GB1489711A - 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the - Google Patents

1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the

Info

Publication number
GB1489711A
GB1489711A GB30392/75A GB3039275A GB1489711A GB 1489711 A GB1489711 A GB 1489711A GB 30392/75 A GB30392/75 A GB 30392/75A GB 3039275 A GB3039275 A GB 3039275A GB 1489711 A GB1489711 A GB 1489711A
Authority
GB
United Kingdom
Prior art keywords
phenoxyphenyl
piperazine
pharmaceutical compositions
preparation
piperazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30392/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to YU01630/75A priority Critical patent/YU163075A/xx
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB30392/75A priority patent/GB1489711A/en
Priority to IE1495/76A priority patent/IE43258B1/en
Priority to OA55883A priority patent/OA05385A/xx
Priority to CH892376A priority patent/CH595368A5/xx
Priority to US05/705,330 priority patent/US4064245A/en
Priority to CA256,967A priority patent/CA1085400A/fr
Priority to DE2631885A priority patent/DE2631885C2/de
Priority to FR7621727A priority patent/FR2318634A1/fr
Priority to GR51295A priority patent/GR61593B/el
Priority to PT65380A priority patent/PT65380B/pt
Priority to AU16039/76A priority patent/AU498329B2/en
Priority to AR263999A priority patent/AR211273A1/es
Priority to AT534376A priority patent/AT350576B/de
Priority to NL7608007.A priority patent/NL162075C/xx
Priority to PH18710A priority patent/PH12743A/en
Priority to ZA764305A priority patent/ZA764305B/xx
Priority to JP51086491A priority patent/JPS5225783A/ja
Priority to BE169088A priority patent/BE844343A/xx
Priority to ES450012A priority patent/ES450012A1/es
Priority to MX001788U priority patent/MX3413E/es
Publication of GB1489711A publication Critical patent/GB1489711A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
GB30392/75A 1975-07-21 1975-07-21 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the Expired GB1489711A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
YU01630/75A YU163075A (en) 1975-07-21 1975-07-02 Process for preparing new phenoxy derivatives
GB30392/75A GB1489711A (en) 1975-07-21 1975-07-21 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the
IE1495/76A IE43258B1 (en) 1975-07-21 1976-07-07 1-phenoxypenyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them
OA55883A OA05385A (fr) 1975-07-21 1976-07-08 Procédé de préparation de nouveaux dérivés phénoxy.
CH892376A CH595368A5 (enExample) 1975-07-21 1976-07-12
US05/705,330 US4064245A (en) 1975-07-21 1976-07-14 N-Phenoxyphenyl-piperazines
CA256,967A CA1085400A (fr) 1975-07-21 1976-07-14 Procede de preparation de nouveaux derives phenoxy
DE2631885A DE2631885C2 (de) 1975-07-21 1976-07-15 1-(4-Phenoxyphenyl)-piperazin-Derivate, ihre Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
FR7621727A FR2318634A1 (fr) 1975-07-21 1976-07-16 Nouveaux derives phenoxy, leur procede de preparation et leur application en therapeutique
GR51295A GR61593B (en) 1975-07-21 1976-07-19 Preparations process of novel phenoxy derivatives
PT65380A PT65380B (fr) 1975-07-21 1976-07-19 Procede de preparation de nouveaux derives phenoxy
AU16039/76A AU498329B2 (en) 1975-07-21 1976-07-20 Phenoxy phenyl piperazine derivatives
AR263999A AR211273A1 (es) 1975-07-21 1976-07-20 Procendimiento de preparacion de nuevas (fenoxi-4-fenil)1-piperazinas
AT534376A AT350576B (de) 1975-07-21 1976-07-20 Verfahren zur herstellung von neuen phenoxy- derivaten und von deren salzen
NL7608007.A NL162075C (nl) 1975-07-21 1976-07-20 Werkwijze voor de bereiding van een preparaat met o.a. een lipidemetabolisme regulerende werking en werkwijze voor de bereiding van verbindingen met een dergelijke werking.
PH18710A PH12743A (en) 1975-07-21 1976-07-20 Phenoxy compounds
ZA764305A ZA764305B (en) 1975-07-21 1976-07-20 Phenoxy derivatives process for their preparation and pharmaceutical compositions containing them
JP51086491A JPS5225783A (en) 1975-07-21 1976-07-20 Preparation method of new phenoxy derivatives
BE169088A BE844343A (fr) 1975-07-21 1976-07-20 Nouveaux derives phenoxy,leur procede de preparation et leur application en therapeutique
ES450012A ES450012A1 (es) 1975-07-21 1976-07-21 Procedimiento de preparacion de nuevos derivados fenoxi y de sus sales de adicion con acidos minerales u organicos.
MX001788U MX3413E (es) 1975-07-21 1976-07-21 Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30392/75A GB1489711A (en) 1975-07-21 1975-07-21 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the

Publications (1)

Publication Number Publication Date
GB1489711A true GB1489711A (en) 1977-10-26

Family

ID=10306953

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30392/75A Expired GB1489711A (en) 1975-07-21 1975-07-21 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the

Country Status (21)

