DK2707380T3 - DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF - Google Patents
DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF Download PDFInfo
- Publication number
- DK2707380T3 DK2707380T3 DK12785572.4T DK12785572T DK2707380T3 DK 2707380 T3 DK2707380 T3 DK 2707380T3 DK 12785572 T DK12785572 T DK 12785572T DK 2707380 T3 DK2707380 T3 DK 2707380T3
- Authority
- DK
- Denmark
- Prior art keywords
- hmos
- diversification
- precursors
- human milk
- milk oligosaccharides
- Prior art date
Links
- JJCKQBSBMWVTRE-UHFFFAOYSA-N C=C1C#CC#CC1=C Chemical compound C=C1C#CC#CC1=C JJCKQBSBMWVTRE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166137 | 2011-05-13 | ||
| PCT/IB2012/051314 WO2012127410A1 (en) | 2011-03-18 | 2012-03-19 | Synthesis of new fucose-containing carbohydrate derivatives |
| PCT/IB2012/052401 WO2012156898A1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2707380T3 true DK2707380T3 (da) | 2020-10-12 |
Family
ID=47176364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12785572.4T DK2707380T3 (da) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9382564B2 (da) |
| EP (2) | EP3744725A1 (da) |
| JP (1) | JP6106160B2 (da) |
| KR (1) | KR20140036226A (da) |
| CN (1) | CN103562214B9 (da) |
| BR (1) | BR112013029203A2 (da) |
| CA (1) | CA2835989A1 (da) |
| DK (1) | DK2707380T3 (da) |
| ES (1) | ES2820429T3 (da) |
| IL (1) | IL229047A0 (da) |
| MX (1) | MX349153B (da) |
| PL (1) | PL2707380T3 (da) |
| RU (1) | RU2013155453A (da) |
| WO (1) | WO2012156898A1 (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140011296A (ko) | 2010-07-16 | 2014-01-28 | 글리콤 에이/에스 | 올리고당의 유도체화 |
| WO2013091660A1 (en) * | 2011-12-23 | 2013-06-27 | Glycom A/S | A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof |
| WO2014090261A1 (en) * | 2012-12-14 | 2014-06-19 | Glycom A/S | Mixture of fucosylate lactoses |
| EP2984104B1 (en) * | 2013-04-12 | 2017-11-01 | Danmarks Tekniske Universitet | A mutant sialidase having trans-sialidase activity for use in production of sialylated glycans |
| GB201306689D0 (en) | 2013-04-12 | 2013-05-29 | Glycom As | Synthesis of sialylated/fucosylated human milk oligosaccharides |
| PL2999358T3 (pl) | 2013-05-22 | 2021-12-20 | Glycom A/S | Syntetyczna mieszanina oligosacharydów do leczenia mikrobioty ssaka |
| WO2015032413A1 (en) | 2013-09-06 | 2015-03-12 | Glycom A/S | Fermentative production of oligosaccharides |
| EP2857410A1 (en) * | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
| CN107108677B (zh) * | 2014-10-24 | 2020-08-07 | 格礼卡姆股份公司 | Hmo的混合物 |
| US10415021B2 (en) | 2014-10-24 | 2019-09-17 | Glycom A/S | Mutated fucosidase |
| DK3212198T3 (en) | 2014-10-29 | 2021-03-29 | Glycom As | Synthetic composition and method for promoting mucosal healing |
| JP7182872B2 (ja) | 2014-10-29 | 2022-12-05 | グリコム・アクティーゼルスカブ | 過敏性腸症候群の治療のための合成組成物および方法 |
| US11040049B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US11040050B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| CN107106584A (zh) | 2014-12-08 | 2017-08-29 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| DK3277287T3 (da) * | 2015-03-31 | 2024-01-08 | Glycom As | Blandinger af humane mælke-oligosaccharider, der omfatter 3 '-o-sialyllactose |
| ES2870973T3 (es) * | 2015-06-09 | 2021-10-28 | Glycom As | Mezclas ternarias de 6'-SL, LNnT y LST c |
| EP3307882B1 (en) * | 2015-06-09 | 2020-04-15 | Glycom A/S | Mutated photobacterium transsialidases |
