MEP51308A - Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže - Google Patents
Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadržeInfo
- Publication number
- MEP51308A MEP51308A MEP-513/08A MEP51308A MEP51308A ME P51308 A MEP51308 A ME P51308A ME P51308 A MEP51308 A ME P51308A ME P51308 A MEP51308 A ME P51308A
- Authority
- ME
- Montenegro
- Prior art keywords
- tiotropium salts
- pharmaceutical formulations
- same
- producing
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pronalazak se odnosi na postupak za dobijanje novih soli titropijuma, na ove nove soli titropijuma kao takve, zatim na farmaceutske formulacije koje ih sadrže, kao i na njihovu primjenu za pripremanje lijeka za liječenje bolesti disajnih puteva, a naročito COPD (chronici obstructive pulmonary disease = hronična obstruktivna bolest pluća) i astme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025075 | 2003-11-03 | ||
PCT/EP2004/012268 WO2005042526A1 (de) | 2003-11-03 | 2004-10-29 | Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend |
Publications (2)
Publication Number | Publication Date |
---|---|
MEP51308A true MEP51308A (bs) | 2011-05-10 |
ME00361B ME00361B (me) | 2011-10-10 |
Family
ID=34530660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2008-513A ME00361B (me) | 2003-11-03 | 2004-10-29 | Postupak za dobijanje soli tiotropijuma |
Country Status (35)
Country | Link |
---|---|
US (1) | US8686148B2 (bs) |
EP (3) | EP1682541B1 (bs) |
JP (1) | JP5165244B2 (bs) |
KR (1) | KR20060117334A (bs) |
CN (3) | CN100549010C (bs) |
AR (1) | AR046317A1 (bs) |
AT (1) | ATE460414T1 (bs) |
AU (1) | AU2004285683C1 (bs) |
BR (1) | BRPI0416136A (bs) |
CA (1) | CA2544348A1 (bs) |
CO (1) | CO5690553A2 (bs) |
CY (2) | CY1110048T1 (bs) |
DE (1) | DE502004010885D1 (bs) |
DK (2) | DK2067779T3 (bs) |
EA (1) | EA012326B1 (bs) |
ES (2) | ES2342468T3 (bs) |
HK (3) | HK1099748A1 (bs) |
HR (1) | HRP20100149T1 (bs) |
IL (1) | IL175023A (bs) |
ME (1) | ME00361B (bs) |
MX (1) | MXPA06004697A (bs) |
MY (1) | MY143364A (bs) |
NO (1) | NO335814B1 (bs) |
NZ (1) | NZ547276A (bs) |
PE (1) | PE20050446A1 (bs) |
PL (2) | PL2067779T3 (bs) |
PT (2) | PT1682541E (bs) |
RS (2) | RS20060292A (bs) |
SG (1) | SG137859A1 (bs) |
SI (2) | SI2067779T1 (bs) |
TW (2) | TWI435876B (bs) |
UA (1) | UA82413C2 (bs) |
UY (1) | UY28590A1 (bs) |
WO (1) | WO2005042526A1 (bs) |
ZA (1) | ZA200602342B (bs) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2067779T1 (sl) | 2003-11-03 | 2013-08-30 | Boehringer Ingelheim International Gmbh | Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo |
RS20060293A (en) * | 2003-11-03 | 2008-08-07 | Boehringer Ingelheim International Gmbh., | Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
WO2006134021A2 (en) * | 2005-06-15 | 2006-12-21 | Boehringer Ingelheim International Gmbh | Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof |
DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
TW200738634A (en) * | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
EP2123650B1 (en) | 2005-12-19 | 2012-04-04 | Sicor, Inc. | Novel form of tiotropium bromide and process for preparation thereof |
KR20080083060A (ko) * | 2006-01-04 | 2008-09-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 중등 지속성 천식의 치료에서 티오트로퓸 염의 용도 |
EP1953156A1 (de) * | 2007-01-29 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopiniumsalzen |
CZ201241A3 (cs) | 2012-01-20 | 2013-07-31 | Zentiva, K.S. | Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy |
EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
JP6042197B2 (ja) * | 2012-12-11 | 2016-12-14 | エア・ウォーター株式会社 | 肺障害治療剤 |
