MX2017002935A - Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones. - Google Patents
Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones.Info
- Publication number
- MX2017002935A MX2017002935A MX2017002935A MX2017002935A MX2017002935A MX 2017002935 A MX2017002935 A MX 2017002935A MX 2017002935 A MX2017002935 A MX 2017002935A MX 2017002935 A MX2017002935 A MX 2017002935A MX 2017002935 A MX2017002935 A MX 2017002935A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- attenuating
- immune responses
- viral transfer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
- A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
En la presente invención se proporcionan métodos y composiciones relacionadas para administrar vectores de transferencia viral e inmunosupresores dirigidos a células que presentan antígeno.
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462047051P | 2014-09-07 | 2014-09-07 | |
US201462047044P | 2014-09-07 | 2014-09-07 | |
US201462047034P | 2014-09-07 | 2014-09-07 | |
US201462047054P | 2014-09-07 | 2014-09-07 | |
US201462051255P | 2014-09-16 | 2014-09-16 | |
US201462051267P | 2014-09-16 | 2014-09-16 | |
US201462051263P | 2014-09-16 | 2014-09-16 | |
US201462051258P | 2014-09-16 | 2014-09-16 | |
US201562101841P | 2015-01-09 | 2015-01-09 | |
US201562101861P | 2015-01-09 | 2015-01-09 | |
US201562101882P | 2015-01-09 | 2015-01-09 | |
US201562101872P | 2015-01-09 | 2015-01-09 | |
PCT/US2015/048771 WO2016037165A1 (en) | 2014-09-07 | 2015-09-07 | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017002935A true MX2017002935A (es) | 2017-05-30 |
Family
ID=54291579
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002932A MX2017002932A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de terapia genetica. |
MX2017002931A MX2017002931A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar respuestas inmunes anti-vector de transferencia viral. |
MX2017002933A MX2017002933A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen. |
MX2017002935A MX2017002935A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones. |
MX2017002934A MX2017002934A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral que modula la expresion de genes. |
MX2023003246A MX2023003246A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral que modula la expresion de genes. |
MX2023003253A MX2023003253A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar respuestas inmunes anti-vector de transferencia viral. |
MX2023003252A MX2023003252A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen. |
MX2023003254A MX2023003254A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de terapia genetica. |
MX2023003249A MX2023003249A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002932A MX2017002932A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de terapia genetica. |
MX2017002931A MX2017002931A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar respuestas inmunes anti-vector de transferencia viral. |
MX2017002933A MX2017002933A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen. |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002934A MX2017002934A (es) | 2014-09-07 | 2015-09-07 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral que modula la expresion de genes. |
MX2023003246A MX2023003246A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral que modula la expresion de genes. |
MX2023003253A MX2023003253A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar respuestas inmunes anti-vector de transferencia viral. |
MX2023003252A MX2023003252A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen. |
MX2023003254A MX2023003254A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de terapia genetica. |
MX2023003249A MX2023003249A (es) | 2014-09-07 | 2017-03-06 | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones. |
Country Status (12)
Country | Link |
---|---|
US (7) | US10046064B2 (es) |
EP (5) | EP3189147A1 (es) |
JP (11) | JP7242178B2 (es) |
KR (7) | KR20170054434A (es) |
CN (6) | CN106714826A (es) |
AU (10) | AU2015311704B2 (es) |
BR (5) | BR112017001470A2 (es) |
CA (5) | CA2957808A1 (es) |
EA (5) | EA201790533A1 (es) |
IL (10) | IL309546A (es) |
MX (10) | MX2017002932A (es) |
WO (5) | WO2016037163A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180026572A (ko) | 2009-05-27 | 2018-03-12 | 셀렉타 바이오사이언시즈, 인크. | 방출 속도가 상이한 성분을 갖는 나노운반체 |
JP6371058B2 (ja) | 2010-05-26 | 2018-08-15 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | 結合していないアジュバントを有するナノキャリア組成物 |
US9994443B2 (en) | 2010-11-05 | 2018-06-12 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
CN103517716A (zh) | 2011-04-29 | 2014-01-15 | 西莱克塔生物科技公司 | 用于诱导调节性b细胞的致耐受性合成纳米载体 |
JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性tリンパ球(ctl)免疫応答を生成する合成ナノキャリア |
SG11201508028QA (en) | 2013-04-16 | 2015-10-29 | Regeneron Pharma | Targeted modification of rat genome |
BR112015027297B1 (pt) | 2013-05-03 | 2023-01-10 | Selecta Biosciences, Inc | Uso de nanocarreadores sintéticos que são fixados a imunossupressores e de uma composição compreendendo os referidos nanocarreadores |
JP6174811B2 (ja) | 2013-12-11 | 2017-08-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ゲノムの標的改変のための方法及び組成物 |
CA2957808A1 (en) * | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
JP7059179B2 (ja) * | 2015-10-20 | 2022-04-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
EP3429632B1 (en) | 2016-03-16 | 2023-01-04 | CRISPR Therapeutics AG | Materials and methods for treatment of hereditary haemochromatosis |
WO2017192573A1 (en) * | 2016-05-02 | 2017-11-09 | Massachusetts Institute Of Technology | Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer |
KR20190104194A (ko) * | 2017-01-07 | 2019-09-06 | 셀렉타 바이오사이언시즈, 인크. | 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여 |
EP3569708A4 (en) * | 2017-01-13 | 2020-09-09 | Jichi Medical University | AAV VECTOR TO DISCONNECT THE COOLAGE RELATED FACTOR ON THE LIVER GENOME |
EP3592389A1 (en) | 2017-03-11 | 2020-01-15 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
AU2018347583A1 (en) * | 2017-10-13 | 2020-05-21 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector IgM responses |
RU2020126574A (ru) * | 2018-01-11 | 2022-02-11 | Кэмилиэн Байосайнсиз, Инк. | Векторы, ускользающие от иммунного надзора, и их применение в генотерапии |
BR112021000675A2 (pt) * | 2018-07-16 | 2021-04-13 | Selecta Biosciences, Inc. | Métodos e composições de construtos e vetores de mma |
