ATE468347T1 - Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)- benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters (sglt) - Google Patents

Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)- benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters (sglt)

Info

Publication number
ATE468347T1
ATE468347T1 AT06777999T AT06777999T ATE468347T1 AT E468347 T1 ATE468347 T1 AT E468347T1 AT 06777999 T AT06777999 T AT 06777999T AT 06777999 T AT06777999 T AT 06777999T AT E468347 T1 ATE468347 T1 AT E468347T1
Authority
AT
Austria
Prior art keywords
cycloalyklethynyl
sglt
glucopyranosyl
transporter
hetero
Prior art date
Application number
AT06777999T
Other languages
English (en)
Inventor
Frank Himmelsbach
Matthias Eckhardt
Peter Eickelmann
Leo Thomas
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE468347T1 publication Critical patent/ATE468347T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
AT06777999T 2005-07-27 2006-07-26 Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)- benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters (sglt) ATE468347T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05016254 2005-07-27
EP05019085 2005-09-02
PCT/EP2006/064702 WO2007014894A2 (en) 2005-07-27 2006-07-26 Glucopyranosyl-substituted ( (hetero) cycloalyklethynyl-benzyl) -benzene derivatives and use thereof as sodium-dependent glucose cotransporter (sglt) inhibitors

Publications (1)

Publication Number Publication Date
ATE468347T1 true ATE468347T1 (de) 2010-06-15

Family

ID=37695147

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777999T ATE468347T1 (de) 2005-07-27 2006-07-26 Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)- benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters (sglt)

Country Status (10)

Country Link
US (1) US7851602B2 (de)
EP (1) EP1910390B1 (de)
JP (1) JP5128474B2 (de)
AR (1) AR054871A1 (de)
AT (1) ATE468347T1 (de)
CA (1) CA2616294A1 (de)
DE (1) DE602006014411D1 (de)
ES (1) ES2346347T3 (de)
TW (1) TW200733966A (de)
WO (1) WO2007014894A2 (de)

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TW200733966A (en) 2007-09-16
ES2346347T3 (es) 2010-10-14
EP1910390B1 (de) 2010-05-19
JP2009502873A (ja) 2009-01-29
AR054871A1 (es) 2007-07-25
EP1910390A2 (de) 2008-04-16
US7851602B2 (en) 2010-12-14
WO2007014894A2 (en) 2007-02-08
CA2616294A1 (en) 2007-02-08
US20070027092A1 (en) 2007-02-01
DE602006014411D1 (de) 2010-07-01
JP5128474B2 (ja) 2013-01-23

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