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US2597329A (en) * | 1947-08-06 | 1952-05-20 | Merck & Co Inc | Process for anion exchange of thiamin salts |
US3551492A (en) * | 1967-10-31 | 1970-12-29 | Ciba Geigy Corp | N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof |
US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
JPS6165885A (ja) * | 1984-09-07 | 1986-04-04 | Tanabe Seiyaku Co Ltd | 新規合成中間体及びその製法 |
PH26882A (en) | 1985-07-30 | 1992-11-16 | Glaxo Group Ltd | Devices for administering medicaments to patients |
US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
JP3302647B2 (ja) * | 1992-04-24 | 2002-07-15 | 小野薬品工業株式会社 | フェニルアルカン酸エステルの塩酸塩、およびその製造方法 |
DE4318455A1 (de) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
JP4023086B2 (ja) | 1999-12-27 | 2007-12-19 | 和光純薬工業株式会社 | スルホニウム塩化合物 |
US6908928B2 (en) * | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
UA75375C2 (en) | 2000-10-12 | 2006-04-17 | Boehringer Ingelheim Pharma | Method for producing powdery preparations for inhaling |
NZ525733A (en) | 2000-10-12 | 2005-01-28 | Boehringer Ingelheim Pharma | Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament |
DZ3477A1 (bs) * | 2000-10-12 | 2002-04-18 | ||
US20020137764A1 (en) * | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
UA78690C2 (uk) * | 2000-10-31 | 2007-04-25 | Boehringer Ingelheim Pharma | Лікарська композиція для інгаляційного застосування у вигляді розчину із сіллю тіотропію |
US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
US20020111363A1 (en) * | 2000-10-31 | 2002-08-15 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
US20020193393A1 (en) * | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
DE10056104A1 (de) * | 2000-11-13 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
US20020193392A1 (en) * | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
DE10061877A1 (de) * | 2000-12-12 | 2002-06-13 | Basf Ag | Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung |
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US6608055B2 (en) * | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
US6919325B2 (en) * | 2001-09-14 | 2005-07-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts |
DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
GB0203193D0 (en) | 2002-02-11 | 2002-03-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
AU2003201745A1 (en) | 2002-02-11 | 2003-09-04 | Pfizer Limited | Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases |
US20030229227A1 (en) * | 2002-03-16 | 2003-12-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions |
DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
WO2003084509A1 (en) | 2002-04-04 | 2003-10-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulations suitable for inhalation |
US20030235538A1 (en) * | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
UA80123C2 (en) | 2002-04-09 | 2007-08-27 | Boehringer Ingelheim Pharma | Inhalation kit comprising inhalable powder of tiotropium |
DE10216036A1 (de) | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
US6908055B2 (en) * | 2003-02-27 | 2005-06-21 | Tandberg Data Asa | System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel |
US20050030040A1 (en) * | 2003-06-27 | 2005-02-10 | Mitch Budniak | Electrical testing device having voice annunciator |
RS20060293A (en) * | 2003-11-03 | 2008-08-07 | Boehringer Ingelheim International Gmbh., | Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
SI2067779T1 (sl) | 2003-11-03 | 2013-08-30 | Boehringer Ingelheim International Gmbh | Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo |
US7968717B2 (en) * | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
SE0303270L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
