HK1260897A1 - 使用四氫異喹啉小分子來結合並調節pcsk9的蛋白活性的組合物和方法 - Google Patents

使用四氫異喹啉小分子來結合並調節pcsk9的蛋白活性的組合物和方法

Info

Publication number
HK1260897A1
HK1260897A1 HK18116353.7A HK18116353A HK1260897A1 HK 1260897 A1 HK1260897 A1 HK 1260897A1 HK 18116353 A HK18116353 A HK 18116353A HK 1260897 A1 HK1260897 A1 HK 1260897A1
Authority
HK
Hong Kong
Prior art keywords
tetrahydroisoquinoline
bind
composition
methods
small molecules
Prior art date
Application number
HK18116353.7A
Other languages
English (en)
Inventor
Thomas E Barta
Jonathan William Bourne
Kyle D Monroe
Michael M Muehlemann
Anjali Pandey
Simeon Bowers
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of HK1260897A1 publication Critical patent/HK1260897A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18116353.7A 2015-08-21 2018-12-20 使用四氫異喹啉小分子來結合並調節pcsk9的蛋白活性的組合物和方法 HK1260897A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562208068P 2015-08-21 2015-08-21
PCT/US2016/047798 WO2017034990A1 (en) 2015-08-21 2016-08-19 Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity

Publications (1)

Publication Number Publication Date
HK1260897A1 true HK1260897A1 (zh) 2019-12-27

Family

ID=58100951

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18116353.7A HK1260897A1 (zh) 2015-08-21 2018-12-20 使用四氫異喹啉小分子來結合並調節pcsk9的蛋白活性的組合物和方法

Country Status (4)

Country Link
US (2) US10865185B2 (zh)
EP (1) EP3337564A4 (zh)
HK (1) HK1260897A1 (zh)
WO (1) WO2017034990A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017034994A1 (en) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity
WO2017034990A1 (en) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity
EP3337788A4 (en) 2015-08-21 2019-03-27 Portola Pharmaceuticals, Inc. PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN / -KEXIN TYPE 9 P (CSK9) MODULATORS AND THEIR USE
CN105214087B (zh) 2015-10-29 2017-12-26 陈敏 Pcsk9单克隆抗体在制备治疗炎症免疫性疾病药物中的应用
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)

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Also Published As

Publication number Publication date
WO2017034990A8 (en) 2018-02-15
US11945782B2 (en) 2024-04-02
US20200207718A1 (en) 2020-07-02
US10865185B2 (en) 2020-12-15
EP3337564A4 (en) 2019-01-23
WO2017034990A1 (en) 2017-03-02
EP3337564A1 (en) 2018-06-27
US20210309613A1 (en) 2021-10-07

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