MX344705B - Composicion de aceite de hierbabuena de liberacion controlada en multiples particulas con recubrimienton enterico y metodo relacionados. - Google Patents
Composicion de aceite de hierbabuena de liberacion controlada en multiples particulas con recubrimienton enterico y metodo relacionados.Info
- Publication number
- MX344705B MX344705B MX2015005913A MX2015005913A MX344705B MX 344705 B MX344705 B MX 344705B MX 2015005913 A MX2015005913 A MX 2015005913A MX 2015005913 A MX2015005913 A MX 2015005913A MX 344705 B MX344705 B MX 344705B
- Authority
- MX
- Mexico
- Prior art keywords
- peppermint oil
- controlled release
- oil composition
- related methods
- enteric coated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe una composición en múltiples partículas que se forma a partir de una pluralidad de núcleos individuales que incluyen una fase hidrofóbica que contiene el aceite de hierbabuena disperso en un gel a base de celulosa microcristalina y una fase hidrofílica que contiene un hidrogel. Un recubrimiento entérico está sobre los núcleos individuales. La composición en múltiples partículas puede usarse para tratar los trastornos gastrointestinales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361815073P | 2013-04-23 | 2013-04-23 | |
US201361880294P | 2013-09-20 | 2013-09-20 | |
PCT/US2013/000217 WO2014175852A1 (en) | 2013-04-23 | 2013-09-23 | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015005913A MX2015005913A (es) | 2015-09-08 |
MX344705B true MX344705B (es) | 2017-01-04 |
Family
ID=51792243
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014915A MX2015014915A (es) | 2013-04-23 | 2013-09-23 | Composicion multiparticulada con recubrimiento enterico que tiene un subrecubrimiento proteinico. |
MX2015005913A MX344705B (es) | 2013-04-23 | 2013-09-23 | Composicion de aceite de hierbabuena de liberacion controlada en multiples particulas con recubrimienton enterico y metodo relacionados. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014915A MX2015014915A (es) | 2013-04-23 | 2013-09-23 | Composicion multiparticulada con recubrimiento enterico que tiene un subrecubrimiento proteinico. |
Country Status (21)
Country | Link |
---|---|
US (7) | US8895086B2 (es) |
EP (2) | EP2872123B1 (es) |
JP (3) | JP5869735B2 (es) |
KR (2) | KR101616679B1 (es) |
CN (2) | CN105263480B (es) |
AU (2) | AU2013387667B2 (es) |
BR (2) | BR112015026283B1 (es) |
CA (2) | CA2881992C (es) |
CY (1) | CY1121582T1 (es) |
DK (1) | DK2988824T3 (es) |
ES (2) | ES2706152T3 (es) |
HR (1) | HRP20190210T1 (es) |
HU (1) | HUE042996T2 (es) |
LT (1) | LT2988824T (es) |
MX (2) | MX2015014915A (es) |
PL (2) | PL2988824T3 (es) |
PT (2) | PT2872123T (es) |
RS (1) | RS58325B1 (es) |
RU (2) | RU2647462C2 (es) |
SI (1) | SI2988824T1 (es) |
WO (3) | WO2014175916A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
EP2900224A1 (en) | 2012-09-26 | 2015-08-05 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
RS58325B1 (sr) | 2013-04-23 | 2019-03-29 | Zx Pharma Llc | Enterosolventno obloženi višečestični preparat sa proteinskom sub-oblogom |
KR20180080189A (ko) | 2015-09-01 | 2018-07-11 | 퍼스트 웨이브 바이오, 인코포레이티드 | 이상 염증 반응과 연관된 질환을 치료하기 위한 방법 및 조성물 |
US10588864B2 (en) | 2016-03-11 | 2020-03-17 | Gateway Pharmaceuticals LLC | Pharmaceutical compositions for colon-specific delivery |
CN109310638A (zh) | 2016-05-06 | 2019-02-05 | 医师印章有限责任公司 | 缬草组合物和相关方法 |
KR102568459B1 (ko) | 2016-10-26 | 2023-08-22 | 에스엘 주식회사 | 차량용 램프 제어 장치 |
CN107049992A (zh) * | 2017-05-31 | 2017-08-18 | 盛林 | 一种egcg微丸胶囊及其制备方法 |
