MXPA04000923A - Resinas de alcohol de tritilo, cargadas con aminoacidos, metodo de produccion de estas resinas de alcohol de tritilo, cargadas con aminoacidos, y las sustancias biologicamente activas y los agentes terapeuticos producidos con las mismas. - Google Patents

Resinas de alcohol de tritilo, cargadas con aminoacidos, metodo de produccion de estas resinas de alcohol de tritilo, cargadas con aminoacidos, y las sustancias biologicamente activas y los agentes terapeuticos producidos con las mismas.

Info

Publication number
MXPA04000923A
MXPA04000923A MXPA04000923A MXPA04000923A MXPA04000923A MX PA04000923 A MXPA04000923 A MX PA04000923A MX PA04000923 A MXPA04000923 A MX PA04000923A MX PA04000923 A MXPA04000923 A MX PA04000923A MX PA04000923 A MXPA04000923 A MX PA04000923A
Authority
MX
Mexico
Prior art keywords
amino acid
alcohol resins
trityl alcohol
acid loaded
biologically active
Prior art date
Application number
MXPA04000923A
Other languages
English (en)
Inventor
Andrew Ziarno Witold
Original Assignee
Rohm & Haas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohm & Haas filed Critical Rohm & Haas
Publication of MXPA04000923A publication Critical patent/MXPA04000923A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a un proceso para obtener una sustancia activa biologicamente o un agente terapeutico, libre de una resina enlazadora de cloruro de clorotritilo. El proceso incluye reaccionar un aminoacido activado o un derivado de un aminoacido activado, con una resina de alcohol de tritilo, sustituida o insustituida, para obtener un producto de la resina CT-AA; y reaccionar este producto de la resina CT-AA con otros bloques de formacion de la sustancia activa biologicamente o el agente terapeutico, para obtener dicha sustancia activa biologicamente o el agente terapeutico. Un producto creado por este proceso taimen se proporciona aqui. La presente invencion es particularmente util para crear agentes terapeuticos de los peptidos T-20 y T-1249.
MXPA04000923A 2003-02-12 2004-01-29 Resinas de alcohol de tritilo, cargadas con aminoacidos, metodo de produccion de estas resinas de alcohol de tritilo, cargadas con aminoacidos, y las sustancias biologicamente activas y los agentes terapeuticos producidos con las mismas. MXPA04000923A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44720203P 2003-02-12 2003-02-12

Publications (1)

Publication Number Publication Date
MXPA04000923A true MXPA04000923A (es) 2004-08-16

Family

ID=32825419

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000923A MXPA04000923A (es) 2003-02-12 2004-01-29 Resinas de alcohol de tritilo, cargadas con aminoacidos, metodo de produccion de estas resinas de alcohol de tritilo, cargadas con aminoacidos, y las sustancias biologicamente activas y los agentes terapeuticos producidos con las mismas.

Country Status (10)

Country Link
US (1) US20040158037A1 (es)
EP (1) EP1447408A1 (es)
JP (1) JP2004262925A (es)
KR (1) KR20040073389A (es)
CN (1) CN1520827A (es)
AU (1) AU2004200374A1 (es)
BR (1) BRPI0400343A (es)
CA (1) CA2453809A1 (es)
MX (1) MXPA04000923A (es)
TW (1) TW200418894A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007248855A1 (en) 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198531A (en) * 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
DE4306839A1 (de) * 1993-03-05 1994-09-08 Bayer Ernst Prof Dr Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
EP1303559A4 (en) * 2000-07-14 2004-06-30 Mimotopes Pty Ltd ACTIVATED, PROPFCOPOLYMERIZED SURFACES IN MODULAR DESIGN

Also Published As

Publication number Publication date
US20040158037A1 (en) 2004-08-12
KR20040073389A (ko) 2004-08-19
CN1520827A (zh) 2004-08-18
BRPI0400343A (pt) 2005-01-04
AU2004200374A1 (en) 2004-08-26
TW200418894A (en) 2004-10-01
JP2004262925A (ja) 2004-09-24
CA2453809A1 (en) 2004-08-12
EP1447408A1 (en) 2004-08-18

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