JP2022500079A (ja) * | 2018-09-10 | 2022-01-04 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals, Inc. | Cln3の発現を調節するための化合物及び方法 |
EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 VACCINES AND THEIR USES |
WO2020186217A1 (en) * | 2019-03-14 | 2020-09-17 | Children's Hospital Medical Center | Methods and compositions for treatment of lysosomal storage disorder |
CN110055278B (zh) * | 2019-04-23 | 2021-10-15 | 深圳市弘际生物科技有限责任公司 | 一种新型腺病毒包装方法在CRISPR/Cas9基因编辑方法中的应用 |
MX2021013163A (es) * | 2019-04-28 | 2022-02-21 | Selecta Biosciences Inc | Métodos para el tratamiento de sujetos con inmunidad preexistente a vectores de transferencia viral. |
MX2021014566A (es) * | 2019-05-28 | 2022-03-22 | Selecta Biosciences Inc | Métodos y composiciones para la respuesta inmune atenuada anti-vector de transferencia viral. |
CN110396524B (zh) * | 2019-05-31 | 2023-05-02 | 海南大学 | 一种用于蚊虫的RNAi纳米颗粒和制备方法及用途 |
WO2021211641A2 (en) * | 2020-04-14 | 2021-10-21 | University Of Florida Researchfoundation, Incorporated | Enhancing aav-mediated delivery and transduction with polyvinyl alcohol |
CN112656763B (zh) * | 2020-12-29 | 2022-07-15 | 吉林大学 | 一种基于剪切力响应的载药纳米胶束的制备方法 |
CN113876765A (zh) * | 2021-10-28 | 2022-01-04 | 青岛大学附属医院 | 蟛蜞菊内酯在制备用于预防和/或治疗疱疹病毒感染的药物和保健品中的应用 |
CN116875621B (zh) * | 2023-07-18 | 2024-03-29 | 浙江大学 | 一种提高转移载体中ires序列介导筛选基因表达效率的方法 |
Family Cites Families (329)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946929A (en) | 1983-03-22 | 1990-08-07 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4806621A (en) | 1986-01-21 | 1989-02-21 | Massachusetts Institute Of Technology | Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article |
CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
DE3875306T2 (de) | 1987-02-24 | 1993-04-01 | Xoma Corp | Immunosuppression bei der auf immunotoxin basierten behandlung von menschen. |
US5912017A (en) | 1987-05-01 | 1999-06-15 | Massachusetts Institute Of Technology | Multiwall polymeric microspheres |
US5019379A (en) | 1987-07-31 | 1991-05-28 | Massachusetts Institute Of Technology | Unsaturated polyanhydrides |
JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
GB8918616D0 (en) | 1989-08-15 | 1989-09-27 | Univ Glasgow | Herpes simplex virus type 1 mutant |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
US5849572A (en) | 1990-10-10 | 1998-12-15 | Regents Of The University Of Michigan | HSV-1 vector containing a lat promoter |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
US5399665A (en) | 1992-11-05 | 1995-03-21 | Massachusetts Institute Of Technology | Biodegradable polymers for cell transplantation |
US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
US5679347A (en) | 1992-12-10 | 1997-10-21 | Brigham And Women's Hospital | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
WO1995003035A1 (en) | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Polymerized liposomes with enhanced stability for oral delivery |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
ES2256842T4 (es) | 1993-10-25 | 2007-02-01 | Canji, Inc. | Vector de adenovirus recombinante y metodos de uso. |
TW249754B (es) | 1993-10-26 | 1995-06-21 | Alpha I Biomedicals Inc | |
DE69518838T2 (de) | 1994-05-18 | 2001-05-03 | Protein Engineering Network Of | Heterodimere trägerzusammensetzung von immunogenen polypeptiden und verfahren zu deren verwendung |
EP1548118A2 (en) | 1994-06-10 | 2005-06-29 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
EP0804076A4 (en) * | 1994-10-19 | 1998-10-21 | Genetic Therapy Inc | GENTHERAPY THROUGH SIMULTANEOUS AND REPEATED ADMINISTRATION OF ADENOVIRUS AND IMMUNE SUPPRESSIVES |
US5716404A (en) | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
EP0805678B1 (en) | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
US6251957B1 (en) * | 1995-02-24 | 2001-06-26 | Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
US6123727A (en) | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
JP3462313B2 (ja) | 1995-08-24 | 2003-11-05 | キッコーマン株式会社 | 変異型ウリカーゼ、変異型ウリカーゼ遺伝子、新規な組み換え体dna及び変異型ウリカーゼの製造法 |
US5801030A (en) | 1995-09-01 | 1998-09-01 | Genvec, Inc. | Methods and vectors for site-specific recombination |
US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
US6095148A (en) | 1995-11-03 | 2000-08-01 | Children's Medical Center Corporation | Neuronal stimulation using electrically conducting polymers |
US5902599A (en) | 1996-02-20 | 1999-05-11 | Massachusetts Institute Of Technology | Biodegradable polymer networks for use in orthopedic and dental applications |
US6893664B1 (en) | 1996-06-17 | 2005-05-17 | Powderject Research Limited | Particle delivery techniques |
AU735648B2 (en) | 1996-07-12 | 2001-07-12 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
EP0889954A1 (en) * | 1996-09-03 | 1999-01-13 | Health Research, Inc. | Treatment of antigen presenting cells to modulate antigen presenting cell function |
US5814500A (en) | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
EP0968226A4 (en) | 1996-12-27 | 2001-02-14 | Icn Pharmaceuticals | OLIGOAPTAMERS WITH G-ENRICHED REGIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE |
US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
US5849561A (en) | 1997-05-22 | 1998-12-15 | Cornell Research Foundation, Inc. | Method for the production of non-group C adenoviral vectors |
AU8067698A (en) | 1997-06-09 | 1998-12-30 | Genvec, Inc. | Chimeric vectors comprising a phage packaging site and a portion derived from a genome of a eukaryotic virus |
US5837752A (en) | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
EP0894853A1 (en) | 1997-07-24 | 1999-02-03 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Transcriptional silencer protein NRF, nucleic acid molecules encoding it and their use |
WO1999006583A1 (en) | 1997-07-31 | 1999-02-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeted hsv vectors |
ATE303448T1 (de) | 1997-09-23 | 2005-09-15 | Genvec Inc | Duale selektionkassette und sie enthaltende plasmide |
BR9714899A (pt) | 1997-10-30 | 2000-08-22 | C B F Letti S A | Processo para produzir um extrato provendo tolerância para aplicação a um indivìduo a fim de prover tolerância contra material alergênico, extrato de material de fonte alergênica, preparação, e,uso da mesma |
US6018817A (en) | 1997-12-03 | 2000-01-25 | International Business Machines Corporation | Error correcting code retrofit method and apparatus for multiple memory configurations |
