MX2019000903A - Metodos para purificar proteinas que contienen fc. - Google Patents
Metodos para purificar proteinas que contienen fc.Info
- Publication number
- MX2019000903A MX2019000903A MX2019000903A MX2019000903A MX2019000903A MX 2019000903 A MX2019000903 A MX 2019000903A MX 2019000903 A MX2019000903 A MX 2019000903A MX 2019000903 A MX2019000903 A MX 2019000903A MX 2019000903 A MX2019000903 A MX 2019000903A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- methods
- purifying
- resin
- elution buffer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Storage Device Security (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662365943P | 2016-07-22 | 2016-07-22 | |
| PCT/US2017/043384 WO2018018011A2 (en) | 2016-07-22 | 2017-07-21 | Methods of purifying fc-containing proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019000903A true MX2019000903A (es) | 2019-05-15 |
Family
ID=59656168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000903A MX2019000903A (es) | 2016-07-22 | 2017-07-21 | Metodos para purificar proteinas que contienen fc. |
| MX2023006291A MX2023006291A (es) | 2016-07-22 | 2019-01-21 | Metodos para purificar proteinas que contienen fc. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023006291A MX2023006291A (es) | 2016-07-22 | 2019-01-21 | Metodos para purificar proteinas que contienen fc. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11312745B2 (https=) |
| EP (1) | EP3487867B1 (https=) |
| JP (2) | JP7092744B2 (https=) |
| KR (2) | KR102579850B1 (https=) |
| CN (2) | CN115925780B (https=) |
| AU (2) | AU2017298984B2 (https=) |
| CA (2) | CA3218290A1 (https=) |
| IL (2) | IL285146B (https=) |
| MA (1) | MA45721A (https=) |
| MX (2) | MX2019000903A (https=) |
| SG (1) | SG11201900573UA (https=) |
| WO (1) | WO2018018011A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202102713TA (en) * | 2018-09-21 | 2021-04-29 | Teneobio Inc | Methods for purifying heterodimeric, multispecific antibodies |
| JP7644706B2 (ja) * | 2018-10-11 | 2025-03-12 | アムジエン・インコーポレーテツド | 二重特異性抗体コンストラクトの下流プロセシング |
| AU2020208360B2 (en) * | 2019-01-16 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Method and system of identifying and quantifying antibody fragmentation |
| KR102286892B1 (ko) * | 2019-07-08 | 2021-08-06 | 삼천당제약주식회사 | 안과용 단백질 제제의 정제방법 |
| CN110724204B (zh) * | 2019-11-18 | 2021-10-22 | 广东菲鹏制药股份有限公司 | Fc融合蛋白的纯化方法 |
| CN112881675A (zh) * | 2019-11-29 | 2021-06-01 | 广东菲鹏生物有限公司 | IgM抗体检测稀释液 |
| JP2023521384A (ja) | 2020-04-09 | 2023-05-24 | シートムエックス セラピューティクス，インコーポレイテッド | 活性化可能抗体を含む組成物 |
| WO2022061035A1 (en) * | 2020-09-16 | 2022-03-24 | Waters Technologies Corporation | Improved size exclusion chromatography utilizing low concentration amino acids in size exclusion chromatography mobile phase |
| CN118414350A (zh) * | 2021-10-19 | 2024-07-30 | 阿特根公司 | 纯化具有igg fc结构域的融合蛋白的方法 |
| CN113980092B (zh) * | 2021-12-09 | 2024-05-14 | 上海药明生物技术有限公司 | 一种蛋白质亲和纯化方法 |
| CN116165290B (zh) * | 2021-12-17 | 2025-06-27 | 复旦大学 | 一种抗体药物研发流程中工程细胞株的筛选方法 |
| CN116271982B (zh) * | 2022-11-30 | 2024-01-09 | 杭州广科安德生物科技有限公司 | 一种血液高丰度蛋白免疫亲和柱的再生方法 |
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| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| CA2325022A1 (en) * | 1998-04-16 | 1999-10-21 | Genentech, Inc. | Secretion of glycosylated proteins using a tissue plasminogen activator pro-sequence |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| AU2005299716B2 (en) * | 2004-10-22 | 2012-09-06 | Amgen Inc. | Methods for refolding of recombinant antibodies |
| ZA200710330B (en) * | 2005-06-17 | 2009-12-30 | Wyeth Corp | Methods of purifying FC region containing proteins |
| WO2007081906A2 (en) * | 2006-01-06 | 2007-07-19 | Amgen Inc. | Purification by column-chromatography using eluants containing organic solvents |
| NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
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| JP6157046B2 (ja) | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | 静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法 |
| SG2013061528A (en) | 2008-08-14 | 2015-03-30 | Merck Sharp & Dohme | Methods for purifying antibodies using protein a affinity chromatography |
| EP3366692A1 (en) * | 2009-06-22 | 2018-08-29 | Amgen, Inc | Refolding proteins using a chemically controlled redox state |
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| CN102382190B (zh) * | 2010-09-01 | 2014-04-09 | 山东新时代药业有限公司 | 分离和去除TNFR-Fc融合蛋白中寡聚体的方法 |
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| DK2729482T3 (en) * | 2011-07-08 | 2018-05-07 | Merck Sharp & Dohme | PROCEDURE FOR CLEANING FC-FUSION PROTEIN |
| EP2831096B1 (en) | 2012-03-28 | 2020-04-29 | GE Healthcare BioProcess R&D AB | Affinity chromatography matrix |
| JP6253584B2 (ja) | 2012-08-27 | 2017-12-27 | 旭化成メディカル株式会社 | 温度応答性クロマトグラフィーによる抗体の精製方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| JP2016538275A (ja) * | 2013-11-04 | 2016-12-08 | グレンマーク ファーマシューティカルズ， エセ．アー． | Ｔ細胞再標的化ヘテロ二量体免疫グロブリン（ｈｅｔｅｒｏ−ｄｉｍｅｒｉｃ ｉｍｍｕｎｏｇｌｏｂｕｌｉｎ）の製造 |
-
2017
- 2017-07-21 KR KR1020227028721A patent/KR102579850B1/ko active Active
- 2017-07-21 CA CA3218290A patent/CA3218290A1/en active Pending
- 2017-07-21 SG SG11201900573UA patent/SG11201900573UA/en unknown
- 2017-07-21 MA MA045721A patent/MA45721A/fr unknown
- 2017-07-21 IL IL285146A patent/IL285146B/en unknown
- 2017-07-21 CN CN202210979746.6A patent/CN115925780B/zh active Active
- 2017-07-21 US US16/093,994 patent/US11312745B2/en active Active
- 2017-07-21 JP JP2019503247A patent/JP7092744B2/ja active Active
- 2017-07-21 WO PCT/US2017/043384 patent/WO2018018011A2/en not_active Ceased
- 2017-07-21 AU AU2017298984A patent/AU2017298984B2/en active Active
- 2017-07-21 KR KR1020197003162A patent/KR102435801B1/ko active Active
- 2017-07-21 CN CN201780045463.1A patent/CN109563125B/zh active Active
- 2017-07-21 CA CA3031469A patent/CA3031469C/en active Active
- 2017-07-21 MX MX2019000903A patent/MX2019000903A/es unknown
- 2017-07-21 EP EP17754514.2A patent/EP3487867B1/en active Active
-
2019
- 2019-01-21 MX MX2023006291A patent/MX2023006291A/es unknown
- 2019-01-21 IL IL264375A patent/IL264375B/en unknown
-
2022
- 2022-06-15 JP JP2022096278A patent/JP7411020B2/ja active Active
-
2023
- 2023-08-31 AU AU2023222915A patent/AU2023222915B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3487867A2 (en) | 2019-05-29 |
| CN115925780A (zh) | 2023-04-07 |
| KR20220120716A (ko) | 2022-08-30 |
| US20190127418A1 (en) | 2019-05-02 |
| CA3218290A1 (en) | 2018-01-25 |
| IL264375A (en) | 2019-02-28 |
| IL285146B (en) | 2022-09-01 |
| CA3031469C (en) | 2025-11-18 |
| IL264375B (en) | 2021-09-30 |
| US11312745B2 (en) | 2022-04-26 |
| SG11201900573UA (en) | 2019-02-27 |
| AU2017298984A1 (en) | 2019-02-07 |
| AU2023222915A1 (en) | 2023-09-21 |
| CN109563125A (zh) | 2019-04-02 |
| MX2023006291A (es) | 2023-06-13 |
| JP7411020B2 (ja) | 2024-01-10 |
| EP3487867B1 (en) | 2026-04-01 |
| AU2017298984B2 (en) | 2023-08-31 |
| JP2019528255A (ja) | 2019-10-10 |
| KR102435801B1 (ko) | 2022-08-25 |
| AU2023222915B2 (en) | 2026-01-22 |
| WO2018018011A3 (en) | 2018-03-01 |
| JP2022120138A (ja) | 2022-08-17 |
| KR20190037247A (ko) | 2019-04-05 |
| KR102579850B1 (ko) | 2023-09-18 |
| WO2018018011A2 (en) | 2018-01-25 |
| JP7092744B2 (ja) | 2022-06-28 |
| CN115925780B (zh) | 2025-11-04 |
| CA3031469A1 (en) | 2018-01-25 |
| IL285146A (en) | 2021-08-31 |
| MA45721A (fr) | 2019-05-29 |
| CN109563125B (zh) | 2022-08-09 |
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