SI2213652T1 - Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov - Google Patents

Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov

Info

Publication number
SI2213652T1
SI2213652T1 SI200531929T SI200531929T SI2213652T1 SI 2213652 T1 SI2213652 T1 SI 2213652T1 SI 200531929 T SI200531929 T SI 200531929T SI 200531929 T SI200531929 T SI 200531929T SI 2213652 T1 SI2213652 T1 SI 2213652T1
Authority
SI
Slovenia
Prior art keywords
binding
amyloid plaques
stilbene derivatives
imaging amyloid
imaging
Prior art date
Application number
SI200531929T
Other languages
English (en)
Slovenian (sl)
Inventor
Hank F. Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of SI2213652T1 publication Critical patent/SI2213652T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200531929T 2004-12-17 2005-12-19 Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov SI2213652T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
EP10161604.3A EP2213652B1 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
SI2213652T1 true SI2213652T1 (sl) 2015-03-31

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531929T SI2213652T1 (sl) 2004-12-17 2005-12-19 Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov

Country Status (25)

Country Link
US (2) US7807135B2 (OSRAM)
EP (3) EP2213652B1 (OSRAM)
JP (1) JP5128956B2 (OSRAM)
KR (1) KR101321619B1 (OSRAM)
AU (1) AU2005316421B2 (OSRAM)
BE (1) BE2015C015I2 (OSRAM)
BR (1) BRPI0516408B8 (OSRAM)
CA (1) CA2591534C (OSRAM)
DK (1) DK2213652T3 (OSRAM)
EA (1) EA012334B1 (OSRAM)
ES (1) ES2526655T3 (OSRAM)
FR (1) FR15C0012I2 (OSRAM)
HU (1) HUS1500014I1 (OSRAM)
IL (2) IL183946A (OSRAM)
LT (1) LTC2213652I2 (OSRAM)
LU (1) LU92647I2 (OSRAM)
MX (1) MX2007007380A (OSRAM)
NL (1) NL300719I2 (OSRAM)
NO (1) NO339195B1 (OSRAM)
NZ (1) NZ555942A (OSRAM)
PL (1) PL2213652T3 (OSRAM)
PT (1) PT2213652E (OSRAM)
SG (1) SG194363A1 (OSRAM)
SI (1) SI2213652T1 (OSRAM)
WO (1) WO2006066104A2 (OSRAM)

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CA2456411C (en) * 2001-08-27 2011-02-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
BRPI0516408B8 (pt) * 2004-12-17 2021-05-25 Univ Pennsylvania derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化
JP5290954B2 (ja) * 2006-03-30 2013-09-18 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
WO2009004914A1 (ja) * 2007-07-04 2009-01-08 Tohoku University フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
US8779002B2 (en) * 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
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HRP20220401T4 (hr) * 2008-02-14 2024-09-27 Eli Lilly And Company Nova vizualizacijska sredstva za detektiranje neurološke disfunkcije
US20100331676A1 (en) * 2008-02-27 2010-12-30 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
US8557222B2 (en) 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
JP2012508889A (ja) * 2008-11-13 2012-04-12 アビッド レディオファーマシューティカルズ、インク． 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法
EP2379757A2 (en) 2008-12-22 2011-10-26 Bayer Pharma Aktiengesellschaft A method for the synthesis of a radionuclide-labeled compound
MY162312A (en) * 2008-12-31 2017-05-31 Avid Radiopharmaceuticals Inc Synthesis of 18f-radiolabeled styrylpyridines from tosylate precersors and stable pharmaceutical compositions thereof
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
WO2011003591A1 (en) 2009-07-10 2011-01-13 Bayer Schering Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
EP2515948A1 (en) 2009-12-23 2012-10-31 Piramal Imaging SA Formulations suitable for pet imaging with hydrophobic pet agents
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
EP2579902B2 (en) * 2010-06-04 2019-08-14 Piramal Imaging SA Method for production of f-18 labeled amyloid beta ligands
CA2801534A1 (en) * 2010-06-04 2011-12-08 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligand
KR20130088118A (ko) 2010-06-04 2013-08-07 피라말 이미징 에스에이 Ｆ-18 표지된 아밀로이드 베타 리간드의 제조 방법
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
KR20140012732A (ko) * 2011-04-21 2014-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 작용화된 자성 나노입자, 그리고 아밀로이드 침착물 및 신경섬유매듭의 영상화에서의 용도
WO2012175641A1 (en) 2011-06-21 2012-12-27 Piramal Imaging Sa Formulations of fluorinated stilbene suitable for pet imaging
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
CA2852840A1 (en) 2011-10-19 2013-04-25 Piramal Imaging Sa Improved method for production of f-18 labeled a.beta. ligands
CN109125745B (zh) 2012-04-10 2022-07-26 蓝瑟斯医学影像公司 放射性药物合成方法
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
US10675365B2 (en) 2016-09-29 2020-06-09 Korea Atomic Energy Research Institute Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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BRPI0516408B8 (pt) * 2004-12-17 2021-05-25 Univ Pennsylvania derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化

Also Published As

Publication number Publication date
EP2213652B1 (en) 2014-10-22
ES2526655T3 (es) 2015-01-14
DK2213652T3 (en) 2015-01-26
EA200701299A1 (ru) 2007-12-28
US7807135B2 (en) 2010-10-05
BRPI0516408B8 (pt) 2021-05-25
NO339195B1 (no) 2016-11-14
NO20073650L (no) 2007-09-14
PL2213652T3 (pl) 2015-04-30
MX2007007380A (es) 2007-10-11
EP1838298A4 (en) 2009-03-04
IL183946A0 (en) 2007-10-31
US20100266500A1 (en) 2010-10-21
SG194363A1 (en) 2013-11-29
AU2005316421A1 (en) 2006-06-22
CA2591534A1 (en) 2006-06-22
BE2015C015I2 (OSRAM) 2025-04-29
BRPI0516408A (pt) 2008-09-02
EP1841465A4 (en) 2009-04-01
FR15C0012I2 (fr) 2015-11-20
PT2213652E (pt) 2015-01-02
IL183946A (en) 2011-08-31
NL300719I1 (OSRAM) 2015-12-29
WO2006066104A2 (en) 2006-06-22
KR101321619B1 (ko) 2013-10-30
LU92647I2 (fr) 2015-11-03
NL300719I2 (OSRAM) 2015-12-29
JP5128956B2 (ja) 2013-01-23
US20060269473A1 (en) 2006-11-30
NZ555942A (en) 2011-01-28
HUS1500014I1 (hu) 2016-11-28
EP1838298A2 (en) 2007-10-03
EP1841465A2 (en) 2007-10-10
AU2005316421B2 (en) 2012-04-05
IL206091A (en) 2013-08-29
BRPI0516408B1 (pt) 2021-03-23
US8465726B2 (en) 2013-06-18
FR15C0012I1 (OSRAM) 2015-03-20
WO2006066104A3 (en) 2006-08-03
EA012334B1 (ru) 2009-08-28
CA2591534C (en) 2013-08-06
EP2213652A1 (en) 2010-08-04
KR20070093427A (ko) 2007-09-18
JP2008524243A (ja) 2008-07-10
LTC2213652I2 (lt) 2016-12-27

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