EP3697398A1 (en) | 2017-10-16 | 2020-08-26 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
CN109864982A (zh) * | 2019-03-22 | 2019-06-11 | 大连医诺生物股份有限公司 | 表没食子儿茶素没食子酸酯微囊粉及其制备方法 |
JP2021003024A (ja) * | 2019-06-26 | 2021-01-14 | アリメント工業株式会社 | 徐放性被覆食品粉体集合体及びその製造方法 |
US20230102999A1 (en) | 2020-01-10 | 2023-03-30 | First Wave Bio, Inc. | Deuterated niclosamide |
US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
WO2021188564A1 (en) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Methods of treating covid-19 with a niclosamide compound |
KR102608047B1 (ko) * | 2020-12-29 | 2023-12-01 | 주식회사 우제아이엠 | 역류성 식도질환 또는 기능성 소화불량의 예방 또는 개선을 위한 균형영양식품 조성물 |
EP4274554A1 (en) * | 2021-01-08 | 2023-11-15 | Société des Produits Nestlé S.A. | Oral solid cannabinoid oil composition for treating central nervous system disorders |
Family Cites Families (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1811777A (en) | 1924-06-19 | 1931-06-23 | Howards & Sons Ltd | Process for making synthetic menthol |
US2366749A (en) | 1942-08-29 | 1945-01-09 | Burton T Bush Inc | Process for making synthetic menthol |
US3515781A (en) | 1967-10-12 | 1970-06-02 | Johnson & Johnson | Cold capsule |
JPS521819A (en) | 1975-06-05 | 1977-01-08 | Nippon Tokushu Toryo Kk | Acoustic lining material for vehicle |
US4080552A (en) | 1976-09-22 | 1978-03-21 | Facet Enterprises, Inc. | Hybrid blocking oscillator for an electromagnetic fuel pump |
EP0015334B1 (en) | 1977-08-04 | 1982-05-19 | J.B. Tillott Limited | Carminative preparations containing peppermint oil or its active components |
JPS61176535A (ja) * | 1985-01-31 | 1986-08-08 | Morishita Jintan Kk | 腸溶性製剤 |
JPS62226926A (ja) * | 1986-03-27 | 1987-10-05 | Teisan Seiyaku Kk | 持続性複合顆粒剤 |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
US4808413A (en) | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
IT1243193B (it) | 1990-08-10 | 1994-05-24 | Medea Res Srl | Composizioni farmaceutiche orali a base di melatonina |
US5418010A (en) | 1990-10-05 | 1995-05-23 | Griffith Laboratories Worldwide, Inc. | Microencapsulation process |
US5169754A (en) * | 1990-10-31 | 1992-12-08 | Coulter Corporation | Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same |
DE122007000073I1 (de) | 1991-05-09 | 2008-01-31 | Neurim Pharma 1991 | Melatonin enthaltene Arzneimittel |
JP3015607B2 (ja) | 1991-10-16 | 2000-03-06 | 信越化学工業株式会社 | フェロモン製剤を用いた交信撹乱方法 |
US7070806B2 (en) | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5397573A (en) | 1993-06-04 | 1995-03-14 | The Procter & Gamble Company | Laxative compositions |
US5417010A (en) * | 1993-08-09 | 1995-05-23 | Ecer; Gunes M. | Light weight seeding sheet |
US5688510A (en) | 1993-11-18 | 1997-11-18 | Nippon Shinyaku Co. Ltd. | Process for producing stable medicinal composition, and pharmaceutical preparation |
US6469044B1 (en) | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
JP2001524131A (ja) | 1997-05-09 | 2001-11-27 | セイジ、ファーマスーティカルズ、インク | 安定な経口医薬品剤形 |
JPH1147581A (ja) | 1997-07-30 | 1999-02-23 | Takasago Internatl Corp | 徐放性カプセル及びその製造方法 |
FR2771292B1 (fr) | 1997-11-21 | 2000-02-18 | Ethypharm Lab Prod Ethiques | Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques |
US6365185B1 (en) * | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
US6673126B2 (en) | 1998-05-14 | 2004-01-06 | Seiko Epson Corporation | Multiple chamber fabrication equipment for thin film transistors in a display or electronic device |
PT2263660T (pt) | 1998-05-18 | 2017-12-19 | Takeda Pharmaceuticals Co | Comprimidos de desintegração oral |