US6197229B1 (en) | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
JP2001526900A (ja) | 1997-12-23 | 2001-12-25 | イントロヘーネ ベスローテン フェンノートシャップ | 標的細胞の染色体dnaへの外来遺伝子情報の組み込みに有用な、アデノ随伴ウイルスおよびアデノウイルスのキメラ組換えウイルス |
CA2317724A1 (en) | 1998-01-09 | 1999-07-15 | Circassia Limited | Methods and compositions for desensitisation |
US6686446B2 (en) | 1998-03-19 | 2004-02-03 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
US6506577B1 (en) | 1998-03-19 | 2003-01-14 | The Regents Of The University Of California | Synthesis and crosslinking of catechol containing copolypeptides |
US6632922B1 (en) | 1998-03-19 | 2003-10-14 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
JP2002512361A (ja) | 1998-04-22 | 2002-04-23 | ジェンベク、インコーポレイティッド | アデノウイルスの効率的精製 |
US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
US5965358A (en) | 1998-08-26 | 1999-10-12 | Genvec, Inc. | Method for assessing the relative purity of viral gene transfer vector stocks |
US6306640B1 (en) | 1998-10-05 | 2001-10-23 | Genzyme Corporation | Melanoma antigenic peptides |
AU1201600A (en) | 1998-10-08 | 2000-04-26 | University Of Massachusetts | Controlling gene expression in living cells |
US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
US6764675B1 (en) | 1999-06-08 | 2004-07-20 | The Uab Research Foundation | Herpes simplex virus expressing foreign genes and method for treating cancers therewith |
DE19951970A1 (de) | 1999-10-28 | 2001-05-03 | Bionetworks Gmbh | Arzneimittel für die Toleranzinduktion |
US6632671B2 (en) | 2000-02-28 | 2003-10-14 | Genesegues, Inc. | Nanoparticle encapsulation system and method |
WO2001068133A1 (en) | 2000-03-14 | 2001-09-20 | Genetics Institute, Inc. | Use of rapamycin and agents that inhibit b7 activity in immunomodulation |
US6168941B1 (en) | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
WO2001085208A2 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
WO2001091802A1 (en) | 2000-05-30 | 2001-12-06 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
AU2001269723B9 (en) | 2000-06-01 | 2006-11-16 | University Of North Carolina At Chapel Hill | Duplexed parvovirus vectors |
US20020095135A1 (en) | 2000-06-19 | 2002-07-18 | David Meeker | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US20020014242A1 (en) * | 2000-07-31 | 2002-02-07 | Abraham Scaria | Use of rapamycin to inhibit immune response and induce tolerance to gene therapy vector and encoded transgene products |
CA2319928A1 (en) | 2000-09-18 | 2002-03-18 | Vasogen Ireland Limited | Apoptosis-mimicking synthetic entities and use thereof in medical treatments |
EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
US6447995B1 (en) | 2000-10-04 | 2002-09-10 | Genvec, Inc. | Utilizing intrinsic fluorescence to detect adenovirus |
GB0025414D0 (en) | 2000-10-16 | 2000-11-29 | Consejo Superior Investigacion | Nanoparticles |
AU2002253836A1 (en) | 2000-10-20 | 2002-08-19 | Canji, Inc | Aptamer-mediated regulation of gene expression |
US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
AU2002338571A1 (en) | 2001-04-11 | 2002-11-11 | Trustees Of The University Of Pennsylvania | Compositions and methods for suppressing immune responses |
ATE472335T1 (de) | 2001-05-31 | 2010-07-15 | Novartis Vaccines & Diagnostic | Chimere alphavirus-replikon-partikel |
ATE527347T1 (de) | 2001-08-02 | 2011-10-15 | Inst Clayton De La Rech | Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen |
US6913915B2 (en) | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
US6818732B2 (en) | 2001-08-30 | 2004-11-16 | The Regents Of The University Of California | Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers |
CN1294268C (zh) * | 2001-09-03 | 2007-01-10 | 上海三维生物技术有限公司 | 可在肿瘤细胞内特异性复制并扩散的重组腺病毒载体 |
JP4790984B2 (ja) | 2001-09-06 | 2011-10-12 | アルファヴァックス,インコーポレイテッド | アルファウイルスレプリコンベクター系 |
KR20040054699A (ko) | 2001-10-02 | 2004-06-25 | 엥스띠뛰 끌레이톤 드 라 러쉐르쉬 | 제한된 발현의 렌티바이러스 벡터 및 이의 적용과 관련된방법 및 조성물 |
JP4261355B2 (ja) | 2001-10-19 | 2009-04-30 | アイソテクニカ インコーポレイテッド | シクロスポリン類似体の合成法 |
EP1453547B1 (en) | 2001-12-17 | 2016-09-21 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor |
GB0207440D0 (en) | 2002-03-28 | 2002-05-08 | Ppl Therapeutics Scotland Ltd | Tolerogenic antigen-presenting cells |
US20040038303A1 (en) | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
US7485314B2 (en) | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
BR0305018A (pt) | 2002-06-04 | 2004-09-21 | Univ Pittsburgh | Células dendrìticas tolerogênicas e usos terapêuticos para as mesmas |
AU2003247880B2 (en) | 2002-07-03 | 2010-09-02 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
CA2392863A1 (en) | 2002-07-08 | 2004-01-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A high capacity recombinant adenoviral vector for treatment of hemophilia a |
US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
US20060127357A1 (en) | 2002-11-29 | 2006-06-15 | Roncarolo Maria G | Rapamycin and il-10 for the treatment of immune diseases |
AU2003296958A1 (en) | 2002-12-13 | 2004-07-09 | Genetix Pharmaceuticals, Inc. | Therapeutic retroviral vectors for gene therapy |
US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
BRPI0408623A (pt) | 2003-03-26 | 2006-03-07 | Cytos Biotechnology Ag | conjugados de partìcula semelhante ao vìrus análogo de peptìdeo de melan-a |
US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
US8198020B2 (en) | 2003-08-22 | 2012-06-12 | Potentia Pharmaceuticals, Inc. | Compositions and methods for enhancing phagocytosis or phagocyte activity |
US20060251711A1 (en) | 2003-08-28 | 2006-11-09 | Vgsk Technologies, Inc. | Sterically stabilized carrier for aerosol therapeutics, compositions and methods for treating diseases of the respiratory tract of a mammal |
US20080160089A1 (en) | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
US20050100890A1 (en) | 2003-10-15 | 2005-05-12 | Davidson Beverly L. | Methods for producing and using in vivo pseudotyped retroviruses |
EP1694301A4 (en) | 2003-12-02 | 2009-11-18 | Cytimmune Sciences Inc | METHOD AND COMPOSITIONS FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES |
EP3242318A1 (en) | 2003-12-19 | 2017-11-08 | The University of North Carolina at Chapel Hill | Monodisperse micro-structure or nano-structure product |
EP2365077B1 (en) | 2004-03-12 | 2013-05-08 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeting VEGF |
