RS54903B1 - Inhibitor fosfoinozitid 3 kinaze sa delom koji vezuje cink - Google Patents
Inhibitor fosfoinozitid 3 kinaze sa delom koji vezuje cinkInfo
- Publication number
- RS54903B1 RS54903B1 RS20160457A RSP20160457A RS54903B1 RS 54903 B1 RS54903 B1 RS 54903B1 RS 20160457 A RS20160457 A RS 20160457A RS P20160457 A RSP20160457 A RS P20160457A RS 54903 B1 RS54903 B1 RS 54903B1
- Authority
- RS
- Serbia
- Prior art keywords
- phosphoinositide
- kinase inhibitor
- binding moiety
- zinc binding
- zinc
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
Abstract
Jedinjenje prema Formuli I:i njihove farmaceutski prihvatljive soli, gde R je vodonik ili acil grupa.Prijava sadrži još 14 patentnih zahteva.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161470849P | 2011-04-01 | 2011-04-01 | |
US201161559489P | 2011-11-14 | 2011-11-14 | |
EP12764605.7A EP2694075B1 (en) | 2011-04-01 | 2012-03-30 | Phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
PCT/US2012/031361 WO2012135571A1 (en) | 2011-04-01 | 2012-03-30 | Phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
RS54903B1 true RS54903B1 (sr) | 2016-10-31 |
Family
ID=46931927
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP20190842 RS59219B1 (sr) | 2011-04-01 | 2012-03-30 | Inhibitor fosfoinozitid 3 kinaze sa delom koji vezuje cink |
RS20160457A RS54903B1 (sr) | 2011-04-01 | 2012-03-30 | Inhibitor fosfoinozitid 3 kinaze sa delom koji vezuje cink |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP20190842 RS59219B1 (sr) | 2011-04-01 | 2012-03-30 | Inhibitor fosfoinozitid 3 kinaze sa delom koji vezuje cink |
Country Status (30)
Country | Link |
---|---|
US (7) | US8710219B2 (sr) |
EP (2) | EP3111938B1 (sr) |
JP (3) | JP6242331B2 (sr) |
KR (2) | KR101902325B1 (sr) |
CN (2) | CN105461736B (sr) |
AU (1) | AU2012236367B2 (sr) |
BR (1) | BR112013025340B1 (sr) |
CA (1) | CA2830822C (sr) |
CL (1) | CL2013002823A1 (sr) |
CY (2) | CY1117785T1 (sr) |
DK (2) | DK2694075T3 (sr) |
EA (1) | EA022434B9 (sr) |
ES (2) | ES2577982T3 (sr) |
HK (1) | HK1194969A1 (sr) |
HR (2) | HRP20160545T1 (sr) |
HU (2) | HUE028910T2 (sr) |
IL (2) | IL228588A (sr) |
LT (1) | LT3111938T (sr) |
ME (2) | ME03523B (sr) |
MX (1) | MX340577B (sr) |
PE (1) | PE20141382A1 (sr) |
PL (2) | PL2694075T3 (sr) |
PT (2) | PT2694075T (sr) |
RS (2) | RS59219B1 (sr) |
SG (2) | SG10201602569RA (sr) |
SI (2) | SI2694075T1 (sr) |
SM (1) | SMT201600179B (sr) |
TW (1) | TWI571469B (sr) |
WO (1) | WO2012135571A1 (sr) |
ZA (2) | ZA201307082B (sr) |
Families Citing this family (10)
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PT2385832E (pt) * | 2009-01-08 | 2015-11-02 | Curis Inc | Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco |
LT3111938T (lt) * | 2011-04-01 | 2019-06-25 | Curis, Inc. | Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi |
HUE033032T2 (hu) | 2011-11-14 | 2017-11-28 | Ignyta Inc | Uracil-származékok mint AXL és c-MET kináz inhibitorok |
CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
CN107849045B (zh) | 2015-04-21 | 2019-12-24 | 贵州百灵企业集团制药股份有限公司 | 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途 |
AU2017301012B2 (en) * | 2016-07-19 | 2020-07-09 | National Institute Of Plant Genome Research | Novel protein against fungal pathogens |
EA201991069A1 (ru) * | 2016-11-02 | 2019-10-31 | Комбинированная терапия ингибитором фосфоинозитид-3-киназы и связывающим цинк агентом | |
