MX3413E - Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazina - Google Patents
Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazinaInfo
- Publication number
- MX3413E MX3413E MX001788U MX178876U MX3413E MX 3413 E MX3413 E MX 3413E MX 001788 U MX001788 U MX 001788U MX 178876 U MX178876 U MX 178876U MX 3413 E MX3413 E MX 3413E
- Authority
- MX
- Mexico
- Prior art keywords
- general formula
- radical
- preparation
- carbon atoms
- halogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparacion de 1-(3 ó 4-fenoxifenil)pipereza de formula general I: (ver figura). en la cual R y R1 que pueden ser iguales o diferentes, representan cada uno un átomo de hidrógeno o de halógeno, un radical alquilo, alcoxi o alquiltio que tienen cada uno de 1 a 5 átomos de carbono, un radical nitro, amino, trifluormetilo, trifluormetiltio, trifluormetoxi, alcoxicarbonilo, en el cual el grupo alcoxi tiene de 1 a 5 átomos de carbono, o un radical dimetilsulfamoilo, asi como de sus sales de adición con ácidos minerales u orgánicos, caracterizado porque se hace reaccionar una fenoxianilina de fórmula general II: (ver figura). en la cual R y R1 tiene los significados anteriormente, con una bis-beta-halogenoetil)amina de fórmula general III: en la cual X representa un átomo de halógeno y luego se alcalinisa el halogenhidrato así formado, y si se desea, se tratan los derivados de fórmula I así obtenidos con ácidos adecuados para obtener las sales de adición ácidas correspondientes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30392/75A GB1489711A (en) | 1975-07-21 | 1975-07-21 | 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3413E true MX3413E (es) | 1980-11-07 |
Family
ID=10306953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX001788U MX3413E (es) | 1975-07-21 | 1976-07-21 | Procedimientos para la preparacion de 1-(3 o 4-fenoxifenil) piperazina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4064245A (es) |
| JP (1) | JPS5225783A (es) |
| AR (1) | AR211273A1 (es) |
| AT (1) | AT350576B (es) |
| AU (1) | AU498329B2 (es) |
| BE (1) | BE844343A (es) |
| CA (1) | CA1085400A (es) |
| CH (1) | CH595368A5 (es) |
| DE (1) | DE2631885C2 (es) |
| ES (1) | ES450012A1 (es) |
| FR (1) | FR2318634A1 (es) |
| GB (1) | GB1489711A (es) |
| GR (1) | GR61593B (es) |
| IE (1) | IE43258B1 (es) |
| MX (1) | MX3413E (es) |
| NL (1) | NL162075C (es) |
| OA (1) | OA05385A (es) |
| PH (1) | PH12743A (es) |
| PT (1) | PT65380B (es) |
| YU (1) | YU163075A (es) |
| ZA (1) | ZA764305B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210646A (en) * | 1978-04-11 | 1980-07-01 | Janssen Pharmaceutica N.V. | Antimicrobial compositions containing 1-(aryloxyphenyl)piperazines |
| DE3235589A1 (de) * | 1982-09-25 | 1984-03-29 | Hoechst Ag, 6230 Frankfurt | Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung |
| JPS63174868U (es) * | 1987-04-14 | 1988-11-14 | ||
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| US7750012B2 (en) | 2005-12-21 | 2010-07-06 | Decode Genetics Ehf | Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| US10568882B2 (en) | 2015-08-21 | 2020-02-25 | Srx Cardio, Llc | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use |
| WO2017034990A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity |
| US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
| US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| WO2020039092A2 (en) * | 2018-08-24 | 2020-02-27 | Xeniopro GmbH | Novel aromatic molecules |
-
1975
- 1975-07-02 YU YU01630/75A patent/YU163075A/xx unknown
- 1975-07-21 GB GB30392/75A patent/GB1489711A/en not_active Expired
-
1976
- 1976-07-07 IE IE1495/76A patent/IE43258B1/en unknown
- 1976-07-08 OA OA55883A patent/OA05385A/xx unknown
- 1976-07-12 CH CH892376A patent/CH595368A5/xx not_active IP Right Cessation
- 1976-07-14 CA CA256,967A patent/CA1085400A/fr not_active Expired
- 1976-07-14 US US05/705,330 patent/US4064245A/en not_active Expired - Lifetime
- 1976-07-15 DE DE2631885A patent/DE2631885C2/de not_active Expired
- 1976-07-16 FR FR7621727A patent/FR2318634A1/fr active Granted
- 1976-07-19 GR GR51295A patent/GR61593B/el unknown
- 1976-07-19 PT PT65380A patent/PT65380B/pt unknown
- 1976-07-20 ZA ZA764305A patent/ZA764305B/xx unknown
- 1976-07-20 AT AT534376A patent/AT350576B/de active
- 1976-07-20 JP JP51086491A patent/JPS5225783A/ja active Granted
- 1976-07-20 BE BE169088A patent/BE844343A/xx unknown
- 1976-07-20 AR AR263999A patent/AR211273A1/es active
- 1976-07-20 NL NL7608007.A patent/NL162075C/xx not_active IP Right Cessation
- 1976-07-20 PH PH18710A patent/PH12743A/en unknown
- 1976-07-20 AU AU16039/76A patent/AU498329B2/en not_active Expired
- 1976-07-21 ES ES450012A patent/ES450012A1/es not_active Expired
- 1976-07-21 MX MX001788U patent/MX3413E/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA764305B (en) | 1977-07-27 |
| CA1085400A (fr) | 1980-09-09 |
| IE43258B1 (en) | 1981-01-14 |
| US4064245A (en) | 1977-12-20 |
| IE43258L (en) | 1977-01-21 |
| JPS558504B2 (es) | 1980-03-04 |
| PT65380A (fr) | 1976-08-01 |
| FR2318634B1 (es) | 1979-06-29 |
| GR61593B (en) | 1978-12-02 |
| NL162075C (nl) | 1980-04-15 |
| OA05385A (fr) | 1981-02-28 |
| AR211273A1 (es) | 1977-11-15 |
| BE844343A (fr) | 1977-01-20 |
| AU498329B2 (en) | 1979-03-01 |
| ATA534376A (de) | 1978-11-15 |
| AT350576B (de) | 1978-06-15 |
| YU163075A (en) | 1982-05-31 |
| NL162075B (nl) | 1979-11-15 |
| PH12743A (en) | 1979-08-09 |
| DE2631885C2 (de) | 1982-07-15 |
| CH595368A5 (es) | 1978-02-15 |
| FR2318634A1 (fr) | 1977-02-18 |
| JPS5225783A (en) | 1977-02-25 |
| GB1489711A (en) | 1977-10-26 |
| ES450012A1 (es) | 1977-07-16 |
| AU1603976A (en) | 1978-01-26 |
| NL7608007A (nl) | 1977-01-25 |
| PT65380B (fr) | 1978-01-19 |
| DE2631885A1 (de) | 1977-02-10 |
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