US6602521B1 (en) | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
JP2000247870A (ja) | 1999-02-24 | 2000-09-12 | Isp Japan Kk | ウィスカー析出が抑制された固形状製剤及びその製造方法 |
US8545880B2 (en) | 1999-02-26 | 2013-10-01 | Andrx Pharmaceuticals, Llc | Controlled release oral dosage form |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
CA2376261A1 (en) | 1999-06-09 | 2000-12-14 | Mochida Pharmaceutical Co., Ltd. | System for release in lower gastrointestinal tract |
BR0013720A (pt) | 1999-09-02 | 2002-07-23 | Nostrum Pharmaceuticals Inc | Formulação em pelota de liberação controlada |
US6627223B2 (en) | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
US6458384B2 (en) | 2000-02-23 | 2002-10-01 | Impetus Ag | Pharmaceutical with predetermined activity profile |
DE50011907D1 (de) | 2000-03-04 | 2006-01-26 | Cognis Ip Man Gmbh | Mikrokapseln |
US6306435B1 (en) | 2000-06-26 | 2001-10-23 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same |
US6423349B1 (en) | 2000-08-24 | 2002-07-23 | Baxter International, Inc. | Therapeutic nutrient composition for pre and post elective surgery |
GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
FR2816507B1 (fr) | 2000-11-16 | 2003-02-28 | Ethypharm Lab Prod Ethiques | Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules |
US20020114832A1 (en) | 2000-12-11 | 2002-08-22 | Dr. Willmar Schwabe Gmbh & Co. | Pharmaceutical preparation comprising peppermint oil and caraway oil in delayed release form |
US20030143272A1 (en) | 2001-03-14 | 2003-07-31 | Waterman Kenneth C. | Pharmaceutical tablet and process for making thereof |
CN100335133C (zh) | 2001-11-22 | 2007-09-05 | 森下仁丹株式会社 | 非胶凝状的胶囊膜组合物和使用其所形成的胶囊 |
US20060009465A1 (en) | 2002-01-18 | 2006-01-12 | Dale Edgar | Treatment of sleep disorders using sleep target modulators |
JP4429590B2 (ja) * | 2002-02-08 | 2010-03-10 | 株式会社協和ウェルネス | ユビキノン含有水可溶性組成物 |
AU2003220551A1 (en) | 2002-03-26 | 2003-10-13 | Euro-Celtique S.A. | Sustained-release gel coated compositions |
US7115282B2 (en) | 2002-04-17 | 2006-10-03 | Salvona Ip Llc | Multi component controlled release system for anhydrous cosmetic compositions |
US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
DE10224087A1 (de) | 2002-05-31 | 2003-12-11 | Symrise Gmbh & Co Kg | Kompaktiertes Menthol |
US20040062778A1 (en) | 2002-09-26 | 2004-04-01 | Adi Shefer | Surface dissolution and/or bulk erosion controlled release compositions and devices |
MXPA05003524A (es) * | 2002-10-01 | 2005-10-04 | Banner Pharmacaps Inc | Preparaciones entericas. |
FR2845289B1 (fr) | 2002-10-04 | 2004-12-03 | Ethypharm Sa | Spheroides, procede de preparation et compositions pharmaceutiques. |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
AU2003263162B2 (en) | 2002-10-24 | 2009-05-07 | Immupharm A/S | Pharmaceutical compositions comprising flavonoids and menthol |
WO2004037232A1 (en) | 2002-10-24 | 2004-05-06 | Micap Plc. | Targeted delivery |
RU2005130103A (ru) | 2003-03-26 | 2006-03-20 | Вм. Ригли Дж. Компани (Us) | Кондитерский продукт, покрытый оболочкой с быстрым высвобождением ароматизатора |
US6737470B1 (en) | 2003-04-04 | 2004-05-18 | Bridgestone Corporation | Curable sealant composition |
CA2539051C (en) * | 2003-09-19 | 2014-08-12 | Penwest Pharmaceuticals Co. | Delayed release dosage forms |
TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
AU2004308962A1 (en) | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
US7670624B2 (en) | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
US20050181047A1 (en) | 2004-02-18 | 2005-08-18 | Jaime Romero | Compositions and methods for timed release of water-soluble nutritional supplements |
