DK2707380T3 - DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF - Google Patents
DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF Download PDFInfo
- Publication number
- DK2707380T3 DK2707380T3 DK12785572.4T DK12785572T DK2707380T3 DK 2707380 T3 DK2707380 T3 DK 2707380T3 DK 12785572 T DK12785572 T DK 12785572T DK 2707380 T3 DK2707380 T3 DK 2707380T3
- Authority
- DK
- Denmark
- Prior art keywords
- hmos
- diversification
- precursors
- human milk
- milk oligosaccharides
- Prior art date
Links
- JJCKQBSBMWVTRE-UHFFFAOYSA-N C=C1C#CC#CC1=C Chemical compound C=C1C#CC#CC1=C JJCKQBSBMWVTRE-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166137 | 2011-05-13 | ||
| PCT/IB2012/051314 WO2012127410A1 (en) | 2011-03-18 | 2012-03-19 | Synthesis of new fucose-containing carbohydrate derivatives |
| PCT/IB2012/052401 WO2012156898A1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2707380T3 true DK2707380T3 (da) | 2020-10-12 |
Family
ID=47176364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12785572.4T DK2707380T3 (da) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9382564B2 (da) |
| EP (2) | EP3744725A1 (da) |
| JP (1) | JP6106160B2 (da) |
| KR (1) | KR20140036226A (da) |
| CN (1) | CN103562214B9 (da) |
| BR (1) | BR112013029203A2 (da) |
| CA (1) | CA2835989A1 (da) |
| DK (1) | DK2707380T3 (da) |
| ES (1) | ES2820429T3 (da) |
| IL (1) | IL229047A0 (da) |
| MX (1) | MX349153B (da) |
| PL (1) | PL2707380T3 (da) |
| RU (1) | RU2013155453A (da) |
| WO (1) | WO2012156898A1 (da) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2013106896A (ru) | 2010-07-16 | 2014-08-27 | Глюком А/С | Синтез новых производных сиалоолигосахаридов |
| WO2013091660A1 (en) * | 2011-12-23 | 2013-06-27 | Glycom A/S | A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof |
| EP2931737A4 (en) * | 2012-12-14 | 2016-11-16 | Glycom As | MIXTURE FROM FUCOSYLATE LACTOSES |
| US10081801B2 (en) * | 2013-04-12 | 2018-09-25 | Danmarks Tekniske Universitet | Mutant sialidase having trans-sialidase activity for use in production of sialylated glycans |
| GB201306689D0 (en) * | 2013-04-12 | 2013-05-29 | Glycom As | Synthesis of sialylated/fucosylated human milk oligosaccharides |
| ES2891731T3 (es) | 2013-05-22 | 2022-01-31 | Glycom As | Mezcla sintética de oligosacáridos para el tratamiento de la microbiota de un mamífero |
| EP3041947A4 (en) | 2013-09-06 | 2017-07-26 | Glycom A/S | Fermentative production of oligosaccharides |
| EP2857410A1 (en) * | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
| WO2016063262A1 (en) | 2014-10-24 | 2016-04-28 | Glycom A/S | MIXTURES OF HMOs |
| US10415021B2 (en) | 2014-10-24 | 2019-09-17 | Glycom A/S | Mutated fucosidase |
| US11040049B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| CN107073021A (zh) | 2014-10-29 | 2017-08-18 | 格礼卡姆股份公司 | 合成组合物以及用于治疗肠易激综合症的方法 |
| US11040050B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US20170258820A1 (en) | 2014-10-29 | 2017-09-14 | Glycom A/S | Synthetic composition and method for promoting mucosal healing |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| CN107106584A (zh) | 2014-12-08 | 2017-08-29 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| DK3277287T3 (da) * | 2015-03-31 | 2024-01-08 | Glycom As | Blandinger af humane mælke-oligosaccharider, der omfatter 3 '-o-sialyllactose |
| ES2798373T3 (es) * | 2015-06-09 | 2020-12-11 | Glycom As | Transsialidasas de photobacterium mutadas |
| ES2870973T3 (es) | 2015-06-09 | 2021-10-28 | Glycom As | Mezclas ternarias de 6'-SL, LNnT y LST c |