KR20120135441A (ko) | 2004-04-08 | 2012-12-13 | 메르크 세로노 에스.에이. | Jnk 저해제 및 시클로스포린을 포함하는 조성물 |
PL1766010T3 (pl) | 2004-06-28 | 2011-07-29 | Univ Western Australia | Antysensowne oligonukleotydy do indukcji pominięcia egzonu i sposoby ich zastosowania |
EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
FR2874384B1 (fr) | 2004-08-17 | 2010-07-30 | Genethon | Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables |
AU2005289633A1 (en) | 2004-09-24 | 2006-04-06 | Nucleonics, Inc. | Targeting opposite strand replication intermediates of single-stranded viruses by RNAi |
US20090017016A1 (en) | 2004-10-05 | 2009-01-15 | Tanox Inc. | Treatment and prevention of hypersensitivity and/or anaphylaxis with anti-ige antibodies in patients receiving replacement therapy |
US7592322B2 (en) | 2004-10-22 | 2009-09-22 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
US7790878B2 (en) | 2004-10-22 | 2010-09-07 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
CN101094659A (zh) | 2004-12-31 | 2007-12-26 | 伊休蒂卡有限公司 | 纳米微粒组合物及其合成方法 |
DK2172549T3 (en) | 2005-02-03 | 2015-11-02 | Benitec Inc | RNAi-ekspressionskonstrukter |
CA2597928A1 (en) | 2005-02-16 | 2006-08-24 | Lentigen Corporation | Lentiviral vectors and their use |
GB0504206D0 (en) | 2005-03-01 | 2005-04-06 | Glaxo Group Ltd | Combination therapy |
CN101137365A (zh) | 2005-03-08 | 2008-03-05 | 生命周期药物公司 | 包含西罗莫司和/或其类似物的药物组合物 |
WO2006101972A2 (en) | 2005-03-17 | 2006-09-28 | Elan Pharma International Limited | Injectable compositions of nanoparticulate immunosuppressive compounds |
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
WO2006110862A2 (en) | 2005-04-12 | 2006-10-19 | Wisconsin Alumni Research Foundation | Micelle composition of polymer and passenger drug |
CA2608086A1 (en) | 2005-05-10 | 2006-11-16 | Emory University | Strategies for delivery of active agents using micelles and particles |
KR20080052512A (ko) | 2005-05-23 | 2008-06-11 | 박신, 인크. | 아데노바이러스-무함유 재조합 아데노바이러스 벡터의 급속생산 |
TW200711649A (en) | 2005-06-17 | 2007-04-01 | Combinatorx Inc | Combination therapy for the treatment of immunoinflammatory disorders |
AU2006261732B2 (en) | 2005-06-27 | 2011-09-15 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of HIF-1 and theraputic uses thereof |
EP1932538A4 (en) | 2005-08-25 | 2009-10-21 | Taiho Pharmaceutical Co Ltd | BIODEGRADABLE NANOTEHICLES WITH IMMOBILIZED OR CAPACITATED T-CELL-RECOGNIZABLE EPITOPEPEPID |
CN1979166A (zh) | 2005-11-30 | 2007-06-13 | 北京有色金属研究总院 | 一种制备免疫检测用纳米胶体金的工艺方法及其反应装置 |
US20070202077A1 (en) | 2005-12-02 | 2007-08-30 | Brodsky Robert A | Use of High-Dose Oxazaphosphorine Drugs for Treating Immune Disorders |
EP1973573B1 (en) | 2005-12-08 | 2013-05-22 | University of Louisville Research Foundation, Inc. | Methods and compositions for expanding t regulatory cells |
WO2007070392A2 (en) | 2005-12-12 | 2007-06-21 | Canji, Inc. | Adenoviral expression vectors having an expression cassette in the e1 region and an inactivated e2b polymerase |
GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
WO2007087341A2 (en) | 2006-01-25 | 2007-08-02 | The Board Of Trustees Of The University Of Illinois | Tolerogenic biodegradable artificial antigen presenting system |
WO2007093036A1 (en) | 2006-02-13 | 2007-08-23 | Oncolytics Biotech Inc. | Use of local immune suppression to enhance oncolytic viral therapy |
US8021689B2 (en) | 2006-02-21 | 2011-09-20 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | Nanoparticles for immunotherapy |
US8568487B2 (en) | 2006-02-27 | 2013-10-29 | Biomet Manufacturing, Llc | Patient-specific hip joint devices |
TW200806789A (en) | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
WO2007127377A2 (en) | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Combinations comprising omega-3 fatty acid compounds for the treatment of cardiovascular disease |
EP2019839B1 (en) | 2006-05-25 | 2011-12-07 | Sangamo BioSciences, Inc. | Methods and compositions for gene inactivation |
EP3023500B1 (en) | 2006-06-21 | 2020-02-12 | uniQure IP B.V. | Insect cells for the production of aav vectors |
EP1880729A1 (en) | 2006-07-20 | 2008-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of soluble CD160 to suppress immunity |
CN101484461B (zh) | 2006-08-18 | 2014-09-17 | 阿哥斯医疗公司 | Cd83在联合治疗中的用途 |
WO2008036374A2 (en) | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
RU2492872C2 (ru) | 2006-10-05 | 2013-09-20 | Дзе Джонс Хопкинс Юниверсити | Вододиспергируемые пероральные, парентеральные и местные композиции для плохо растворимых в воде лекарственных препаратов, включающие улучшающие их свойства полимерные наночастицы |
US9017697B2 (en) | 2006-10-12 | 2015-04-28 | The University Of Queensland | Compositions and methods for modulating immune responses |
CN101646418B (zh) | 2006-10-12 | 2013-07-17 | 昆士兰大学 | 调节免疫应答的组合物和方法 |
US20100112077A1 (en) | 2006-11-06 | 2010-05-06 | Abraxis Bioscience, Llc | Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer |
US20100172994A1 (en) | 2006-11-22 | 2010-07-08 | University Of Florida Research Foundation, Inc. | Nanoparticles for Protection of Cells from Oxidative Stress |
WO2008069942A2 (en) | 2006-12-05 | 2008-06-12 | Biogen Idec Ma Inc. | Novel methods of enhancing delivery of a gene therapy vector using steroids |
AU2007334468B2 (en) | 2006-12-14 | 2013-02-07 | Corteva Agriscience Llc | Optimized non-canonical zinc finger proteins |
JP5694668B2 (ja) | 2006-12-29 | 2015-04-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 自己免疫疾患の診断上および治療上の標的ならびにその用途 |
WO2008103392A2 (en) | 2007-02-21 | 2008-08-28 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cdid molecules |
KR20080078204A (ko) | 2007-02-22 | 2008-08-27 | 크레아젠 주식회사 | 면역억제능이 증가된 간엽줄기세포-매개 자가유래수지상세포 |
CA3201293A1 (en) | 2007-03-07 | 2008-09-12 | Abraxis Bioscience, Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
JP5650406B2 (ja) | 2007-03-07 | 2015-01-07 | ユーティーアイ リミテッド パートナーシップ | 自己免疫状態の予防および治療のための組成物および方法 |
JP2010523554A (ja) | 2007-04-04 | 2010-07-15 | シグモイド・ファーマ・リミテッド | タクロリムスの医薬組成物 |
US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
AU2008236566A1 (en) | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
WO2008127532A1 (en) | 2007-04-12 | 2008-10-23 | Emory University | Novel strategies for delivery of active agents using micelles and particles |
US8877917B2 (en) | 2007-04-23 | 2014-11-04 | Alnylam Pharmaceuticals, Inc. | Glycoconjugates of RNA interference agents |