US20050202079A1 (en) | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
EP1746980B1 (en) * | 2004-05-07 | 2011-11-02 | Nycomed GmbH | Pharmaceutical dosage form comprising pellets as well as its manufacturing process |
JP5154924B2 (ja) | 2004-05-11 | 2013-02-27 | エガレット エイ/エス | ジェランガムを含む膨張可能な投与形態 |
US20050281876A1 (en) | 2004-06-18 | 2005-12-22 | Shun-Por Li | Solid dosage form for acid-labile active ingredient |
DE102004036437A1 (de) | 2004-07-27 | 2006-03-23 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
ITMI20041689A1 (it) | 2004-09-01 | 2004-12-02 | Bojidar Mihaylov Stankov | Nuove formulazioni di rilascio controllato contenenti 5-idrossitriptofano e triptofano |
ATE397442T1 (de) * | 2004-11-18 | 2008-06-15 | Bristol Myers Squibb Co | Magensaftresistent beschichtetes pellet mit ixabepilon |
US8535640B1 (en) | 2005-01-04 | 2013-09-17 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US8361439B1 (en) | 2005-01-04 | 2013-01-29 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US8574544B1 (en) | 2005-01-04 | 2013-11-05 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US8337811B1 (en) | 2005-01-04 | 2012-12-25 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
JP5282208B2 (ja) | 2005-03-16 | 2013-09-04 | シムライズ アーゲー | メントール含有固体組成物 |
US9149439B2 (en) * | 2005-03-21 | 2015-10-06 | Sandoz Ag | Multi-particulate, modified-release composition |
JP2008534531A (ja) | 2005-03-29 | 2008-08-28 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 調節物質の送達に影響を及ぼすマトリックスを有するペレットを有する多粒子の医薬剤形 |
US20060257469A1 (en) | 2005-04-05 | 2006-11-16 | Bulka Yochanan R | Enhanced indoleamine and catecholamine bio-availability via catechin inhibition of L-Dopa decarboxylase |
KR20080005575A (ko) * | 2005-04-28 | 2008-01-14 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 안정화 조성물 |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US20060280795A1 (en) | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
WO2007012857A1 (en) | 2005-07-28 | 2007-02-01 | University Of Hull | Topical formulations containing sporopollenin |
US20070048366A1 (en) | 2005-08-26 | 2007-03-01 | Jen-Chi Chen | Gelatin-based coatings having improved durability |
JP2007197378A (ja) | 2006-01-27 | 2007-08-09 | Kowa Co | 糖衣製剤 |
US20070292510A1 (en) | 2006-06-19 | 2007-12-20 | Hugh Huang | Enteric coated particles containing an active ingredient |
WO2008057802A2 (en) * | 2006-10-27 | 2008-05-15 | The Curators Of The University Of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
JP5201819B2 (ja) | 2006-11-22 | 2013-06-05 | エスエス製薬株式会社 | 固形組成物 |
KR20090091321A (ko) | 2006-11-28 | 2009-08-27 | 마리누스 파마슈티컬스 | 나노입자 제형, 이의 제조방법 및 이의 용도 |
AR063983A1 (es) | 2006-11-28 | 2009-03-04 | Wyeth Corp | Formulacion de liberacion controlada de agonistas y antagonistas de piperazina -piperidina del receptor 5-ht1a que tienen una disolucion intestinal mejorada |
US20080139510A1 (en) | 2006-12-07 | 2008-06-12 | Abe Rose | Treatment of migraine headaches with sublingual amino acids |
EP1953625A1 (en) | 2007-02-02 | 2008-08-06 | Melik Gencel | Peripheral inputting device for computers |
CA2683436C (en) | 2007-04-11 | 2016-07-26 | John A. Mccarty | Melatonin tablet and methods of preparation and use |
WO2008134807A1 (en) | 2007-05-04 | 2008-11-13 | The University Of Sydney | Method for manufacturing a porous polymer matrix |
US20090004281A1 (en) | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
WO2009007749A2 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
