MEP10509A - Postupak za dobijanje n-alkilnaltrekson halida - Google Patents

Postupak za dobijanje n-alkilnaltrekson halida

Info

Publication number
MEP10509A
MEP10509A MEP-105/09A MEP10509A MEP10509A ME P10509 A MEP10509 A ME P10509A ME P10509 A MEP10509 A ME P10509A ME P10509 A MEP10509 A ME P10509A
Authority
ME
Montenegro
Prior art keywords
carbonate
halides
preparing
reacting
reaction medium
Prior art date
Application number
MEP-105/09A
Other languages
English (en)
Inventor
Alain Dlubala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ME00613B publication Critical patent/ME00613B/me
Publication of MEP10509A publication Critical patent/MEP10509A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ovaj pronalazak se odnosi na novi postupak za dobijanje N-meti lnaltrekson bromida, koji sadrži najmanje korake koji se sastoje od: (i) reakcije N- meti lnaltrekson meti l sulfata u vodenom rastvoru sa nekim alkalnim reagensom koje se bira iz grupe koju čine natrijum karbonat, kalijum karbonat, kalcijum karbonat, magnezijum karbonat, cezijum karbonat,i stroncijum karbonat, i njihove smješe, pri pH vodene reakcione sredine između 7 i 10, i zati m od (ii) reakcije tako dobijenog proizvoda sa bromovodoničnom kisjelinom pri pH vodene reakcione sredine između 0,5 i 5, i pri tome se dobija N-meti lnaltrekson bromida.
MEP-105/09A 2006-09-21 2007-09-19 Postupak za dobijanje n-alkilnaltrekson halida MEP10509A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone
PCT/FR2007/001516 WO2008034973A1 (fr) 2006-09-21 2007-09-19 Procede de preparation d'halogenures de n-alkyl naltrexone

Publications (2)

Publication Number Publication Date
ME00613B ME00613B (me) 2011-12-20
MEP10509A true MEP10509A (bs) 2011-12-20

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-105/09A MEP10509A (bs) 2006-09-21 2007-09-19 Postupak za dobijanje n-alkilnaltrekson halida

Country Status (36)

Country Link
US (2) US7645880B2 (bs)
EP (1) EP2069362B1 (bs)
JP (1) JP5214615B2 (bs)
KR (1) KR101434693B1 (bs)
CN (2) CN101516892B (bs)
AR (1) AR062918A1 (bs)
AU (1) AU2007298855B2 (bs)
BR (1) BRPI0718440A2 (bs)
CA (1) CA2663509C (bs)
CL (1) CL2007002711A1 (bs)
CO (1) CO6170362A2 (bs)
CR (1) CR10660A (bs)
DO (1) DOP2011000307A (bs)
EA (1) EA015426B1 (bs)
ES (1) ES2531093T3 (bs)
FR (1) FR2906252B1 (bs)
GT (1) GT200900060A (bs)
HK (1) HK1135389A1 (bs)
HN (1) HN2009000503A (bs)
IL (1) IL197402A (bs)
JO (1) JO3023B1 (bs)
MA (1) MA30793B1 (bs)
ME (1) MEP10509A (bs)
MX (1) MX2009003084A (bs)
MY (1) MY148094A (bs)
NI (1) NI200900035A (bs)
NO (1) NO20091561L (bs)
NZ (1) NZ575417A (bs)
PE (1) PE20080867A1 (bs)
SV (1) SV2009003192A (bs)
TN (1) TN2009000080A1 (bs)
TW (1) TWI465451B (bs)
UA (1) UA96957C2 (bs)
UY (1) UY30599A1 (bs)
WO (1) WO2008034973A1 (bs)
ZA (1) ZA200901846B (bs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN102325775A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-6-羟基-吗啡喃或(+)-6-氨基-吗啡喃衍生物
NZ595591A (en) 2009-04-24 2013-11-29 Univ Brock Processes for the preparation of morphinane and morphinone compounds
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
SI2635586T1 (sl) 2010-11-05 2017-07-31 H. Lundbeck A/S Metoda za izdelavo naltreksona
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
JP2014526467A (ja) 2011-09-08 2014-10-06 マリンクロッド エルエルシー 中間体の単離なしでのアルカロイドの調製
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
AR090916A1 (es) 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
EP4225312A1 (en) 2020-10-06 2023-08-16 Scilex Holding Company Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
EP1562953B1 (en) * 2002-11-08 2009-09-30 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
CN101516892A (zh) 2009-08-26
CA2663509A1 (fr) 2008-03-27
US8288547B2 (en) 2012-10-16
SV2009003192A (es) 2009-10-27
TWI465451B (zh) 2014-12-21
NZ575417A (en) 2011-09-30
ES2531093T3 (es) 2015-03-10
TN2009000080A1 (en) 2010-08-19
NO20091561L (no) 2009-06-16
JO3023B1 (ar) 2016-09-05
CA2663509C (fr) 2014-03-18
UA96957C2 (ru) 2011-12-26
FR2906252B1 (fr) 2008-11-28
CO6170362A2 (es) 2010-06-18
CR10660A (es) 2009-06-24
HN2009000503A (es) 2011-03-02
GT200900060A (es) 2011-01-04
AU2007298855B2 (en) 2012-09-13
PE20080867A1 (es) 2008-08-22
US20100145051A1 (en) 2010-06-10
AU2007298855A1 (en) 2008-03-27
EP2069362A1 (fr) 2009-06-17
JP2010504308A (ja) 2010-02-12
KR20090057031A (ko) 2009-06-03
IL197402A0 (en) 2009-12-24
US20080214817A1 (en) 2008-09-04
MX2009003084A (es) 2009-04-02
ZA200901846B (en) 2010-07-28
UY30599A1 (es) 2008-05-02
MA30793B1 (fr) 2009-10-01
DOP2011000307A (es) 2011-10-31
FR2906252A1 (fr) 2008-03-28
ME00613B (me) 2011-12-20
NI200900035A (es) 2010-01-26
IL197402A (en) 2012-12-31
EP2069362B1 (fr) 2014-07-09
TW200821314A (en) 2008-05-16
EA015426B1 (ru) 2011-08-30
BRPI0718440A2 (pt) 2013-11-19
EA200970307A1 (ru) 2009-12-30
HK1135389A1 (en) 2010-06-04
WO2008034973A1 (fr) 2008-03-27
CN101516892B (zh) 2012-06-20
CN102225939A (zh) 2011-10-26
CL2007002711A1 (es) 2008-04-18
MY148094A (en) 2013-02-28
US7645880B2 (en) 2010-01-12
KR101434693B1 (ko) 2014-08-27
JP5214615B2 (ja) 2013-06-19
AR062918A1 (es) 2008-12-17

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