MX2009006075A - Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes. - Google Patents

Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes.

Info

Publication number
MX2009006075A
MX2009006075A MX2009006075A MX2009006075A MX2009006075A MX 2009006075 A MX2009006075 A MX 2009006075A MX 2009006075 A MX2009006075 A MX 2009006075A MX 2009006075 A MX2009006075 A MX 2009006075A MX 2009006075 A MX2009006075 A MX 2009006075A
Authority
MX
Mexico
Prior art keywords
binding
amyloid plaques
methods
imaging amyloid
acetylene derivatives
Prior art date
Application number
MX2009006075A
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Original Assignee
Trustees Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Univ Pennsylvania filed Critical Trustees Univ Pennsylvania
Publication of MX2009006075A publication Critical patent/MX2009006075A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/34—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having amino groups and esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se relaciona con compuestos radiomarcados y su uso en métodos para el diagnóstico por imágenes de depósitos amiloides, y método para su fabricación. La invención se relaciona también con compuestos para inhibir la agregación de las proteínas amiloides que forman los depósitos amiloides, métodos para administrar agentes terapéuticos en depósitos amiloides y métodos para preparar compuestos que inhiben la agregación de proteínas amiloides.
MX2009006075A 2006-12-07 2007-12-07 Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes. MX2009006075A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87324906P 2006-12-07 2006-12-07
US11/951,612 US7678819B2 (en) 2006-12-07 2007-12-06 Acetylene derivatives and their use for binding and imaging amyloid plaques
PCT/US2007/025177 WO2008073350A2 (en) 2006-12-07 2007-12-07 Acetylene derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
MX2009006075A true MX2009006075A (es) 2009-06-30

Family

ID=39512287

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006075A MX2009006075A (es) 2006-12-07 2007-12-07 Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes.

Country Status (16)

Country Link
US (1) US7678819B2 (es)
EP (1) EP2089110A2 (es)
JP (1) JP2010512325A (es)
KR (1) KR20090090370A (es)
AU (1) AU2007332818A1 (es)
BR (1) BRPI0720590A2 (es)
CA (1) CA2672187A1 (es)
CO (1) CO6190627A2 (es)
CR (1) CR10842A (es)
EA (1) EA200970551A1 (es)
IL (1) IL199201A (es)
MX (1) MX2009006075A (es)
NO (1) NO20092567L (es)
NZ (1) NZ577458A (es)
SV (1) SV2009003289A (es)
WO (1) WO2008073350A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
US8318132B2 (en) 2008-02-14 2012-11-27 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological dysfunction
EP2323697A2 (en) 2008-07-24 2011-05-25 Siemens Medical Solutions USA, Inc. Imaging agents useful for identifying ad pathology
CN102186504B (zh) * 2008-09-18 2018-04-06 西塞医疗中心 用于检测阿尔兹海默病的光学方法
CN103739605B (zh) * 2009-03-23 2016-08-17 伊莱利利公司 用于检测神经障碍的显像剂
US8691187B2 (en) * 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
WO2014097474A1 (ja) * 2012-12-21 2014-06-26 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
US9895324B2 (en) 2014-03-26 2018-02-20 University Of Kentucky Research Foundation Halogenated diarylacetylenes and methods of treating cancer
MY191791A (en) 2015-04-08 2022-07-15 Biomendics Llc Formulation and process for modulating wound healing
WO2020032080A1 (ja) 2018-08-07 2020-02-13 学校法人慶應義塾 化合物、化合物の塩、神経機能調節物質、神経機能調節物質の評価方法、化合物の製造方法、及び化合物の塩の製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4111990B4 (de) * 1990-04-19 2005-06-02 Merck Patent Gmbh Di- und Trifluortolane
JPH07324045A (ja) * 1994-05-27 1995-12-12 Seimi Chem Co Ltd トラン誘導体化合物およびそれを含有する液晶組成物
JPH0812599A (ja) * 1994-06-27 1996-01-16 Sumitomo Chem Co Ltd トラン化合物の製造法
JP2001089407A (ja) 1999-09-24 2001-04-03 Fuji Photo Film Co Ltd ジフェニルアセチレン化合物及び該化合物の製造方法
AU2001288250A1 (en) * 2000-08-15 2002-02-25 Kent State University Methods for treating subjects infected with a herpes virus or neisseria gonorrheae
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
CN100338506C (zh) * 2002-01-21 2007-09-19 石家庄永生华清液晶有限公司 多稳态液晶材料显示器及其制备方法
AU2003302117A1 (en) * 2002-02-01 2004-06-15 William Marsh Rice University Method of making a molecule-surface interface
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
US7022703B2 (en) * 2003-07-24 2006-04-04 Janssen Pharmaceutica, N.V. Acetylenic compound useful in treating inflammatory disorders
DE602005017129D1 (de) 2004-03-22 2009-11-26 Lilly Co Eli Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten
JP4868493B2 (ja) * 2004-08-13 2012-02-01 独立行政法人産業技術総合研究所 ヘテロ環アゾ化合物による光応答性材料とそれを用いた光情報記録媒体
JP2006089485A (ja) * 2004-08-24 2006-04-06 Santen Pharmaceut Co Ltd ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
WO2006113458A1 (en) * 2005-04-15 2006-10-26 Bristol-Myers Squibb Company Heterocyclic inhibitors of protein arginine methyl transferases
US20090306115A1 (en) 2005-04-22 2009-12-10 Cosford Nicholas D Phenyl ethyne compounds