| RU2724590C2 (ru) | 2015-08-04 | 2020-06-25 | Сосьете Де Продюи Нестле С.А. | Питательные композиции с 2fl и lnnt для применения при индукции кишечной микробиоты, которая похожа на кишечную микробиоту младенцев на грудном вскармливании |
| PL3349763T3 (pl) | 2015-09-14 | 2022-01-03 | Glycom A/S | Kompozycja do zastosowania w modulowaniu mikrobioty |
| US10780103B2 (en) | 2015-10-28 | 2020-09-22 | Glycom A/S | Synthetic composition and method for modulating emotion and mood disorders |
| EP3368046B1 (en) * | 2015-10-28 | 2022-07-27 | Glycom A/S | Synthetic composition and method for modulating brain function and behaviour |
| CN108348536B (zh) | 2015-11-17 | 2021-09-24 | 格礼卡姆股份公司 | 治疗抗生素相关性并发症的合成组合物 |
| CN108289492A (zh) | 2015-12-15 | 2018-07-17 | 雀巢产品技术援助有限公司 | Hmo的混合物 |
| US10857168B2 (en) | 2016-02-24 | 2020-12-08 | Glycom A/S | Synthetic composition for microbiota modulation |
| EP3452050B1 (en) | 2016-05-05 | 2022-11-23 | Glycom A/S | Composition comprising hmos for the treatment of non-infectious diarrhoea |
| ES2924137T3 (es) | 2016-05-05 | 2022-10-04 | Glycom As | Composición que comprende HMOS para uso en el tratamiento de la hipersensibilidad y/o dolor visceral mediados por mastocitos |
| EP3458073B1 (en) | 2016-05-19 | 2023-10-25 | Glycom A/S | Use of human milk oligosaccharides for treating migraine in patients with inflammatory bowel syndrome |
| EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
| KR102502459B1 (ko) | 2016-07-28 | 2023-02-21 | 폰테라 코-오퍼레이티브 그룹 리미티드 | 유제품과 방법 |
| WO2018157900A1 (en) | 2017-03-01 | 2018-09-07 | Glycom A/S | Synthetic composition for microbiota modulation |
| EP3634429A4 (en) | 2017-05-09 | 2020-11-04 | Glycom A/S | SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION |
| WO2018215960A1 (en) | 2017-05-24 | 2018-11-29 | Glycom A/S | Synthetic composition comprising one or more human milk oligosaccharides (hmos) |
| US11541068B2 (en) | 2017-05-24 | 2023-01-03 | Glycom A/S | HMO compositions and methods for reducing autism spectrum disorder symptoms |
| US20200123184A1 (en) | 2017-06-30 | 2020-04-23 | Glycom A/S | Purification of oligosaccharides |
| EP3672600A4 (en) | 2017-08-21 | 2021-05-19 | Glycom A/S | SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| US11541069B2 (en) | 2017-11-02 | 2023-01-03 | Glycom A/S | One or more HMOs for reducing or preventing fatigue and/or improving focus or concentration |
| WO2019106618A1 (en) | 2017-11-30 | 2019-06-06 | Glycom A/S | Mixture of hmos for treating wheat sensitivity |
| EP3720446A4 (en) | 2017-12-05 | 2021-09-15 | Glycom A/S | HUMAN MILK OLIGOSACCHARIDES FOR THE TREATMENT OF MIGRAINE |
| JP7273725B2 (ja) * | 2017-12-08 | 2023-05-15 | 森永乳業株式会社 | 新規ビフィドバクテリウム属細菌及び当該細菌を含む組成物 |
| CN111683666A (zh) | 2017-12-22 | 2020-09-18 | 格礼卡姆股份公司 | 预防或减少伤害感受的包含hmo的组合物 |
| US11554131B2 (en) | 2018-05-31 | 2023-01-17 | Glycom A/S | Mixture of HMOs for treating autoimmune diseases |
| BR112021011071A2 (pt) | 2018-12-19 | 2021-08-31 | Glycom A/S | Composição e método para o tratamento de seres humanos utilizando dietas com baixo teor de fodmap |
| CN110016066B (zh) * | 2019-04-02 | 2021-11-02 | 江西师范大学 | 一种i型n-聚糖天线的合成方法 |
| CN114350640B (zh) * | 2019-12-13 | 2023-09-08 | 中国科学院天津工业生物技术研究所 | 一株表达几丁质酶重组菌的构建及高酶活突变体的筛选 |
| WO2022089707A1 (en) | 2020-10-30 | 2022-05-05 | Mille International Aps | A method of producing a human milk oligosaccharide (hmo) |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2022223430A1 (en) | 2021-04-19 | 2022-10-27 | Dsm Ip Assets B.V. | A composition of enzymes and human milk oligosaccharides |
| CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
| DK202200588A1 (en) | 2022-06-20 | 2024-02-23 | Dsm Ip Assets Bv | Mixture of fucosylated HMOs |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018787A1 (en) | 1992-03-25 | 1993-09-30 | New York University | Trans-sialidase and methods of use and making thereof |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| ATE222294T1 (de) | 1995-04-11 | 2002-08-15 | Neose Technologies Inc | Verbesserte verfahren zur enzymatischen synthese von oligosacchariden |
| US6323008B1 (en) * | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| JP2005500058A (ja) * | 2001-08-17 | 2005-01-06 | ネオーズ テクノロジーズ， インコーポレイテッド | シアリル化したオリゴサッカリドの化学的酵素的合成 |
| US7893041B2 (en) | 2003-12-05 | 2011-02-22 | Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
| CA2601917C (en) * | 2005-02-21 | 2013-12-10 | Nestec S.A. | Oligosaccharide mixture |
| JP4937288B2 (ja) | 2009-03-02 | 2012-05-23 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| CN105330705A (zh) * | 2010-02-19 | 2016-02-17 | 格礼卡姆股份公司 | 用于制备含n-乙酰乳糖胺的四糖乳糖-n-新四糖(lnnt)的方法 |
| RU2013106896A (ru) | 2010-07-16 | 2014-08-27 | Глюком А/С | Синтез новых производных сиалоолигосахаридов |
| RU2013146524A (ru) | 2011-03-18 | 2015-04-27 | Глюком А/С | Синтез новых фукозо-содержащих производных углеводородов |
-
2012
- 2012-05-14 JP JP2014510920A patent/JP6106160B2/ja active Active
- 2012-05-14 BR BR112013029203A patent/BR112013029203A2/pt not_active IP Right Cessation
- 2012-05-14 ES ES12785572T patent/ES2820429T3/es active Active
- 2012-05-14 PL PL12785572T patent/PL2707380T3/pl unknown
- 2012-05-14 DK DK12785572.4T patent/DK2707380T3/da active
- 2012-05-14 EP EP20182361.4A patent/EP3744725A1/en active Pending
- 2012-05-14 CN CN201280023818.4A patent/CN103562214B9/zh active Active
- 2012-05-14 WO PCT/IB2012/052401 patent/WO2012156898A1/en active Application Filing
- 2012-05-14 CA CA2835989A patent/CA2835989A1/en not_active Abandoned
- 2012-05-14 KR KR1020137032961A patent/KR20140036226A/ko not_active Application Discontinuation
- 2012-05-14 RU RU2013155453/04A patent/RU2013155453A/ru not_active Application Discontinuation
- 2012-05-14 EP EP12785572.4A patent/EP2707380B1/en active Active
- 2012-05-14 US US14/117,332 patent/US9382564B2/en active Active
- 2012-05-14 MX MX2013013027A patent/MX349153B/es active IP Right Grant
-
2013
- 2013-10-24 IL IL229047A patent/IL229047A0/en unknown
-
2016
- 2016-05-23 US US15/161,887 patent/US9963729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX349153B (es) | 2017-07-14 |
| RU2013155453A (ru) | 2015-06-20 |
| PL2707380T3 (pl) | 2021-01-11 |
| MX2013013027A (es) | 2013-12-02 |
| US9382564B2 (en) | 2016-07-05 |
| EP2707380A1 (en) | 2014-03-19 |
| JP6106160B2 (ja) | 2017-03-29 |
| ES2820429T3 (es) | 2021-04-21 |
| US20160289721A1 (en) | 2016-10-06 |
| JP2014513986A (ja) | 2014-06-19 |
| EP3744725A1 (en) | 2020-12-02 |
| WO2012156898A1 (en) | 2012-11-22 |
| EP2707380B1 (en) | 2020-07-08 |
| US20140212930A1 (en) | 2014-07-31 |
| CA2835989A1 (en) | 2012-11-22 |
| US9963729B2 (en) | 2018-05-08 |
| BR112013029203A2 (pt) | 2016-08-09 |
| CN103562214A (zh) | 2014-02-05 |
| KR20140036226A (ko) | 2014-03-25 |
| IL229047A0 (en) | 2013-12-31 |
| EP2707380A4 (en) | 2014-10-08 |
| CN103562214B9 (zh) | 2016-12-14 |
| CN103562214B (zh) | 2016-10-19 |
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