ES2526655T3 - Derivados de estilbeno y su uso para la unión y la visualización de placas amiloides - Google Patents

Derivados de estilbeno y su uso para la unión y la visualización de placas amiloides Download PDF

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Publication number
ES2526655T3
ES2526655T3 ES10161604.3T ES10161604T ES2526655T3 ES 2526655 T3 ES2526655 T3 ES 2526655T3 ES 10161604 T ES10161604 T ES 10161604T ES 2526655 T3 ES2526655 T3 ES 2526655T3
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ES
Spain
Prior art keywords
ethoxy
compound
phenyl
mmol
vinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10161604.3T
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English (en)
Spanish (es)
Inventor
Hank F. Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
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University of Pennsylvania Penn
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Publication of ES2526655T3 publication Critical patent/ES2526655T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10161604.3T 2004-12-17 2005-12-19 Derivados de estilbeno y su uso para la unión y la visualización de placas amiloides Expired - Lifetime ES2526655T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US636696P 2004-12-17
US68639505P 2005-06-02 2005-06-02
US686395P 2005-06-02

Publications (1)

Publication Number Publication Date
ES2526655T3 true ES2526655T3 (es) 2015-01-14

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10161604.3T Expired - Lifetime ES2526655T3 (es) 2004-12-17 2005-12-19 Derivados de estilbeno y su uso para la unión y la visualización de placas amiloides

Country Status (25)

Country Link
US (2) US7807135B2 (OSRAM)
EP (3) EP1838298A4 (OSRAM)
JP (1) JP5128956B2 (OSRAM)
KR (1) KR101321619B1 (OSRAM)
AU (1) AU2005316421B2 (OSRAM)
BE (1) BE2015C015I2 (OSRAM)
BR (1) BRPI0516408B8 (OSRAM)
CA (1) CA2591534C (OSRAM)
DK (1) DK2213652T3 (OSRAM)
EA (1) EA012334B1 (OSRAM)
ES (1) ES2526655T3 (OSRAM)
FR (1) FR15C0012I2 (OSRAM)
HU (1) HUS1500014I1 (OSRAM)
IL (2) IL183946A (OSRAM)
LT (1) LTC2213652I2 (OSRAM)
LU (1) LU92647I2 (OSRAM)
MX (1) MX2007007380A (OSRAM)
NL (1) NL300719I2 (OSRAM)
NO (1) NO339195B1 (OSRAM)
NZ (1) NZ555942A (OSRAM)
PL (1) PL2213652T3 (OSRAM)
PT (1) PT2213652E (OSRAM)
SG (1) SG194363A1 (OSRAM)
SI (1) SI2213652T1 (OSRAM)
WO (1) WO2006066104A2 (OSRAM)

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WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
EP1838298A4 (en) * 2004-12-17 2009-03-04 Univ Pennsylvania STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE
US20070031328A1 (en) * 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
JP5290954B2 (ja) 2006-03-30 2013-09-18 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
WO2009004914A1 (ja) * 2007-07-04 2009-01-08 Tohoku University フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
EP2772136B1 (en) * 2007-10-15 2015-09-09 The Salk Institute for Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
DK2247558T4 (da) * 2008-02-14 2024-07-29 Lilly Co Eli Nye billeddannelsesmidler til detektering af neurologisk dysfunktion
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
AU2009219406A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled A-beta binding compounds
US8557222B2 (en) * 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
US20100145194A1 (en) * 2008-11-13 2010-06-10 Avid Radiopharmaceuticals, Inc. Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases
KR20110106895A (ko) * 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
UA105914C2 (uk) * 2008-12-31 2014-07-10 Евід Рейдіофармасьютікалз, Інк. Синтез стирилпіридину, міченого радіоізотопом 18f, з тозилатного прекурсора та стабільна фармацевтична композиція на його основі
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
EP2451760A1 (en) * 2009-07-10 2012-05-16 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
EP2515948A1 (en) * 2009-12-23 2012-10-31 Piramal Imaging SA Formulations suitable for pet imaging with hydrophobic pet agents
CN103269724B (zh) 2010-06-04 2017-06-23 皮拉马影像股份公司 生产F‑18标记的β‑淀粉样蛋白配体的方法
WO2011151281A1 (en) 2010-06-04 2011-12-08 Bayer Pharma Aktiengesellschaft Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
US20130217920A1 (en) * 2010-06-04 2013-08-22 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
KR20140012732A (ko) 2011-04-21 2014-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 작용화된 자성 나노입자, 그리고 아밀로이드 침착물 및 신경섬유매듭의 영상화에서의 용도
SI2723394T1 (sl) * 2011-06-21 2018-10-30 Piramal Imaging Sa Formulacije fluoriranega stilbena, primerne za PET slikanje
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
IN2014MN00875A (OSRAM) 2011-10-19 2015-04-17 Piramal Imaging Sa
SG10201608370TA (en) 2012-04-10 2016-11-29 Lantheus Medical Imaging Inc Radiopharmaceutical synthesis methods
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
CN109790184B (zh) 2016-09-29 2021-06-29 韩国原子力研究院 姜黄素衍生物、其制备方法、以及用于检测β-淀粉样蛋白斑的包含该姜黄素衍生物的光声成像剂
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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EP1838298A4 (en) * 2004-12-17 2009-03-04 Univ Pennsylvania STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE
WO2006078384A2 (en) 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
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Also Published As

Publication number Publication date
PT2213652E (pt) 2015-01-02
AU2005316421A1 (en) 2006-06-22
PL2213652T3 (pl) 2015-04-30
EP1841465A2 (en) 2007-10-10
NZ555942A (en) 2011-01-28
DK2213652T3 (en) 2015-01-26
IL183946A (en) 2011-08-31
NL300719I1 (OSRAM) 2015-12-29
US8465726B2 (en) 2013-06-18
IL206091A (en) 2013-08-29
HUS1500014I1 (hu) 2016-11-28
FR15C0012I2 (fr) 2015-11-20
US7807135B2 (en) 2010-10-05
EP2213652B1 (en) 2014-10-22
BRPI0516408B1 (pt) 2021-03-23
JP5128956B2 (ja) 2013-01-23
NO339195B1 (no) 2016-11-14
EA200701299A1 (ru) 2007-12-28
BRPI0516408B8 (pt) 2021-05-25
JP2008524243A (ja) 2008-07-10
US20060269473A1 (en) 2006-11-30
SG194363A1 (en) 2013-11-29
KR101321619B1 (ko) 2013-10-30
LU92647I2 (fr) 2015-11-03
SI2213652T1 (sl) 2015-03-31
LTC2213652I2 (lt) 2016-12-27
WO2006066104A3 (en) 2006-08-03
AU2005316421B2 (en) 2012-04-05
EP1838298A4 (en) 2009-03-04
WO2006066104A2 (en) 2006-06-22
FR15C0012I1 (OSRAM) 2015-03-20
NO20073650L (no) 2007-09-14
KR20070093427A (ko) 2007-09-18
MX2007007380A (es) 2007-10-11
EP1841465A4 (en) 2009-04-01
CA2591534A1 (en) 2006-06-22
BRPI0516408A (pt) 2008-09-02
BE2015C015I2 (OSRAM) 2025-04-29
US20100266500A1 (en) 2010-10-21
CA2591534C (en) 2013-08-06
NL300719I2 (OSRAM) 2015-12-29
IL183946A0 (en) 2007-10-31
EP1838298A2 (en) 2007-10-03
EA012334B1 (ru) 2009-08-28
EP2213652A1 (en) 2010-08-04

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