MX3413E - Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazina - Google Patents
Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazinaInfo
- Publication number
- MX3413E MX3413E MX001788U MX178876U MX3413E MX 3413 E MX3413 E MX 3413E MX 001788 U MX001788 U MX 001788U MX 178876 U MX178876 U MX 178876U MX 3413 E MX3413 E MX 3413E
- Authority
- MX
- Mexico
- Prior art keywords
- general formula
- radical
- preparation
- carbon atoms
- halogen atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- -1 4-phenoxyphenyl Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- GYNAVKULVOETAD-UHFFFAOYSA-N n-phenoxyaniline Chemical compound C=1C=CC=CC=1NOC1=CC=CC=C1 GYNAVKULVOETAD-UHFFFAOYSA-N 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30392/75A GB1489711A (en) | 1975-07-21 | 1975-07-21 | 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3413E true MX3413E (es) | 1980-11-07 |
Family
ID=10306953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX001788U MX3413E (es) | 1975-07-21 | 1976-07-21 | Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4064245A (enExample) |
| JP (1) | JPS5225783A (enExample) |
| AR (1) | AR211273A1 (enExample) |
| AT (1) | AT350576B (enExample) |
| AU (1) | AU498329B2 (enExample) |
| BE (1) | BE844343A (enExample) |
| CA (1) | CA1085400A (enExample) |
| CH (1) | CH595368A5 (enExample) |
| DE (1) | DE2631885C2 (enExample) |
| ES (1) | ES450012A1 (enExample) |
| FR (1) | FR2318634A1 (enExample) |
| GB (1) | GB1489711A (enExample) |
| GR (1) | GR61593B (enExample) |
| IE (1) | IE43258B1 (enExample) |
| MX (1) | MX3413E (enExample) |
| NL (1) | NL162075C (enExample) |
| OA (1) | OA05385A (enExample) |
| PH (1) | PH12743A (enExample) |
| PT (1) | PT65380B (enExample) |
| YU (1) | YU163075A (enExample) |
| ZA (1) | ZA764305B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210646A (en) * | 1978-04-11 | 1980-07-01 | Janssen Pharmaceutica N.V. | Antimicrobial compositions containing 1-(aryloxyphenyl)piperazines |
| DE3235589A1 (de) * | 1982-09-25 | 1984-03-29 | Hoechst Ag, 6230 Frankfurt | Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung |
| JPS63174868U (enExample) * | 1987-04-14 | 1988-11-14 | ||
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| EP1968961A2 (en) | 2005-12-21 | 2008-09-17 | Decode Genetics EHF | Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
| HK1260897A1 (zh) | 2015-08-21 | 2019-12-27 | Portola Pharmaceuticals, Inc. | 使用四氢异喹啉小分子来结合并调节pcsk9的蛋白活性的组合物和方法 |
| US10568882B2 (en) | 2015-08-21 | 2020-02-25 | Srx Cardio, Llc | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use |
| WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| IL315313A (en) * | 2018-08-24 | 2024-10-01 | Xeniopro GmbH | Aromatic molecules for use in the treatment of pathological conditions |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
-
1975
- 1975-07-02 YU YU01630/75A patent/YU163075A/xx unknown
- 1975-07-21 GB GB30392/75A patent/GB1489711A/en not_active Expired
-
1976
- 1976-07-07 IE IE1495/76A patent/IE43258B1/en unknown
- 1976-07-08 OA OA55883A patent/OA05385A/xx unknown
- 1976-07-12 CH CH892376A patent/CH595368A5/xx not_active IP Right Cessation
- 1976-07-14 CA CA256,967A patent/CA1085400A/fr not_active Expired
- 1976-07-14 US US05/705,330 patent/US4064245A/en not_active Expired - Lifetime
- 1976-07-15 DE DE2631885A patent/DE2631885C2/de not_active Expired
- 1976-07-16 FR FR7621727A patent/FR2318634A1/fr active Granted
- 1976-07-19 PT PT65380A patent/PT65380B/pt unknown
- 1976-07-19 GR GR51295A patent/GR61593B/el unknown
- 1976-07-20 AU AU16039/76A patent/AU498329B2/en not_active Expired
- 1976-07-20 JP JP51086491A patent/JPS5225783A/ja active Granted
- 1976-07-20 PH PH18710A patent/PH12743A/en unknown
- 1976-07-20 BE BE169088A patent/BE844343A/xx unknown
- 1976-07-20 AR AR263999A patent/AR211273A1/es active
- 1976-07-20 NL NL7608007.A patent/NL162075C/xx not_active IP Right Cessation
- 1976-07-20 AT AT534376A patent/AT350576B/de active
- 1976-07-20 ZA ZA764305A patent/ZA764305B/xx unknown
- 1976-07-21 ES ES450012A patent/ES450012A1/es not_active Expired
- 1976-07-21 MX MX001788U patent/MX3413E/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT65380B (fr) | 1978-01-19 |
| IE43258B1 (en) | 1981-01-14 |
| US4064245A (en) | 1977-12-20 |
| ATA534376A (de) | 1978-11-15 |
| DE2631885C2 (de) | 1982-07-15 |
| FR2318634B1 (enExample) | 1979-06-29 |
| AU498329B2 (en) | 1979-03-01 |
| NL162075B (nl) | 1979-11-15 |
| IE43258L (en) | 1977-01-21 |
| GB1489711A (en) | 1977-10-26 |
| ZA764305B (en) | 1977-07-27 |
| PT65380A (fr) | 1976-08-01 |
| JPS5225783A (en) | 1977-02-25 |
| FR2318634A1 (fr) | 1977-02-18 |
| YU163075A (en) | 1982-05-31 |
| NL7608007A (nl) | 1977-01-25 |
| BE844343A (fr) | 1977-01-20 |
| CH595368A5 (enExample) | 1978-02-15 |
| AR211273A1 (es) | 1977-11-15 |
| GR61593B (en) | 1978-12-02 |
| AT350576B (de) | 1978-06-15 |
| AU1603976A (en) | 1978-01-26 |
| PH12743A (en) | 1979-08-09 |
| OA05385A (fr) | 1981-02-28 |
| ES450012A1 (es) | 1977-07-16 |
| NL162075C (nl) | 1980-04-15 |
| CA1085400A (fr) | 1980-09-09 |
| DE2631885A1 (de) | 1977-02-10 |
| JPS558504B2 (enExample) | 1980-03-04 |
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