MX2021003330A - Bacteria dise?ada por ingenieria genetica que comprende una trayectoria de fermentacion que genera energia. - Google Patents
Bacteria dise?ada por ingenieria genetica que comprende una trayectoria de fermentacion que genera energia.Info
- Publication number
- MX2021003330A MX2021003330A MX2021003330A MX2021003330A MX2021003330A MX 2021003330 A MX2021003330 A MX 2021003330A MX 2021003330 A MX2021003330 A MX 2021003330A MX 2021003330 A MX2021003330 A MX 2021003330A MX 2021003330 A MX2021003330 A MX 2021003330A
- Authority
- MX
- Mexico
- Prior art keywords
- energy
- genetically engineered
- engineered bacterium
- fermentation pathway
- buk
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
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- C12P7/28—Acetone-containing products
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
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- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
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- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
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- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
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- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01019—Phosphate butyryltransferase (2.3.1.19)
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02001—Acetate kinase (2.7.2.1)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02007—Butyrate kinase (2.7.2.7)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/0202—Acyl-CoA hydrolase (3.1.2.20)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Microbiology (AREA)
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- Molecular Biology (AREA)
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- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
La presente invención se refiere a una bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía y métodos relacionados a esta. En particular, la invención proporciona una bacteria que comprende una fosfato butiriltransferasa (Ptb) y una butirato cinasa (Buk) (Ptb-Buk) que actúa en sustratos no nativos para producir una amplia variedad de productos e intermediarios. En ciertas modalidades, la invención se refiere a la introducción de Ptb-Buk en un microorganismo que se fija a C1 capaz de producir productos a partir de un sustrato gaseoso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562240850P | 2015-10-13 | 2015-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021003330A true MX2021003330A (es) | 2021-05-14 |
Family
ID=58499646
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023003058A MX2023003058A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
MX2018004642A MX2018004642A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
MX2022003568A MX2022003568A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
MX2021003330A MX2021003330A (es) | 2015-10-13 | 2018-04-13 | Bacteria dise?ada por ingenieria genetica que comprende una trayectoria de fermentacion que genera energia. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023003058A MX2023003058A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
MX2018004642A MX2018004642A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
MX2022003568A MX2022003568A (es) | 2015-10-13 | 2016-10-13 | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
Country Status (13)
Country | Link |
---|---|
US (3) | US9738875B2 (es) |
EP (2) | EP3901267A1 (es) |
JP (2) | JP6905518B2 (es) |
KR (2) | KR20210037002A (es) |
CN (2) | CN108884467A (es) |
AU (2) | AU2016339989B2 (es) |
BR (1) | BR112018007338A2 (es) |
CA (6) | CA3001596C (es) |
EA (2) | EA201890952A1 (es) |
MX (4) | MX2023003058A (es) |
MY (1) | MY194651A (es) |
WO (1) | WO2017066498A1 (es) |
ZA (5) | ZA201802346B (es) |
Families Citing this family (41)
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MA40644A (fr) * | 2014-09-17 | 2016-03-24 | Global Bioenergies | Procédés pour produire de l'acide 3-hydroxy-3-méthylbutyrique |
WO2016210384A2 (en) | 2015-06-25 | 2016-12-29 | Synlogic, Inc. | Bacteria engineered to treat metabolic diseases |
MY194651A (en) * | 2015-10-13 | 2022-12-09 | Lanzatech Nz Inc | Genetically engineered bacterium for the production of isobutylene |
GB201603915D0 (en) * | 2016-03-07 | 2016-04-20 | Chain Biotechnology Ltd | Method and microbes for the production of chiral compounds |
EP3464559A4 (en) | 2016-05-14 | 2020-02-12 | Lanzatech, Inc. | MODIFIED ALDEHYDE / FERREDOXIN OXYDOREDUCTASE MICROORGANISM AND RELATED METHODS |
WO2018098349A1 (en) | 2016-11-22 | 2018-05-31 | The Penn State Research Foundation | Devices and methods for generating electrical current from methane |
CN107177609B (zh) * | 2017-05-15 | 2020-12-11 | 大连理工大学 | 一种fruB基因过表达的重组梭菌、其构建方法及应用 |
CN107083406B (zh) * | 2017-05-27 | 2021-02-02 | 浙江华睿生物技术有限公司 | (r)-3-羟基丁酸的生产方法 |
US11634733B2 (en) * | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
PT3679149T (pt) | 2017-09-08 | 2022-09-05 | Lanzatech Inc | Processos para produção de metabolitos usando substratos contendo c1 ricos em hidrogénio |
US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
EA202090833A1 (ru) * | 2017-09-28 | 2020-07-16 | Ланцатек, Инк. | Нокауты в генах микроорганизмов вуда-льюнгдаля |
EP3719121A4 (en) * | 2017-11-30 | 2021-12-15 | Toray Industries, Inc. | GENE-MODIFIED MICROORGANISM FOR THE PRODUCTION OF 3-HYDROXYADIPIC ACID, -HYDROMUCONIC ACID AND / OR ADIPIC ACID AND THE MANUFACTURING METHOD FOR THESE CHEMICAL PRODUCTS |
AU2018393075B2 (en) | 2017-12-19 | 2024-03-21 | Lanzatech, Inc. | Microorganisms and methods for the biological production of ethylene glycol |
EP3743520A4 (en) * | 2018-01-23 | 2021-11-10 | Lanzatech, Inc. | TWO-STAGE FERMENTATION PROCESS FOR MANUFACTURING A PRODUCT |
US11661613B2 (en) | 2018-02-01 | 2023-05-30 | Inv Nylon Chemicals Americas, Llc | Methods and materials for the biosynthesis of hydroxy fatty acid anions and/or derivatives thereof and/or compounds related thereto |
CN111683731B (zh) | 2018-02-12 | 2022-09-02 | 朗泽科技有限公司 | 用于提高碳转化效率的工艺 |
ES2960999T3 (es) | 2018-04-20 | 2024-03-07 | Lanzatech Inc | Proceso de fermentación para producir etanol |
CN109251940B (zh) * | 2018-10-30 | 2020-10-16 | 浙江华睿生物技术有限公司 | 一种产β-羟基-β-甲基丁酸工程菌的构建方法 |
SG11202105051SA (en) | 2018-11-19 | 2021-06-29 | Lanzatech Inc | Integration of fermentation and gasification |
KR20210100749A (ko) | 2019-02-08 | 2021-08-17 | 란자테크, 인크. | 유사한 비등점 생성물의 회수 방법 |
US20220145336A1 (en) | 2019-03-20 | 2022-05-12 | Global Bioenergies | Means and methods for producing isobutene from acetyl-coa |
FR3096373A1 (fr) * | 2019-05-24 | 2020-11-27 | IFP Energies Nouvelles | Outil genetique optimisé pour modifier les bacteries |
KR20210134988A (ko) | 2019-07-11 | 2021-11-11 | 란자테크, 인크. | 가스 이용률을 최적화하는 방법 |
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