MX2022001407A - Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer. - Google Patents

Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.

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Publication number
MX2022001407A
MX2022001407A MX2022001407A MX2022001407A MX2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A
Authority
MX
Mexico
Prior art keywords
imidazol
sting
carboxamide
agonists
cancer
Prior art date
Application number
MX2022001407A
Other languages
English (en)
Spanish (es)
Inventor
Joshua D Thomas
Dorin Toader
Jeremy R Duvall
Keith W Bentley
Brian D Jones
Eugene W Kelleher
Soumya S Ray
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of MX2022001407A publication Critical patent/MX2022001407A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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MX2022001407A 2019-08-02 2020-07-31 Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer. MX2022001407A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962882081P 2019-08-02 2019-08-02
US201962944643P 2019-12-06 2019-12-06
US202062982935P 2020-02-28 2020-02-28
PCT/US2020/044538 WO2021026009A1 (en) 2019-08-02 2020-07-31 Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2022001407A true MX2022001407A (es) 2022-04-27

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Application Number Title Priority Date Filing Date
MX2022001407A MX2022001407A (es) 2019-08-02 2020-07-31 Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.
MX2025006327A MX2025006327A (es) 2019-08-02 2022-02-01 Compuestos derivados y relacionados de bis-[n-((5- carbamoil)-1hbenzo[d]imidazol-2-yl)-pyrazol-5- carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.

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MX2025006327A MX2025006327A (es) 2019-08-02 2022-02-01 Compuestos derivados y relacionados de bis-[n-((5- carbamoil)-1hbenzo[d]imidazol-2-yl)-pyrazol-5- carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.

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US (3) US11155567B2 (enExample)
EP (1) EP4007758A1 (enExample)
JP (1) JP7843695B2 (enExample)
KR (1) KR20220056176A (enExample)
CN (1) CN114585623A (enExample)
AU (1) AU2020324388A1 (enExample)
BR (1) BR112022001931A2 (enExample)
CA (1) CA3149482A1 (enExample)
IL (1) IL290212A (enExample)
MX (2) MX2022001407A (enExample)
TW (1) TW202120500A (enExample)
WO (1) WO2021026009A1 (enExample)
ZA (1) ZA202201505B (enExample)

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JP7843695B2 (ja) 2019-08-02 2026-04-10 メルサナ セラピューティクス インコーポレイテッド がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物
IL296901A (en) * 2020-04-02 2022-12-01 Mersana Therapeutics Inc Antibody-drug conjugates comprising sting agonists
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法
WO2022177307A1 (ko) * 2021-02-17 2022-08-25 한국화학연구원 벤즈이미다졸 유도체를 유효 성분으로 포함하는 인터페론 유전자 자극제 조성물
WO2022247743A1 (en) * 2021-05-24 2022-12-01 Fulgent Genetics, Inc. Compounds and their use as vaccine adjuvants
CN114948955A (zh) * 2022-06-06 2022-08-30 中国科学技术大学 靶向环鸟苷酸-腺苷酸合成酶的小分子共价抑制剂及其用途
TW202432101A (zh) * 2022-11-08 2024-08-16 韓商瑞嘉化學生物科學股份有限公司 Sting促效劑
WO2024174863A1 (zh) * 2023-02-22 2024-08-29 深圳众格生物科技有限公司 Sting激动剂及其制备方法和医药用途
JP2026508759A (ja) * 2023-02-27 2026-03-12 バイオンテック・エスイー ヒドラジド、ヒドラジン、及びヒドロキサム酸官能基を含有するｓｔｉｎｇアゴニスト
WO2024186626A1 (en) * 2023-03-03 2024-09-12 Bolt Biotherapeutics, Inc. Aza-bicyclic sting agonist immunoconjugates, and uses thereof
WO2024192017A1 (en) 2023-03-13 2024-09-19 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists, combinations and methods of use
WO2025029832A2 (en) 2023-07-31 2025-02-06 Sutro Biopharma, Inc. Sting agonist compounds and conjugates
CN117229310B (zh) * 2023-09-18 2026-03-31 上海皓元生物医药科技有限公司 一种sting激动剂及其中间体的制备方法
US20260053942A1 (en) 2024-05-30 2026-02-26 Astellas Pharama Inc. Sting agonist immunostimulatory antibody drug conjugates
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

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