1 (en) * | 2022-06-02 | 2023-12-07 | Bee-Io Honey Technologies Ltd. | Cultured buffalo milk production methods, systems, compositions and uses thereof |
| DK202200588A1 (en) | 2022-06-20 | 2024-02-23 | Dsm Ip Assets Bv | Mixture of fucosylated HMOs |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
| WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
| DK202201151A1 (en) | 2022-12-14 | 2024-07-02 | Dsm Ip Assets Bv | Mutated lacto-n-biosidase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018787A1 (en) | 1992-03-25 | 1993-09-30 | New York University | Trans-sialidase and methods of use and making thereof |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| AU5445396A (en) | 1995-04-11 | 1996-10-30 | Cytel Corporation | Improved enzymatic synthesis of oligosaccharides |
| US6323008B1 (en) * | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| WO2003016469A2 (en) | 2001-08-17 | 2003-02-27 | Neose Technologies, Inc. | Chemo-enzymatic synthesis of sialylated oligosaccharides |
| MXPA06006392A (es) * | 2003-12-05 | 2007-03-15 | Childrens Hosp Medical Center | Composiciones de oligosacaridos y uso de estas en el tratamiento de infecciones. |
| WO2006087391A1 (en) * | 2005-02-21 | 2006-08-24 | Nestec S.A. | Oligosaccharide mixture |
| JP4937288B2 (ja) | 2009-03-02 | 2012-05-23 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| WO2011100980A1 (en) | 2010-02-19 | 2011-08-25 | Glycom A/S | A method for preparation of the tetrasaccharide lacto-n-neotetraose (lnnt) containing n-acetyllactosamine |
| CA2805499A1 (en) | 2010-07-16 | 2012-01-19 | Glycom A/S | Derivatization of oligosaccharides |
| US20140228554A1 (en) | 2011-03-18 | 2014-08-14 | Glycom A/S | Synthesis of new fucose-containing carbohydrate derivatives |
-
2012
- 2012-05-14 JP JP2014510920A patent/JP6106160B2/ja active Active
- 2012-05-14 WO PCT/IB2012/052401 patent/WO2012156898A1/en active Application Filing
- 2012-05-14 KR KR1020137032961A patent/KR20140036226A/ko not_active Application Discontinuation
- 2012-05-14 CN CN201280023818.4A patent/CN103562214B9/zh active Active
- 2012-05-14 BR BR112013029203A patent/BR112013029203A2/pt not_active IP Right Cessation
- 2012-05-14 DK DK12785572.4T patent/DK2707380T3/da active
- 2012-05-14 US US14/117,332 patent/US9382564B2/en active Active
- 2012-05-14 PL PL12785572T patent/PL2707380T3/pl unknown
- 2012-05-14 RU RU2013155453/04A patent/RU2013155453A/ru not_active Application Discontinuation
- 2012-05-14 CA CA2835989A patent/CA2835989A1/en not_active Abandoned
- 2012-05-14 MX MX2013013027A patent/MX349153B/es active IP Right Grant
- 2012-05-14 EP EP20182361.4A patent/EP3744725A1/en active Pending
- 2012-05-14 EP EP12785572.4A patent/EP2707380B1/en active Active
- 2012-05-14 ES ES12785572T patent/ES2820429T3/es active Active
-
2013
- 2013-10-24 IL IL229047A patent/IL229047A0/en unknown
-
2016
- 2016-05-23 US US15/161,887 patent/US9963729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2835989A1 (en) | 2012-11-22 |
| KR20140036226A (ko) | 2014-03-25 |
| WO2012156898A1 (en) | 2012-11-22 |
| CN103562214B9 (zh) | 2016-12-14 |
| EP2707380A4 (en) | 2014-10-08 |
| CN103562214A (zh) | 2014-02-05 |
| MX349153B (es) | 2017-07-14 |
| RU2013155453A (ru) | 2015-06-20 |
| US9963729B2 (en) | 2018-05-08 |
| US20160289721A1 (en) | 2016-10-06 |
| US9382564B2 (en) | 2016-07-05 |
| US20140212930A1 (en) | 2014-07-31 |
| EP3744725A1 (en) | 2020-12-02 |
| JP2014513986A (ja) | 2014-06-19 |
| ES2820429T3 (es) | 2021-04-21 |
| MX2013013027A (es) | 2013-12-02 |
| DK2707380T3 (da) | 2020-10-12 |
| CN103562214B (zh) | 2016-10-19 |
| JP6106160B2 (ja) | 2017-03-29 |
| IL229047A0 (en) | 2013-12-31 |
| EP2707380B1 (en) | 2020-07-08 |
| EP2707380A1 (en) | 2014-03-19 |
| PL2707380T3 (pl) | 2021-01-11 |
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