Country Link
US (1) US4064245A (enExample)
JP (1) JPS5225783A (enExample)
AR (1) AR211273A1 (enExample)
AT (1) AT350576B (enExample)
AU (1) AU498329B2 (enExample)
BE (1) BE844343A (enExample)
CA (1) CA1085400A (enExample)
CH (1) CH595368A5 (enExample)
DE (1) DE2631885C2 (enExample)
ES (1) ES450012A1 (enExample)
FR (1) FR2318634A1 (enExample)
GB (1) GB1489711A (enExample)
GR (1) GR61593B (enExample)
IE (1) IE43258B1 (enExample)
MX (1) MX3413E (enExample)
NL (1) NL162075C (enExample)
OA (1) OA05385A (enExample)
PH (1) PH12743A (enExample)
PT (1) PT65380B (enExample)
YU (1) YU163075A (enExample)
ZA (1) ZA764305B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104572A1 (de) * 1982-09-25 1984-04-04 Hoechst Aktiengesellschaft Benzylether von Phenol-Mannich-Basen, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen, Zwischenprodukte und Verfahren zu deren Herstellung
WO2003029232A1 (en) * 2001-10-04 2003-04-10 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
WO2007078335A3 (en) * 2005-12-21 2007-11-29 Decode Genetics Inc Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
EA027783B1 (ru) * 2007-11-13 2017-09-29 Х. Лундбекк А/С Способ лечения бессонницы

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210646A (en) * 1978-04-11 1980-07-01 Janssen Pharmaceutica N.V. Antimicrobial compositions containing 1-(aryloxyphenyl)piperazines
JPS63174868U (enExample) * 1987-04-14 1988-11-14
WO2017034997A1 (en) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (pcsk9) modulators and their use
WO2017034994A1 (en) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity
US10865185B2 (en) 2015-08-21 2020-12-15 Srx Cardio, Llc Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity
WO2017147328A1 (en) 2016-02-23 2017-08-31 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
IL315313A (en) * 2018-08-24 2024-10-01 Xeniopro GmbH Aromatic molecules for use in the treatment of pathological conditions
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104572A1 (de) * 1982-09-25 1984-04-04 Hoechst Aktiengesellschaft Benzylether von Phenol-Mannich-Basen, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen, Zwischenprodukte und Verfahren zu deren Herstellung
KR100842702B1 (ko) 2001-10-04 2008-07-01 하. 룬트벡 아크티에 셀스카브 세로토닌 재흡수 억제제로서 페닐-피페라진 유도체
EA007537B1 (ru) * 2001-10-04 2006-10-27 Х. Лундбекк А/С Азотсодержащие гетероциклические производные, содержащая их фармацевтическая композиция, их применение и способ лечения
US7138407B2 (en) 2001-10-04 2006-11-21 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US7144884B2 (en) 2001-10-04 2006-12-05 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US7148238B2 (en) 2001-10-04 2006-12-12 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
CN1319958C (zh) * 2001-10-04 2007-06-06 H·隆德贝克有限公司 作为血清素再摄取抑制剂的苯基哌嗪衍生物
KR100770194B1 (ko) 2001-10-04 2007-10-25 하. 룬트벡 아크티에 셀스카브 세로토닌 재흡수 억제제로서 페닐-피페라진 유도체
US10844029B2 (en) 2001-10-04 2020-11-24 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
WO2003029232A1 (en) * 2001-10-04 2003-04-10 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
KR100783346B1 (ko) 2001-10-04 2007-12-07 하. 룬트벡 아크티에 셀스카브 세로토닌 재흡수 억제제로서 페닐-피페라진 유도체
US9708280B2 (en) 2001-10-04 2017-07-18 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US7683053B2 (en) 2001-10-04 2010-03-23 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
MY140950A (en) * 2001-10-04 2010-02-12 Lundbeck & Co As H Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US8110567B2 (en) 2001-10-04 2012-02-07 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US8476279B2 (en) 2001-10-04 2013-07-02 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
EA007537B3 (ru) * 2001-10-04 2015-02-27 Х. Лундбекк А/С 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазин – ингибитор обратного захвата серотонина
US9090575B2 (en) 2001-10-04 2015-07-28 H. Lundbeck A/S Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US7750012B2 (en) 2005-12-21 2010-07-06 Decode Genetics Ehf Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation
WO2007078335A3 (en) * 2005-12-21 2007-11-29 Decode Genetics Inc Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
EA027783B1 (ru) * 2007-11-13 2017-09-29 Х. Лундбекк А/С Способ лечения бессонницы

Also Published As

Publication number Publication date
AT350576B (de) 1978-06-15
DE2631885C2 (de) 1982-07-15
NL162075C (nl) 1980-04-15
FR2318634A1 (fr) 1977-02-18
JPS5225783A (en) 1977-02-25
DE2631885A1 (de) 1977-02-10
ES450012A1 (es) 1977-07-16
YU163075A (en) 1982-05-31
AU1603976A (en) 1978-01-26
FR2318634B1 (enExample) 1979-06-29
IE43258L (en) 1977-01-21
CA1085400A (fr) 1980-09-09
NL7608007A (nl) 1977-01-25
AR211273A1 (es) 1977-11-15
BE844343A (fr) 1977-01-20
ATA534376A (de) 1978-11-15
AU498329B2 (en) 1979-03-01
GR61593B (en) 1978-12-02
CH595368A5 (enExample) 1978-02-15
JPS558504B2 (enExample) 1980-03-04
MX3413E (es) 1980-11-07
NL162075B (nl) 1979-11-15
ZA764305B (en) 1977-07-27
IE43258B1 (en) 1981-01-14
OA05385A (fr) 1981-02-28
PH12743A (en) 1979-08-09
PT65380A (fr) 1976-08-01
US4064245A (en) 1977-12-20
PT65380B (fr) 1978-01-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee