MX2007001683A - Inhibidores de la replicacion del virus de la hepatitis c (vhc). - Google Patents
Inhibidores de la replicacion del virus de la hepatitis c (vhc).Info
- Publication number
- MX2007001683A MX2007001683A MX2007001683A MX2007001683A MX2007001683A MX 2007001683 A MX2007001683 A MX 2007001683A MX 2007001683 A MX2007001683 A MX 2007001683A MX 2007001683 A MX2007001683 A MX 2007001683A MX 2007001683 A MX2007001683 A MX 2007001683A
- Authority
- MX
- Mexico
- Prior art keywords
- mmol
- hcv
- alkyl
- compound
- cyclohexyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title description 4
- 230000010076 replication Effects 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 299
- 239000000203 mixture Substances 0.000 claims abstract description 231
- 238000000034 method Methods 0.000 claims abstract description 86
- 230000000694 effects Effects 0.000 claims abstract description 47
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- 125000000217 alkyl group Chemical group 0.000 claims description 90
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- 150000003839 salts Chemical class 0.000 claims description 60
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 45
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 39
- 239000001257 hydrogen Substances 0.000 claims description 39
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 37
- 125000003118 aryl group Chemical group 0.000 claims description 33
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- 125000001424 substituent group Chemical group 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 25
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 24
- 125000003545 alkoxy group Chemical group 0.000 claims description 23
- 125000003282 alkyl amino group Chemical group 0.000 claims description 21
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 20
- 125000005842 heteroatom Chemical group 0.000 claims description 20
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 19
- 229910052760 oxygen Inorganic materials 0.000 claims description 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 18
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 15
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 13
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- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 8
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- 125000005080 alkoxycarbonylalkenyl group Chemical group 0.000 claims description 6
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- 238000011161 development Methods 0.000 claims description 6
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- 125000002541 furyl group Chemical group 0.000 claims description 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 5
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims description 4
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 4
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- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
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- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 3
- 125000004104 aryloxy group Chemical group 0.000 claims description 3
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- 241000711549 Hepacivirus C Species 0.000 abstract description 73
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- 239000000243 solution Substances 0.000 description 260
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- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- IHQAEFJMAYTYRJ-UHFFFAOYSA-N methyl 1-(2-amino-2-oxoethyl)-2-(3-bromopyridin-2-yl)-3-cyclohexylindole-6-carboxylate Chemical compound N=1C=CC=C(Br)C=1C=1N(CC(N)=O)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 IHQAEFJMAYTYRJ-UHFFFAOYSA-N 0.000 description 1
- WFCFSRMOAWICHJ-UHFFFAOYSA-N methyl 1-[(2-bromophenyl)methyl]-3-cyclohexylindole-6-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2C(C2CCCCC2)=CN1CC1=CC=CC=C1Br WFCFSRMOAWICHJ-UHFFFAOYSA-N 0.000 description 1
- YCEZYRPSIQHMAZ-UHFFFAOYSA-N methyl 1-[2-(2-bromopyridin-3-yl)oxyethyl]-3-cyclohexylindole-6-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2C(C2CCCCC2)=CN1CCOC1=CC=CN=C1Br YCEZYRPSIQHMAZ-UHFFFAOYSA-N 0.000 description 1
- NGSYUWDXTLMGQV-UHFFFAOYSA-N methyl 1-[3-(2-bromophenyl)propyl]-3-cyclohexylindole-6-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2C(C2CCCCC2)=CN1CCCC1=CC=CC=C1Br NGSYUWDXTLMGQV-UHFFFAOYSA-N 0.000 description 1
- MRCXSYNMVGRCHP-UHFFFAOYSA-N methyl 13-cyclohexyl-6-(morpholine-4-carbonyl)-5h-indolo[2,1-a][2]benzazepine-10-carboxylate Chemical compound C=12C3=CC=CC=C3CC(C(=O)N3CCOCC3)=CN2C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 MRCXSYNMVGRCHP-UHFFFAOYSA-N 0.000 description 1
- LPUDZWZEQKEDJE-UHFFFAOYSA-N methyl 13-cyclohexyl-6-oxo-5,7-dihydroindolo[1,2-d][1,4]benzodiazepine-10-carboxylate Chemical compound C=12C3=CC=CC=C3NC(=O)CN2C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 LPUDZWZEQKEDJE-UHFFFAOYSA-N 0.000 description 1
