MX2013013027A - Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismsos. - Google Patents

Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismsos.

Info

Publication number
MX2013013027A
MX2013013027A MX2013013027A MX2013013027A MX2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A MX 2013013027 A MX2013013027 A MX 2013013027A
Authority
MX
Mexico
Prior art keywords
lacto
independently
compound
general formula
derivatives
Prior art date
Application number
MX2013013027A
Other languages
English (en)
Other versions
MX349153B (es
Inventor
Gyula Dekany
Elise Champion
Andreas Schroven
Markus Hederos
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/051314 external-priority patent/WO2012127410A1/en
Application filed by Glycom As filed Critical Glycom As
Publication of MX2013013027A publication Critical patent/MX2013013027A/es
Publication of MX349153B publication Critical patent/MX349153B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Dairy Products (AREA)

Abstract

Un método de diversificación de oligosacáridos de leche humana (HMO) o precursores de estos, compuestos obtenibles por el método y usos y composiciones que comprenden estos compuestos. El método comprende los pasos de a) proporcionar al menos un compuesto o una mezcla de los compuestos seleccionados del grupo que consiste de: derivados de lactosa opcionalmente sialidados y/o fucosilados de la fórmula general 2 y sales de estos; 2) en donde R es grupo removible por hidrogenólisis, R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 2 no es R-glicósido de lactosa, si se proporciona solo; derivados de lactosa opcionalmente sialilados y/o fucosilados de la fórmula general 4 y sales de estos; 4) donde R1 independientemente uno de otro es fucosilo o H, R4 independientemente uno de otro es sialilo o H, con la condición que el compuesto de la fórmula general 4 no es lactosa, si se proporciona solo; lacto-N-tetraosa (LNT); I) derivados de lacto-N-tetraosa (LNT) de la siguiente fórmula: II) en donde R1 es un grupo removible por hidrogenólisis; lacto-N-neotetraosa (LNnT); III) derivados de lacto-N-neotetraosa (LNnT) de la siguiente fórmula. IV) en donde R es un grupo removible por hidrogenólisis; b) adicionar al menos una enzima que comprende una actividad de trans-glicosidasa al por lo menos un compuesto o una mezcla de compuestos proporcionados de acuerdo al paso a); y c) incubar la mezcla definida de acuerdo al paso b).
MX2013013027A 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos. MX349153B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11166137 2011-05-13
PCT/IB2012/051314 WO2012127410A1 (en) 2011-03-18 2012-03-19 Synthesis of new fucose-containing carbohydrate derivatives
PCT/IB2012/052401 WO2012156898A1 (en) 2011-05-13 2012-05-14 DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

Publications (2)

Publication Number Publication Date
MX2013013027A true MX2013013027A (es) 2013-12-02
MX349153B MX349153B (es) 2017-07-14

Family

ID=47176364

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013027A MX349153B (es) 2011-05-13 2012-05-14 Diversificacion de oligosacaridos de leche humana (hmo) o precursores de los mismos.

Country Status (14)

Country Link
US (2) US9382564B2 (es)
EP (2) EP3744725A1 (es)
JP (1) JP6106160B2 (es)
KR (1) KR20140036226A (es)
CN (1) CN103562214B9 (es)
BR (1) BR112013029203A2 (es)
CA (1) CA2835989A1 (es)
DK (1) DK2707380T3 (es)
ES (1) ES2820429T3 (es)
IL (1) IL229047A0 (es)
MX (1) MX349153B (es)
PL (1) PL2707380T3 (es)
RU (1) RU2013155453A (es)
WO (1) WO2012156898A1 (es)