US8048921B2 (en) | 2007-09-18 | 2011-11-01 | Ronald Kramer | Amino acid compounds |
US8969400B2 (en) | 2007-10-01 | 2015-03-03 | Duke University | Pharmaceutical compositions of 5-hydroxytryptophan and serotonin-enhancing compound |
GB0724550D0 (en) * | 2007-12-18 | 2008-01-30 | Univ Hull | Formulations |
US20090238905A1 (en) * | 2008-03-20 | 2009-09-24 | Symrise, Inc. | Inflammation reducing action of synergistic mixtures of bisabolol and ginger extracts |
US20090246301A1 (en) | 2008-03-31 | 2009-10-01 | Ehrenpreis Ben Z | Method for treating irritable bowel syndrome and other functional gastrointestinal disorders |
DE102008023345B4 (de) | 2008-05-13 | 2014-12-04 | Lts Lohmann Therapie-Systeme Ag | Filmförmige Zubereitung mit öligen Substanzen zur oralen Verabreichung |
CN101596166B (zh) | 2008-06-04 | 2011-08-17 | 永信药品工业(昆山)有限公司 | 阿司匹林肠溶微丸 |
AU2009258120B2 (en) * | 2008-06-10 | 2014-11-27 | Teva Pharmaceutical Industries, Ltd. | Rasagiline soft gelatin capsules |
US20110053866A1 (en) | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
US20120128764A1 (en) * | 2009-02-23 | 2012-05-24 | Aptalis Pharmatech, Inc. | Controlled-release compositions comprising a proton pump inhibitor |
AU2010262738A1 (en) | 2009-05-20 | 2011-10-13 | Lingual Consegna Pty Ltd | Buccal and/or sublingual therapeutic formulation |
EP2305742B1 (en) | 2009-10-01 | 2017-02-22 | Symrise AG | Spherical core-shell-particle |
WO2011046609A2 (en) | 2009-10-15 | 2011-04-21 | Appleton Papers Inc. | Encapsulation |
US9050264B2 (en) * | 2009-11-07 | 2015-06-09 | University Of Iowa Research Foundation | Cellulose capsules and methods for making them |
WO2011111027A2 (en) | 2010-03-11 | 2011-09-15 | Dexcel Pharma Technologies Ltd. | Oral dispersible delayed release tablet formulation |
WO2011146078A1 (en) | 2010-05-21 | 2011-11-24 | Board Of Regents, The University Of Texas System | Encapsulated particles for enteric release |
JP2010189443A (ja) | 2010-06-07 | 2010-09-02 | Ss Pharmaceut Co Ltd | 揮散防止型固形製剤およびその製造方法 |
BR112013012184B1 (pt) | 2010-11-16 | 2022-07-12 | Provimi North America, Inc | Suplemento de ração para gado |
BE1019142A3 (fr) * | 2011-01-21 | 2012-03-06 | Vesale Pharma S A | Substance probiotique microencapsulee. |
US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
TR201808978T4 (tr) * | 2011-02-11 | 2018-07-23 | Zx Pharma Llc | Çok partiküllü l-mentol formülasyonları ve ilgili yöntemler. |
JP2014517843A (ja) | 2011-05-24 | 2014-07-24 | テバ ファーマシューティカル インダストリーズ リミティド | 医薬組成物用の圧縮コア |
US20120301546A1 (en) | 2011-05-26 | 2012-11-29 | Hassan Emadeldin M | Acid-resistant soft gel compositions |
US20120315337A1 (en) * | 2011-06-07 | 2012-12-13 | Shah Syed | Multiparticulate 5-htp compositions and related methods |
WO2012170488A1 (en) * | 2011-06-07 | 2012-12-13 | Zx Pharma, Llc | Multiparticulate s-adenosylmethionine compositions and related methods |
DE102012001731A1 (de) * | 2012-01-20 | 2013-07-25 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Systemische Darreichungsformen mit kontrollierter Freisetzung und verbesserter Stabilität |
JP6227546B2 (ja) | 2012-10-26 | 2017-11-08 | 田辺三菱製薬株式会社 | メントールウィスカーの析出を抑制する方法 |
US20140178468A1 (en) | 2012-12-24 | 2014-06-26 | Ranbaxy Laboratories Limited | Multiparticulate extended-release composition of mesalamine |
RS58325B1 (sr) | 2013-04-23 | 2019-03-29 | Zx Pharma Llc | Enterosolventno obloženi višečestični preparat sa proteinskom sub-oblogom |
JP2015024986A (ja) | 2013-06-20 | 2015-02-05 | 大正製薬株式会社 | 固形製剤 |
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