MX2019001631A - Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos. - Google Patents
Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos.Info
- Publication number
- MX2019001631A MX2019001631A MX2019001631A MX2019001631A MX2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A MX 2019001631 A MX2019001631 A MX 2019001631A
- Authority
- MX
- Mexico
- Prior art keywords
- udp
- host cell
- glycosyltransferase
- nucleotide sequence
- sequence encoding
- Prior art date
Links
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 229930188195 rebaudioside Natural products 0.000 title 1
- 239000004383 Steviol glycoside Substances 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 229930182488 steviol glycoside Natural products 0.000 abstract 3
- 235000019411 steviol glycoside Nutrition 0.000 abstract 3
- 150000008144 steviol glycosides Chemical class 0.000 abstract 3
- 235000019202 steviosides Nutrition 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 240000005498 Setaria italica Species 0.000 abstract 1
- 235000007226 Setaria italica Nutrition 0.000 abstract 1
- -1 but not limited to Chemical class 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- GSGVXNMGMKBGQU-PHESRWQRSA-N rebaudioside M Chemical compound C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13CC(=C)[C@@](C1)(CC[C@@H]23)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GSGVXNMGMKBGQU-PHESRWQRSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374408P | 2016-08-12 | 2016-08-12 | |
| PCT/US2017/046637 WO2018031955A2 (en) | 2016-08-12 | 2017-08-11 | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001631A true MX2019001631A (es) | 2019-08-05 |
Family
ID=59700219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001631A MX2019001631A (es) | 2016-08-12 | 2017-08-11 | Glicosiltransferasa dependiente de uridina difosfato para la produccion de alta eficiencia de rebaudiosidos. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11091743B2 (https=) |
| EP (1) | EP3497222B1 (https=) |
| JP (2) | JP7404068B2 (https=) |
| KR (1) | KR102331018B1 (https=) |
| CN (1) | CN109804073B (https=) |
| AU (1) | AU2017308143B2 (https=) |
| BR (1) | BR112018074999A2 (https=) |
| CA (1) | CA3031162A1 (https=) |
| ES (1) | ES2906310T3 (https=) |
| MX (1) | MX2019001631A (https=) |
| MY (1) | MY194280A (https=) |
| PT (1) | PT3497222T (https=) |
| SG (1) | SG11201900930UA (https=) |
| WO (1) | WO2018031955A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113549664B (zh) * | 2014-09-19 | 2025-10-28 | 谱赛科有限责任公司 | 高纯度甜菊醇糖苷 |
| AU2017308143B2 (en) | 2016-08-12 | 2022-04-07 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| CA3175070A1 (en) | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| CN111093390A (zh) * | 2017-05-15 | 2020-05-01 | 谱赛科美国股份有限公司 | 高纯度甜菊醇糖苷 |
| CN111868252B (zh) * | 2018-03-12 | 2025-06-03 | 科纳根公司 | 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产 |
| CN112424218A (zh) | 2018-04-30 | 2021-02-26 | 帝斯曼知识产权资产管理有限公司 | 甜菊糖苷转运 |
| WO2020028039A1 (en) | 2018-07-30 | 2020-02-06 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| MX2021004192A (es) | 2018-10-15 | 2021-05-27 | Amyris Inc | Variantes de acido kaurenoico hidroxilasa de stevia rebaudiana para la produccion de rebaudiosidos de alta eficiencia. |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| PH12021551733A1 (en) | 2019-01-24 | 2022-07-25 | Amyris Inc | Abc transporters for the high efficiency production of rebaudiosides |
| US12467039B2 (en) | 2019-05-03 | 2025-11-11 | Amyris, Inc. | Kaurenoic acid 13-hydroxylase (KAH) variants and uses thereof |
| CA3171399A1 (en) * | 2020-03-13 | 2021-09-16 | Stanley W. HERRMANN | Rebaudioside m sweetener compositions |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| CN111518782B (zh) * | 2020-03-24 | 2022-09-02 | 广东广业清怡食品科技股份有限公司 | 一种糖基转移酶ugtzj1突变体及其应用 |
