GB1490507A - Piperazine derivatives - Google Patents
Piperazine derivativesInfo
- Publication number
- GB1490507A GB1490507A GB1392376A GB1392376A GB1490507A GB 1490507 A GB1490507 A GB 1490507A GB 1392376 A GB1392376 A GB 1392376A GB 1392376 A GB1392376 A GB 1392376A GB 1490507 A GB1490507 A GB 1490507A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hal
- april
- piperazine derivatives
- novel compounds
- hypocholesterolaemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1490507 Piperazine derivatives PARCOR 6 April 1976 [7 April 1975] 13923/76 Heading C2C Novel compounds of formula where R 1 is halogen, alkyl, alkoxy or trifluoromethyl, and either R 2 and R 3 together complete a 4- to 8-membered saturated heterocyclic ring which may contain an oxygen or nitrogen atom as a second hetero atom, or R 2 is H and R 3 is cycloalkyl, and salts thereof, are prepared by reacting with B, wherein A is H and B is Hal(CH 2 ) 3 NR 2 R 3 or A is -(CH 2 ) 3 Hal and B is HNR 2 R 3 , or by condensing a cycloalkanone with an appropriate amine and reducing the resulting imine. Pharmaceutical compositions comprising the above novel compounds have hypocholesterolaemic, anti-inflammatory and analgesic activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7510729A FR2306694A1 (en) | 1975-04-07 | 1975-04-07 | DERIVATIVES OF PIPERAZINE |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1490507A true GB1490507A (en) | 1977-11-02 |
Family
ID=9153579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1392376A Expired GB1490507A (en) | 1975-04-07 | 1976-04-06 | Piperazine derivatives |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS51118780A (en) |
BE (1) | BE840326A (en) |
DE (1) | DE2609746A1 (en) |
DK (1) | DK140142B (en) |
ES (1) | ES446598A1 (en) |
FR (1) | FR2306694A1 (en) |
GB (1) | GB1490507A (en) |
IE (1) | IE43222B1 (en) |
LU (1) | LU74701A1 (en) |
NL (1) | NL7603508A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0015615A1 (en) * | 1979-03-01 | 1980-09-17 | Duphar International Research B.V | Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them |
EP0103357A2 (en) * | 1982-06-22 | 1984-03-21 | Warner-Lambert Company | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
BR0307429A (en) * | 2002-02-05 | 2004-12-28 | Novo Nordisk As | Compound, use thereof, pharmaceutical composition, and method for treating h3 histamine receptor related disorders or diseases |
CN103110635A (en) | 2005-07-04 | 2013-05-22 | 海波因特制药有限责任公司 | Histamine H3 receptor antagonist |
EP2038256A1 (en) | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament |
EA016026B1 (en) | 2006-05-29 | 2012-01-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
-
1975
- 1975-04-07 FR FR7510729A patent/FR2306694A1/en active Granted
-
1976
- 1976-03-09 DE DE19762609746 patent/DE2609746A1/en active Pending
- 1976-03-23 DK DK125476A patent/DK140142B/en not_active IP Right Cessation
- 1976-03-29 JP JP51035056A patent/JPS51118780A/en active Pending
- 1976-04-01 ES ES446598A patent/ES446598A1/en not_active Expired
- 1976-04-02 BE BE165796A patent/BE840326A/en unknown
- 1976-04-05 NL NL7603508A patent/NL7603508A/en not_active Application Discontinuation
- 1976-04-05 LU LU74701A patent/LU74701A1/xx unknown
- 1976-04-06 GB GB1392376A patent/GB1490507A/en not_active Expired
- 1976-04-06 IE IE72076A patent/IE43222B1/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0015615A1 (en) * | 1979-03-01 | 1980-09-17 | Duphar International Research B.V | Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them |
EP0103357A2 (en) * | 1982-06-22 | 1984-03-21 | Warner-Lambert Company | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production |
EP0103357A3 (en) * | 1982-06-22 | 1986-01-08 | Warner-Lambert Company | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production |
Also Published As
Publication number | Publication date |
---|---|
DK140142B (en) | 1979-06-25 |
ES446598A1 (en) | 1977-06-16 |
FR2306694B1 (en) | 1980-01-04 |
JPS51118780A (en) | 1976-10-18 |
DK125476A (en) | 1976-10-08 |
BE840326A (en) | 1976-10-04 |
LU74701A1 (en) | 1976-11-11 |
DK140142C (en) | 1979-11-19 |
IE43222L (en) | 1976-10-07 |
IE43222B1 (en) | 1981-01-14 |
DE2609746A1 (en) | 1976-10-14 |
FR2306694A1 (en) | 1976-11-05 |
NL7603508A (en) | 1976-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |