MX2018002483A - Equipos y métodos novedosos para detectar trastornos de ciclo de urea que usan espectrometría de masas. - Google Patents

Equipos y métodos novedosos para detectar trastornos de ciclo de urea que usan espectrometría de masas.

Info

Publication number
MX2018002483A
MX2018002483A MX2018002483A MX2018002483A MX2018002483A MX 2018002483 A MX2018002483 A MX 2018002483A MX 2018002483 A MX2018002483 A MX 2018002483A MX 2018002483 A MX2018002483 A MX 2018002483A MX 2018002483 A MX2018002483 A MX 2018002483A
Authority
MX
Mexico
Prior art keywords
kits
mass spectrometry
disorders
urea cycle
novel methods
Prior art date
Application number
MX2018002483A
Other languages
English (en)
Inventor
Carrard Géraldine
Fingert Ralph
Original Assignee
Labsystems Diagnostics Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labsystems Diagnostics Oy filed Critical Labsystems Diagnostics Oy
Publication of MX2018002483A publication Critical patent/MX2018002483A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0081—Tandem in time, i.e. using a single spectrometer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a equipos y métodos de examen de recién nacidos, y se proporcionan normas internas estables isotópicamente marcadas o solución de norma interna para el examen y análisis de alto rendimiento de trastornos metabólicos usando cromatografía líquidaespectrometría de masa (LC-MS). Los trastornos metabólicos pueden ser trastornos de oxidación de ácidos grasos, ácidos orgánicos o aminoácidos, y particularmente trastornos o deficiencias del ciclo de urea, hiperamonemia, hiperornitinemia-hiperamonemia-homocitrulinuria (HHH), y/o aciduria argininosuccínica. Los equipos de examen de recién nacidos, métodos, normas internas estables isotópicamente marcadas o solución de norma interna son particularmente útiles para examen de recién nacidos (NBS) de trastornos metabólicos.
MX2018002483A 2015-09-02 2016-09-02 Equipos y métodos novedosos para detectar trastornos de ciclo de urea que usan espectrometría de masas. MX2018002483A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15183561 2015-09-02
EP15188615.7A EP3139171B1 (en) 2015-09-02 2015-10-06 Novel methods and kits for detecting of urea cycle disorders using mass spectrometry
PCT/EP2016/070724 WO2017037237A1 (en) 2015-09-02 2016-09-02 Novel methods and kits for detecting urea cycle disorders using mass spectrometry

Publications (1)

Publication Number Publication Date
MX2018002483A true MX2018002483A (es) 2018-11-09

Family

ID=54064158

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018002483A MX2018002483A (es) 2015-09-02 2016-09-02 Equipos y métodos novedosos para detectar trastornos de ciclo de urea que usan espectrometría de masas.

Country Status (9)