DE102004041253A1 (de) * | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen |
WO2006134021A2 (en) * | 2005-06-15 | 2006-12-21 | Boehringer Ingelheim International Gmbh | Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof |
-
2004
- 2004-10-29 SI SI200432055T patent/SI2067779T1/sl unknown
- 2004-10-29 CN CNB2004800325281A patent/CN100549010C/zh active Active
- 2004-10-29 UY UY28590A patent/UY28590A1/es not_active Application Discontinuation
- 2004-10-29 RS YUP-2006/0292A patent/RS20060292A/sr unknown
- 2004-10-29 KR KR1020067010832A patent/KR20060117334A/ko not_active Application Discontinuation
- 2004-10-29 NZ NZ547276A patent/NZ547276A/xx unknown
- 2004-10-29 EA EA200600886A patent/EA012326B1/ru not_active IP Right Cessation
- 2004-10-29 PL PL09153379T patent/PL2067779T3/pl unknown
- 2004-10-29 EP EP04791028A patent/EP1682541B1/de active Active
- 2004-10-29 AT AT04791028T patent/ATE460414T1/de active
- 2004-10-29 EP EP10180163A patent/EP2336126A1/de not_active Withdrawn
- 2004-10-29 PT PT04791028T patent/PT1682541E/pt unknown
- 2004-10-29 ES ES04791028T patent/ES2342468T3/es active Active
- 2004-10-29 EP EP09153379.4A patent/EP2067779B9/de active Active
- 2004-10-29 ME MEP-2008-513A patent/ME00361B/me unknown
- 2004-10-29 DK DK09153379.4T patent/DK2067779T3/da active
- 2004-10-29 DE DE502004010885T patent/DE502004010885D1/de active Active
- 2004-10-29 DK DK04791028.6T patent/DK1682541T3/da active
- 2004-10-29 PE PE2004001045A patent/PE20050446A1/es not_active Application Discontinuation
- 2004-10-29 CN CN2010105807004A patent/CN102070630B/zh active Active
- 2004-10-29 SI SI200431403T patent/SI1682541T1/sl unknown
- 2004-10-29 WO PCT/EP2004/012268 patent/WO2005042526A1/de active Application Filing
- 2004-10-29 SG SG200718011-0A patent/SG137859A1/en unknown
- 2004-10-29 JP JP2006537207A patent/JP5165244B2/ja active Active
- 2004-10-29 US US10/977,753 patent/US8686148B2/en active Active
- 2004-10-29 PL PL04791028T patent/PL1682541T3/pl unknown
- 2004-10-29 MX MXPA06004697A patent/MXPA06004697A/es active IP Right Grant
- 2004-10-29 ES ES09153379T patent/ES2422729T3/es active Active
- 2004-10-29 CA CA002544348A patent/CA2544348A1/en not_active Abandoned
- 2004-10-29 AU AU2004285683A patent/AU2004285683C1/en active Active
- 2004-10-29 RS RS20060292A patent/RS51758B/en unknown
- 2004-10-29 UA UAA200605764A patent/UA82413C2/uk unknown
- 2004-10-29 BR BRPI0416136-0A patent/BRPI0416136A/pt not_active IP Right Cessation
- 2004-10-29 CN CN2008101664856A patent/CN101407514B/zh active Active
- 2004-10-29 PT PT91533794T patent/PT2067779E/pt unknown
- 2004-11-01 MY MYPI20044526A patent/MY143364A/en unknown
- 2004-11-02 TW TW101107080A patent/TWI435876B/zh active
- 2004-11-02 TW TW093133283A patent/TWI363758B/zh active
- 2004-11-03 AR ARP040104038A patent/AR046317A1/es unknown
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2006
- 2006-03-22 ZA ZA200602342A patent/ZA200602342B/en unknown
- 2006-03-30 NO NO20061440A patent/NO335814B1/no unknown
- 2006-04-20 IL IL175023A patent/IL175023A/en active IP Right Grant
- 2006-05-02 CO CO06041171A patent/CO5690553A2/es not_active Application Discontinuation
-
2007
- 2007-05-25 HK HK07105532.7A patent/HK1099748A1/xx unknown
- 2007-05-25 HK HK09108607.9A patent/HK1129111A1/xx unknown
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2010
- 2010-03-16 HR HR20100149T patent/HRP20100149T1/hr unknown
- 2010-05-17 CY CY20101100435T patent/CY1110048T1/el unknown
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2011
- 2011-07-26 HK HK11107748.7A patent/HK1153409A1/xx unknown
-
2013
- 2013-07-17 CY CY20131100607T patent/CY1114157T1/el unknown
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