AU2018360845B2 (en) * | 2017-11-06 | 2024-05-02 | Cold Spring Harbor Laboratory | Method and compositions for forming a copper-containing complex and uses thereof |
JP7467423B2 (ja) | 2018-09-11 | 2024-04-15 | キュリス,インコーポレイテッド | 亜鉛結合部分を有するホスホイノシチド3-キナーゼ阻害剤との併用療法 |
WO2023212574A1 (en) * | 2022-04-26 | 2023-11-02 | Olivia Szu Hsieh Lee Nakaya | Compositions and methods for modulating rhythmic activity of pacemaker cardiomyocytes |
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EA201991069A1 (ru) * | 2016-11-02 | 2019-10-31 | Комбинированная терапия ингибитором фосфоинозитид-3-киназы и связывающим цинк агентом |
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2012
- 2012-03-30 LT LTEP16166266.3T patent/LT3111938T/lt unknown
- 2012-03-30 SG SG10201602569RA patent/SG10201602569RA/en unknown
- 2012-03-30 PE PE2013002160A patent/PE20141382A1/es active IP Right Grant
- 2012-03-30 TW TW101111283A patent/TWI571469B/zh active
- 2012-03-30 PT PT127646057T patent/PT2694075T/pt unknown
- 2012-03-30 US US13/435,062 patent/US8710219B2/en active Active
- 2012-03-30 DK DK12764605.7T patent/DK2694075T3/en active
- 2012-03-30 CN CN201610034817.XA patent/CN105461736B/zh active Active
- 2012-03-30 BR BR112013025340-1A patent/BR112013025340B1/pt active IP Right Grant
- 2012-03-30 RS RSP20190842 patent/RS59219B1/sr unknown
- 2012-03-30 RS RS20160457A patent/RS54903B1/sr unknown
- 2012-03-30 MX MX2013011132A patent/MX340577B/es active IP Right Grant
- 2012-03-30 AU AU2012236367A patent/AU2012236367B2/en active Active
- 2012-03-30 SI SI201230597A patent/SI2694075T1/sl unknown
- 2012-03-30 SG SG2013070883A patent/SG193563A1/en unknown
- 2012-03-30 JP JP2014502821A patent/JP6242331B2/ja active Active
- 2012-03-30 PT PT16166266T patent/PT3111938T/pt unknown
- 2012-03-30 ME MEP-2019-179A patent/ME03523B/me unknown
- 2012-03-30 SI SI201231625T patent/SI3111938T1/sl unknown
- 2012-03-30 PL PL12764605.7T patent/PL2694075T3/pl unknown
- 2012-03-30 CN CN201280026400.9A patent/CN103582483B/zh active Active
- 2012-03-30 EP EP16166266.3A patent/EP3111938B1/en active Active
- 2012-03-30 DK DK16166266.3T patent/DK3111938T3/da active
- 2012-03-30 KR KR1020137028748A patent/KR101902325B1/ko active IP Right Grant
- 2012-03-30 WO PCT/US2012/031361 patent/WO2012135571A1/en active Application Filing
- 2012-03-30 CA CA2830822A patent/CA2830822C/en active Active
- 2012-03-30 ME MEP-2016-116A patent/ME02451B/me unknown
- 2012-03-30 EP EP12764605.7A patent/EP2694075B1/en active Active
- 2012-03-30 ES ES12764605.7T patent/ES2577982T3/es active Active
- 2012-03-30 HU HUE12764605A patent/HUE028910T2/en unknown
- 2012-03-30 PL PL16166266T patent/PL3111938T3/pl unknown
- 2012-03-30 EA EA201301114A patent/EA022434B9/ru unknown
- 2012-03-30 ES ES16166266T patent/ES2733128T3/es active Active
- 2012-03-30 KR KR1020187026847A patent/KR20180108848A/ko not_active Application Discontinuation
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2013
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- 2013-09-29 IL IL228588A patent/IL228588A/en active IP Right Grant
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2014
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2015
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2016
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2017
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2018
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2019
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2021
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