MX2020009469A - Conjugados de anticuerpo y farmaco anti-her2 biparatopicos y metodos de uso. - Google Patents
Conjugados de anticuerpo y farmaco anti-her2 biparatopicos y metodos de uso.Info
- Publication number
- MX2020009469A MX2020009469A MX2020009469A MX2020009469A MX2020009469A MX 2020009469 A MX2020009469 A MX 2020009469A MX 2020009469 A MX2020009469 A MX 2020009469A MX 2020009469 A MX2020009469 A MX 2020009469A MX 2020009469 A MX2020009469 A MX 2020009469A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- drug conjugates
- antibody
- adcs
- dar
- Prior art date
Links
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 6
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 5
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 108010044540 auristatin Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
Classifications
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- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
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US201862743884P | 2018-10-10 | 2018-10-10 | |
PCT/CA2019/050303 WO2019173911A1 (en) | 2018-03-13 | 2019-03-12 | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
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TW202003585A (zh) | 2020-01-16 |
EP3765525A1 (en) | 2021-01-20 |
US11000598B2 (en) | 2021-05-11 |
PT3765525T (pt) | 2023-10-03 |
KR20200131840A (ko) | 2020-11-24 |
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ES2958933T3 (es) | 2024-02-16 |
EP3765525B1 (en) | 2023-07-19 |
US20210346508A1 (en) | 2021-11-11 |
EP4253421A2 (en) | 2023-10-04 |
EP4253421A3 (en) | 2024-01-03 |
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