IE43222L - Piperazine derivatives - Google Patents
Piperazine derivativesInfo
- Publication number
- IE43222L IE43222L IE72076A IE72076A IE43222L IE 43222 L IE43222 L IE 43222L IE 72076 A IE72076 A IE 72076A IE 72076 A IE72076 A IE 72076A IE 43222 L IE43222 L IE 43222L
- Authority
- IE
- Ireland
- Prior art keywords
- hal
- april
- piperazine derivatives
- novel compounds
- gb1490507a
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1490507 Piperazine derivatives PARCOR 6 April 1976 [7 April 1975] 13923/76 Heading C2C Novel compounds of formula where R 1 is halogen, alkyl, alkoxy or trifluoromethyl, and either R 2 and R 3 together complete a 4- to 8-membered saturated heterocyclic ring which may contain an oxygen or nitrogen atom as a second hetero atom, or R 2 is H and R 3 is cycloalkyl, and salts thereof, are prepared by reacting with B, wherein A is H and B is Hal(CH 2 ) 3 NR 2 R 3 or A is -(CH 2 ) 3 Hal and B is HNR 2 R 3 , or by condensing a cycloalkanone with an appropriate amine and reducing the resulting imine. Pharmaceutical compositions comprising the above novel compounds have hypocholesterolaemic, anti-inflammatory and analgesic activity.
[GB1490507A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7510729A FR2306694A1 (en) | 1975-04-07 | 1975-04-07 | DERIVATIVES OF PIPERAZINE |
Publications (2)
Publication Number | Publication Date |
---|---|
IE43222L true IE43222L (en) | 1976-10-07 |
IE43222B1 IE43222B1 (en) | 1981-01-14 |
Family
ID=9153579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE72076A IE43222B1 (en) | 1975-04-07 | 1976-04-06 | Piperazine derivatives |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS51118780A (en) |
BE (1) | BE840326A (en) |
DE (1) | DE2609746A1 (en) |
DK (1) | DK140142B (en) |
ES (1) | ES446598A1 (en) |
FR (1) | FR2306694A1 (en) |
GB (1) | GB1490507A (en) |
IE (1) | IE43222B1 (en) |
LU (1) | LU74701A1 (en) |
NL (1) | NL7603508A (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU532411B2 (en) * | 1979-03-01 | 1983-09-29 | Duphar International Research B.V. | Phenyl piperazine derivatives |
US4452798A (en) * | 1982-06-22 | 1984-06-05 | Warner-Lambert Company | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents |
US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
AU2003203148A1 (en) * | 2002-02-05 | 2003-09-02 | High Point Pharmaceuticals, Llc | Novel aryl- and heteroarylpiperazines |
MX2007015675A (en) | 2005-07-04 | 2008-02-20 | Novo Nordisk As | Hists1mine h3 receptor antagonists. |
EP2038256A1 (en) | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament |
CN101460487A (en) | 2006-05-29 | 2009-06-17 | 高点制药有限责任公司 | 3- (1, 3-benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist |
EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
-
1975
- 1975-04-07 FR FR7510729A patent/FR2306694A1/en active Granted
-
1976
- 1976-03-09 DE DE19762609746 patent/DE2609746A1/en active Pending
- 1976-03-23 DK DK125476A patent/DK140142B/en not_active IP Right Cessation
- 1976-03-29 JP JP51035056A patent/JPS51118780A/en active Pending
- 1976-04-01 ES ES446598A patent/ES446598A1/en not_active Expired
- 1976-04-02 BE BE165796A patent/BE840326A/en unknown
- 1976-04-05 LU LU74701A patent/LU74701A1/xx unknown
- 1976-04-05 NL NL7603508A patent/NL7603508A/en not_active Application Discontinuation
- 1976-04-06 IE IE72076A patent/IE43222B1/en unknown
- 1976-04-06 GB GB1392376A patent/GB1490507A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE43222B1 (en) | 1981-01-14 |
DK140142B (en) | 1979-06-25 |
DK140142C (en) | 1979-11-19 |
DK125476A (en) | 1976-10-08 |
JPS51118780A (en) | 1976-10-18 |
DE2609746A1 (en) | 1976-10-14 |
NL7603508A (en) | 1976-10-11 |
FR2306694A1 (en) | 1976-11-05 |
BE840326A (en) | 1976-10-04 |
LU74701A1 (en) | 1976-11-11 |
ES446598A1 (en) | 1977-06-16 |
FR2306694B1 (en) | 1980-01-04 |
GB1490507A (en) | 1977-11-02 |
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