MX2012008626A - Composiciones y metodos para potenciar la actividad de proteasoma. - Google Patents

Composiciones y metodos para potenciar la actividad de proteasoma.

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Publication number
MX2012008626A
MX2012008626A MX2012008626A MX2012008626A MX2012008626A MX 2012008626 A MX2012008626 A MX 2012008626A MX 2012008626 A MX2012008626 A MX 2012008626A MX 2012008626 A MX2012008626 A MX 2012008626A MX 2012008626 A MX2012008626 A MX 2012008626A
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Mexico
Prior art keywords
proteasome
methods
compositions
proteasome activity
proteinopathies
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MX2012008626A
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English (en)
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MX336731B (es
Inventor
Randall W King
Daniel Finley
Min Jae Lee
Byung-Hoon Lee
Timothy C Gahman
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Harvard College
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Publication of MX2012008626A publication Critical patent/MX2012008626A/es
Publication of MX336731B publication Critical patent/MX336731B/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Se describen proteinopatías que resultan de la proteasoma que no actúa lo suficientemente eficiente para eliminar las proteínas dañinas y prevenir la formación de agregados patogénicos. Como se describe en la presente, la inhibición de deubiquitinasa asociada a la proteasoma Usp 14 resulta en la eficiencia de proteasoma incrementada. Por lo tanto la invención actual proporciona composiciones y métodos novedosos para la inhibición de Usp14, potenciamiento de actividad de proteasoma y el tratamiento de proteinopatías.
MX2012008626A 2010-01-28 2011-01-28 Composiciones y metodos para potenciar la actividad de proteasoma. MX336731B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33695910P 2010-01-28 2010-01-28
US37340410P 2010-08-13 2010-08-13
PCT/US2011/022929 WO2011094545A2 (en) 2010-01-28 2011-01-28 Compositions and methods for enhancing proteasome activity

Publications (2)

Publication Number Publication Date
MX2012008626A true MX2012008626A (es) 2012-08-15
MX336731B MX336731B (es) 2016-01-28

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MX2012008626A MX336731B (es) 2010-01-28 2011-01-28 Composiciones y metodos para potenciar la actividad de proteasoma.

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US (2) US20130045992A1 (es)
EP (1) EP2528911B1 (es)
JP (2) JP2013518129A (es)
KR (1) KR20120117905A (es)
CN (1) CN102844313B (es)
AU (1) AU2011210765A1 (es)
BR (1) BR112012018631A8 (es)
CA (1) CA2787785C (es)
MX (1) MX336731B (es)
RU (1) RU2012136451A (es)
SG (1) SG182662A1 (es)
WO (1) WO2011094545A2 (es)

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