WO2012038979A3 - A process for preparation of ertapenem - Google Patents

A process for preparation of ertapenem Download PDF

Info

Publication number
WO2012038979A3
WO2012038979A3 PCT/IN2011/000656 IN2011000656W WO2012038979A3 WO 2012038979 A3 WO2012038979 A3 WO 2012038979A3 IN 2011000656 W IN2011000656 W IN 2011000656W WO 2012038979 A3 WO2012038979 A3 WO 2012038979A3
Authority
WO
WIPO (PCT)
Prior art keywords
ertapenem
preparation
monosodium
ertapenenm
monoprotected
Prior art date
Application number
PCT/IN2011/000656
Other languages
French (fr)
Other versions
WO2012038979A2 (en
Inventor
Gnanaprakasam Andrew
Veeramani Ganapathy
Shahul Hameed Syed Ibrahim
Murugesan Karthikeyan
Thangavel Sivasamy
Sekar Jeyaraj Michael
Thangavel Arulmoli
Original Assignee
Sequent Anti Biotics Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequent Anti Biotics Private Limited filed Critical Sequent Anti Biotics Private Limited
Publication of WO2012038979A2 publication Critical patent/WO2012038979A2/en
Publication of WO2012038979A3 publication Critical patent/WO2012038979A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel process for the preparation of 1 β- methylcarbapenem antibiotic, Ertapenem of formula I. The process comprises isolation of monoprotected Ertapenem acid or its monosodium salt and further deprotection to obtain Ertapenenm monosodium.
PCT/IN2011/000656 2010-09-24 2011-09-22 A process for preparation of ertapenem WO2012038979A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2809/CHE/2010 2010-09-24
IN2809CH2010 2010-09-24

Publications (2)

Publication Number Publication Date
WO2012038979A2 WO2012038979A2 (en) 2012-03-29
WO2012038979A3 true WO2012038979A3 (en) 2012-05-18

Family

ID=45874222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000656 WO2012038979A2 (en) 2010-09-24 2011-09-22 A process for preparation of ertapenem

Country Status (1)

Country Link
WO (1) WO2012038979A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102363617B (en) * 2011-11-09 2013-09-18 上海希迈医药科技有限公司 Ertapenem monosodium salt crystal and preparation method thereof
EP2834242A4 (en) * 2012-04-04 2016-01-06 Hospira Inc An improved process for the preparation of carbapenem antibiotic
ES2731242T3 (en) 2014-03-27 2019-11-14 Johnson Matthey Plc Preparation procedure for a carbapenem antibiotic
CN110642860A (en) * 2018-06-27 2020-01-03 杭州森泽医药科技有限公司 Method for purifying ertapenem sodium
CN110698480B (en) * 2018-07-09 2023-09-08 武汉启瑞药业有限公司 Synthesis and purification method of ertapenem intermediate
CN113416193B (en) * 2021-08-23 2021-12-17 凯莱英医药集团（天津）股份有限公司 Novel ertapenem sodium crystal form and preparation method thereof
CN114105988B (en) * 2022-01-24 2022-04-29 深圳市海滨制药有限公司 Synthetic method of ertapenem sodium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063931A1 (en) * 2001-01-16 2004-04-01 William John M. Process for carbapenem synthesis
US20040235817A1 (en) * 2001-09-26 2004-11-25 Brands Karel M. J. Crystalline forms of ertapenem sodium
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063931A1 (en) * 2001-01-16 2004-04-01 William John M. Process for carbapenem synthesis
US20040235817A1 (en) * 2001-09-26 2004-11-25 Brands Karel M. J. Crystalline forms of ertapenem sodium
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILLIAMS ET AL.: "Practical Synthesis of New Carbapenem Antibiotic Ertapenem Sodium", J. ORG. CHEM. 2005, vol. 70, 13 August 2005 (2005-08-13), pages 7479 - 7487, XP002591997, DOI: doi:10.1021/jo0501442 *

Also Published As

Publication number Publication date
WO2012038979A2 (en) 2012-03-29

Similar Documents

Publication Publication Date Title
WO2011138281A3 (en) Process for the preparation of dithiine tetracarboxydiimides
WO2012038979A3 (en) A process for preparation of ertapenem
MY156938A (en) Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application
CA2826751C (en) Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
WO2012125488A8 (en) C4-monomethyl triterpenoid derivatives and methods of use thereof
WO2012083306A3 (en) Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
WO2011012816A3 (en) Pharmaceutical formulation
WO2012122011A3 (en) Amino-quinolines as kinase inhibitors
WO2010092090A3 (en) Novel salts of sitagliptin
WO2012025944A3 (en) Sitagliptin, salts and polymorphs thereof
WO2012004396A3 (en) Process of preparing a thrombin specific inhibitor
WO2013040286A3 (en) Pharmaceutical compositions
WO2008155615A3 (en) An improved process for the preparation of cephalosporin antibiotic
WO2011088027A8 (en) Compounds and methods
WO2009100936A3 (en) Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds, and the use thereof
AU2011327113A8 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
WO2011157722A3 (en) Solid ivabradine-containing composition
WO2013128294A8 (en) Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
CA2798007C (en) Preparation of posaconazole intermediates
WO2011143503A3 (en) Tetracycline compositions
WO2013093931A3 (en) Novel prodrugs of phenolic drugs
WO2010129918A8 (en) Triptolide prodrugs
HRP20181437T1 (en) Method for the preparation of (3s,3s') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
MX2011009898A (en) Process for the preparation of propionic acid derivatives.
WO2010079045A3 (en) Crystalline salt forms of flibanserine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11826517

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11826517

Country of ref document: EP

Kind code of ref document: A2