US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
WO2008150868A1 (en) | 2007-05-29 | 2008-12-11 | The Board Of Trustees Of The University Of Illinois | Methods for inducing therapeutic t cells for immune diseases |
US20100183602A1 (en) | 2007-06-05 | 2010-07-22 | Novartis Ag | Induction of Tolerogenic Phenotype in Mature Dendritic Cells |
US20090004259A1 (en) | 2007-06-14 | 2009-01-01 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) | Methods of preparing a therapeutic formulation comprising galectin-induced tolerogenic dendritic cells |
CA2692720A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
MX342449B (es) | 2007-08-03 | 2016-09-29 | Pasteur Institut | Vectores de transferencia de gen lentiviral y sus aplicaciones medicinales. |
ATE482721T1 (de) | 2007-08-15 | 2010-10-15 | Circassia Ltd | Peptide zur desensibilisierung gegenüber allergenen |
EP2200932A4 (en) | 2007-09-21 | 2014-09-10 | Cytimmune Sciences Inc | NANOTHERAPEUTIC COLLOIDAL METAL COMPOSITIONS AND METHODS |
EP2630967A1 (en) | 2007-10-12 | 2013-08-28 | Massachusetts Institute of Technology | Vaccine nanotechnology |
ES2732735T3 (es) | 2007-10-31 | 2019-11-25 | Prec Biosciences Inc | Meganucleasas monocatenarias diseñadas racionalmente con secuencias de reconocimiento no palindrómicas |
WO2009062502A1 (en) | 2007-11-13 | 2009-05-22 | Dandrit Biotech A/S | Method for generating tolerogenic dendritic cells employing decreased temperature |
WO2009076292A2 (en) | 2007-12-07 | 2009-06-18 | Precision Biosciences, Inc. | Rationally-designed meganucleases with recognition sequences found in dnase hypersensitive regions of the human genome |
JP2011512326A (ja) | 2007-12-31 | 2011-04-21 | ナノコア セラピューティクス,インコーポレイテッド | 心不全の治療用のrna干渉 |
EP2249900A4 (en) | 2008-02-08 | 2013-11-06 | Terumo Corp | DEVICE FOR LOCAL INTRALUMINAL TRANSPORT OF A BIOLOGICALLY AND PHYSIOLOGICALLY ACTIVE AGENCY |
EP2262489A2 (en) | 2008-02-28 | 2010-12-22 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Hollow nanoparticles and uses thereof |
WO2009114321A2 (en) | 2008-03-11 | 2009-09-17 | Precision Biosciencs, Inc. | Rationally-designed meganucleases for maize genome engineering |
WO2009146179A1 (en) | 2008-04-15 | 2009-12-03 | University Of Iowa Research Foundation | Zinc finger nuclease for the cftr gene and methods of use thereof |
CA2722184A1 (en) | 2008-04-25 | 2009-10-29 | Duke University | Regulatory b cells and their uses |
JP5727367B2 (ja) | 2008-05-15 | 2015-06-03 | ダイナバックス テクノロジーズ コーポレイション | 免疫賦活オリゴヌクレオチドを使用する長期疾患改良 |
JP5549014B2 (ja) | 2008-05-27 | 2014-07-16 | 国立大学法人名古屋大学 | 免疫調節剤及びその利用 |
WO2010005726A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences Inc. | Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same |
PL2774608T3 (pl) | 2008-06-16 | 2020-05-18 | Pfizer Inc. | Polimerowe nanocząstki napełnione lekiem oraz sposoby ich wytwarzania i zastosowania |
US20120034156A1 (en) | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
WO2010018384A1 (en) | 2008-08-15 | 2010-02-18 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of il-10 production |
US8323696B2 (en) | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
EP2341953B1 (en) | 2008-09-04 | 2018-11-21 | The General Hospital Corporation | Hydrogels for vocal cord and soft tissue augmentation and repair |
US8871515B2 (en) | 2008-09-17 | 2014-10-28 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
CN101676291B (zh) | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
US8889124B2 (en) | 2008-09-25 | 2014-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Tolerogenic populations of dendritic cells |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
US8343498B2 (en) * | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
JP5552630B2 (ja) | 2008-10-24 | 2014-07-16 | 学校法人 聖マリアンナ医科大学 | Htlv−i関連脊髄症を治療または予防するための医薬、およびhtlv−i関連脊髄症の患者に対する抗体療法の効果を試験する方法 |
LT3133160T (lt) | 2008-10-24 | 2019-04-10 | Sarepta Therapeutics, Inc. | Kompozicijos su egzono praleidimu dmd gydymui |
WO2010047839A1 (en) | 2008-10-25 | 2010-04-29 | Aura Biosciences | Modified plant virus particles and uses therefor |
US20100216804A1 (en) * | 2008-12-15 | 2010-08-26 | Zale Stephen E | Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents |
JP2012515722A (ja) * | 2009-01-20 | 2012-07-12 | ノースウェスタン ユニバーシティ | 抗原特異的寛容の誘導のための組成物および方法 |
EP2620447B1 (en) | 2009-02-04 | 2015-09-09 | Universität Leipzig | Vector(s) containing an inducible gene encoding a CDK4/CDK6 inhibitor useful for treating neurodegenerative disorders |
EP2891662A1 (en) | 2009-02-05 | 2015-07-08 | Circassia Limited | Grass peptides for vaccine |
KR20100099849A (ko) | 2009-03-04 | 2010-09-15 | 동국대학교 산학협력단 | 면역억제제와 트랜스글루타미나제 2의 억제제를 함유한 아토피 피부염 치료용 조성물 |
US8679837B2 (en) | 2009-04-02 | 2014-03-25 | University Of Florida Research Foundation, Inc. | Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors |
GB0906159D0 (en) | 2009-04-09 | 2009-05-20 | Summit Corp Plc | Drug combination for the treatment of proteostatic diseases |
KR20120022984A (ko) | 2009-04-21 | 2012-03-12 | 셀렉타 바이오사이언시즈, 인크. | Th1 편향 반응을 제공하는 면역나노치료법 |
US20100273220A1 (en) | 2009-04-22 | 2010-10-28 | Massachusetts Institute Of Technology | Innate immune suppression enables repeated delivery of long rna molecules |
DK2424890T3 (en) | 2009-04-27 | 2018-09-17 | Immuron Ltd | ANTI-LPS ENHANCED IMMUNOGLOBULIN PREPARATION FOR USE IN TREATMENT AND / OR PROPHYLAXY NONALCOHOLIC STEATOHEPATITIS |
KR20180026572A (ko) | 2009-05-27 | 2018-03-12 | 셀렉타 바이오사이언시즈, 인크. | 방출 속도가 상이한 성분을 갖는 나노운반체 |
RU2535038C2 (ru) | 2009-06-25 | 2014-12-10 | Криэлта Фармасьютикалз ЭлЭлСи | Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови |
WO2011031298A1 (en) | 2009-08-26 | 2011-03-17 | Selecta Biosciences, Inc. | Compositions that induce t cell help |
AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
EP2305277A1 (en) | 2009-09-18 | 2011-04-06 | Forskarpatent I Syd AB | Use of tolerogenic dendritic cells in treatment and prevention of atherosclerosis |
US8802437B2 (en) | 2009-09-24 | 2014-08-12 | Cellectis | Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations |
WO2011043719A1 (en) | 2009-10-05 | 2011-04-14 | Ya-Fang Mei | Replicating viral vectors for gene therapy |
CN101703781A (zh) | 2009-10-28 | 2010-05-12 | 陕西北美基因股份有限公司 | 一种免疫抑制剂的磁性载药方法 |
US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
CA2780563A1 (en) | 2009-11-12 | 2011-05-19 | The University Of Western Australia | Antisense molecules and methods for treating pathologies |