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WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
US20150320780A1 (en) * 2012-12-14 2015-11-12 Glycom A/S Mixture of fucosylate lactoses
BR112015025951A2 (pt) * 2013-04-12 2017-10-17 Univ Danmarks Tekniske sialidase mutante com atividade trans-sialidase, para uso em produção de glicanos sialilados
GB201306689D0 (en) * 2013-04-12 2013-05-29 Glycom As Synthesis of sialylated/fucosylated human milk oligosaccharides
US20160113952A1 (en) 2013-05-22 2016-04-28 Glycom As Synthetic Mixture of Oligosaccharides for Treating a Microbiota of a Mammal
US10364449B2 (en) 2013-09-06 2019-07-30 Glycom A/S Fermentative production of oligosaccharides
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EP3209673B2 (en) 2014-10-24 2023-07-26 Glycom A/S Mixtures of human milk oligosaccharides
US10415021B2 (en) 2014-10-24 2019-09-17 Glycom A/S Mutated fucosidase
US20170258820A1 (en) 2014-10-29 2017-09-14 Glycom A/S Synthetic composition and method for promoting mucosal healing
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
EP3212197A4 (en) 2014-10-29 2018-07-11 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
WO2016091265A1 (en) 2014-12-08 2016-06-16 Glycom A/S Synthetic composition for treating metabolic disorders
US10588917B2 (en) * 2015-03-31 2020-03-17 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 ′-O-sialyllactose
PL3307752T3 (pl) 2015-06-09 2021-11-02 Glycom A/S Mieszaniny trójskładnikowe 6’-sl, lnnt i lst c
DK3307882T3 (da) * 2015-06-09 2020-05-18 Glycom As Mutated photobacterium transsialidases
US20180220690A1 (en) 2015-08-04 2018-08-09 Nestec S.A. Nutritional compositions with 2fl and lnnt for use in inducing a gut microbiota close to the one of breast fed infants
DK3349763T3 (en) 2015-09-14 2021-11-15 Glycom As Composition for use in microbiota modulation
WO2017071715A1 (en) 2015-10-28 2017-05-04 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
EP3368047B1 (en) 2015-10-28 2023-04-26 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
US10864224B2 (en) 2015-11-17 2020-12-15 Glycom A/S Synthetic composition for treating antibiotic associated complications
US11957148B2 (en) 2015-12-15 2024-04-16 Societe Des Produits Nestle S.A. Mixture of human milk oligosaccharides(HMOs)
EP3419630A4 (en) 2016-02-24 2019-11-06 Glycom A/S SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION
PL3452050T3 (pl) 2016-05-05 2023-06-12 Glycom A/S Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej
ES2924137T3 (es) 2016-05-05 2022-10-04 Glycom As Composición que comprende HMOS para uso en el tratamiento de la hipersensibilidad y/o dolor visceral mediados por mastocitos
EP3458073B1 (en) 2016-05-19 2023-10-25 Glycom A/S Use of human milk oligosaccharides for treating migraine in patients with inflammatory bowel syndrome
US11419884B2 (en) 2016-06-24 2022-08-23 Glycom A/S Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections
MX2019000881A (es) 2016-07-28 2019-07-01 Fonterra Cooperative Group Ltd Producto lacteo y proceso.
EP3589139A4 (en) 2017-03-01 2020-12-23 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
WO2018207110A1 (en) 2017-05-09 2018-11-15 Glycom A/S Synthetic composition for microbiota modulation
US11541067B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing detrimental proteolytic metabolites
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
WO2019003135A1 (en) 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CN111526879A (zh) 2017-11-02 2020-08-11 格礼卡姆股份公司 用于减少或预防疲劳和/或改善注意力或专注力的一种或多种hmo
US11452736B2 (en) 2017-11-30 2022-09-27 Glycom A/S Mixture of HMOs for treating wheat sensitivity
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CN110016066B (zh) * 2019-04-02 2021-11-02 江西师范大学 一种i型n-聚糖天线的合成方法
CN114350640B (zh) * 2019-12-13 2023-09-08 中国科学院天津工业生物技术研究所 一株表达几丁质酶重组菌的构建及高酶活突变体的筛选
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Also Published As

Publication number Publication date
KR20140036226A (ko) 2014-03-25
ES2820429T3 (es) 2021-04-21
US9963729B2 (en) 2018-05-08
IL229047A0 (en) 2013-12-31
DK2707380T3 (da) 2020-10-12
CN103562214A (zh) 2014-02-05
JP6106160B2 (ja) 2017-03-29
EP2707380A4 (en) 2014-10-08
BR112013029203A2 (pt) 2016-08-09
EP3744725A1 (en) 2020-12-02
US9382564B2 (en) 2016-07-05
CN103562214B9 (zh) 2016-12-14
CA2835989A1 (en) 2012-11-22
US20140212930A1 (en) 2014-07-31
US20160289721A1 (en) 2016-10-06
PL2707380T3 (pl) 2021-01-11
CN103562214B (zh) 2016-10-19
MX349153B (es) 2017-07-14
JP2014513986A (ja) 2014-06-19
EP2707380B1 (en) 2020-07-08
EP2707380A1 (en) 2014-03-19
RU2013155453A (ru) 2015-06-20
WO2012156898A1 (en) 2012-11-22

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