| MX2018001117A (es) | 2015-08-04 | 2018-04-20 | Nestec Sa | Composiciones nutricionales con 2fl y lnnt para usar en la induccion de una microbiota intestinal cercana a la de los infantes alimentados por lactancia materna. |
| DK3349763T3 (en) | 2015-09-14 | 2021-11-15 | Glycom As | Composition for use in microbiota modulation |
| PL3368046T3 (pl) * | 2015-10-28 | 2022-11-28 | Glycom A/S | Syntetyczna kompozycja i sposób modulowania funkcji mózgu i zachowania |
| US10780103B2 (en) | 2015-10-28 | 2020-09-22 | Glycom A/S | Synthetic composition and method for modulating emotion and mood disorders |
| CN108348536B (zh) | 2015-11-17 | 2021-09-24 | 格礼卡姆股份公司 | 治疗抗生素相关性并发症的合成组合物 |
| MY186217A (en) | 2015-12-15 | 2021-06-30 | Nestle Sa | Mixture of hmos |
| EP3419630A4 (en) | 2016-02-24 | 2019-11-06 | Glycom A/S | SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION |
| WO2017190755A1 (en) | 2016-05-05 | 2017-11-09 | Glycom A/S | Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain |
| PL3452050T3 (pl) | 2016-05-05 | 2023-06-12 | Glycom A/S | Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej |
| WO2017198276A1 (en) | 2016-05-19 | 2017-11-23 | Glycom A/S | Synthetic composition |
| US11419884B2 (en) | 2016-06-24 | 2022-08-23 | Glycom A/S | Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections |
| RU2019105567A (ru) | 2016-07-28 | 2020-08-28 | Фонтерра Ко-Оперэйтив Груп Лимитед | Молочный продукт и способ |
| WO2018157900A1 (en) | 2017-03-01 | 2018-09-07 | Glycom A/S | Synthetic composition for microbiota modulation |
| EP3634429A4 (en) | 2017-05-09 | 2020-11-04 | Glycom A/S | SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION |
| EP3630123A4 (en) | 2017-05-24 | 2020-10-28 | Glycom A/S | SYNTHETIC COMPOSITION WITH ONE OR MORE HUMAN MILK OLIGOSACCHARIDES (HMOS) |
| US11541068B2 (en) | 2017-05-24 | 2023-01-03 | Glycom A/S | HMO compositions and methods for reducing autism spectrum disorder symptoms |
| US20200123184A1 (en) | 2017-06-30 | 2020-04-23 | Glycom A/S | Purification of oligosaccharides |
| US11524019B2 (en) | 2017-08-21 | 2022-12-13 | Glycom A/S | Synthetic composition for reducing allergy symptoms |
| EP3450443A1 (en) | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| EP3703698A4 (en) | 2017-11-02 | 2021-08-18 | Glycom A/S | ONE OR MORE HMOS TO REDUCE OR PREVENT FATIGUE AND / OR IMPROVE CONCENTRATION |
| KR20200096263A (ko) | 2017-11-30 | 2020-08-11 | 글리콤 에이/에스 | 밀 민감증을 치료하기 위한 hmo 혼합물 |
| US11602545B2 (en) | 2017-12-05 | 2023-03-14 | Glycom A/S | Human milk oligosaccharides for treating migraine |
| US11566219B2 (en) * | 2017-12-08 | 2023-01-31 | Morinaga Milk Industry Co., Ltd. | Bifidobacterium bacteria and composition including novel bifidobacterium bacteria |
| US11304966B2 (en) | 2017-12-22 | 2022-04-19 | Glycom A/S | Composition comprising HMOs for preventing or reducing nociception |
| KR20210016557A (ko) | 2018-05-31 | 2021-02-16 | 글리콤 에이/에스 | 자가면역 질환 치료를 위한 hmo 혼합물 |
| JP2022513524A (ja) | 2018-12-19 | 2022-02-08 | グリコム・アクティーゼルスカブ | 低ｆｏｄｍａｐ食を使用してヒトを治療するための組成物および方法 |
| CN110016066B (zh) * | 2019-04-02 | 2021-11-02 | 江西师范大学 | 一种i型n-聚糖天线的合成方法 |
| CN112831510B (zh) * | 2019-12-13 | 2022-04-22 | 中国科学院天津工业生物技术研究所 | 一株高效表达几丁质酶重组菌的构建及高酶活突变体的筛选 |
| WO2022089707A1 (en) | 2020-10-30 | 2022-05-05 | Mille International Aps | A method of producing a human milk oligosaccharide (hmo) |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2022223430A1 (en) | 2021-04-19 | 2022-10-27 | Dsm Ip Assets B.V. | A composition of enzymes and human milk oligosaccharides |
| CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