BR112012014080A2 (pt) | 2009-12-10 | 2015-10-27 | Univ Iowa State Res Found | método para modificação do material genético, método para geração de um ácido nucleico, monômero de endonuclease efetora tal, método para geração de um aninal, método para geração de uma planta, método para recombinação genética direcionada, ácido nucleico, cassete de expressão e célula hospedeira |
KR101267813B1 (ko) | 2009-12-30 | 2013-06-04 | 주식회사 삼양바이오팜 | 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물 |
US20110171248A1 (en) | 2010-01-08 | 2011-07-14 | Selecta Biosciences, Inc. | Synthetic virus-like particles conjugated to human papillomavirus capsid peptides for use as vaccines |
WO2011097511A1 (en) | 2010-02-05 | 2011-08-11 | The United States Of America, As Represented By The Secretary Department Of Health & Human Services | REGULATORY B CELLS (tBREGS) AND THEIR USE |
US9255259B2 (en) | 2010-02-09 | 2016-02-09 | Sangamo Biosciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
EA201290876A1 (ru) | 2010-03-05 | 2013-03-29 | Президент Энд Феллоуз Оф Гарвард Колледж | Композиции индуцированных дендритных клеток и их использование |
US20110272836A1 (en) | 2010-04-12 | 2011-11-10 | Selecta Biosciences, Inc. | Eccentric vessels |
US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
US8927514B2 (en) | 2010-04-30 | 2015-01-06 | City Of Hope | Recombinant adeno-associated vectors for targeted treatment |
SG2014014724A (en) | 2010-05-07 | 2014-07-30 | Xoma Technology Ltd | METHODS FOR THE TREATMENT OF IL-1ß RELATED CONDITIONS |
JP6371058B2 (ja) | 2010-05-26 | 2018-08-15 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | 結合していないアジュバントを有するナノキャリア組成物 |
SG10201504590WA (en) | 2010-06-07 | 2015-07-30 | Abraxis Bioscience Llc | Combination Therapy Methods For Treating Proliferative Diseases |
US10131875B2 (en) | 2010-08-04 | 2018-11-20 | Duke University | Regulatory B cells and their uses |
US9518087B2 (en) * | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
AU2011291522A1 (en) | 2010-08-20 | 2013-01-24 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza A virus M2E |
WO2012027365A2 (en) | 2010-08-23 | 2012-03-01 | Selecta Biosciences, Inc. | Targeted multi-epitope dosage forms for induction of an immune response to antigens |
CA2810842C (en) | 2010-09-09 | 2018-06-26 | Micell Technologies, Inc. | Macrolide dosage forms |
JP2013540162A (ja) | 2010-10-22 | 2013-10-31 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 抗原特異的な寛容を誘導する微粒子およびその使用 |
US9994443B2 (en) | 2010-11-05 | 2018-06-12 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
WO2012092552A1 (en) | 2010-12-30 | 2012-07-05 | Selecta Biosciences, Inc. | Synthetic nanocarriers with reactive groups that release biologically active agents |
WO2012109296A1 (en) * | 2011-02-08 | 2012-08-16 | The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center | Antisense oligonucleotides |
CA2827375C (en) | 2011-02-14 | 2022-07-19 | The Children's Hospital Of Philadelphia | Improved aav8 vector with enhanced functional activity and methods of use thereof |
US8654487B2 (en) | 2011-03-11 | 2014-02-18 | Siemens Industry, Inc. | Methods, systems, and apparatus and for detecting parallel electrical arc faults |
KR20140022025A (ko) | 2011-03-25 | 2014-02-21 | 셀렉타 바이오사이언시즈, 인크. | 삼투적 매개 방출 합성 나노담체 |
WO2012145509A2 (en) | 2011-04-19 | 2012-10-26 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors, and viruses |
WO2012145572A1 (en) | 2011-04-20 | 2012-10-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
CN103517716A (zh) | 2011-04-29 | 2014-01-15 | 西莱克塔生物科技公司 | 用于诱导调节性b细胞的致耐受性合成纳米载体 |
JP6174572B2 (ja) | 2011-05-16 | 2017-08-02 | ジェンザイム・コーポレーション | メトトレキサートを用いる免疫寛容の誘導 |
JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性tリンパ球(ctl)免疫応答を生成する合成ナノキャリア |
WO2013036297A1 (en) | 2011-09-06 | 2013-03-14 | Selecta Biosciences, Inc. | Therapeutic protein-specific induced tolerogenic dendritic cells and methods of use |
EP2753362A4 (en) | 2011-09-08 | 2015-04-15 | Univ Florida | MATERIALS AND METHODS FOR MODULATING THE IMMUNE RESPONSE |
US8865487B2 (en) | 2011-09-20 | 2014-10-21 | General Electric Company | Large area hermetic encapsulation of an optoelectronic device using vacuum lamination |
US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
JP2014530607A (ja) | 2011-10-11 | 2014-11-20 | アリオフタ・アーゲーAliophtha Ag | 人工転写因子の送達による受容体発現の調節 |
WO2013058812A1 (en) | 2011-10-19 | 2013-04-25 | President And Fellows Of Harvard College | Targeted delivery to pancreatic islet endothelial cells |
EP2591801A1 (en) | 2011-11-14 | 2013-05-15 | Universitätsklinikum Hamburg-Eppendorf | Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions |
ES2800065T3 (es) | 2011-11-18 | 2020-12-23 | Alnylam Pharmaceuticals Inc | Agentes de iARN, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (TTR) |
AU2012340567B2 (en) | 2011-11-22 | 2017-11-23 | The Children's Hospital Of Philadelphia | Virus vectors for highly efficient transgene delivery |
KR102057540B1 (ko) | 2012-02-17 | 2019-12-19 | 더 칠드런스 호스피탈 오브 필라델피아 | 세포, 기관 및 조직으로의 유전자 전이를 위한 aav 벡터 조성물 및 방법 |
KR101833589B1 (ko) | 2012-02-24 | 2018-03-02 | 프레드 헛친슨 켄서 리서치 센터 | 이상혈색소증 치료를 위한 조성물 및 방법 |
CN103316356B (zh) | 2012-03-22 | 2016-08-17 | 北京三诺佳邑生物技术有限责任公司 | 一种重组慢病毒载体制剂 |
US9506041B2 (en) | 2012-03-26 | 2016-11-29 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Delivery of packaged RNA to mammalian cells |
AU2013249202B2 (en) | 2012-04-18 | 2018-08-09 | The Children's Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using AAV capsid variants |
DK2841097T3 (da) | 2012-04-24 | 2022-11-28 | Ohio State Innovation Foundation | Sammensætninger og fremgangsmåder til behandling og forebyggelse af porcint reproduktions- og respirationssyndrom |
US9738879B2 (en) | 2012-04-27 | 2017-08-22 | Duke University | Genetic correction of mutated genes |
US9708607B2 (en) | 2012-08-03 | 2017-07-18 | Alnylam Pharmaceuticals, Inc. | Modified RNAi agents |
US20150231241A1 (en) | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
EP2892617B1 (en) | 2012-09-06 | 2018-06-13 | The University of Chicago | Antisense polynucleotides to induce exon skipping and methods of treating dystrophies |
JP2015529466A (ja) | 2012-09-14 | 2015-10-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 鎌状赤血球症の幹細胞遺伝子治療のためのレンチウイルスベクター |