- AYYOZKHMSABVRP-UHFFFAOYSA-N methyl 1h-indole-6-carboxylate Chemical compound COC(=O)C1=CC=C2C=CNC2=C1 AYYOZKHMSABVRP-UHFFFAOYSA-N 0.000 description 1
- DFMAFKYWBPKAPP-UHFFFAOYSA-N methyl 2-(3-bromopyridin-2-yl)-3-cyclohexyl-1h-indole-6-carboxylate Chemical compound N=1C=CC=C(Br)C=1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 DFMAFKYWBPKAPP-UHFFFAOYSA-N 0.000 description 1
- CFTUQSLVERGMHL-UHFFFAOYSA-N methyl 2-(bromomethyl)prop-2-enoate Chemical compound COC(=O)C(=C)CBr CFTUQSLVERGMHL-UHFFFAOYSA-N 0.000 description 1
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 1
- CREXRYSSRHNKIH-UHFFFAOYSA-N methyl 2-bromo-3-cyclohexyl-1-(2-ethoxy-2-oxoethyl)indole-6-carboxylate Chemical compound C12=CC=C(C(=O)OC)C=C2N(CC(=O)OCC)C(Br)=C1C1CCCCC1 CREXRYSSRHNKIH-UHFFFAOYSA-N 0.000 description 1
- RPSJUPMRMXVLJI-UHFFFAOYSA-N methyl 2-bromo-3-cyclohexyl-1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]indole-6-carboxylate Chemical compound BrC=1N(CC(=O)OC(C)(C)C)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 RPSJUPMRMXVLJI-UHFFFAOYSA-N 0.000 description 1
- VARFHAHNEKOSCR-UHFFFAOYSA-N methyl 3-cyclohexyl-1-(2-hydroxyethyl)indole-6-carboxylate Chemical compound C=1N(CCO)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 VARFHAHNEKOSCR-UHFFFAOYSA-N 0.000 description 1
- QESCQTRNDBLZIL-UHFFFAOYSA-N methyl 3-cyclohexyl-1-(2-phenylmethoxyethyl)-2-(2-phenylmethoxypyridin-3-yl)indole-6-carboxylate Chemical compound C=1C=CN=C(OCC=2C=CC=CC=2)C=1C=1N(CCOCC=2C=CC=CC=2)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 QESCQTRNDBLZIL-UHFFFAOYSA-N 0.000 description 1
- XYFYQLXKZAPJCA-UHFFFAOYSA-N methyl 3-cyclohexyl-1-(2-phenylmethoxyethyl)indole-6-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2C(C2CCCCC2)=CN1CCOCC1=CC=CC=C1 XYFYQLXKZAPJCA-UHFFFAOYSA-N 0.000 description 1
- RYRNTDXBRZOSMQ-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(2-ethenyl-4-phenylmethoxyphenyl)-1h-indole-6-carboxylate Chemical compound C=1C=C(OCC=2C=CC=CC=2)C=C(C=C)C=1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 RYRNTDXBRZOSMQ-UHFFFAOYSA-N 0.000 description 1
- SKKQLURWDQITCV-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(2-ethenylphenyl)-1-prop-2-enylindole-6-carboxylate Chemical compound C=1C=CC=C(C=C)C=1C=1N(CC=C)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 SKKQLURWDQITCV-UHFFFAOYSA-N 0.000 description 1
- VNSQSNZYEWTQQU-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(2-ethenylpyridin-3-yl)-1h-indole-6-carboxylate Chemical compound C=1C=CN=C(C=C)C=1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 VNSQSNZYEWTQQU-UHFFFAOYSA-N 0.000 description 1
- NYMZDSLDPNXYHI-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(2-formylfuran-3-yl)-1h-indole-6-carboxylate Chemical compound C1=COC(C=O)=C1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 NYMZDSLDPNXYHI-UHFFFAOYSA-N 0.000 description 1
- YYRKDUZWMBHTAY-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1h-indole-6-carboxylate Chemical compound C=1C=CC=C(O)C=1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 YYRKDUZWMBHTAY-UHFFFAOYSA-N 0.000 description 1
- JMQNBDPDMRVMRP-UHFFFAOYSA-N methyl 3-cyclohexyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-6-carboxylate Chemical compound O1C(C)(C)C(C)(C)OB1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 JMQNBDPDMRVMRP-UHFFFAOYSA-N 0.000 description 1
- FRSNMANVEIOEQU-UHFFFAOYSA-N methyl 3-cyclohexyl-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]-1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]indole-6-carboxylate Chemical compound C=1C=CC=C(NC(=O)OC(C)(C)C)C=1C=1N(CC(=O)OC(C)(C)C)C2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 FRSNMANVEIOEQU-UHFFFAOYSA-N 0.000 description 1
- HQMJCEPQKMMYSX-UHFFFAOYSA-N methyl 3-cyclohexyl-2-[4,5-dibromo-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-1H-indole-6-carboxylate Chemical compound N=1C(Br)=C(Br)N(COCC[Si](C)(C)C)C=1C=1NC2=CC(C(=O)OC)=CC=C2C=1C1CCCCC1 HQMJCEPQKMMYSX-UHFFFAOYSA-N 0.000 description 1
- CVXXHXPNTZBZEL-UHFFFAOYSA-N methyl 4-carbonochloridoylbenzoate Chemical compound COC(=O)C1=CC=C(C(Cl)=O)C=C1 CVXXHXPNTZBZEL-UHFFFAOYSA-N 0.000 description 1
- RAVVJKCSZXAIQP-UHFFFAOYSA-N methyl 5-bromopentanoate Chemical compound COC(=O)CCCCBr RAVVJKCSZXAIQP-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
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- 210000004897 n-terminal region Anatomy 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
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- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
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- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 1
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- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical compound NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 description 1
