MX2007007380A - Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides. - Google Patents

Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.

Info

Publication number
MX2007007380A
MX2007007380A MX2007007380A MX2007007380A MX2007007380A MX 2007007380 A MX2007007380 A MX 2007007380A MX 2007007380 A MX2007007380 A MX 2007007380A MX 2007007380 A MX2007007380 A MX 2007007380A MX 2007007380 A MX2007007380 A MX 2007007380A
Authority
MX
Mexico
Prior art keywords
binding
amyloid plaques
stilbene derivatives
imaging amyloid
amyloid deposits
Prior art date
Application number
MX2007007380A
Other languages
English (en)
Spanish (es)
Inventor
Hank F Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2007007380A publication Critical patent/MX2007007380A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2007007380A 2004-12-17 2005-12-19 Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides. MX2007007380A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
PCT/US2005/045682 WO2006066104A2 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
MX2007007380A true MX2007007380A (es) 2007-10-11

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007380A MX2007007380A (es) 2004-12-17 2005-12-19 Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.

Country Status (25)

Country Link
US (2) US7807135B2 (OSRAM)
EP (3) EP2213652B1 (OSRAM)
JP (1) JP5128956B2 (OSRAM)
KR (1) KR101321619B1 (OSRAM)
AU (1) AU2005316421B2 (OSRAM)
BE (1) BE2015C015I2 (OSRAM)
BR (1) BRPI0516408B8 (OSRAM)
CA (1) CA2591534C (OSRAM)
DK (1) DK2213652T3 (OSRAM)
EA (1) EA012334B1 (OSRAM)
ES (1) ES2526655T3 (OSRAM)
FR (1) FR15C0012I2 (OSRAM)
HU (1) HUS1500014I1 (OSRAM)
IL (2) IL183946A (OSRAM)
LT (1) LTC2213652I2 (OSRAM)
LU (1) LU92647I2 (OSRAM)
MX (1) MX2007007380A (OSRAM)
NL (1) NL300719I2 (OSRAM)
NO (1) NO339195B1 (OSRAM)
NZ (1) NZ555942A (OSRAM)
PL (1) PL2213652T3 (OSRAM)
PT (1) PT2213652E (OSRAM)
SG (1) SG194363A1 (OSRAM)
SI (1) SI2213652T1 (OSRAM)
WO (1) WO2006066104A2 (OSRAM)

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EP1432453B1 (en) * 2001-08-27 2013-08-14 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
MX2007007380A (es) * 2004-12-17 2007-10-11 Univ Pennsylvania Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
EP1893245A4 (en) * 2005-06-24 2009-06-24 Univ Pennsylvania RADIOMARQUE PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS
JP5290954B2 (ja) 2006-03-30 2013-09-18 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
CA2699965A1 (en) * 2007-07-04 2009-01-08 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
ES2552764T3 (es) * 2007-10-15 2015-12-02 The Salk Institute For Biological Studies Métodos para el tratamiento de varias enfermedades y afecciones, y compuestos útiles para los mismos
EP2599763A1 (en) * 2008-02-14 2013-06-05 Siemens Molecular Imaging, Inc. Novel imaging agents for detecting neurological dysfunction
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
WO2009108606A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
JP2012508889A (ja) * 2008-11-13 2012-04-12 アビッド レディオファーマシューティカルズ、インク． 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法
KR20110106895A (ko) * 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
KR20110119670A (ko) * 2008-12-31 2011-11-02 애비드 라디오파마슈티컬스, 인크. 토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
KR20120034724A (ko) * 2009-07-10 2012-04-12 바이엘 파마 악티엔게젤샤프트 저압 내지 중간압 액체 크로마토그래피의 사용에 의한 방사성추적자의 정제
CN102762229B9 (zh) * 2009-12-23 2020-12-01 皮拉马影像股份公司 适用于用疏水pet试剂pet成像的配方
BR112012030935B1 (pt) * 2010-04-06 2020-11-17 Life Molecular Imaging Sa método para a produção de ligantes de beta-amiloide marcados com f-18
US20130217920A1 (en) * 2010-06-04 2013-08-22 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
SG185783A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
WO2012051170A2 (en) * 2010-10-12 2012-04-19 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives
EP3345545B1 (en) 2011-04-21 2021-10-20 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
HRP20181081T1 (hr) 2011-06-21 2018-09-21 Piramal Imaging Sa Formulacije fluoriranog stilbena pogodne za pet vizualizaciju
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
WO2013057199A1 (en) 2011-10-19 2013-04-25 Piramal Imaging Sa IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
US10568978B2 (en) 2012-04-10 2020-02-25 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
CN109790184B (zh) 2016-09-29 2021-06-29 韩国原子力研究院 姜黄素衍生物、其制备方法、以及用于检测β-淀粉样蛋白斑的包含该姜黄素衍生物的光声成像剂
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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DD234666A1 (de) 1984-11-01 1986-04-09 Univ Leipzig Verfahren zur herstellung von einfachen und substituierten 4-dimethylamino-alpha-halogenstilbenen
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MX2007007380A (es) * 2004-12-17 2007-10-11 Univ Pennsylvania Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
EP1893245A4 (en) * 2005-06-24 2009-06-24 Univ Pennsylvania RADIOMARQUE PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS

Also Published As

Publication number Publication date
IL206091A (en) 2013-08-29
EA200701299A1 (ru) 2007-12-28
KR101321619B1 (ko) 2013-10-30
FR15C0012I2 (fr) 2015-11-20
EP1838298A2 (en) 2007-10-03
EP2213652A1 (en) 2010-08-04
BRPI0516408A (pt) 2008-09-02
EP1838298A4 (en) 2009-03-04
PT2213652E (pt) 2015-01-02
KR20070093427A (ko) 2007-09-18
US20100266500A1 (en) 2010-10-21
EP2213652B1 (en) 2014-10-22
HUS1500014I1 (hu) 2016-11-28
EP1841465A4 (en) 2009-04-01
US7807135B2 (en) 2010-10-05
NZ555942A (en) 2011-01-28
WO2006066104A2 (en) 2006-06-22
BRPI0516408B1 (pt) 2021-03-23
IL183946A0 (en) 2007-10-31
US20060269473A1 (en) 2006-11-30
CA2591534A1 (en) 2006-06-22
CA2591534C (en) 2013-08-06
BRPI0516408B8 (pt) 2021-05-25
US8465726B2 (en) 2013-06-18
JP2008524243A (ja) 2008-07-10
NO339195B1 (no) 2016-11-14
JP5128956B2 (ja) 2013-01-23
AU2005316421A1 (en) 2006-06-22
EP1841465A2 (en) 2007-10-10
ES2526655T3 (es) 2015-01-14
NO20073650L (no) 2007-09-14
AU2005316421B2 (en) 2012-04-05
SG194363A1 (en) 2013-11-29
NL300719I1 (OSRAM) 2015-12-29
IL183946A (en) 2011-08-31
EA012334B1 (ru) 2009-08-28
NL300719I2 (OSRAM) 2015-12-29
FR15C0012I1 (OSRAM) 2015-03-20
LTC2213652I2 (lt) 2016-12-27
BE2015C015I2 (OSRAM) 2025-04-29
WO2006066104A3 (en) 2006-08-03
LU92647I2 (fr) 2015-11-03
PL2213652T3 (pl) 2015-04-30
DK2213652T3 (en) 2015-01-26
SI2213652T1 (sl) 2015-03-31

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