| DK202200588A1 (en) | 2022-06-20 | 2024-02-23 | Dsm Ip Assets Bv | Mixture of fucosylated HMOs |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
| WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0586687A4 (en) | 1992-03-25 | 1996-04-17 | Univ New York | Trans-sialidase and methods of use and making thereof |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5409817A (en) * | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| ATE222294T1 (de) * | 1995-04-11 | 2002-08-15 | Neose Technologies Inc | Verbesserte verfahren zur enzymatischen synthese von oligosacchariden |
| US6323008B1 (en) | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| CA2456725A1 (en) * | 2001-08-17 | 2003-02-27 | Neose Technologies, Inc. | Chemo-enzymatic synthesis of sialylated oligosaccharides |
| WO2005055944A2 (en) | 2003-12-05 | 2005-06-23 | Cincinnati Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
| AU2006215603A1 (en) * | 2005-02-21 | 2006-08-24 | Nestec S.A. | Oligosaccharide mixture |
| JP4937288B2 (ja) | 2009-03-02 | 2012-05-23 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| US8993740B2 (en) * | 2010-02-19 | 2015-03-31 | Glycom A/S | Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine |
| KR20140011296A (ko) | 2010-07-16 | 2014-01-28 | 글리콤 에이/에스 | 올리고당의 유도체화 |
| WO2012127410A1 (en) | 2011-03-18 | 2012-09-27 | Glycom A/S | Synthesis of new fucose-containing carbohydrate derivatives |
-
2012
- 2012-05-14 KR KR1020137032961A patent/KR20140036226A/ko not_active Application Discontinuation
- 2012-05-14 BR BR112013029203A patent/BR112013029203A2/pt not_active IP Right Cessation
- 2012-05-14 RU RU2013155453/04A patent/RU2013155453A/ru not_active Application Discontinuation
- 2012-05-14 DK DK12785572.4T patent/DK2707380T3/da active
- 2012-05-14 EP EP20182361.4A patent/EP3744725A1/en active Pending
- 2012-05-14 EP EP12785572.4A patent/EP2707380B1/en active Active
- 2012-05-14 ES ES12785572T patent/ES2820429T3/es active Active
- 2012-05-14 WO PCT/IB2012/052401 patent/WO2012156898A1/en active Application Filing
- 2012-05-14 JP JP2014510920A patent/JP6106160B2/ja active Active
- 2012-05-14 US US14/117,332 patent/US9382564B2/en active Active
- 2012-05-14 CN CN201280023818.4A patent/CN103562214B9/zh active Active
- 2012-05-14 CA CA2835989A patent/CA2835989A1/en not_active Abandoned
- 2012-05-14 MX MX2013013027A patent/MX349153B/es active IP Right Grant
- 2012-05-14 PL PL12785572T patent/PL2707380T3/pl unknown
-
2013
- 2013-10-24 IL IL229047A patent/IL229047A0/en unknown
-
2016
- 2016-05-23 US US15/161,887 patent/US9963729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9382564B2 (en) | 2016-07-05 |
| EP3744725A1 (en) | 2020-12-02 |
| CN103562214A (zh) | 2014-02-05 |
| US9963729B2 (en) | 2018-05-08 |
| JP6106160B2 (ja) | 2017-03-29 |
| WO2012156898A1 (en) | 2012-11-22 |
| MX2013013027A (es) | 2013-12-02 |
| KR20140036226A (ko) | 2014-03-25 |
| BR112013029203A2 (pt) | 2016-08-09 |
| US20140212930A1 (en) | 2014-07-31 |
| CN103562214B9 (zh) | 2016-12-14 |
| EP2707380A4 (en) | 2014-10-08 |
| PL2707380T3 (pl) | 2021-01-11 |
| EP2707380B1 (en) | 2020-07-08 |
| JP2014513986A (ja) | 2014-06-19 |
| RU2013155453A (ru) | 2015-06-20 |
| EP2707380A1 (en) | 2014-03-19 |
| CA2835989A1 (en) | 2012-11-22 |
| US20160289721A1 (en) | 2016-10-06 |
| MX349153B (es) | 2017-07-14 |
| ES2820429T3 (es) | 2021-04-21 |
| IL229047A0 (en) | 2013-12-31 |
| CN103562214B (zh) | 2016-10-19 |
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