Country Link
US (1) US20170059535A1 (es)
EP (1) EP3139171B1 (es)
CN (1) CN106483208A (es)
AU (1) AU2016316796A1 (es)
CA (1) CA2996655A1 (es)
ES (1) ES2604055B1 (es)
MX (1) MX2018002483A (es)
RU (1) RU2018111431A (es)
WO (1) WO2017037237A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6779500B2 (ja) * 2017-03-30 2020-11-04 株式会社島津製作所 クロマトグラフ質量分析方法及び装置
CN108732254A (zh) * 2017-04-18 2018-11-02 深圳华大基因研究院 一种用于氨基酸检测的方法及其应用
WO2018231415A1 (en) * 2017-06-16 2018-12-20 C2N Diagnostics Llc Methods for extracting and measuring concentrations of biomolecules in complex matrices without the need for immunocapture
CN111295577A (zh) * 2017-11-01 2020-06-16 小利兰·斯坦福大学托管委员会 分析物检测方法
CN108008031A (zh) * 2017-11-17 2018-05-08 深圳华大生命科学研究院 同时检测氨基酸、肉碱、酮类、激素的方法和试剂盒
CN108051494A (zh) * 2017-11-17 2018-05-18 深圳华大生命科学研究院 一种同时检测多种遗传代谢疾病相关物质的方法和试剂盒
CN110187012A (zh) * 2018-02-23 2019-08-30 上海可力梅塔生物医药科技有限公司 一种非衍生化法检测试剂盒
CN110220984A (zh) * 2018-03-01 2019-09-10 上海可力梅塔生物医药科技有限公司 一种衍生化法检测试剂盒
CN112689762B (zh) * 2018-06-01 2024-08-23 美国控股实验室公司 用于lc-ms/ms蛋白质组学基因分型的方法和系统
JP2022512591A (ja) * 2018-10-05 2022-02-07 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 原発性免疫不全症、シスチン症、及びウィルソン病に関する新生児スクリーニング
CN113892029A (zh) * 2019-05-31 2022-01-04 梅塔博隆股份有限公司 用于检测代谢物的质谱分析方法
US11906510B2 (en) * 2020-03-20 2024-02-20 Stanford Junior University Metabolic profiling by reverse-phase/ion-exchange mass spectrometry
CN111638287A (zh) * 2020-06-11 2020-09-08 成都益康谱科技有限公司 一种检测人体干尿滤纸片中多种有机酸的定量检测方法
CN114152706A (zh) * 2021-04-14 2022-03-08 上海义准生物有限公司 一种同时检测干血片中多种新生儿筛查代谢物的方法
CN114076701A (zh) * 2021-07-22 2022-02-22 上海安谱实验科技股份有限公司 一种用于新生儿筛查的干血斑质控品及其制备方法
CN114609270B (zh) * 2022-02-18 2023-08-04 复旦大学附属中山医院 血清月桂酰基肉碱作为哮喘诊断标志物的用途
WO2024010854A1 (en) * 2022-07-07 2024-01-11 Diagnose Early, Inc. Rapid generation of breath-based health reports and systems for use in the same
CN115326953A (zh) * 2022-08-02 2022-11-11 云谱康(大连)生物科技有限公司 一种代谢物组合及应用和检测试剂盒与使用
CN115389756B (zh) * 2022-10-24 2023-02-17 首都医科大学附属北京安贞医院 一种预测房颤发生风险的检测试剂盒及其应用
US20240310389A1 (en) * 2023-01-12 2024-09-19 Population Bio, Inc. Methods and compositions for screening and treating alzheimer's disease
CN118671241A (zh) * 2024-08-20 2024-09-20 杭州度安医学检验实验室有限公司 一种基于hplc-ms/ms的人血清中鸟氨酸氨基甲酰转移酶活性的检测方法和试剂盒

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100277911B1 (ko) 1996-06-10 2001-02-01 김영환 반도체소자 제조방법
WO2010002911A2 (en) * 2008-06-30 2010-01-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Methods and materials for monitoring myeloma using quantitative mass spetrometry
JP2012197258A (ja) * 2011-03-23 2012-10-18 Tohoku Univ 個別化治療診断のためのマーカータンパク質絶対量の定量方法
KR101968485B1 (ko) * 2011-07-21 2019-04-12 후지필름 와코 준야꾸 가부시키가이샤 혈장중 아미노산 분석용 표준액
CA2863819C (en) * 2012-02-09 2021-11-23 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US10274496B2 (en) * 2014-01-17 2019-04-30 University Of Washington Biomarkers for detecting and monitoring colon cancer

Also Published As

Publication number Publication date
RU2018111431A3 (es) 2019-12-27
US20170059535A1 (en) 2017-03-02
ES2604055B1 (es) 2017-11-28
ES2604055A2 (es) 2017-03-02
AU2016316796A1 (en) 2018-03-15
CA2996655A1 (en) 2017-03-09
WO2017037237A1 (en) 2017-03-09
EP3139171B1 (en) 2020-02-12
ES2604055R1 (es) 2017-05-24
CN106483208A (zh) 2017-03-08
RU2018111431A (ru) 2019-10-02
EP3139171A1 (en) 2017-03-08

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