MX2009002585A - Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc. - Google Patents
Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc.Info
- Publication number
- MX2009002585A MX2009002585A MX2009002585A MX2009002585A MX2009002585A MX 2009002585 A MX2009002585 A MX 2009002585A MX 2009002585 A MX2009002585 A MX 2009002585A MX 2009002585 A MX2009002585 A MX 2009002585A MX 2009002585 A MX2009002585 A MX 2009002585A
- Authority
- MX
- Mexico
- Prior art keywords
- binding moiety
- egfr inhibitors
- zinc binding
- inhibitors containing
- based egfr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención es concerniente con quinazolina que contiene derivados a base de porción de enlace de zinc que tienen propiedades mejoradas e inesperadas como inhibidores del receptor del factor de crecimiento epidérmico - tirosina cinasa (EGFR-TK) y su uso en el tratamiento de enfermedades relacionadas con EGFR-TK y alteraciones tales como cáncer. Los derivados pueden actuar además como inhibidores de HDAC.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84364406P | 2006-09-11 | 2006-09-11 | |
US89587307P | 2007-03-20 | 2007-03-20 | |
PCT/US2007/077977 WO2008033749A2 (en) | 2006-09-11 | 2007-09-10 | Quinazoline based egfr inhibitors containing a zinc binding moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009002585A true MX2009002585A (es) | 2009-08-24 |
Family
ID=39184477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009002585A MX2009002585A (es) | 2006-09-11 | 2007-09-10 | Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc. |
Country Status (13)
Country | Link |
---|---|
US (5) | US8604044B2 (es) |
EP (1) | EP2061773A4 (es) |
JP (1) | JP5580592B2 (es) |
KR (2) | KR101434164B1 (es) |
CN (1) | CN101535279B (es) |
AU (1) | AU2007296746B2 (es) |
BR (1) | BRPI0715016A2 (es) |
CA (1) | CA2662617C (es) |
IL (1) | IL197451A (es) |
MX (1) | MX2009002585A (es) |
SG (1) | SG174774A1 (es) |
TW (2) | TWI399204B (es) |
WO (1) | WO2008033749A2 (es) |
Families Citing this family (54)
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US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
US20080090233A1 (en) | 2004-05-27 | 2008-04-17 | The Regents Of The University Of Colorado | Methods for Prediction of Clinical Outcome to Epidermal Growth Factor Receptor Inhibitors by Cancer Patients |
US7547781B2 (en) * | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
EP2061469B8 (en) | 2006-09-11 | 2014-02-26 | Curis, Inc. | Quinazoline based egfr inhibitors |
US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
KR101434164B1 (ko) | 2006-09-11 | 2014-08-26 | 쿠리스 인코퍼레이션 | 아연 결합 부분을 함유한 퀴나졸린 계열 egfr 억제제 |
US8119616B2 (en) * | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
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KR100832594B1 (ko) * | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
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JP2010501572A (ja) | 2006-08-22 | 2010-01-21 | コンサート ファーマシューティカルズ インコーポレイテッド | 4−アミノキナゾリン誘導体およびその使用方法 |
US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
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EP2061469B8 (en) * | 2006-09-11 | 2014-02-26 | Curis, Inc. | Quinazoline based egfr inhibitors |
BRPI0718089A2 (pt) | 2006-10-28 | 2013-11-05 | Methylgene Inc | Composto, uso do composto, composição, e, métodos para inibir histona desacetilase e para tratar uma doença de expansão da poliglutamina |
TWI377944B (en) | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
US8119616B2 (en) | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
AU2008299896B2 (en) | 2007-09-10 | 2012-02-02 | Curis, Inc. | Tartrate salts or complexes of quinazoline based EGFR inhibitors containing a zinc binding moiety |
-
2007
- 2007-09-10 KR KR1020137002341A patent/KR101434164B1/ko not_active IP Right Cessation
- 2007-09-10 CN CN200780041896.6A patent/CN101535279B/zh not_active Expired - Fee Related
- 2007-09-10 CA CA2662617A patent/CA2662617C/en active Active
- 2007-09-10 AU AU2007296746A patent/AU2007296746B2/en not_active Ceased
- 2007-09-10 US US11/852,604 patent/US8604044B2/en not_active Expired - Fee Related
- 2007-09-10 KR KR1020097007433A patent/KR20090067169A/ko not_active Application Discontinuation
- 2007-09-10 JP JP2009527603A patent/JP5580592B2/ja not_active Expired - Fee Related
- 2007-09-10 WO PCT/US2007/077977 patent/WO2008033749A2/en active Application Filing
- 2007-09-10 MX MX2009002585A patent/MX2009002585A/es active IP Right Grant
- 2007-09-10 EP EP07842116A patent/EP2061773A4/en not_active Withdrawn
- 2007-09-10 BR BRPI0715016-4A patent/BRPI0715016A2/pt not_active IP Right Cessation
- 2007-09-10 SG SG2011063971A patent/SG174774A1/en unknown
- 2007-09-11 TW TW096133860A patent/TWI399204B/zh not_active IP Right Cessation
- 2007-09-11 TW TW096133859A patent/TWI495470B/zh not_active IP Right Cessation
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2009
- 2009-03-05 IL IL197451A patent/IL197451A/en not_active IP Right Cessation
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2011
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2012
- 2012-12-06 US US13/707,130 patent/US9108929B2/en not_active Expired - Fee Related
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2013
- 2013-11-25 US US14/088,804 patent/US9024024B2/en not_active Expired - Fee Related
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- 2015-04-15 US US14/687,174 patent/US20150284340A1/en not_active Abandoned
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TWI399204B (zh) | 2013-06-21 |
US20110295004A1 (en) | 2011-12-01 |
EP2061773A2 (en) | 2009-05-27 |
TW200829248A (en) | 2008-07-16 |
US20150284340A1 (en) | 2015-10-08 |
SG174774A1 (en) | 2011-10-28 |
JP2010502744A (ja) | 2010-01-28 |
US20080194578A1 (en) | 2008-08-14 |
US20140005391A1 (en) | 2014-01-02 |
TWI495470B (zh) | 2015-08-11 |
IL197451A0 (en) | 2009-12-24 |
KR20130028970A (ko) | 2013-03-20 |
JP5580592B2 (ja) | 2014-08-27 |
AU2007296746A1 (en) | 2008-03-20 |
WO2008033749A2 (en) | 2008-03-20 |
KR20090067169A (ko) | 2009-06-24 |
WO2008033749A3 (en) | 2008-12-04 |
KR101434164B1 (ko) | 2014-08-26 |
BRPI0715016A2 (pt) | 2013-05-28 |
CN101535279A (zh) | 2009-09-16 |
US8604044B2 (en) | 2013-12-10 |
TW200829249A (en) | 2008-07-16 |
US20140221403A1 (en) | 2014-08-07 |
CA2662617A1 (en) | 2008-03-20 |
CN101535279B (zh) | 2015-05-20 |
CA2662617C (en) | 2014-11-18 |
US9024024B2 (en) | 2015-05-05 |
US9108929B2 (en) | 2015-08-18 |
EP2061773A4 (en) | 2011-01-19 |
AU2007296746B2 (en) | 2012-07-05 |
US8349856B2 (en) | 2013-01-08 |
IL197451A (en) | 2015-08-31 |
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