JP7843695B2 - がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物 - Google Patents

がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物

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JP7843695B2
JP7843695B2 JP2022506588A JP2022506588A JP7843695B2 JP 7843695 B2 JP7843695 B2 JP 7843695B2 JP 2022506588 A JP2022506588 A JP 2022506588A JP 2022506588 A JP2022506588 A JP 2022506588A JP 7843695 B2 JP7843695 B2 JP 7843695B2
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alkyl
optionally substituted
alkoxy
substituted
amino
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JP2022543086A (ja
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ジェレミー アール． デュヴァル
キース ダブリュ． ベントレー
ブライアン ディー． ジョーンズ
ユージーン ダブリュ． ケレハー
ソウミャ エス． レイ
ジョシュア ディー． トーマス
ドリン トーダー
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メルサナ セラピューティクス インコーポレイテッド
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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JP2022506588A 2019-08-02 2020-07-31 がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物 Active JP7843695B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962882081P 2019-08-02 2019-08-02
US62/882,081 2019-08-02
US201962944643P 2019-12-06 2019-12-06
US62/944,643 2019-12-06
US202062982935P 2020-02-28 2020-02-28
US62/982,935 2020-02-28
PCT/US2020/044538 WO2021026009A1 (en) 2019-08-02 2020-07-31 Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer

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JP2022543086A JP2022543086A (ja) 2022-10-07
JP2022543086A5 JP2022543086A5 (enExample) 2023-06-27
JP7843695B2 true JP7843695B2 (ja) 2026-04-10

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AU (1) AU2020324388A1 (enExample)
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CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
CA3058360A1 (en) 2017-03-29 2018-10-04 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
CN113563313B (zh) * 2019-01-31 2022-11-04 成都先导药物开发股份有限公司 一种免疫调节剂
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
JP7843695B2 (ja) 2019-08-02 2026-04-10 メルサナ セラピューティクス インコーポレイテッド がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物
IL296901A (en) * 2020-04-02 2022-12-01 Mersana Therapeutics Inc Antibody-drug conjugates comprising sting agonists
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法
WO2022177307A1 (ko) * 2021-02-17 2022-08-25 한국화학연구원 벤즈이미다졸 유도체를 유효 성분으로 포함하는 인터페론 유전자 자극제 조성물
WO2022247743A1 (en) * 2021-05-24 2022-12-01 Fulgent Genetics, Inc. Compounds and their use as vaccine adjuvants
CN114948955A (zh) * 2022-06-06 2022-08-30 中国科学技术大学 靶向环鸟苷酸-腺苷酸合成酶的小分子共价抑制剂及其用途
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