US9181535B2 (en) | 2012-09-24 | 2015-11-10 | The Chinese University Of Hong Kong | Transcription activator-like effector nucleases (TALENs) |
CN102871966B (zh) | 2012-10-19 | 2013-11-20 | 东南大学 | 用于改善雷帕霉素生物利用度的纳米载药颗粒及其制备方法 |
US9624510B2 (en) | 2013-03-01 | 2017-04-18 | The Wistar Institute | Adenoviral vectors comprising partial deletions of E3 |
CA2903718A1 (en) | 2013-03-13 | 2014-10-02 | Cour Pharmaceuticals Development Co., Inc. | Immune-modifying particles for the treatment of inflammation |
US20160038575A1 (en) | 2013-03-15 | 2016-02-11 | Haplomics, Inc. | Compositions and methods for immune tolerance induction to factor viii replacement therapies in subjects with hemophilia a |
CN105307723A (zh) | 2013-03-15 | 2016-02-03 | 萨勒普塔医疗公司 | 改进的用于治疗肌营养不良的组合物 |
EP2983707B1 (en) | 2013-04-08 | 2019-06-12 | University of Iowa Research Foundation | Chimeric adeno-associated virus/ bocavirus parvovirus vector |
BR112015027297B1 (pt) | 2013-05-03 | 2023-01-10 | Selecta Biosciences, Inc | Uso de nanocarreadores sintéticos que são fixados a imunossupressores e de uma composição compreendendo os referidos nanocarreadores |
AU2014262164B2 (en) | 2013-05-03 | 2020-02-27 | Selecta Biosciences, Inc. | Dosing combinations for reducing undesired humoral immune responses |
SG10201804472YA (en) | 2013-05-22 | 2018-07-30 | Alnylam Pharmaceuticals Inc | SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
US9873907B2 (en) | 2013-05-29 | 2018-01-23 | Agilent Technologies, Inc. | Method for fragmenting genomic DNA using CAS9 |
MX2015016691A (es) | 2013-06-04 | 2016-04-04 | Selecta Biosciences Inc | Administracion repetida de inmunoterapeuticos especificos de antigeno no inmunosupresores. |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
AU2014329437B2 (en) | 2013-10-06 | 2018-10-18 | F. Hoffmann-La Roche Ag | Modified Pseudomonas exotoxin A |
US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
US9300930B2 (en) * | 2014-02-18 | 2016-03-29 | Microvision, Inc. | Multi-segment brightness compensation |
US10737320B2 (en) * | 2014-02-27 | 2020-08-11 | Ningxia Orient Tantalum Industry Co., Ltd. | High-purity tantalum powder and preparation method thereof |
US10339920B2 (en) * | 2014-03-04 | 2019-07-02 | Amazon Technologies, Inc. | Predicting pronunciation in speech recognition |
EP2916319A1 (en) * | 2014-03-07 | 2015-09-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Concept for encoding of information |
DK3116900T3 (da) | 2014-03-09 | 2020-09-28 | Univ Pennsylvania | Sammensætninger som kan anvendes til behandling af ornithintranscarbamylase (otc) defekt |
GB201407322D0 (en) | 2014-04-25 | 2014-06-11 | Ospedale San Raffaele | Gene therapy |
US20160220501A1 (en) | 2015-02-03 | 2016-08-04 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins |
US20150359865A1 (en) | 2014-06-17 | 2015-12-17 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers for t-cell-mediated autoimmune disease |
AU2015279738A1 (en) | 2014-06-25 | 2016-12-22 | Selecta Biosciences, Inc. | Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors |
CA2957808A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
CN113244191A (zh) | 2014-11-05 | 2021-08-13 | 西莱克塔生物科技公司 | 与具有处于稳定的超饱和状态之雷帕霉素的合成纳米颗粒相关的方法和组合物 |
WO2017139212A1 (en) | 2016-02-08 | 2017-08-17 | Cyta Therapeutics, Inc. | Particle delivery of rapamycin to the liver |
WO2017138983A1 (en) | 2016-02-10 | 2017-08-17 | Pfizer Inc. | Therapeutic nanoparticles having egfr ligands and methods of making and using same |
MX2018011012A (es) | 2016-03-11 | 2019-03-28 | Selecta Biosciences Inc | Formulaciones y dosis de uricasa pegilada. |
US10545815B2 (en) * | 2016-08-03 | 2020-01-28 | Futurewei Technologies, Inc. | System and method for data redistribution in a database |
US20180071394A1 (en) | 2016-08-25 | 2018-03-15 | Selecta Biosciences, Inc. | Polyester polymer matrices for the delivery of allergens |
CA3038089A1 (en) | 2016-09-27 | 2018-04-05 | Selecta Biosciences, Inc. | Recombinant immunotoxins for use in the treatment of cancer |
WO2018127382A1 (en) | 2017-01-03 | 2018-07-12 | Ethris Gmbh | Ornithine transcarbamylase coding polyribonucleotides and formulations thereof |
KR20190104194A (ko) | 2017-01-07 | 2019-09-06 | 셀렉타 바이오사이언시즈, 인크. | 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여 |
EP3592389A1 (en) | 2017-03-11 | 2020-01-15 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
AU2018347583A1 (en) | 2017-10-13 | 2020-05-21 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector IgM responses |
JP7416430B2 (ja) | 2018-02-26 | 2024-01-17 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム リミテッド | 薬物送達システム |
AU2019265632A1 (en) | 2018-05-09 | 2021-01-07 | Yale University | Particles for spatiotemporal release of agents |
BR112021000675A2 (pt) | 2018-07-16 | 2021-04-13 | Selecta Biosciences, Inc. | Métodos e composições de construtos e vetores de mma |
JP2021531282A (ja) | 2018-07-16 | 2021-11-18 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences, Inc. | Otcコンストラクトおよびベクターの方法および組成物 |
MX2021013163A (es) | 2019-04-28 | 2022-02-21 | Selecta Biosciences Inc | Métodos para el tratamiento de sujetos con inmunidad preexistente a vectores de transferencia viral. |
MX2021014566A (es) | 2019-05-28 | 2022-03-22 | Selecta Biosciences Inc | Métodos y composiciones para la respuesta inmune atenuada anti-vector de transferencia viral. |
US20200399628A1 (en) | 2019-06-04 | 2020-12-24 | Selecta Biosciences, Inc. | Formulations and doses of pegylated uricase |
JP2022553345A (ja) | 2019-10-21 | 2022-12-22 | セレクタ バイオサイエンシーズ インコーポレーテッド | 肝疾患および肝障害を処置するための方法および組成物 |
CA3160642A1 (en) | 2019-11-08 | 2021-05-14 | Selecta Biosciences, Inc. | Formulations and doses of pegylated uricase |
BR112022018070A2 (pt) | 2020-03-11 | 2022-10-25 | Selecta Biosciences Inc | Métodos e composições relacionados a nanoveículos sintéticos |
-
2015
- 2015-09-07 CA CA2957808A patent/CA2957808A1/en active Pending
- 2015-09-07 US US14/846,967 patent/US10046064B2/en active Active
- 2015-09-07 WO PCT/US2015/048769 patent/WO2016037163A1/en active Application Filing
- 2015-09-07 IL IL309546A patent/IL309546A/en unknown
- 2015-09-07 WO PCT/US2015/048768 patent/WO2016037162A1/en active Application Filing
- 2015-09-07 EA EA201790533A patent/EA201790533A1/ru unknown
- 2015-09-07 US US14/846,952 patent/US20160074531A1/en active Pending
- 2015-09-07 JP JP2017513038A patent/JP7242178B2/ja active Active
- 2015-09-07 US US14/846,964 patent/US10071114B2/en active Active