Also Published As

Publication number Publication date
SV2009003289A (es) 2009-10-02
CR10842A (es) 2009-10-13
CO6190627A2 (es) 2010-08-19
EP2089110A2 (en) 2009-08-19
NO20092567L (no) 2009-09-04
WO2008073350A3 (en) 2008-08-14
EA200970551A1 (ru) 2009-12-30
WO2008073350A2 (en) 2008-06-19
JP2010512325A (ja) 2010-04-22
KR20090090370A (ko) 2009-08-25
IL199201A (en) 2013-05-30
US7678819B2 (en) 2010-03-16
US20080166299A1 (en) 2008-07-10
BRPI0720590A2 (pt) 2014-04-08
AU2007332818A1 (en) 2008-06-19
CA2672187A1 (en) 2008-06-19
NZ577458A (en) 2012-01-12

Similar Documents

Publication Publication Date Title
MX2009006075A (es) Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes.
MX2007007380A (es) Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.
HUS1300028I1 (hu) Sztiril-piridin-származékok és alkalmazásuk amyloid-plakkok megkötésére és leképezésére
MX2009008253A (es) Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
MX2009011810A (es) Tiazoles y pirazoles utiles como inhibidores de cinasa.
MX2009009592A (es) Aminopiridinas utiles como inhibidores de proteinas cinasas.
HK1123282A1 (en) Oxygen linked pyrimidine derivatives
MX2009012719A (es) Tiazoles y pirazoles utiles como inhibidores de cinasa.
IL200793A0 (en) Aminopyrimidines, compositions comprising the same and use thereof for inhibiting protein kinases
MX2009006345A (es) Compuestos utiles como inhibidores de proteina cinasa.
MX2010003865A (es) Aril amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
MX2010003864A (es) Amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
MY148253A (en) Azaadamantane derivatives and methods of use
WO2006078384A3 (en) Stilbene derivatives and their use
UA93709C2 (ru) 12-имидазолил-1-додеканол и его применение b изготовлении фармацевтических композиций
ZA201003352B (en) Heterocyclic derivatives as modulators of ion channels
MX2010003563A (es) Inhibidores de proteina cinasa de c-met.
MX2009005231A (es) Composiciones utiles como inhibidores de proteina cinasa.
MX2015005734A (es) Metodos de tratamiento de enfermedades hepaticas.
MX2009013126A (es) Nuevos compuestos 892.
UA91996C2 (ru) Производные стильбена и их применение для связывания и визуализации амилоидных бляшек
WO2010135493A3 (en) Alzheimer's disease imaging agents

Legal Events

Date Code Title Description
FG Grant or registration