MX2020012997A - Conjugados de anticuerpo modulador de empalme-farmaco y metodos de uso. - Google Patents
Conjugados de anticuerpo modulador de empalme-farmaco y metodos de uso.Info
- Publication number
- MX2020012997A MX2020012997A MX2020012997A MX2020012997A MX2020012997A MX 2020012997 A MX2020012997 A MX 2020012997A MX 2020012997 A MX2020012997 A MX 2020012997A MX 2020012997 A MX2020012997 A MX 2020012997A MX 2020012997 A MX2020012997 A MX 2020012997A
- Authority
- MX
- Mexico
- Prior art keywords
- drug conjugates
- methods
- splicing modulator
- antibody
- drug
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 4
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
Classifications
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Abstract
Se describen compuestos de enlazador-fármaco y conjugados anticuerpo-fármaco que se unen a blancos de oncología humana. Los compuestos de enlazador-fármaco y los conjugados anticuerpo-fármaco comprenden un resto farmacológico de modulador de empalme. La descripción además se refiere a métodos y composiciones para usar en el tratamiento de trastornos neoplásicos administrando los conjugados anticuerpo-fármaco proporcionados en la presente. En una modalidad, el modulador de empalme comprende una pladienolida o un derivado de pladienolida.
Applications Claiming Priority (4)
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US201862679631P | 2018-06-01 | 2018-06-01 | |
US201862679672P | 2018-06-01 | 2018-06-01 | |
US201862779324P | 2018-12-13 | 2018-12-13 | |
PCT/US2019/035015 WO2019232449A1 (en) | 2018-06-01 | 2019-05-31 | Splicing modulator antibody-drug conjugates and methods of use |
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MX2020012997A true MX2020012997A (es) | 2021-03-29 |
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MX2020012997A MX2020012997A (es) | 2018-06-01 | 2019-05-31 | Conjugados de anticuerpo modulador de empalme-farmaco y metodos de uso. |
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EP (1) | EP3801632A1 (es) |
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AU (1) | AU2019277700A1 (es) |
BR (1) | BR112020024549A2 (es) |
CA (1) | CA3099920A1 (es) |
CL (3) | CL2020003117A1 (es) |
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US11945868B2 (en) | 2017-10-02 | 2024-04-02 | Visterra, Inc. | Antibody molecules to CD138 and uses thereof |
WO2019232433A2 (en) | 2018-06-01 | 2019-12-05 | Eisai R&D Management Co., Ltd. | Methods of using splicing modulators |
JP2022512401A (ja) * | 2018-12-13 | 2022-02-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハーボキシジエンスプライシング調節薬抗体-薬物コンジュゲート及びその使用方法 |
WO2020157760A1 (en) | 2019-01-31 | 2020-08-06 | Bar Ilan University | Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy |
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MX2022007798A (es) * | 2019-12-23 | 2022-07-19 | Eisai R&D Man Co Ltd | Metodo de produccion de conjugado de anticuerpo-farmaco a base de eribulina. |
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IL279062A (en) | 2021-01-31 |
EP3801632A1 (en) | 2021-04-14 |
SG11202010341PA (en) | 2020-11-27 |
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US20210299269A1 (en) | 2021-09-30 |
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CN112218663A (zh) | 2021-01-12 |
WO2019232449A1 (en) | 2019-12-05 |
BR112020024549A2 (pt) | 2021-03-02 |
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