| US20250320470A1 (en) * | 2020-12-23 | 2025-10-16 | Samyang Corporation | Glycosyltransferase and steviol glucoside preparation method using same |
| US20240182941A1 (en) * | 2021-03-01 | 2024-06-06 | Cargill, Incorporated | Xylosylated steviol glycosides and enzymatic methods for production |
| WO2022216922A1 (en) * | 2021-04-08 | 2022-10-13 | Conagen Inc. | Biosynthetic production of steviol glycosides |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| EP4417699A4 (en) * | 2021-10-19 | 2025-12-24 | Cj Cheiljedang Corp | PROCESS FOR THE PRODUCTION OF REBAUDIOSIDE D AND REBAUDIOSIDE M |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| WO2023121426A1 (ko) * | 2021-12-24 | 2023-06-29 | 주식회사 삼양사 | 레바우디오사이드의 생산 |
| US20250320538A1 (en) * | 2022-05-19 | 2025-10-16 | Amyris, Inc. | Compositions and methods for improved production of steviol glycosides |
| WO2024042405A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the synthesis of bio-based polymers |
| WO2024042486A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the production of polyurethanes |
| WO2024116153A1 (en) | 2022-12-02 | 2024-06-06 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for using previously cultured cells |
| WO2025159542A1 (ko) * | 2024-01-24 | 2025-07-31 | 씨제이제일제당 (주) | 신규한 변이형 당전이 효소 폴리펩티드 및 이를 이용한 스테비올배당체 생산 방법 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7838044B2 (en) | 2004-12-21 | 2010-11-23 | Purecircle Sdn Bhd | Extraction, separation and modification of sweet glycosides from the Stevia rebaudiana plant |
| CN107033200A (zh) | 2008-10-03 | 2017-08-11 | 守田化学工业株式会社 | 新的甜菊醇糖苷 |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| EP3461342A1 (en) | 2009-11-12 | 2019-04-03 | PureCircle USA Inc. | Granulation of a stevia sweetener |
| US10888099B2 (en) | 2009-11-12 | 2021-01-12 | Purecircle Sdn Bhd. | Granulation of a Stevia sweetener |
| EP2544538B1 (en) | 2010-03-12 | 2022-06-15 | PureCircle USA Inc. | High-purity steviol glycosides |
| JP5056897B2 (ja) | 2010-05-14 | 2012-10-24 | トヨタ自動車株式会社 | ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物 |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| CA2819253A1 (en) * | 2010-11-30 | 2012-06-07 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| WO2012135591A2 (en) | 2011-03-30 | 2012-10-04 | Amyris, Inc. | Microbial isoprenoid production using a heterologous dxp pathway |
| CN108396044A (zh) * | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| AU2013211605B2 (en) | 2012-01-23 | 2017-04-06 | Dsm Ip Assets B.V. | Diterpene production |
| US10000783B2 (en) | 2012-03-16 | 2018-06-19 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| EP2832858B1 (en) | 2012-03-27 | 2020-07-08 | Suntory Holdings Limited | Method for producing steviol glycoside |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| BR112014028819A2 (pt) | 2012-05-22 | 2017-07-25 | Purecircle Sdn Bhd | glicosídeos de esteviol de pureza elevada |
| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| KR101404728B1 (ko) | 2013-02-28 | 2014-06-09 | 씨제이제일제당 (주) | 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법 |
| BR112015023476A8 (pt) | 2013-03-15 | 2019-12-03 | Cargill Inc | composição, processo para a preparação de uma composição e extrato |
| US10689681B2 (en) | 2013-05-31 | 2020-06-23 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| EP3021689B1 (en) | 2013-07-15 | 2021-03-24 | DSM IP Assets B.V. | Diterpene production |
| AU2014298420B2 (en) | 2013-07-31 | 2018-10-04 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| BR112016002526B1 (pt) | 2013-08-07 | 2021-11-23 | Total Marketing Services | Método para produção de um composto heterólogo não catabólico, e, composição de fermentação |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| ES2805014T3 (es) | 2014-08-19 | 2021-02-10 | Purecircle Sdn Bhd | Método para preparar rebaudiósido I |
