CY1121825T1 - Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου - Google Patents

Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου

Info

Publication number
CY1121825T1
CY1121825T1 CY20191100760T CY191100760T CY1121825T1 CY 1121825 T1 CY1121825 T1 CY 1121825T1 CY 20191100760 T CY20191100760 T CY 20191100760T CY 191100760 T CY191100760 T CY 191100760T CY 1121825 T1 CY1121825 T1 CY 1121825T1
Authority
CY
Cyprus
Prior art keywords
phosphoinositide
zinc
kinase inhibitor
binding module
kinase
Prior art date
Application number
CY20191100760T
Other languages
English (en)
Inventor
Cai Xiong
Haixiao Zhai
Chengjung Lai
Changgeng Qian
Rudi Bao
Original Assignee
Curis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis, Inc. filed Critical Curis, Inc.
Publication of CY1121825T1 publication Critical patent/CY1121825T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση παρέχει μια ένωση του Χημικού Τύπου I και μια μέθοδο για την παρασκευή της, φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις και τη χρήση τέτοιων ενώσεων στη θεραπευτική αντιμετώπιση σχετιζόμενων με φωσφοϊνοσιτιδίου 3-κινάση παθήσεων και διαταραχών όπως ο καρκίνος. Η τρέχουσα αίτηση αναφέρεται περαιτέρω στη θεραπευτική αντιμετώπιση σχετιζόμενων με ιστονική απακετυλάση διαταραχών και παθήσεων που σχετίζονται τόσο με ιστονική απακετυλάση όσο και με φωσφοϊνοσιτιδίου 3-κινάση.
CY20191100760T 2011-04-01 2019-07-17 Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου CY1121825T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161470849P 2011-04-01 2011-04-01
US201161559489P 2011-11-14 2011-11-14
EP12764605.7A EP2694075B1 (en) 2011-04-01 2012-03-30 Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
PCT/US2012/031361 WO2012135571A1 (en) 2011-04-01 2012-03-30 Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

Publications (1)

Publication Number Publication Date
CY1121825T1 true CY1121825T1 (el) 2020-07-31

Family

ID=46931927

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100683T CY1117785T1 (el) 2011-04-01 2016-07-14 Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου
CY20191100760T CY1121825T1 (el) 2011-04-01 2019-07-17 Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου

Family Applications Before (1)

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CY20161100683T CY1117785T1 (el) 2011-04-01 2016-07-14 Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου

Country Status (30)

Country Link
US (7) US8710219B2 (el)
EP (2) EP3111938B1 (el)
JP (3) JP6242331B2 (el)
KR (2) KR101902325B1 (el)
CN (2) CN103582483B (el)
AU (1) AU2012236367B2 (el)
BR (1) BR112013025340B1 (el)
CA (1) CA2830822C (el)
CL (1) CL2013002823A1 (el)
CY (2) CY1117785T1 (el)
DK (2) DK2694075T3 (el)
EA (1) EA022434B9 (el)
ES (2) ES2577982T3 (el)
HK (1) HK1194969A1 (el)
HR (2) HRP20160545T1 (el)
HU (2) HUE028910T2 (el)
IL (2) IL228588A (el)
LT (1) LT3111938T (el)
ME (2) ME03523B (el)
MX (1) MX340577B (el)
PE (1) PE20141382A1 (el)
PL (2) PL2694075T3 (el)
PT (2) PT3111938T (el)
RS (2) RS54903B1 (el)
SG (2) SG193563A1 (el)
SI (2) SI3111938T1 (el)
SM (1) SMT201600179B (el)
TW (1) TWI571469B (el)
WO (1) WO2012135571A1 (el)
ZA (2) ZA201307082B (el)

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US11135205B2 (en) 2021-10-05
KR20140023333A (ko) 2014-02-26
NZ615586A (en) 2015-02-27
BR112013025340B1 (pt) 2021-12-21
MX2013011132A (es) 2014-03-12
CL2013002823A1 (es) 2014-04-11
JP6275784B2 (ja) 2018-02-07
HRP20191091T1 (hr) 2019-09-20
EP2694075B1 (en) 2016-04-27
IL248597A0 (en) 2016-12-29
MX340577B (es) 2016-07-13
US9249156B2 (en) 2016-02-02
ZA201406167B (en) 2015-03-25
PL3111938T3 (pl) 2019-09-30
CN105461736B (zh) 2018-06-12
US20160185796A1 (en) 2016-06-30
RS54903B1 (sr) 2016-10-31
ES2577982T3 (es) 2016-07-19
US10111864B2 (en) 2018-10-30
KR20180108848A (ko) 2018-10-04
EP2694075A1 (en) 2014-02-12
SG10201602569RA (en) 2016-05-30
CN103582483B (zh) 2016-02-17
TWI571469B (zh) 2017-02-21
TW201247678A (en) 2012-12-01
JP2014509653A (ja) 2014-04-21
EP3111938B1 (en) 2019-05-08
IL228588A0 (en) 2013-12-31
EA022434B1 (ru) 2015-12-30
JP2016188255A (ja) 2016-11-04
CA2830822C (en) 2018-10-02
PT2694075T (pt) 2016-07-11
SI3111938T1 (sl) 2019-08-30
LT3111938T (lt) 2019-06-25
HRP20160545T1 (hr) 2016-06-17
CY1117785T1 (el) 2017-05-17
PT3111938T (pt) 2019-07-10
US20140243330A1 (en) 2014-08-28
DK3111938T3 (da) 2019-07-01
EA022434B9 (ru) 2016-02-29
US10543197B2 (en) 2020-01-28
CN105461736A (zh) 2016-04-06
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US20130090335A1 (en) 2013-04-11
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PL2694075T3 (pl) 2016-09-30
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AU2012236367A1 (en) 2013-04-18
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US20220168284A1 (en) 2022-06-02
PE20141382A1 (es) 2014-11-04
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