- 2015-09-07 AU AU2015311704A patent/AU2015311704B2/en active Active
- 2015-09-07 EP EP15778406.7A patent/EP3189147A1/en active Pending
- 2015-09-07 IL IL292577A patent/IL292577A/en unknown
- 2015-09-07 IL IL292574A patent/IL292574A/en unknown
- 2015-09-07 BR BR112017001470A patent/BR112017001470A2/pt not_active Application Discontinuation
- 2015-09-07 IL IL292575A patent/IL292575A/en unknown
- 2015-09-07 US US14/846,958 patent/US20160074532A1/en active Pending
- 2015-09-07 JP JP2017513048A patent/JP7242180B2/ja active Active
- 2015-09-07 EA EA201790534A patent/EA201790534A1/ru unknown
- 2015-09-07 KR KR1020177009110A patent/KR20170054434A/ko not_active Application Discontinuation
- 2015-09-07 CN CN201580047807.3A patent/CN106714826A/zh active Pending
- 2015-09-07 JP JP2017512898A patent/JP7272746B2/ja active Active
- 2015-09-07 JP JP2017513047A patent/JP7242179B2/ja active Active
- 2015-09-07 AU AU2015311706A patent/AU2015311706A1/en not_active Abandoned
- 2015-09-07 CN CN201580047634.5A patent/CN107073091A/zh active Pending
- 2015-09-07 EA EA201790550A patent/EA201790550A1/ru unknown
- 2015-09-07 WO PCT/US2015/048767 patent/WO2016037161A2/en active Application Filing
- 2015-09-07 AU AU2015311705A patent/AU2015311705B2/en active Active
- 2015-09-07 KR KR1020177009113A patent/KR20170045347A/ko not_active Application Discontinuation
- 2015-09-07 KR KR1020177009112A patent/KR20170045346A/ko not_active Application Discontinuation
- 2015-09-07 BR BR112017001245A patent/BR112017001245A2/pt not_active Application Discontinuation
- 2015-09-07 MX MX2017002932A patent/MX2017002932A/es unknown
- 2015-09-07 BR BR112017001359A patent/BR112017001359A2/pt not_active Application Discontinuation
- 2015-09-07 BR BR112017001311A patent/BR112017001311A2/pt active Search and Examination
- 2015-09-07 US US14/846,949 patent/US11633422B2/en active Active
- 2015-09-07 MX MX2017002931A patent/MX2017002931A/es unknown
- 2015-09-07 CA CA2957737A patent/CA2957737A1/en active Pending
- 2015-09-07 CN CN201580047633.0A patent/CN107075499A/zh active Pending
- 2015-09-07 IL IL292580A patent/IL292580A/en unknown
- 2015-09-07 CA CA2957793A patent/CA2957793A1/en active Pending
- 2015-09-07 IL IL250865A patent/IL250865B1/en unknown
- 2015-09-07 CA CA2957800A patent/CA2957800A1/en active Pending
- 2015-09-07 AU AU2015311707A patent/AU2015311707B2/en active Active
- 2015-09-07 AU AU2015311708A patent/AU2015311708A1/en not_active Abandoned
- 2015-09-07 EA EA201790551A patent/EA201790551A1/ru unknown
- 2015-09-07 JP JP2017512897A patent/JP7242177B2/ja active Active
- 2015-09-07 WO PCT/US2015/048770 patent/WO2016037164A1/en active Application Filing
- 2015-09-07 CN CN201580047806.9A patent/CN107073050A/zh active Pending
- 2015-09-07 CN CN202111297024.4A patent/CN114146167A/zh active Pending
- 2015-09-07 KR KR1020177009109A patent/KR20170045344A/ko not_active IP Right Cessation
- 2015-09-07 EA EA201790532A patent/EA201790532A1/ru unknown
- 2015-09-07 MX MX2017002933A patent/MX2017002933A/es unknown
- 2015-09-07 EP EP15778405.9A patent/EP3189146A1/en active Pending
- 2015-09-07 KR KR1020237012021A patent/KR20230053709A/ko not_active Application Discontinuation
- 2015-09-07 EP EP15838667.2A patent/EP3189138A4/en active Pending
- 2015-09-07 CN CN201580047585.5A patent/CN106715699A/zh active Pending
- 2015-09-07 MX MX2017002935A patent/MX2017002935A/es unknown
- 2015-09-07 KR KR1020237012024A patent/KR20230053710A/ko not_active Application Discontinuation
- 2015-09-07 MX MX2017002934A patent/MX2017002934A/es unknown
- 2015-09-07 BR BR112017001601A patent/BR112017001601A2/pt not_active Application Discontinuation
- 2015-09-07 WO PCT/US2015/048771 patent/WO2016037165A1/en active Application Filing
- 2015-09-07 EP EP15837503.0A patent/EP3193896A4/en active Pending
- 2015-09-07 KR KR1020177009111A patent/KR20170045345A/ko not_active IP Right Cessation
- 2015-09-07 EP EP15837338.1A patent/EP3188742A4/en active Pending
- 2015-09-07 CA CA2957802A patent/CA2957802A1/en active Pending
-
2017
- 2017-03-01 IL IL250873A patent/IL250873B/en unknown
- 2017-03-01 IL IL250872A patent/IL250872B/en unknown
- 2017-03-01 IL IL250877A patent/IL250877B/en unknown
- 2017-03-01 IL IL250874A patent/IL250874B/en unknown
- 2017-03-06 MX MX2023003246A patent/MX2023003246A/es unknown
- 2017-03-06 MX MX2023003253A patent/MX2023003253A/es unknown
- 2017-03-06 MX MX2023003252A patent/MX2023003252A/es unknown
- 2017-03-06 MX MX2023003254A patent/MX2023003254A/es unknown
- 2017-03-06 MX MX2023003249A patent/MX2023003249A/es unknown
-
2018
- 2018-08-09 US US16/100,040 patent/US20190076458A1/en active Pending
-
2021
- 2021-01-29 JP JP2021012709A patent/JP7395522B2/ja active Active
- 2021-05-19 JP JP2021084907A patent/JP2021152013A/ja active Pending
- 2021-05-19 JP JP2021084897A patent/JP2021152012A/ja active Pending
- 2021-05-19 JP JP2021084913A patent/JP7425767B2/ja active Active
- 2021-05-19 JP JP2021084901A patent/JP2021176845A/ja active Pending
- 2021-05-25 AU AU2021203376A patent/AU2021203376A1/en active Pending
- 2021-05-25 AU AU2021203379A patent/AU2021203379A1/en active Pending
-
2022
- 2022-02-25 AU AU2022201323A patent/AU2022201323A1/en active Pending
- 2022-02-27 AU AU2022201350A patent/AU2022201350A1/en active Pending
- 2022-02-27 AU AU2022201349A patent/AU2022201349A1/en active Pending
-
2023
- 2023-03-17 US US18/185,891 patent/US20230364124A1/en active Pending
- 2023-08-28 JP JP2023137900A patent/JP2024004492A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2023003249A (es) | Metodos y composiciones para atenuar las respuestas inmunes anti-vector de transferencia viral de saltado de exones. | |
PH12019500627A1 (en) | Affinity-oligonucleotide conjugates and uses thereof | |
HK1257410A1 (zh) | 逃避抗體的病毒載體的方法和組合物 | |
IL265953A (en) | Gene insertion is targeted for improved immune cell therapy | |
EP3224353C0 (en) | TARGETED REMOVAL OF BACTERIAL GENES | |
MX2017016405A (es) | Reguladores de nrf2. | |
EP3245220C0 (en) | METHODS AND COMPOSITIONS FOR TARGETED GENE TRANSFER | |
TW201613966A (en) | SynTac polypeptides and uses thereof | |
PH12017500602A1 (en) | Methods for treating ocular conditions | |
SG11201708466VA (en) | Incubation tray | |
MY187959A (en) | Reactor | |
GB2553092B (en) | Plant propagation tray assembly | |
GB201519554D0 (en) | Genetically modified microorganisms | |
GB201416975D0 (en) | Personal protective sports equipment (PPSE) |