| AU2015314251A1 (en) * | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| DK3200615T3 (da) | 2014-10-03 | 2019-08-19 | Conagen Inc | Kaloriefrie sødestoffer og fremgangsmåder til syntetisering |
| EP3215629B1 (en) * | 2014-11-05 | 2024-08-07 | Manus Bio Inc. | Microbial production of steviol glycosides |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN104726523B (zh) * | 2015-03-28 | 2018-08-10 | 南京工业大学 | 一种酶法制备莱鲍迪苷m的方法 |
| EP4134442A1 (en) | 2015-05-29 | 2023-02-15 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high ph |
| JP2018516081A (ja) | 2015-05-29 | 2018-06-21 | カーギル・インコーポレイテッド | 配糖体を産生するための熱処理 |
| CA2991662A1 (en) | 2015-07-10 | 2017-01-19 | Dsm Ip Assets B.V. | Steviol glycoside composition |
| BR112018000550B1 (pt) | 2015-07-10 | 2022-05-10 | Dsm Ip Assets B.V. | Método para preparar uma composição de glicosídeo de esteviol |
| US20180230505A1 (en) | 2015-08-13 | 2018-08-16 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| MX2018006599A (es) | 2015-11-30 | 2018-09-21 | Purecircle Sdn Bhd | Proceso para producir glicosidos de esteviol de alta pureza. |
| JP2019503670A (ja) | 2015-12-10 | 2019-02-14 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組換え宿主内でのステビオールグリコシドの産生 |
| ES2877475T3 (es) * | 2016-03-01 | 2021-11-16 | Univation Tech Llc | Método para mejorar la actividad del catalizador ziegler-natta |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201809483UA (en) | 2016-05-16 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| BR112019002417B1 (pt) | 2016-08-09 | 2023-05-02 | Dsm Ip Assets B.V. | Cristalização de glicosídeos de esteviol |
| AU2017308143B2 (en) * | 2016-08-12 | 2022-04-07 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN111093390A (zh) | 2017-05-15 | 2020-05-01 | 谱赛科美国股份有限公司 | 高纯度甜菊醇糖苷 |
| SG11202001058TA (en) * | 2017-08-11 | 2020-03-30 | Amyris Inc | Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides |
| WO2019099649A1 (en) | 2017-11-20 | 2019-05-23 | Manus Bio, Inc. | Microbial host cells for production of steviol glycosides |
| US20190270971A1 (en) | 2018-03-01 | 2019-09-05 | Jason Donald | Increasing productivity of microbial host cells that functionally express p450 enzymes |
| GB201805576D0 (en) | 2018-04-04 | 2018-05-16 | Optibiotix Ltd | Sweeteners and methods of production thereof |
| CN112424218A (zh) | 2018-04-30 | 2021-02-26 | 帝斯曼知识产权资产管理有限公司 | 甜菊糖苷转运 |
| WO2020028039A1 (en) | 2018-07-30 | 2020-02-06 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| WO2020264179A1 (en) | 2019-06-25 | 2020-12-30 | Manus Bio, Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
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2017
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| PT3497222T (pt) | 2022-02-09 |
| US11091743B2 (en) | 2021-08-17 |
| AU2017308143A1 (en) | 2019-02-07 |
| ES2906310T3 (es) | 2022-04-18 |
| JP7404068B2 (ja) | 2023-12-25 |
| KR20190038612A (ko) | 2019-04-08 |
| EP3497222B1 (en) | 2021-12-22 |
| AU2017308143B2 (en) | 2022-04-07 |
| CA3031162A1 (en) | 2018-02-15 |
| WO2018031955A2 (en) | 2018-02-15 |
| JP2019524134A (ja) | 2019-09-05 |
| US20210355458A1 (en) | 2021-11-18 |
| US20240174987A1 (en) | 2024-05-30 |
| CN109804073B (zh) | 2023-05-16 |
| RU2019104496A (ru) | 2020-09-14 |
| KR102331018B1 (ko) | 2021-11-26 |
| RU2019104496A3 (https=) | 2021-04-09 |
| WO2018031955A3 (en) | 2018-03-15 |
| MY194280A (en) | 2022-11-25 |
| CN109804073A (zh) | 2019-05-24 |
| EP3497222A2 (en) | 2019-06-19 |
| US11866738B2 (en) | 2024-01-09 |
| SG11201900930UA (en) | 2019-02-27 |
| US20190185826A1 (en) | 2019-06-20 |
| US12371677B2 (en) | 2025-07-29 |
| BR112018074999A2 (pt) | 2019-03-12 |
| JP2022137061A (ja) | 2022-09-21 |
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