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
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- 235000011007 phosphoric acid Nutrition 0.000 description 1
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- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
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- RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 description 1
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- 238000005498 polishing Methods 0.000 description 1
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- 229920001610 polycaprolactone Polymers 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003140 primary amides Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
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- 230000000750 progressive effect Effects 0.000 description 1
- SJMCLWCCNYAWRQ-UHFFFAOYSA-N propane-2-sulfonamide Chemical compound CC(C)S(N)(=O)=O SJMCLWCCNYAWRQ-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- JQRYUMGHOUYJFW-UHFFFAOYSA-N pyridine;trihydrobromide Chemical compound [Br-].[Br-].[Br-].C1=CC=[NH+]C=C1.C1=CC=[NH+]C=C1.C1=CC=[NH+]C=C1 JQRYUMGHOUYJFW-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000003161 ribonuclease inhibitor Substances 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 229940005550 sodium alginate Drugs 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- QKSQWQOAUQFORH-UHFFFAOYSA-N tert-butyl n-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate Chemical compound CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C QKSQWQOAUQFORH-UHFFFAOYSA-N 0.000 description 1
- ZZALFEVNLNLHTF-UHFFFAOYSA-N tert-butyl n-pyrrolidin-1-ylsulfonylcarbamate Chemical compound CC(C)(C)OC(=O)NS(=O)(=O)N1CCCC1 ZZALFEVNLNLHTF-UHFFFAOYSA-N 0.000 description 1
- WPCQASPMIALUEE-UHFFFAOYSA-N tert-butyl n-sulfamoylcarbamate Chemical compound CC(C)(C)OC(=O)NS(N)(=O)=O WPCQASPMIALUEE-UHFFFAOYSA-N 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 238000011285 therapeutic regimen Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003556 thioamides Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
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- 238000000844 transformation Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 229940066528 trichloroacetate Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 150000008648 triflates Chemical class 0.000 description 1
- PWLROCHXTREGKR-UHFFFAOYSA-N trimethyl-[2-[(2,4,5-tribromoimidazol-1-yl)methoxy]ethyl]silane Chemical compound C[Si](C)(C)CCOCN1C(Br)=NC(Br)=C1Br PWLROCHXTREGKR-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
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- 210000000605 viral structure Anatomy 0.000 description 1
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- 239000008215 water for injection Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
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Applications Claiming Priority (4)
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| US60893204P | 2004-08-09 | 2004-08-09 | |
| US66055505P | 2005-03-11 | 2005-03-11 | |
| US11/181,639 US7153848B2 (en) | 2004-08-09 | 2005-07-14 | Inhibitors of HCV replication |
| PCT/US2005/025234 WO2006020082A1 (en) | 2004-08-09 | 2005-07-15 | Inhibitors of hcv replication |
Publications (1)
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| MX2007001683A true MX2007001683A (es) | 2007-04-12 |
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| MX2007001683A MX2007001683A (es) | 2004-08-09 | 2005-07-15 | Inhibidores de la replicacion del virus de la hepatitis c (vhc). |
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| EP (1) | EP1776368A1 (enExample) |
| JP (1) | JP2008509218A (enExample) |
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| BR (1) | BRPI0514176A (enExample) |
| CA (1) | CA2576421A1 (enExample) |
| IL (1) | IL180738A0 (enExample) |
| MX (1) | MX2007001683A (enExample) |
| NO (1) | NO20070751L (enExample) |
| WO (1) | WO2006020082A1 (enExample) |
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- 2005-07-15 BR BRPI0514176-1A patent/BRPI0514176A/pt not_active IP Right Cessation
- 2005-07-15 KR KR1020077003052A patent/KR20070049635A/ko not_active Withdrawn
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- 2005-07-15 CA CA002576421A patent/CA2576421A1/en not_active Abandoned
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2007
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| US20060046983A1 (en) | 2006-03-02 |
| AU2005274959A1 (en) | 2006-02-23 |
| BRPI0514176A (pt) | 2008-06-03 |
| US7153848B2 (en) | 2006-12-26 |
| NO20070751L (no) | 2007-05-07 |
| WO2006020082A1 (en) | 2006-02-23 |
| JP2008509218A (ja) | 2008-03-27 |
| EP1776368A1 (en) | 2007-04-25 |
| CA2576421A1 (en) | 2006-02-23 |
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