MX2013013094A - Cocristales de l-prolina y acido citrico de (2s,3r,4r,5s,6r)-2-(3- ((5-(4-fluorofenil) tiofen-2-il)metil)-4-metilfenil)-6-(hidroximet il)tetrahidro-2h-piran-3, 4.5-triol. - Google Patents

Cocristales de l-prolina y acido citrico de (2s,3r,4r,5s,6r)-2-(3- ((5-(4-fluorofenil) tiofen-2-il)metil)-4-metilfenil)-6-(hidroximet il)tetrahidro-2h-piran-3, 4.5-triol.

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Publication number
MX2013013094A
MX2013013094A MX2013013094A MX2013013094A MX2013013094A MX 2013013094 A MX2013013094 A MX 2013013094A MX 2013013094 A MX2013013094 A MX 2013013094A MX 2013013094 A MX2013013094 A MX 2013013094A MX 2013013094 A MX2013013094 A MX 2013013094A
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MX
Mexico
Prior art keywords
crystals
thiophen
pyran
fluorophenyl
proline
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MX2013013094A
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English (en)
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MX347178B (es
Inventor
Minh Nguyen
Edwin A Collier
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2013013094A publication Critical patent/MX2013013094A/es
Publication of MX347178B publication Critical patent/MX347178B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/22—Tricarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención está dirigida a cocristales de L-prolina y ácido cítrico de (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorofenil)tiofen-2 -iI)metil)-4-metilfenhl)-6-(hidroximethil)tetrahidro-2H-piran-3,4 ,5-triol, composiciones farmacéuticas que contienen esos cocristales, y su uso en el tratamiento de trastornos relacionados con la glucosa, tales como la diabetes mellitus tipo 2 y el síndrome X.
MX2013013094A 2011-05-09 2012-05-09 Cocristales de l-prolina y acido citrico de (2s,3r,4r,5s,6r)-2-(3- ((5-(4-fluorofenil) tiofen-2-il)metil)-4-metilfenil)-6-(hidroximet il)tetrahidro-2h-piran-3, 4.5-triol. MX347178B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161483887P 2011-05-09 2011-05-09
PCT/US2012/037062 WO2012154812A1 (en) 2011-05-09 2012-05-09 L-proline and citric acid co-crystals of (2s, 3r, 4r, 5s, 6r )- 2- (3- ((5- (4-fluorophenyl)thiophen-2-yl) methyl) -4-methylphenyl)-6- (hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol

Publications (2)

Publication Number Publication Date
MX2013013094A true MX2013013094A (es) 2013-12-16
MX347178B MX347178B (es) 2017-04-17

Family

ID=46147741

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013094A MX347178B (es) 2011-05-09 2012-05-09 Cocristales de l-prolina y acido citrico de (2s,3r,4r,5s,6r)-2-(3- ((5-(4-fluorofenil) tiofen-2-il)metil)-4-metilfenil)-6-(hidroximet il)tetrahidro-2h-piran-3, 4.5-triol.

Country Status (31)

Country Link
US (1) US9035044B2 (es)
EP (1) EP2707366B1 (es)
JP (1) JP6106661B2 (es)
KR (1) KR101795514B1 (es)
CN (2) CN103502245B (es)
AR (1) AR086320A1 (es)
AU (1) AU2012253613B2 (es)
BR (1) BR112013028744B1 (es)
CA (2) CA2835704C (es)
CL (1) CL2013003209A1 (es)
CY (1) CY1116550T1 (es)
DK (1) DK2707366T3 (es)
EA (1) EA023496B1 (es)
ES (1) ES2546904T3 (es)
HR (1) HRP20151011T1 (es)
HU (1) HUE027642T2 (es)
IL (1) IL229232A (es)
ME (1) ME02175B (es)
MX (1) MX347178B (es)
MY (1) MY166774A (es)
PL (1) PL2707366T3 (es)
PT (1) PT2707366E (es)
RS (1) RS54205B1 (es)
SG (1) SG194767A1 (es)
SI (1) SI2707366T1 (es)
SM (1) SMT201500194B (es)
TW (1) TWI542596B (es)
UA (1) UA111199C2 (es)
UY (1) UY34061A (es)
WO (1) WO2012154812A1 (es)
ZA (1) ZA201309212B (es)

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KR20140097258A (ko) * 2011-10-31 2014-08-06 시노팜 타이완 리미티드 Sglt2 억제제의 결정성 및 비-결정성 형태
CN103965267A (zh) * 2013-01-24 2014-08-06 江苏豪森医药集团连云港宏创医药有限公司 1-(β-D-吡喃葡糖基)-4-甲基-3-[5-(4-氟苯基)-2-噻吩基甲基]苯与L-苯丙氨酸共晶物及其制备方法
MX355831B (es) 2013-05-08 2018-05-02 Lek Pharmaceuticals NOVEDOSOS HIDRATOS CRISTALINOS DE 1-(ß-D-GLUCOPIRANOSIL)-4-METIL-3 -[5-(4-FLUORO-FENIL)-2-TIENIL-METIL]-BENCENO.
CN103694230B (zh) * 2013-12-06 2016-04-13 江苏奥赛康药业股份有限公司 一种高纯度卡格列净化合物及其制备方法
CN104693191A (zh) * 2013-12-09 2015-06-10 天津药物研究院 一种共结晶i及其制备方法和应用
CN103980261B (zh) * 2014-04-01 2016-06-29 天津大学 卡格列净的a晶型及其结晶制备方法
CN103980262B (zh) * 2014-04-01 2016-06-22 天津大学 卡格列净的b晶型及其结晶制备方法
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WO2017060924A1 (en) * 2015-10-09 2017-04-13 Harman Finochem Limited A novel pipecolic acid co-crystal of canagliflozin and process for the preparation thereof
WO2017064679A1 (en) 2015-10-15 2017-04-20 Lupin Limited Process for the preparation of amorphous canagliflozin
CN105503802A (zh) * 2016-01-15 2016-04-20 中山大学 一种达格列净-柠檬酸共晶的制备方法
US11008277B2 (en) 2016-06-13 2021-05-18 Syneurx International (Taiwan) Corp. Co-crystals of sodium benzoate and uses thereof
US10815184B2 (en) * 2016-06-13 2020-10-27 Syneurx International (Taiwan) Corp. Co-crystals of lithium benzoate and uses thereof
KR20200141985A (ko) * 2018-02-07 2020-12-21 리아타 파마슈티컬즈, 아이엔씨. 노보비오신 유사체 및 프롤린의 공-결정 형태
WO2020031078A1 (en) * 2018-08-06 2020-02-13 Hikal Limited A co-crystal of canagliflozin with alpha-methyl-l-proline and process for the preparation thereof
MX2021003545A (es) * 2018-09-26 2021-05-27 Lexicon Pharmaceuticals Inc Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis.
CN114213399A (zh) * 2021-12-20 2022-03-22 上海启讯医药科技有限公司 一种卡格列净丙酮水合物及其制备方法和用途

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